Q9HMP2 - HALSA - GREMLIN Contacts

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Q9HMP2 - Aminopeptidase homolog

UniProt:	Q9HMP2	Sequences: MDSRIRQHAAVIVDRCIDLQPDENVVVSLPPVAEDLRVALYEKIGEVGANPVMLARGDRGIGTDRAARAYLQAIDAEDLSTPEHLLQLYEHADAAVVGRPHRNVTEQSDVSTELGAAFAEAHRDVLNARLSTKWCLTQYPAPADAQLAGMSTAAYEDFVYDAVNKDWDAVEDHQQQMVDILNPAEEVRIVSGDTTDVTMSVADMTTLNDCGSNNLPAGEVFTAPVPDSVEGEVVFDKPVYHQAREIQGAALTFEDGEVVSFSAEQNEDVLAAILDTDDGARRLGELGIGMNRDIDRFTYNMLFDEKMGDTVHMALGRAYPETVGEGVEQNDSAKHVDMIVDMSEDSFIEVDGEIVQRNGTFVFEDGFDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	369 (347)
Sequences:	1689 (1167)
Seq/√Len:	62.6

BACSU - AMPS
HALSA - Q9HMP2 Q9HSK5 Q9HMH0 Q9HSS8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
248_G	264_E	4.804	1.00
252_T	260_S	4.179	1.00
349_E	353_E	3.820	1.00
258_V	315_L	3.813	1.00
200_S	228_S	3.764	1.00
19_L	25_V	3.574	1.00
43_K	46_E	3.519	1.00
247_Q	265_Q	3.457	1.00
29_L	37_R	3.371	1.00
230_E	255_D	3.169	1.00
267_E	271_A	3.148	1.00
10_A	43_K	3.134	1.00
236_D	342_M	3.048	1.00
67_A	110_V	2.876	1.00
186_E	198_T	2.869	1.00
12_I	137_T	2.805	1.00
275_D	281_R	2.800	1.00
10_A	14_D	2.774	1.00
346_S	357_R	2.691	1.00
171_E	212_S	2.674	1.00
6_R	43_K	2.551	1.00
232_E	252_T	2.535	1.00
13_V	47_V	2.495	1.00
75_D	117_A	2.418	1.00
13_V	40_L	2.392	1.00
253_F	283_L	2.358	1.00
354_I	357_R	2.309	1.00
188_R	196_D	2.213	1.00
14_D	47_V	2.210	1.00
19_L	94_A	2.159	1.00
261_F	271_A	2.155	1.00
146_Q	151_S	2.152	1.00
17_I	96_V	2.133	1.00
250_A	262_S	2.086	1.00
257_E	281_R	2.033	1.00
175_Q	179_D	2.031	1.00
105_T	147_L	2.018	1.00
27_V	40_L	2.015	1.00
63_T	109_D	2.005	1.00
12_I	96_V	1.993	1.00
274_L	281_R	1.966	1.00
232_E	250_A	1.854	1.00
83_E	87_Q	1.840	1.00
41_Y	61_I	1.839	1.00
161_D	166_D	1.836	1.00
25_V	96_V	1.820	1.00
199_M	313_M	1.815	1.00
96_V	135_C	1.806	1.00
271_A	275_D	1.791	1.00
262_S	267_E	1.770	1.00
71_L	114_L	1.757	0.99
23_E	94_A	1.752	0.99
179_D	183_P	1.749	0.99
24_N	50_N	1.743	0.99
226_P	282_R	1.730	0.99
25_V	44_I	1.728	0.99
234_V	250_A	1.697	0.99
86_L	90_E	1.681	0.99
26_V	93_D	1.664	0.99
44_I	49_A	1.663	0.99
198_T	230_E	1.658	0.99
6_R	39_A	1.655	0.99
229_V	282_R	1.648	0.99
100_P	141_A	1.621	0.99
203_D	350_V	1.605	0.99
46_E	68_R	1.605	0.99
