Q9HMP3 - HALSA - GREMLIN Contacts

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Q9HMP3 - L-allo-threonine aldolase

UniProt:	Q9HMP3	Sequences: MFRNVTGRMTFPPGGGCPDMIDLRSDTVATPTEAMREAAAQAPVEHGEHGDDPAVAAVEATAADAVGMAAAVFVPSRTMANQIGAQVHTARGQSVLVERASHSYRRGSGGLAQHAGVQARAFDGGETGCPTAEQVAAEITAGGGHRPEVGLACVEIAHGANGGVVAPVDAFAAAVETAHEHDVPVHVDGTRVFSAATALGVDAATLLSPVDSVAVCLSTGLGAPMGAVLAGSESFVASARRVQEMYGGGMQQAGMVAAAGVCALENRHRVHEDHENARRLAEDLDALPGVTAAEPDTNIVLADTRDADVTAAAFLAGCEEEGVLGTADGEYTVRFCTHRDIGGADIAAVVSAAGEVV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	357 (328)
Sequences:	3501 (2378)
Seq/√Len:	131.3

HALSA - Q9HMP3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
175_V	179_H	4.779	1.00
283_D	350_V	4.544	1.00
37_E	41_Q	4.362	1.00
279_R	347_A	4.039	1.00
136_A	180_E	3.711	1.00
276_N	343_G	3.281	1.00
61_T	261_V	3.210	1.00
217_L	260_G	3.048	1.00
152_A	178_A	2.938	1.00
61_T	265_E	2.787	1.00
279_R	343_G	2.718	1.00
99_R	123_D	2.481	1.00
187_V	210_V	2.390	1.00
175_V	185_V	2.374	1.00
135_V	174_A	2.368	1.00
57_A	261_V	2.337	1.00
178_A	185_V	2.324	1.00
342_G	345_D	2.239	1.00
225_M	256_V	2.232	1.00
131_T	134_Q	2.222	1.00
152_A	174_A	2.188	1.00
34_A	268_H	2.165	1.00
281_A	295_P	2.151	1.00
129_C	170_A	2.107	1.00
85_A	151_L	2.097	1.00
272_E	276_N	2.072	1.00
103_S	153_C	2.069	1.00
132_A	177_T	2.036	1.00
212_S	235_F	1.997	1.00
150_G	184_P	1.989	1.00
74_V	83_I	1.946	1.00
32_T	267_R	1.939	1.00
271_H	275_E	1.930	1.00
98_E	124_G	1.902	1.00
291_T	303_D	1.887	1.00
275_E	343_G	1.871	1.00
34_A	266_N	1.846	1.00
104_Y	121_A	1.761	1.00
74_V	80_A	1.739	1.00
90_A	93_Q	1.737	1.00
262_C	266_N	1.717	1.00
185_V	210_V	1.712	1.00
88_H	212_S	1.711	1.00
154_V	171_F	1.706	1.00
168_V	201_V	1.703	1.00
280_L	346_I	1.701	1.00
278_R	282_E	1.693	1.00
37_E	40_A	1.690	1.00
319_E	324_L	1.688	1.00
57_A	265_E	1.682	1.00
172_A	209_P	1.643	1.00
93_Q	148_E	1.637	1.00
202_D	205_T	1.632	1.00
139_I	177_T	1.632	1.00
176_E	180_E	1.623	1.00
136_A	181_H	1.613	1.00
57_A	61_T	1.587	1.00
169_D	173_A	1.582	1.00
60_A	64_D	1.574	1.00
279_R	283_D	1.551	1.00
318_C	352_A	1.534	1.00
56_A	59_E	1.522	1.00
61_T	65_A	1.514	1.00
96_L	135_V	1.490	1.00
55_V	253_A	1.478	1.00
69_A	233_E	1.473	1.00
33_E	37_E	1.470	1.00
193_F	215_V	1.468	1.00
94_S	120_R	1.468	1.00
169_D	172_A	1.464	1.00
261_V	265_E	1.458	1.00
75_P	79_M	1.450	1.00
286_A	354_G	1.446	1.00
348_A	352_A	1.445	1.00
62_A	215_V	1.441	1.00
84_G	229_L	1.439	1.00
192_V	203_A	1.435	1.00
31_P	223_A	1.430	1.00
36_R	40_A	1.428	1.00
