GREMLIN Database
Q9HMP3 - L-allo-threonine aldolase
UniProt: Q9HMP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (328)
Sequences: 3501 (2378)
Seq/√Len: 131.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_V179_H4.7791.00
283_D350_V4.5441.00
37_E41_Q4.3621.00
279_R347_A4.0391.00
136_A180_E3.7111.00
276_N343_G3.2811.00
61_T261_V3.2101.00
217_L260_G3.0481.00
152_A178_A2.9381.00
61_T265_E2.7871.00
279_R343_G2.7181.00
99_R123_D2.4811.00
187_V210_V2.3901.00
175_V185_V2.3741.00
135_V174_A2.3681.00
57_A261_V2.3371.00
178_A185_V2.3241.00
342_G345_D2.2391.00
225_M256_V2.2321.00
131_T134_Q2.2221.00
152_A174_A2.1881.00
34_A268_H2.1651.00
281_A295_P2.1511.00
129_C170_A2.1071.00
85_A151_L2.0971.00
272_E276_N2.0721.00
103_S153_C2.0691.00
132_A177_T2.0361.00
212_S235_F1.9971.00
150_G184_P1.9891.00
74_V83_I1.9461.00
32_T267_R1.9391.00
271_H275_E1.9301.00
98_E124_G1.9021.00
291_T303_D1.8871.00
275_E343_G1.8711.00
34_A266_N1.8461.00
104_Y121_A1.7611.00
74_V80_A1.7391.00
90_A93_Q1.7371.00
262_C266_N1.7171.00
185_V210_V1.7121.00
88_H212_S1.7111.00
154_V171_F1.7061.00
168_V201_V1.7031.00
280_L346_I1.7011.00
278_R282_E1.6931.00
37_E40_A1.6901.00
319_E324_L1.6881.00
57_A265_E1.6821.00
172_A209_P1.6431.00
93_Q148_E1.6371.00
202_D205_T1.6321.00
139_I177_T1.6321.00
176_E180_E1.6231.00
136_A181_H1.6131.00
57_A61_T1.5871.00
169_D173_A1.5821.00
60_A64_D1.5741.00
279_R283_D1.5511.00
318_C352_A1.5341.00
56_A59_E1.5221.00
61_T65_A1.5141.00
96_L135_V1.4901.00
55_V253_A1.4781.00
69_A233_E1.4731.00
33_E37_E1.4701.00
193_F215_V1.4681.00
94_S120_R1.4681.00
169_D172_A1.4641.00
261_V265_E1.4581.00
75_P79_M1.4501.00
286_A354_G1.4461.00
348_A352_A1.4451.00
62_A215_V1.4411.00
84_G229_L1.4391.00
192_V203_A1.4351.00
31_P223_A1.4301.00
36_R40_A1.4281.00
93_Q150_G1.4271.00
343_G347_A1.4261.00
67_G204_A1.3951.00
85_A117_V1.3931.00
172_A176_E1.3911.00
165_V198_A1.3781.00
54_A261_V1.3611.00
282_E286_A1.3461.00
187_V206_L1.3411.00
75_P250_M1.3311.00
299_I336_C1.3241.00
280_L283_D1.3181.00
172_A208_S1.3081.00
177_T181_H1.3061.00
277_A300_V1.3051.00
34_A37_E1.3041.00
59_E240_R1.3041.00
139_I181_H1.2991.00
269_R272_E1.2971.00
168_V172_A1.2921.00
276_N279_R1.2741.00
348_A351_S1.2741.00
30_T340_D1.2731.00
302_A335_F1.2701.00
35_M262_C1.2581.00
90_A238_S1.2571.00
133_E136_A1.2471.00
47_G53_P1.2451.00
23_L349_V1.2421.00
154_V174_A1.2411.00
217_L228_V1.2161.00
122_F138_E1.2091.00
111_L119_A1.2091.00
157_A297_T1.2030.99
87_V235_F1.2030.99
55_V257_A1.2020.99
49_H326_T1.1930.99
135_V177_T1.1910.99
156_I187_V1.1890.99
193_F270_V1.1830.99
283_D286_A1.1770.99
89_T117_V1.1680.99