66_A	74_I	1.602	0.99
257_E	282_R	1.602	0.99
6_R	42_E	1.575	0.99
116_A	120_E	1.572	0.99
200_S	225_V	1.571	0.99
36_L	40_L	1.571	0.99
296_R	360_T	1.566	0.99
97_V	136_L	1.564	0.99
261_F	267_E	1.547	0.99
71_L	75_D	1.530	0.99
163_V	215_L	1.524	0.99
258_V	274_L	1.519	0.98
241_H	246_I	1.516	0.98
311_V	340_V	1.512	0.98
180_I	184_A	1.502	0.98
27_V	37_R	1.500	0.98
223_A	318_A	1.466	0.98
193_D	344_E	1.458	0.98
138_Q	303_F	1.458	0.98
225_V	228_S	1.458	0.98
223_A	322_T	1.447	0.98
171_E	210_C	1.446	0.98
15_R	168_D	1.431	0.98
233_V	313_M	1.425	0.98
274_L	280_A	1.415	0.98
69_A	74_I	1.409	0.98
36_L	139_Y	1.408	0.98
185_E	204_M	1.387	0.97
254_E	259_V	1.382	0.97
188_R	198_T	1.378	0.97
63_T	67_A	1.375	0.97
347_F	357_R	1.358	0.97
99_R	138_Q	1.356	0.97
65_R	69_A	1.342	0.97
39_A	42_E	1.331	0.96
40_L	96_V	1.325	0.96
261_F	274_L	1.324	0.96
127_N	130_L	1.318	0.96
20_Q	23_E	1.298	0.96
25_V	135_C	1.272	0.95
142_P	152_T	1.261	0.95
7_Q	10_A	1.256	0.95
276_T	333_A	1.250	0.95
71_L	117_A	1.249	0.95
317_R	331_D	1.248	0.95
13_V	44_I	1.248	0.95
274_L	315_L	1.232	0.95
86_L	128_A	1.224	0.94
346_S	354_I	1.217	0.94
98_G	137_T	1.216	0.94
280_A	334_K	1.211	0.94
39_A	43_K	1.201	0.94
83_E	86_L	1.194	0.94
19_L	44_I	1.190	0.93
223_A	319_Y	1.180	0.93
151_S	154_A	1.170	0.93
197_V	313_M	1.163	0.93
272_A	275_D	1.162	0.93
171_E	209_D	1.160	0.93
313_M	340_V	1.158	0.93
187_V	286_L	1.151	0.92
311_V	345_D	1.145	0.92
192_G	344_E	1.140	0.92
186_E	348_I	1.140	0.92
126_L	130_L	1.139	0.92
23_E	133_K	1.138	0.92
37_R	96_V	1.134	0.92
103_N	143_A	1.132	0.92
3_S	6_R	1.131	0.92
258_V	281_R	1.130	0.92
260_S	271_A	1.130	0.92
251_L	274_L	1.130	0.92
193_D	234_V	1.126	0.91
12_I	135_C	1.099	0.90
67_A	109_D	1.077	0.90
25_V	94_A	1.076	0.89
19_L	47_V	1.076	0.89
171_E	211_G	1.072	0.89
42_E	46_E	1.071	0.89
240_Y	245_E	1.063	0.89
30_P	100_P	1.062	0.89
209_D	217_A	1.061	0.89
87_Q	91_H	1.058	0.89
64_D	67_A	1.046	0.88
344_E	358_N	1.045	0.88
225_V	282_R	1.044	0.88
251_L	258_V	1.043	0.88
111_S	114_L	1.041	0.88
233_V	340_V	1.038	0.88
185_E	350_V	1.037	0.88
43_K	47_V	1.025	0.87
199_M	229_V	1.023	0.87
172_D	176_Q	1.019	0.87
184_A	347_F	1.018	0.87
185_E	202_A	1.016	0.87
221_F	321_E	1.009	0.86
186_E	352_G	1.009	0.86
288_I	348_I	1.007	0.86