93_Q	150_G	1.427	1.00
343_G	347_A	1.426	1.00
67_G	204_A	1.395	1.00
85_A	117_V	1.393	1.00
172_A	176_E	1.391	1.00
165_V	198_A	1.378	1.00
54_A	261_V	1.361	1.00
282_E	286_A	1.346	1.00
187_V	206_L	1.341	1.00
75_P	250_M	1.331	1.00
299_I	336_C	1.324	1.00
280_L	283_D	1.318	1.00
172_A	208_S	1.308	1.00
177_T	181_H	1.306	1.00
277_A	300_V	1.305	1.00
34_A	37_E	1.304	1.00
59_E	240_R	1.304	1.00
139_I	181_H	1.299	1.00
269_R	272_E	1.297	1.00
168_V	172_A	1.292	1.00
276_N	279_R	1.274	1.00
348_A	351_S	1.274	1.00
30_T	340_D	1.273	1.00
302_A	335_F	1.270	1.00
35_M	262_C	1.258	1.00
90_A	238_S	1.257	1.00
133_E	136_A	1.247	1.00
47_G	53_P	1.245	1.00
23_L	349_V	1.242	1.00
154_V	174_A	1.241	1.00
217_L	228_V	1.216	1.00
122_F	138_E	1.209	1.00
111_L	119_A	1.209	1.00
157_A	297_T	1.203	0.99
87_V	235_F	1.203	0.99
55_V	257_A	1.202	0.99
49_H	326_T	1.193	0.99
135_V	177_T	1.191	0.99
156_I	187_V	1.189	0.99
193_F	270_V	1.183	0.99
283_D	286_A	1.177	0.99
89_T	117_V	1.168	0.99
133_E	173_A	1.167	0.99
284_L	335_F	1.154	0.99
262_C	267_R	1.153	0.99
184_P	232_S	1.153	0.99
80_A	214_A	1.148	0.99
205_T	208_S	1.143	0.99
88_H	151_L	1.137	0.99
187_V	213_V	1.136	0.99
86_Q	115_A	1.133	0.99
66_V	203_A	1.129	0.99
212_S	232_S	1.128	0.99
106_R	160_A	1.126	0.99
335_F	349_V	1.125	0.99
170_A	173_A	1.107	0.99
172_A	205_T	1.106	0.99
112_A	118_Q	1.105	0.99
280_L	337_T	1.102	0.99
58_V	261_V	1.099	0.99
82_Q	115_A	1.098	0.99
25_S	28_V	1.091	0.99
71_A	228_V	1.088	0.99
171_F	209_P	1.078	0.99
269_R	339_R	1.074	0.99
47_G	54_A	1.072	0.99
122_F	130_P	1.071	0.99
186_H	212_S	1.069	0.99
94_S	147_P	1.063	0.99
316_A	320_E	1.063	0.99
21_I	345_D	1.062	0.99
88_H	235_F	1.059	0.99
171_F	206_L	1.058	0.99
280_L	335_F	1.058	0.99
220_G	270_V	1.057	0.99
57_A	60_A	1.056	0.99
123_D	134_Q	1.054	0.99
29_A	338_H	1.039	0.98
312_A	316_A	1.039	0.98
144_G	240_R	1.035	0.98
34_A	262_C	1.028	0.98
136_A	177_T	1.020	0.98
288_P	291_T	1.014	0.98
284_L	353_A	1.014	0.98
150_G	183_V	1.013	0.98
61_T	64_D	1.013	0.98
36_R	44_V	1.012	0.98
229_L	239_A	1.012	0.98
66_V	192_V	1.005	0.98
164_V	296_D	1.004	0.98
206_L	209_P	1.004	0.98
30_T	43_P	1.002	0.98
135_V	152_A	1.001	0.98
282_E	285_D	1.001	0.98
66_V	230_A	1.000	0.98
345_D	348_A	1.000	0.98
47_G	254_G	0.998	0.98
145_H	244_E	0.998	0.98
200_G	271_H	0.997	0.98
320_E	323_V	0.991	0.98
113_Q	245_M	0.989	0.98
175_V	209_P	0.985	0.98
42_A	254_G	0.983	0.98
58_V	257_A	0.983	0.98
327_A	330_E	0.978	0.98
66_V	215_V	0.973	0.98
347_A	351_S	0.971	0.98
283_D	346_I	0.970	0.98
306_D	331_Y	0.961	0.97