133_E173_A1.1670.99
284_L335_F1.1540.99
262_C267_R1.1530.99
184_P232_S1.1530.99
80_A214_A1.1480.99
205_T208_S1.1430.99
88_H151_L1.1370.99
187_V213_V1.1360.99
86_Q115_A1.1330.99
66_V203_A1.1290.99
212_S232_S1.1280.99
106_R160_A1.1260.99
335_F349_V1.1250.99
170_A173_A1.1070.99
172_A205_T1.1060.99
112_A118_Q1.1050.99
280_L337_T1.1020.99
58_V261_V1.0990.99
82_Q115_A1.0980.99
25_S28_V1.0910.99
71_A228_V1.0880.99
171_F209_P1.0780.99
269_R339_R1.0740.99
47_G54_A1.0720.99
122_F130_P1.0710.99
186_H212_S1.0690.99
94_S147_P1.0630.99
316_A320_E1.0630.99
21_I345_D1.0620.99
88_H235_F1.0590.99
171_F206_L1.0580.99
280_L335_F1.0580.99
220_G270_V1.0570.99
57_A60_A1.0560.99
123_D134_Q1.0540.99
29_A338_H1.0390.98
312_A316_A1.0390.98
144_G240_R1.0350.98
34_A262_C1.0280.98
136_A177_T1.0200.98
288_P291_T1.0140.98
284_L353_A1.0140.98
150_G183_V1.0130.98
61_T64_D1.0130.98
36_R44_V1.0120.98
229_L239_A1.0120.98
66_V192_V1.0050.98
164_V296_D1.0040.98
206_L209_P1.0040.98
30_T43_P1.0020.98
135_V152_A1.0010.98
282_E285_D1.0010.98
66_V230_A1.0000.98
345_D348_A1.0000.98
47_G254_G0.9980.98
145_H244_E0.9980.98
200_G271_H0.9970.98
320_E323_V0.9910.98
113_Q245_M0.9890.98
175_V209_P0.9850.98
42_A254_G0.9830.98
58_V257_A0.9830.98
327_A330_E0.9780.98
66_V215_V0.9730.98
347_A351_S0.9710.98
283_D346_I0.9700.98
306_D331_Y0.9610.97
242_V245_M0.9560.97
132_A170_A0.9550.97
230_A239_A0.9530.97
82_Q246_Y0.9480.97
56_A60_A0.9470.97
171_F187_V0.9460.97
207_L213_V0.9450.97
68_M230_A0.9410.97
285_D291_T0.9380.97
35_M258_A0.9360.97
22_D28_V0.9210.97
97_V119_A0.9190.97
201_V206_L0.9160.97
234_S237_A0.9150.97
142_G237_A0.9130.97
43_P57_A0.9110.97
23_L346_I0.9100.96
130_P166_A0.9080.96
175_V178_A0.9060.96
83_I242_V0.9040.96
46_H340_D0.9000.96
62_A228_V0.8980.96
29_A340_D0.8960.96
63_A71_A0.8870.96
39_A259_A0.8840.96
201_V205_T0.8830.96
59_E72_V0.8820.96
96_L138_E0.8810.96
262_C265_E0.8780.96
287_L350_V0.8780.96
71_A230_A0.8770.96
313_A316_A0.8760.96
108_S245_M0.8680.95
87_V242_V0.8670.95
175_V210_V0.8670.95
285_D294_E0.8600.95
124_G161_N0.8580.95
86_Q242_V0.8570.95
280_L349_V0.8550.95
153_C186_H0.8550.95
65_A264_L0.8520.95
66_V207_L0.8510.95
73_F256_V0.8440.95
129_C167_P0.8430.95
168_V206_L0.8400.95
129_C166_A0.8380.94
88_H184_P0.8340.94
196_A199_L0.8330.94
134_Q137_A0.8290.94
287_L354_G0.8280.94
179_H185_V0.8280.94
108_S241_R0.8260.94
267_R339_R0.8250.94
95_V119_A0.8240.94
32_T269_R0.8230.94
50_G56_A0.8230.94
217_L222_G0.8210.94
199_L206_L0.8180.94
29_A46_H0.8170.94
72_V239_A0.8100.93
38_A262_C0.8060.93
232_S235_F0.8050.93
95_V103_S0.8050.93
325_G335_F0.8050.93
