Q9HMP6 - HALSA - GREMLIN Contacts

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Q9HMP6 - Uncharacterized protein

UniProt:	Q9HMP6	Sequences: MAYSGPPKHHAQPSGPHHRPQRSHAPTHYATPMIAVLADTHSDTDHALTGHARQAVADADAVVHAGDFTTESSLDAFHDAATRLHAVHGNADSPAVRDRLPPARTITTAGLRIALTHREPGGDTALSLFGRERGADIVVSGHTHTPTLTTTPTAVLLNPGSHADPRGSPAAHATLHPTDHGVRIAISTRDGDTIRSTHVSRD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	202 (159)
Sequences:	2626 (2044)
Seq/√Len:	162.1

ECOLI - YFCE
BACSU - YSNB
HALSA - Q9HMP6 Q9HMV3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_L	173_A	3.561	1.00
63_V	115_L	3.392	1.00
55_A	172_H	3.388	1.00
65_A	139_V	2.975	1.00
35_A	56_V	2.889	1.00
53_R	76_A	2.609	1.00
35_A	59_A	2.563	1.00
113_I	137_I	2.495	1.00
114_A	135_A	2.449	1.00
148_L	155_V	2.340	1.00
50_G	76_A	2.305	1.00
36_V	139_V	2.248	1.00
64_H	86_A	2.067	1.00
59_A	174_T	2.045	1.00
57_A	185_A	2.037	1.00
159_P	173_A	1.997	1.00
65_A	115_L	1.922	1.00
61_A	85_H	1.850	1.00
140_S	156_L	1.836	1.00
143_T	158_N	1.755	1.00
33_M	176_H	1.743	1.00
37_L	56_V	1.741	1.00
101_P	105_T	1.711	1.00
76_A	80_A	1.685	1.00
64_H	68_F	1.667	1.00
68_F	86_A	1.658	1.00
146_P	171_A	1.647	1.00
70_T	91_A	1.637	1.00
71_E	75_D	1.621	1.00
56_V	62_V	1.616	1.00
167_G	171_A	1.615	1.00
85_H	104_R	1.557	1.00
189_R	192_D	1.552	1.00
112_R	136_D	1.544	1.00
44_T	72_S	1.536	1.00
115_L	139_V	1.536	1.00
40_T	162_H	1.530	1.00
126_L	129_F	1.529	1.00
107_T	112_R	1.517	1.00
76_A	79_D	1.517	1.00
107_T	110_G	1.497	1.00
38_A	141_G	1.487	1.00
40_T	64_H	1.483	1.00
50_G	54_Q	1.451	1.00
118_R	143_T	1.411	1.00
68_F	73_S	1.410	1.00
62_V	84_L	1.407	1.00
33_M	174_T	1.401	1.00
34_I	61_A	1.380	1.00
37_L	52_A	1.353	1.00
186_I	189_R	1.336	1.00
111_L	136_D	1.336	1.00
36_V	175_L	1.300	1.00
92_D	96_V	1.294	1.00
105_T	112_R	1.234	1.00
88_H	93_S	1.220	1.00
38_A	65_A	1.217	1.00
167_G	186_I	1.214	1.00
90_N	142_H	1.189	1.00
55_A	185_A	1.189	1.00
35_A	52_A	1.181	1.00
43_D	48_L	1.168	1.00
139_V	175_L	1.144	1.00
40_T	49_T	1.135	1.00
106_I	113_I	1.127	1.00
91_A	164_D	1.122	1.00
80_A	83_R	1.118	1.00
126_L	130_G	1.113	1.00
184_I	189_R	1.088	1.00
56_V	59_A	1.029	0.99
44_T	50_G	1.018	0.99
36_V	157_L	1.006	0.99
191_G	194_I	0.999	0.99
45_D	194_I	0.998	0.99
139_V	159_P	0.994	0.99
51_H	55_A	0.991	0.99
39_D	144_H	0.983	0.99
91_A	166_R	0.982	0.99
101_P	104_R	0.965	0.99
56_V	172_H	0.963	0.99
105_T	135_A	0.960	0.99
80_A	84_L	0.959	0.99
113_I	177_P	0.955	0.99
176_H	183_R	0.947	0.99
120_P	126_L	0.946	0.99
37_L	40_T	0.938	0.99
33_M	60_D	0.938	0.99
37_L	64_H	0.937	0.99
69_T	91_A	0.936	0.99
190_D	193_T	0.933	0.98
44_T	76_A	0.932	0.98
185_A	189_R	0.929	0.98
41_H	144_H	0.928	0.98
135_A	138_V	0.924	0.98
98_D	101_P	0.922	0.98
171_A	186_I	0.920	0.98
37_L	62_V	0.914	0.98
93_S	97_R	0.913	0.98
92_D	95_A	0.911	0.98
140_S	143_T	0.911	0.98
52_A	170_A	0.905	0.98
140_S	147_T	0.902	0.98
150_T	153_T	0.895	0.98
48_L	163_A	0.895	0.98
43_D	163_A	0.891	0.98
48_L	162_H	0.890	0.98
161_S	165_P	0.890	0.98
36_V	63_V	0.889	0.98
150_T	155_V	0.886	0.98
100_L	104_R	0.878	0.98
104_R	115_L	0.870	0.98
125_A	128_L	0.869	0.98
42_S	163_A	0.869	0.98
87_V	108_T	0.850	0.97
111_L	180_H	0.848	0.97
120_P	123_D	0.845	0.97
35_A	62_V	0.845	0.97
55_A	187_S	0.833	0.97