242_V	245_M	0.956	0.97
132_A	170_A	0.955	0.97
230_A	239_A	0.953	0.97
82_Q	246_Y	0.948	0.97
56_A	60_A	0.947	0.97
171_F	187_V	0.946	0.97
207_L	213_V	0.945	0.97
68_M	230_A	0.941	0.97
285_D	291_T	0.938	0.97
35_M	258_A	0.936	0.97
22_D	28_V	0.921	0.97
97_V	119_A	0.919	0.97
201_V	206_L	0.916	0.97
234_S	237_A	0.915	0.97
142_G	237_A	0.913	0.97
43_P	57_A	0.911	0.97
23_L	346_I	0.910	0.96
130_P	166_A	0.908	0.96
175_V	178_A	0.906	0.96
83_I	242_V	0.904	0.96
46_H	340_D	0.900	0.96
62_A	228_V	0.898	0.96
29_A	340_D	0.896	0.96
63_A	71_A	0.887	0.96
39_A	259_A	0.884	0.96
201_V	205_T	0.883	0.96
59_E	72_V	0.882	0.96
96_L	138_E	0.881	0.96
262_C	265_E	0.878	0.96
287_L	350_V	0.878	0.96
71_A	230_A	0.877	0.96
313_A	316_A	0.876	0.96
108_S	245_M	0.868	0.95
87_V	242_V	0.867	0.95
175_V	210_V	0.867	0.95
285_D	294_E	0.860	0.95
124_G	161_N	0.858	0.95
86_Q	242_V	0.857	0.95
280_L	349_V	0.855	0.95
153_C	186_H	0.855	0.95
65_A	264_L	0.852	0.95
66_V	207_L	0.851	0.95
73_F	256_V	0.844	0.95
129_C	167_P	0.843	0.95
168_V	206_L	0.840	0.95
129_C	166_A	0.838	0.94
88_H	184_P	0.834	0.94
196_A	199_L	0.833	0.94
134_Q	137_A	0.829	0.94
287_L	354_G	0.828	0.94
179_H	185_V	0.828	0.94
108_S	241_R	0.826	0.94
267_R	339_R	0.825	0.94
95_V	119_A	0.824	0.94
32_T	269_R	0.823	0.94
50_G	56_A	0.823	0.94
217_L	222_G	0.821	0.94
199_L	206_L	0.818	0.94
29_A	46_H	0.817	0.94
72_V	239_A	0.810	0.93
38_A	262_C	0.806	0.93
232_S	235_F	0.805	0.93
95_V	103_S	0.805	0.93
325_G	335_F	0.805	0.93
233_E	237_A	0.801	0.93
171_F	175_V	0.800	0.93
86_Q	246_Y	0.797	0.93
318_C	325_G	0.796	0.93
272_E	275_E	0.794	0.93
317_G	320_E	0.789	0.92
87_V	239_A	0.788	0.92
312_A	315_L	0.785	0.92
139_I	183_V	0.785	0.92
166_A	170_A	0.783	0.92
126_E	134_Q	0.783	0.92
48_E	249_G	0.780	0.92
323_V	349_V	0.779	0.92
212_S	230_A	0.774	0.92
279_R	350_V	0.774	0.92
54_A	258_A	0.771	0.92
79_M	248_G	0.769	0.91
233_E	236_V	0.768	0.91
295_P	300_V	0.767	0.91
268_H	271_H	0.754	0.91
58_V	260_G	0.753	0.91
148_E	238_S	0.751	0.91
196_A	206_L	0.749	0.90
122_F	134_Q	0.749	0.90
202_D	206_L	0.748	0.90
176_E	179_H	0.744	0.90
72_V	236_V	0.743	0.90
279_R	346_I	0.742	0.90
207_L	210_V	0.742	0.90
313_A	317_G	0.740	0.90
84_G	228_V	0.740	0.90
283_D	287_L	0.740	0.90
204_A	208_S	0.739	0.90
131_T	170_A	0.738	0.90
74_V	228_V	0.737	0.90
95_V	111_L	0.735	0.90
281_A	294_E	0.734	0.89
168_V	171_F	0.730	0.89
230_A	236_V	0.728	0.89
347_A	350_V	0.727	0.89
197_T	274_H	0.726	0.89
272_E	343_G	0.726	0.89
106_R	146_R	0.725	0.89
253_A	257_A	0.725	0.89