233_E237_A0.8010.93
171_F175_V0.8000.93
86_Q246_Y0.7970.93
318_C325_G0.7960.93
272_E275_E0.7940.93
317_G320_E0.7890.92
87_V239_A0.7880.92
312_A315_L0.7850.92
139_I183_V0.7850.92
166_A170_A0.7830.92
126_E134_Q0.7830.92
48_E249_G0.7800.92
323_V349_V0.7790.92
212_S230_A0.7740.92
279_R350_V0.7740.92
54_A258_A0.7710.92
79_M248_G0.7690.91
233_E236_V0.7680.91
295_P300_V0.7670.91
268_H271_H0.7540.91
58_V260_G0.7530.91
148_E238_S0.7510.91
196_A206_L0.7490.90
122_F134_Q0.7490.90
202_D206_L0.7480.90
176_E179_H0.7440.90
72_V236_V0.7430.90
279_R346_I0.7420.90
207_L210_V0.7420.90
313_A317_G0.7400.90
84_G228_V0.7400.90
283_D287_L0.7400.90
204_A208_S0.7390.90
131_T170_A0.7380.90
74_V228_V0.7370.90
95_V111_L0.7350.90
281_A294_E0.7340.89
168_V171_F0.7300.89
230_A236_V0.7280.89
347_A350_V0.7270.89
197_T274_H0.7260.89
272_E343_G0.7260.89
106_R146_R0.7250.89
253_A257_A0.7250.89
82_Q110_G0.7230.89
100_A160_A0.7230.89
84_G212_S0.7220.89
282_E347_A0.7210.89
76_S225_M0.7140.88
192_V213_V0.7140.88
197_T270_V0.7130.88
317_G352_A0.7110.88
99_R121_A0.7110.88
276_N341_I0.7110.88
89_T150_G0.7090.88
127_T296_D0.7080.88
39_A256_V0.7070.88
127_T164_V0.7010.87
166_A174_A0.6980.87
179_H211_D0.6980.87
344_A347_A0.6950.87
114_H246_Y0.6890.86
45_E54_A0.6890.86
168_V199_L0.6840.86
228_V260_G0.6830.86
278_R281_A0.6830.86
171_F185_V0.6830.86
97_V103_S0.6820.86
281_A285_D0.6820.86
97_V104_Y0.6820.86
105_R160_A0.6810.86
45_E53_P0.6810.86
104_Y118_Q0.6790.86
31_P36_R0.6770.85
143_G146_R0.6760.85
196_A201_V0.6740.85
76_S250_M0.6740.85
136_A140_T0.6710.85
152_A183_V0.6700.85
270_V274_H0.6680.85
149_V183_V0.6670.85
337_T346_I0.6670.85
287_L353_A0.6660.84
124_G130_P0.6620.84
39_A42_A0.6590.84
341_I346_I0.6580.84
278_R295_P0.6580.84
156_I195_A0.6560.84
262_C339_R0.6560.84
157_A165_V0.6550.83
323_V352_A0.6550.83
243_Q249_G0.6540.83
132_A173_A0.6520.83
165_V296_D0.6520.83
322_G325_G0.6510.83
338_H341_I0.6500.83
173_A176_E0.6470.83
65_A203_A0.6450.83
193_F220_G0.6450.83
24_R28_V0.6440.82
53_P57_A0.6420.82
83_I246_Y0.6410.82
326_T332_T0.6400.82
222_G225_M0.6400.82
93_Q238_S0.6400.82
31_P35_M0.6380.82
75_P83_I0.6380.82
171_F210_V0.6380.82
118_Q147_P0.6370.82
222_G267_R0.6370.82
196_A203_A0.6360.82
85_A111_L0.6350.82
194_S220_G0.6350.82
142_G148_E0.6320.81
222_G263_A0.6310.81
152_A177_T0.6270.81
148_E241_R0.6270.81
97_V101_S0.6270.81
83_I239_A0.6250.81
165_V297_T0.6250.81
68_M207_L0.6250.81
275_E279_R0.6240.80
192_V215_V0.6240.80
154_V185_V0.6230.80
170_A174_A0.6230.80
36_R255_M0.6220.80
333_V353_A0.6210.80
42_A54_A0.6170.80
230_A235_F0.6160.80
288_P292_A0.6160.80
40_A44_V0.6160.80
