GREMLIN Database
Q9HMP5 - Uncharacterized protein
UniProt: Q9HMP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (195)
Sequences: 157 (142)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_V190_G4.9721.00
54_P76_E3.5030.97
75_L122_L3.4380.97
87_R91_K3.2410.95
83_E96_S3.1390.95
58_A62_E3.1300.94
89_S92_G2.4630.83
81_V200_G2.4220.82
23_V104_P2.2430.77
23_V125_L2.1990.75
21_V58_A2.1470.74
65_L91_K2.1210.73
64_S67_N2.1140.72
64_S95_M1.9750.67
43_I46_A1.9680.67
78_A86_T1.9480.66
34_A70_Y1.9470.66
138_A142_V1.8670.62
20_V125_L1.8590.62
41_R64_S1.8550.62
21_V87_R1.8420.61
32_L91_K1.7460.57
55_S62_E1.7360.56
184_E192_L1.7000.55
28_A71_H1.6940.55
100_A106_V1.6900.54
186_V191_G1.6740.54
79_A107_L1.6720.54
131_A135_A1.6720.54
10_E61_M1.6570.53
23_V197_L1.6560.53
72_L81_V1.6560.53
48_H100_A1.6050.50
150_V169_D1.6040.50
25_S115_G1.6010.50
18_P109_A1.5910.50
44_Y65_L1.5840.49
46_A63_T1.5820.49
12_S131_A1.5520.48
48_H69_Q1.5260.47
27_D111_S1.5170.46
48_H102_D1.5040.46
18_P33_S1.4060.41
62_E72_L1.3960.41
88_Y94_E1.3880.41
52_S57_L1.3860.40
118_V195_V1.3500.39
53_T64_S1.3460.39
43_I108_F1.3400.38
86_T92_G1.3270.38
85_D97_V1.3260.38
70_Y121_A1.3180.37
19_R67_N1.3160.37
63_T109_A1.3020.37
66_Q95_M1.3010.37
132_V195_V1.2940.36
35_L140_Q1.2920.36
158_A164_A1.2840.36
54_P121_A1.2720.35
55_S59_A1.2710.35
142_V175_M1.2620.35
67_N105_V1.2550.35
135_A187_V1.2450.34
41_R66_Q1.2450.34
81_V188_A1.2330.34
10_E20_V1.2280.34
70_Y130_G1.2090.33
41_R95_M1.1970.32
126_F129_I1.1850.32
32_L93_R1.1820.32
121_A203_I1.1810.32
25_S71_H1.1750.31
154_T166_T1.1750.31
155_G178_A1.1650.31
28_A82_Q1.1640.31
43_I57_L1.1590.31
67_N85_D1.1580.31
19_R88_Y1.1550.31
36_G112_E1.1550.31
68_I176_Q1.1540.31
25_S79_A1.1520.31
176_Q182_L1.1490.30
34_A75_L1.1460.30
14_S122_L1.1230.29
16_D104_P1.1040.29
61_M105_V1.1020.29
89_S94_E1.0970.28
149_G160_A1.0940.28
69_Q102_D1.0860.28
56_E186_V1.0850.28
158_A194_V1.0780.28
65_L69_Q1.0760.28
100_A110_G1.0730.28
67_N88_Y1.0570.27
31_L59_A1.0530.27
20_V107_L1.0430.26
66_Q88_Y1.0410.26
154_T157_A1.0350.26
62_E184_E1.0350.26
71_H191_G1.0240.26
150_V162_P1.0150.25
72_L79_A1.0030.25
39_T92_G0.9980.25
39_T184_E0.9970.25
65_L106_V0.9950.25
26_D77_G0.9920.25
149_G163_G0.9880.25
29_D37_S0.9810.24
46_A144_G0.9740.24
107_L188_A0.9730.24
178_A193_L0.9690.24
171_V176_Q0.9660.24
152_I183_R0.9560.23
26_D65_L0.9490.23
79_A123_S0.9470.23
32_L67_N0.9430.23
165_A168_W0.9420.23
68_I192_L0.9330.23
25_S32_L0.9320.23
20_V91_K0.9260.22
161_A185_A0.9180.22
151_Q154_T0.9180.22
72_L127_G0.9150.22
120_A180_Y0.9150.22
20_V54_P0.9140.22
11_P14_S0.9020.22
151_Q168_W0.8970.22
75_L92_G0.8960.22
54_P104_P0.8880.21
32_L87_R0.8840.21
34_A90_S0.8830.21
71_H95_M0.8810.21
57_L130_G0.8720.21
74_R107_L0.8690.21
74_R194_V0.8670.21
46_A60_D0.8630.20
24_D71_H0.8630.20
41_R53_T0.8610.20
149_G153_G0.8610.20
22_G117_S0.8600.20
69_Q72_L0.8570.20
39_T118_V0.8440.20
83_E102_D0.8390.20
91_K106_V0.8310.20
51_P187_V0.8250.19
86_T128_G0.8240.19
27_D35_L0.8190.19
34_A78_A0.8170.19
59_A166_T0.8170.19
26_D85_D0.8160.19
157_A171_V0.8150.19
31_L52_S0.8080.19
53_T103_T0.8050.19
77_G89_S0.7970.19
17_G202_V0.7960.19