82_Q	110_G	0.723	0.89
100_A	160_A	0.723	0.89
84_G	212_S	0.722	0.89
282_E	347_A	0.721	0.89
76_S	225_M	0.714	0.88
192_V	213_V	0.714	0.88
197_T	270_V	0.713	0.88
317_G	352_A	0.711	0.88
99_R	121_A	0.711	0.88
276_N	341_I	0.711	0.88
89_T	150_G	0.709	0.88
127_T	296_D	0.708	0.88
39_A	256_V	0.707	0.88
127_T	164_V	0.701	0.87
166_A	174_A	0.698	0.87
179_H	211_D	0.698	0.87
344_A	347_A	0.695	0.87
114_H	246_Y	0.689	0.86
45_E	54_A	0.689	0.86
168_V	199_L	0.684	0.86
228_V	260_G	0.683	0.86
278_R	281_A	0.683	0.86
171_F	185_V	0.683	0.86
97_V	103_S	0.682	0.86
281_A	285_D	0.682	0.86
97_V	104_Y	0.682	0.86
105_R	160_A	0.681	0.86
45_E	53_P	0.681	0.86
104_Y	118_Q	0.679	0.86
31_P	36_R	0.677	0.85
143_G	146_R	0.676	0.85
196_A	201_V	0.674	0.85
76_S	250_M	0.674	0.85
136_A	140_T	0.671	0.85
152_A	183_V	0.670	0.85
270_V	274_H	0.668	0.85
149_V	183_V	0.667	0.85
337_T	346_I	0.667	0.85
287_L	353_A	0.666	0.84
124_G	130_P	0.662	0.84
39_A	42_A	0.659	0.84
341_I	346_I	0.658	0.84
278_R	295_P	0.658	0.84
156_I	195_A	0.656	0.84
262_C	339_R	0.656	0.84
157_A	165_V	0.655	0.83
323_V	352_A	0.655	0.83
243_Q	249_G	0.654	0.83
132_A	173_A	0.652	0.83
165_V	296_D	0.652	0.83
322_G	325_G	0.651	0.83
338_H	341_I	0.650	0.83
173_A	176_E	0.647	0.83
65_A	203_A	0.645	0.83
193_F	220_G	0.645	0.83
24_R	28_V	0.644	0.82
53_P	57_A	0.642	0.82
83_I	246_Y	0.641	0.82
326_T	332_T	0.640	0.82
222_G	225_M	0.640	0.82
93_Q	238_S	0.640	0.82
31_P	35_M	0.638	0.82
75_P	83_I	0.638	0.82
171_F	210_V	0.638	0.82
118_Q	147_P	0.637	0.82
222_G	267_R	0.637	0.82
196_A	203_A	0.636	0.82
85_A	111_L	0.635	0.82
194_S	220_G	0.635	0.82
142_G	148_E	0.632	0.81
222_G	263_A	0.631	0.81
152_A	177_T	0.627	0.81
148_E	241_R	0.627	0.81
97_V	101_S	0.627	0.81
83_I	239_A	0.625	0.81
165_V	297_T	0.625	0.81
68_M	207_L	0.625	0.81
275_E	279_R	0.624	0.80
192_V	215_V	0.624	0.80
154_V	185_V	0.623	0.80
170_A	174_A	0.623	0.80
36_R	255_M	0.622	0.80
333_V	353_A	0.621	0.80
42_A	54_A	0.617	0.80
230_A	235_F	0.616	0.80
288_P	292_A	0.616	0.80
40_A	44_V	0.616	0.80
161_N	166_A	0.615	0.79
343_G	346_I	0.609	0.79
99_R	124_G	0.609	0.79
82_Q	111_L	0.609	0.79
152_A	185_V	0.603	0.78
62_A	230_A	0.603	0.78
270_V	273_D	0.603	0.78
63_A	70_A	0.599	0.78
222_G	339_R	0.599	0.78
80_A	229_L	0.598	0.78
95_V	117_V	0.597	0.77
197_T	268_H	0.597	0.77
70_A	236_V	0.596	0.77
72_V	240_R	0.595	0.77
231_G	236_V	0.593	0.77
279_R	282_E	0.593	0.77
203_A	215_V	0.593	0.77
30_T	44_V	0.592	0.77
94_S	140_T	0.592	0.77
315_L	325_G	0.591	0.77
321_E	352_A	0.589	0.76
63_A	69_A	0.587	0.76