161_N166_A0.6150.79
343_G346_I0.6090.79
99_R124_G0.6090.79
82_Q111_L0.6090.79
152_A185_V0.6030.78
62_A230_A0.6030.78
270_V273_D0.6030.78
63_A70_A0.5990.78
222_G339_R0.5990.78
80_A229_L0.5980.78
95_V117_V0.5970.77
197_T268_H0.5970.77
70_A236_V0.5960.77
72_V240_R0.5950.77
231_G236_V0.5930.77
279_R282_E0.5930.77
203_A215_V0.5930.77
30_T44_V0.5920.77
94_S140_T0.5920.77
315_L325_G0.5910.77
321_E352_A0.5890.76
63_A69_A0.5870.76
131_T135_V0.5860.76
68_M209_P0.5840.76
254_G258_A0.5830.76
32_T222_G0.5820.76
285_D288_P0.5800.75
140_T147_P0.5790.75
216_C227_A0.5780.75
157_A198_A0.5770.75
59_E243_Q0.5760.75
231_G235_F0.5750.75
311_A331_Y0.5740.75
27_T251_Q0.5730.75
36_R43_P0.5690.74
179_H209_P0.5670.74
36_R39_A0.5660.74
123_D126_E0.5650.73
82_Q247_G0.5630.73
91_R242_V0.5620.73
145_H249_G0.5620.73
114_H245_M0.5620.73
65_A265_E0.5600.73
59_E63_A0.5590.73
317_G321_E0.5580.73
100_A105_R0.5570.72
283_D347_A0.5570.72
28_V338_H0.5560.72
311_A315_L0.5560.72
283_D353_A0.5550.72
96_L183_V0.5520.72
167_P170_A0.5500.71
198_A278_R0.5500.71
21_I348_A0.5500.71
48_E244_E0.5480.71
193_F203_A0.5470.71
54_A254_G0.5440.71
57_A64_D0.5430.71
250_M253_A0.5420.70
32_T262_C0.5410.70
62_A65_A0.5410.70
292_A295_P0.5410.70
215_V264_L0.5410.70
228_V239_A0.5400.70
128_G164_V0.5380.70
38_A41_Q0.5370.70
62_A217_L0.5370.70
130_P154_V0.5350.69
349_V353_A0.5340.69
304_T333_V0.5340.69
221_L226_G0.5310.69
318_C321_E0.5290.69
42_A258_A0.5280.68
85_A103_S0.5280.68
42_A45_E0.5270.68
225_M253_A0.5270.68
130_P134_Q0.5260.68
62_A260_G0.5250.68
124_G127_T0.5250.68
87_V238_S0.5240.68
89_T151_L0.5240.68
276_N342_G0.5230.68
94_S149_V0.5230.68
80_A228_V0.5210.67
77_R227_A0.5210.67
192_V230_A0.5190.67
184_P235_F0.5180.67
168_V207_L0.5180.67
71_A233_E0.5170.67
165_V199_L0.5160.67
66_V204_A0.5160.67
195_A300_V0.5150.67
70_A233_E0.5150.67
129_C164_V0.5150.67
130_P152_A0.5140.66
344_A348_A0.5140.66
109_G118_Q0.5130.66
51_D157_A0.5110.66
223_A226_G0.5110.66
90_A150_G0.5070.65
132_A174_A0.5070.65
23_L341_I0.5070.65
75_P224_P0.5070.65
130_P135_V0.5050.65
135_V185_V0.5050.65
299_I337_T0.5040.65
40_A43_P0.5030.65
243_Q248_G0.5010.64
35_M263_A0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jg8A 4 0.944 100 0.541 Contact Map
1v72A 4 0.93 100 0.597 Contact Map
4lnjA 4 0.9244 100 0.602 Contact Map
3wgcA 4 0.9244 100 0.631 Contact Map
3lwsA 2 0.9524 100 0.643 Contact Map
3pj0A 2 0.9608 100 0.643 Contact Map
2oqxA 4 0.9692 100 0.649 Contact Map
1svvA 4 0.9272 100 0.683 Contact Map
2ez2A 4 0.9692 100 0.696 Contact Map
1ax4A 4 0.9692 100 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.