GREMLIN Database
Q9HMP6 - Uncharacterized protein
UniProt: Q9HMP6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (159)
Sequences: 2626 (2044)
Seq/√Len: 162.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_L173_A3.5611.00
63_V115_L3.3921.00
55_A172_H3.3881.00
65_A139_V2.9751.00
35_A56_V2.8891.00
53_R76_A2.6091.00
35_A59_A2.5631.00
113_I137_I2.4951.00
114_A135_A2.4491.00
148_L155_V2.3401.00
50_G76_A2.3051.00
36_V139_V2.2481.00
64_H86_A2.0671.00
59_A174_T2.0451.00
57_A185_A2.0371.00
159_P173_A1.9971.00
65_A115_L1.9221.00
61_A85_H1.8501.00
140_S156_L1.8361.00
143_T158_N1.7551.00
33_M176_H1.7431.00
37_L56_V1.7411.00
101_P105_T1.7111.00
76_A80_A1.6851.00
64_H68_F1.6671.00
68_F86_A1.6581.00
146_P171_A1.6471.00
70_T91_A1.6371.00
71_E75_D1.6211.00
56_V62_V1.6161.00
167_G171_A1.6151.00
85_H104_R1.5571.00
189_R192_D1.5521.00
112_R136_D1.5441.00
44_T72_S1.5361.00
115_L139_V1.5361.00
40_T162_H1.5301.00
126_L129_F1.5291.00
107_T112_R1.5171.00
76_A79_D1.5171.00
107_T110_G1.4971.00
38_A141_G1.4871.00
40_T64_H1.4831.00
50_G54_Q1.4511.00
118_R143_T1.4111.00
68_F73_S1.4101.00
62_V84_L1.4071.00
33_M174_T1.4011.00
34_I61_A1.3801.00
37_L52_A1.3531.00
186_I189_R1.3361.00
111_L136_D1.3361.00
36_V175_L1.3001.00
92_D96_V1.2941.00
105_T112_R1.2341.00
88_H93_S1.2201.00
38_A65_A1.2171.00
167_G186_I1.2141.00
90_N142_H1.1891.00
55_A185_A1.1891.00
35_A52_A1.1811.00
43_D48_L1.1681.00
139_V175_L1.1441.00
40_T49_T1.1351.00
106_I113_I1.1271.00
91_A164_D1.1221.00
80_A83_R1.1181.00
126_L130_G1.1131.00
184_I189_R1.0881.00
56_V59_A1.0290.99
44_T50_G1.0180.99
36_V157_L1.0060.99
191_G194_I0.9990.99
45_D194_I0.9980.99
139_V159_P0.9940.99
51_H55_A0.9910.99
39_D144_H0.9830.99
91_A166_R0.9820.99
101_P104_R0.9650.99
56_V172_H0.9630.99
105_T135_A0.9600.99
80_A84_L0.9590.99
113_I177_P0.9550.99
176_H183_R0.9470.99
120_P126_L0.9460.99
37_L40_T0.9380.99
33_M60_D0.9380.99
37_L64_H0.9370.99
69_T91_A0.9360.99
190_D193_T0.9330.98
44_T76_A0.9320.98
185_A189_R0.9290.98
41_H144_H0.9280.98
135_A138_V0.9240.98
98_D101_P0.9220.98
171_A186_I0.9200.98
37_L62_V0.9140.98
93_S97_R0.9130.98
92_D95_A0.9110.98
140_S143_T0.9110.98
52_A170_A0.9050.98
140_S147_T0.9020.98
150_T153_T0.8950.98
48_L163_A0.8950.98
43_D163_A0.8910.98
48_L162_H0.8900.98
161_S165_P0.8900.98
36_V63_V0.8890.98
150_T155_V0.8860.98
100_L104_R0.8780.98
104_R115_L0.8700.98
125_A128_L0.8690.98
42_S163_A0.8690.98
87_V108_T0.8500.97
111_L180_H0.8480.97
120_P123_D0.8450.97
35_A62_V0.8450.97
55_A187_S0.8330.97
174_T185_A0.8240.97
130_G154_A0.8000.96
67_D90_N0.7990.96
45_D50_G0.7820.96
92_D171_A0.7780.95
75_D78_H0.7770.95
148_L184_I0.7760.95
73_S76_A0.7670.95
120_P124_T0.7580.95