53_T87_R0.7940.18
67_N127_G0.7940.18
81_V85_D0.7910.18
121_A133_S0.7900.18
67_N109_A0.7900.18
23_V84_C0.7830.18
171_V180_Y0.7820.18
72_L95_M0.7790.18
156_A162_P0.7760.18
16_D79_A0.7750.18
40_A45_A0.7660.18
86_T89_S0.7630.18
160_A177_V0.7620.18
57_L186_V0.7620.18
78_A92_G0.7620.18
124_G189_G0.7580.18
12_S176_Q0.7530.17
157_A163_G0.7520.17
19_R66_Q0.7470.17
153_G185_A0.7460.17
151_Q179_R0.7450.17
44_Y60_D0.7370.17
151_Q171_V0.7350.17
148_S181_G0.7350.17
68_I93_R0.7300.17
16_D21_V0.7250.17
69_Q91_K0.7240.17
158_A161_A0.7240.17
76_E104_P0.7210.17
66_Q92_G0.7160.16
57_L72_L0.7130.16
53_T95_M0.7120.16
119_R147_A0.7060.16
21_V79_A0.7020.16
162_P170_A0.7020.16
108_F192_L0.7010.16
148_S168_W0.7000.16
154_T168_W0.6970.16
35_L74_R0.6940.16
103_T107_L0.6890.16
175_M179_R0.6880.16
17_G126_F0.6870.16
80_L94_E0.6860.16
54_P95_M0.6820.16
148_S164_A0.6800.16
53_T80_L0.6770.15
184_E187_V0.6740.15
54_P191_G0.6720.15
28_A97_V0.6670.15
141_H154_T0.6630.15
116_E197_L0.6620.15
37_S87_R0.6620.15
25_S93_R0.6610.15
55_S80_L0.6610.15
130_G145_G0.6590.15
47_V72_L0.6550.15
41_R62_E0.6450.15
136_T182_L0.6440.15
25_S129_I0.6410.15
82_Q139_V0.6380.15
170_A175_M0.6370.14
29_D109_A0.6370.14
29_D67_N0.6330.14
177_V183_R0.6310.14
19_R69_Q0.6290.14
25_S31_L0.6270.14
47_V69_Q0.6270.14
115_G133_S0.6240.14
54_P65_L0.6240.14
50_T185_A0.6160.14
175_M185_A0.6150.14
53_T96_S0.6130.14
177_V180_Y0.6100.14
116_E203_I0.6080.14
68_I107_L0.6080.14
53_T119_R0.6080.14
43_I87_R0.6070.14
44_Y117_S0.6030.14
40_A195_V0.6010.14
64_S109_A0.6000.14
42_D113_E0.5980.14
11_P119_R0.5960.14
69_Q109_A0.5920.13
115_G121_A0.5910.13
102_D125_L0.5910.13
34_A188_A0.5900.13
174_L182_L0.5900.13
23_V67_N0.5860.13
174_L183_R0.5860.13
26_D126_F0.5840.13
155_G177_V0.5840.13
81_V193_L0.5820.13
179_R182_L0.5760.13
58_A81_V0.5730.13
31_L125_L0.5710.13
55_S88_Y0.5680.13
37_S71_H0.5680.13
142_V157_A0.5660.13
22_G91_K0.5630.13
66_Q97_V0.5610.13
34_A86_T0.5600.13
84_C99_G0.5550.13
156_A169_D0.5540.13
55_S69_Q0.5520.13
131_A167_S0.5510.13
97_V106_V0.5470.13
51_P62_E0.5470.13
47_V105_V0.5440.12
104_P140_Q0.5370.12
99_G202_V0.5330.12
47_V99_G0.5320.12
129_I196_G0.5320.12
51_P94_E0.5310.12
133_S163_G0.5310.12
21_V96_S0.5290.12
37_S95_M0.5290.12
130_G186_V0.5290.12
167_S180_Y0.5280.12
152_I169_D0.5260.12
43_I144_G0.5260.12
67_N95_M0.5250.12
29_D39_T0.5240.12
67_N99_G0.5230.12
20_V131_A0.5220.12
154_T174_L0.5210.12
55_S97_V0.5200.12
68_I82_Q0.5190.12
69_Q125_L0.5180.12
48_H107_L0.5150.12
36_G79_A0.5130.12
153_G166_T0.5120.12
88_Y203_I0.5090.12
138_A171_V0.5060.12
50_T53_T0.5060.12
60_D171_V0.5040.12
21_V183_R0.5020.12
91_K108_F0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f6vA 2 0.4524 99 0.834 Contact Map
1q1hA 1 0.3952 98.9 0.839 Contact Map
4g6qA 4 0.6952 98.9 0.84 Contact Map
4k2eA 2 0.4524 98.7 0.85 Contact Map
1r1tA 2 0.4619 98.7 0.851 Contact Map
2qlzA 2 0.7762 98.7 0.852 Contact Map
2oqgA 4 0.5238 98.6 0.852 Contact Map
1y0uA 2 0.4 98.6 0.853 Contact Map
1u2wA 2 0.5143 98.6 0.853 Contact Map
2zkzA 2 0.419 98.6 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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