174_T	185_A	0.824	0.97
130_G	154_A	0.800	0.96
67_D	90_N	0.799	0.96
45_D	50_G	0.782	0.96
92_D	171_A	0.778	0.95
75_D	78_H	0.777	0.95
148_L	184_I	0.776	0.95
73_S	76_A	0.767	0.95
120_P	124_T	0.758	0.95
109_A	180_H	0.755	0.95
35_A	55_A	0.753	0.94
172_H	187_S	0.751	0.94
137_I	175_L	0.748	0.94
52_A	56_V	0.743	0.94
101_P	110_G	0.740	0.94
128_L	132_E	0.739	0.94
141_G	159_P	0.737	0.94
32_P	176_H	0.732	0.94
188_T	192_D	0.729	0.93
61_A	110_G	0.718	0.93
37_L	49_T	0.717	0.93
35_A	172_H	0.706	0.92
49_T	163_A	0.703	0.92
34_I	175_L	0.701	0.92
43_D	69_T	0.698	0.92
112_R	134_G	0.688	0.91
52_A	187_S	0.688	0.91
123_D	149_T	0.688	0.91
69_T	74_L	0.681	0.91
88_H	96_V	0.676	0.91
139_V	157_L	0.675	0.91
69_T	92_D	0.674	0.91
75_D	99_R	0.668	0.90
146_P	173_A	0.661	0.90
37_L	77_F	0.660	0.90
74_L	100_L	0.659	0.90
52_A	162_H	0.659	0.90
88_H	101_P	0.657	0.89
142_H	166_R	0.657	0.89
39_D	90_N	0.655	0.89
122_G	126_L	0.655	0.89
116_T	140_S	0.652	0.89
103_A	114_A	0.649	0.89
71_E	74_L	0.648	0.89
34_I	177_P	0.647	0.89
68_F	88_H	0.647	0.89
111_L	177_P	0.646	0.89
36_V	159_P	0.644	0.88
87_V	92_D	0.643	0.88
37_L	153_T	0.642	0.88
137_I	155_V	0.640	0.88
189_R	194_I	0.637	0.88
68_F	84_L	0.636	0.88
44_T	163_A	0.635	0.88
127_S	151_T	0.634	0.88
122_G	125_A	0.632	0.88
110_G	180_H	0.620	0.87
129_F	132_E	0.620	0.87
77_F	84_L	0.613	0.86
45_D	193_T	0.612	0.86
48_L	170_A	0.611	0.86
146_P	186_I	0.610	0.86
35_A	57_A	0.608	0.85
92_D	186_I	0.604	0.85
35_A	58_D	0.604	0.85
147_T	156_L	0.602	0.85
103_A	116_T	0.601	0.85
77_F	100_L	0.598	0.85
72_S	76_A	0.593	0.84
178_T	181_G	0.591	0.84
157_L	182_V	0.590	0.84
189_R	193_T	0.590	0.84
70_T	164_D	0.590	0.84
73_S	169_P	0.588	0.84
127_S	131_R	0.587	0.83
32_P	177_P	0.586	0.83
118_R	165_P	0.584	0.83
63_V	106_I	0.581	0.83
130_G	138_V	0.580	0.83
186_I	191_G	0.574	0.82
185_A	190_D	0.572	0.82
70_T	166_R	0.569	0.82
187_S	190_D	0.567	0.81
121_G	125_A	0.567	0.81
116_T	166_R	0.564	0.81
61_A	108_T	0.563	0.81
148_L	157_L	0.561	0.81
38_A	64_H	0.558	0.80
116_T	138_V	0.555	0.80
107_T	180_H	0.554	0.80
133_R	138_V	0.552	0.80
52_A	172_H	0.552	0.80
58_D	134_G	0.550	0.79
164_D	169_P	0.548	0.79
52_A	55_A	0.546	0.79
61_A	84_L	0.546	0.79
109_A	177_P	0.544	0.79
88_H	97_R	0.537	0.78
130_G	152_P	0.536	0.78
36_V	105_T	0.535	0.77
155_V	184_I	0.534	0.77
67_D	142_H	0.533	0.77
41_H	142_H	0.531	0.77
42_S	45_D	0.527	0.76
38_A	161_S	0.526	0.76
146_P	184_I	0.525	0.76
165_P	170_A	0.521	0.76
119_E	172_H	0.519	0.75
49_T	73_S	0.517	0.75
54_Q	153_T	0.517	0.75
35_A	174_T	0.516	0.75
118_R	158_N	0.513	0.74
43_D	189_R	0.506	0.73
91_A	94_P	0.504	0.73
88_H	102_P	0.504	0.73
61_A	83_R	0.503	0.73
58_D	152_P	0.503	0.73
42_S	49_T	0.503	0.73
138_V	156_L	0.501	0.73
125_A	129_F	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nnwA	2	0.8366	100	0.428	Contact Map
3qfmA	2	0.8366	100	0.438	Contact Map
3rqzA	1	0.8416	100	0.453	Contact Map
2kknA	1	0.7475	100	0.469	Contact Map
1z2wA	2	0.8317	100	0.478	Contact Map
3ck2A	1	0.8168	100	0.483	Contact Map
2a22A	1	0.9109	100	0.486	Contact Map
1s3lA	1	0.7525	100	0.486	Contact Map
1su1A	3	0.802	100	0.502	Contact Map
1uf3A	6	0.7574	99.9	0.546	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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