109_A180_H0.7550.95
35_A55_A0.7530.94
172_H187_S0.7510.94
137_I175_L0.7480.94
52_A56_V0.7430.94
101_P110_G0.7400.94
128_L132_E0.7390.94
141_G159_P0.7370.94
32_P176_H0.7320.94
188_T192_D0.7290.93
61_A110_G0.7180.93
37_L49_T0.7170.93
35_A172_H0.7060.92
49_T163_A0.7030.92
34_I175_L0.7010.92
43_D69_T0.6980.92
112_R134_G0.6880.91
52_A187_S0.6880.91
123_D149_T0.6880.91
69_T74_L0.6810.91
88_H96_V0.6760.91
139_V157_L0.6750.91
69_T92_D0.6740.91
75_D99_R0.6680.90
146_P173_A0.6610.90
37_L77_F0.6600.90
74_L100_L0.6590.90
52_A162_H0.6590.90
88_H101_P0.6570.89
142_H166_R0.6570.89
39_D90_N0.6550.89
122_G126_L0.6550.89
116_T140_S0.6520.89
103_A114_A0.6490.89
71_E74_L0.6480.89
34_I177_P0.6470.89
68_F88_H0.6470.89
111_L177_P0.6460.89
36_V159_P0.6440.88
87_V92_D0.6430.88
37_L153_T0.6420.88
137_I155_V0.6400.88
189_R194_I0.6370.88
68_F84_L0.6360.88
44_T163_A0.6350.88
127_S151_T0.6340.88
122_G125_A0.6320.88
110_G180_H0.6200.87
129_F132_E0.6200.87
77_F84_L0.6130.86
45_D193_T0.6120.86
48_L170_A0.6110.86
146_P186_I0.6100.86
35_A57_A0.6080.85
92_D186_I0.6040.85
35_A58_D0.6040.85
147_T156_L0.6020.85
103_A116_T0.6010.85
77_F100_L0.5980.85
72_S76_A0.5930.84
178_T181_G0.5910.84
157_L182_V0.5900.84
189_R193_T0.5900.84
70_T164_D0.5900.84
73_S169_P0.5880.84
127_S131_R0.5870.83
32_P177_P0.5860.83
118_R165_P0.5840.83
63_V106_I0.5810.83
130_G138_V0.5800.83
186_I191_G0.5740.82
185_A190_D0.5720.82
70_T166_R0.5690.82
187_S190_D0.5670.81
121_G125_A0.5670.81
116_T166_R0.5640.81
61_A108_T0.5630.81
148_L157_L0.5610.81
38_A64_H0.5580.80
116_T138_V0.5550.80
107_T180_H0.5540.80
133_R138_V0.5520.80
52_A172_H0.5520.80
58_D134_G0.5500.79
164_D169_P0.5480.79
52_A55_A0.5460.79
61_A84_L0.5460.79
109_A177_P0.5440.79
88_H97_R0.5370.78
130_G152_P0.5360.78
36_V105_T0.5350.77
155_V184_I0.5340.77
67_D142_H0.5330.77
41_H142_H0.5310.77
42_S45_D0.5270.76
38_A161_S0.5260.76
146_P184_I0.5250.76
165_P170_A0.5210.76
119_E172_H0.5190.75
49_T73_S0.5170.75
54_Q153_T0.5170.75
35_A174_T0.5160.75
118_R158_N0.5130.74
43_D189_R0.5060.73
91_A94_P0.5040.73
88_H102_P0.5040.73
61_A83_R0.5030.73
58_D152_P0.5030.73
42_S49_T0.5030.73
138_V156_L0.5010.73
125_A129_F0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nnwA 2 0.8366 100 0.428 Contact Map
3qfmA 2 0.8366 100 0.438 Contact Map
3rqzA 1 0.8416 100 0.453 Contact Map
2kknA 1 0.7475 100 0.469 Contact Map
1z2wA 2 0.8317 100 0.478 Contact Map
3ck2A 1 0.8168 100 0.483 Contact Map
2a22A 1 0.9109 100 0.486 Contact Map
1s3lA 1 0.7525 100 0.486 Contact Map
1su1A 3 0.802 100 0.502 Contact Map
1uf3A 6 0.7574 99.9 0.546 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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