131_T	135_V	0.586	0.76
68_M	209_P	0.584	0.76
254_G	258_A	0.583	0.76
32_T	222_G	0.582	0.76
285_D	288_P	0.580	0.75
140_T	147_P	0.579	0.75
216_C	227_A	0.578	0.75
157_A	198_A	0.577	0.75
59_E	243_Q	0.576	0.75
231_G	235_F	0.575	0.75
311_A	331_Y	0.574	0.75
27_T	251_Q	0.573	0.75
36_R	43_P	0.569	0.74
179_H	209_P	0.567	0.74
36_R	39_A	0.566	0.74
123_D	126_E	0.565	0.73
82_Q	247_G	0.563	0.73
91_R	242_V	0.562	0.73
145_H	249_G	0.562	0.73
114_H	245_M	0.562	0.73
65_A	265_E	0.560	0.73
59_E	63_A	0.559	0.73
317_G	321_E	0.558	0.73
100_A	105_R	0.557	0.72
283_D	347_A	0.557	0.72
28_V	338_H	0.556	0.72
311_A	315_L	0.556	0.72
283_D	353_A	0.555	0.72
96_L	183_V	0.552	0.72
167_P	170_A	0.550	0.71
198_A	278_R	0.550	0.71
21_I	348_A	0.550	0.71
48_E	244_E	0.548	0.71
193_F	203_A	0.547	0.71
54_A	254_G	0.544	0.71
57_A	64_D	0.543	0.71
250_M	253_A	0.542	0.70
32_T	262_C	0.541	0.70
62_A	65_A	0.541	0.70
292_A	295_P	0.541	0.70
215_V	264_L	0.541	0.70
228_V	239_A	0.540	0.70
128_G	164_V	0.538	0.70
38_A	41_Q	0.537	0.70
62_A	217_L	0.537	0.70
130_P	154_V	0.535	0.69
349_V	353_A	0.534	0.69
304_T	333_V	0.534	0.69
221_L	226_G	0.531	0.69
318_C	321_E	0.529	0.69
42_A	258_A	0.528	0.68
85_A	103_S	0.528	0.68
42_A	45_E	0.527	0.68
225_M	253_A	0.527	0.68
130_P	134_Q	0.526	0.68
62_A	260_G	0.525	0.68
124_G	127_T	0.525	0.68
87_V	238_S	0.524	0.68
89_T	151_L	0.524	0.68
276_N	342_G	0.523	0.68
94_S	149_V	0.523	0.68
80_A	228_V	0.521	0.67
77_R	227_A	0.521	0.67
192_V	230_A	0.519	0.67
184_P	235_F	0.518	0.67
168_V	207_L	0.518	0.67
71_A	233_E	0.517	0.67
165_V	199_L	0.516	0.67
66_V	204_A	0.516	0.67
195_A	300_V	0.515	0.67
70_A	233_E	0.515	0.67
129_C	164_V	0.515	0.67
130_P	152_A	0.514	0.66
344_A	348_A	0.514	0.66
109_G	118_Q	0.513	0.66
51_D	157_A	0.511	0.66
223_A	226_G	0.511	0.66
90_A	150_G	0.507	0.65
132_A	174_A	0.507	0.65
23_L	341_I	0.507	0.65
75_P	224_P	0.507	0.65
130_P	135_V	0.505	0.65
135_V	185_V	0.505	0.65
299_I	337_T	0.504	0.65
40_A	43_P	0.503	0.65
243_Q	248_G	0.501	0.64
35_M	263_A	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jg8A	4	0.944	100	0.541	Contact Map
1v72A	4	0.93	100	0.597	Contact Map
4lnjA	4	0.9244	100	0.602	Contact Map
3wgcA	4	0.9244	100	0.631	Contact Map
3lwsA	2	0.9524	100	0.643	Contact Map
3pj0A	2	0.9608	100	0.643	Contact Map
2oqxA	4	0.9692	100	0.649	Contact Map
1svvA	4	0.9272	100	0.683	Contact Map
2ez2A	4	0.9692	100	0.696	Contact Map
1ax4A	4	0.9692	100	0.717	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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