42_E	64_D	1.006	0.86
95_A	132_T	1.003	0.86
28_S	55_A	0.997	0.86
261_F	275_D	0.996	0.85
271_A	281_R	0.995	0.85
13_V	25_V	0.994	0.85
119_A	242_Q	0.992	0.85
4_R	7_Q	0.975	0.84
55_A	84_H	0.975	0.84
112_T	272_A	0.966	0.84
291_N	360_T	0.963	0.84
97_V	319_Y	0.960	0.83
136_L	319_Y	0.958	0.83
201_V	222_T	0.956	0.83
258_V	280_A	0.954	0.83
15_R	212_S	0.947	0.82
24_N	91_H	0.946	0.82
276_T	334_K	0.944	0.82
32_V	141_A	0.939	0.82
42_E	68_R	0.933	0.82
162_A	297_F	0.932	0.81
270_L	273_I	0.932	0.81
197_V	283_L	0.922	0.81
126_L	129_R	0.914	0.80
239_V	336_V	0.911	0.80
209_D	212_S	0.909	0.80
17_I	94_A	0.908	0.80
189_I	197_V	0.907	0.80
118_F	122_H	0.903	0.79
147_L	299_Y	0.902	0.79
197_V	229_V	0.899	0.79
24_N	93_D	0.897	0.79
315_L	334_K	0.897	0.79
189_I	199_M	0.897	0.79
140_P	156_E	0.895	0.79
70_Y	73_A	0.894	0.79
177_M	355_V	0.893	0.79
164_N	170_V	0.887	0.78
18_D	212_S	0.886	0.78
249_A	301_M	0.885	0.78
184_A	349_E	0.883	0.78
36_L	39_A	0.875	0.77
194_T	250_A	0.875	0.77
285_E	312_H	0.875	0.77
120_E	124_D	0.875	0.77
239_V	301_M	0.871	0.77
204_M	323_V	0.868	0.77
113_E	272_A	0.866	0.76
62_G	107_Q	0.863	0.76
280_A	315_L	0.862	0.76
138_Q	141_A	0.860	0.76
42_E	60_G	0.859	0.76
246_I	270_L	0.857	0.76
178_V	210_C	0.856	0.76
194_T	234_V	0.853	0.75
139_Y	156_E	0.853	0.75
350_V	353_E	0.850	0.75
250_A	260_S	0.850	0.75
312_H	335_H	0.847	0.75
13_V	19_L	0.844	0.75
176_Q	180_I	0.844	0.75
100_P	138_Q	0.843	0.74
90_E	128_A	0.840	0.74
103_N	146_Q	0.839	0.74
157_D	166_D	0.837	0.74
69_A	114_L	0.833	0.74
40_L	98_G	0.833	0.74
168_D	171_E	0.832	0.74
224_P	283_L	0.831	0.73
249_A	338_M	0.831	0.73
175_Q	208_N	0.826	0.73
142_P	146_Q	0.819	0.72
257_E	278_D	0.818	0.72
4_R	160_Y	0.817	0.72
28_S	95_A	0.817	0.72
285_E	335_H	0.812	0.72
178_V	209_D	0.812	0.72
189_I	286_L	0.811	0.72
35_D	60_G	0.807	0.71
34_E	38_V	0.806	0.71
260_S	267_E	0.803	0.71
69_A	73_A	0.802	0.71
186_E	200_S	0.797	0.70
244_R	269_V	0.797	0.70
11_V	164_N	0.796	0.70
171_E	178_V	0.793	0.70
117_A	121_A	0.793	0.70
154_A	157_D	0.789	0.70
177_M	362_V	0.789	0.70
171_E	175_Q	0.788	0.69
30_P	33_A	0.786	0.69
163_V	303_F	0.783	0.69
258_V	261_F	0.782	0.69
174_Q	220_V	0.778	0.68
158_F	162_A	0.775	0.68
113_E	117_A	0.771	0.68
279_G	332_S	0.770	0.68
54_L	61_I	0.769	0.68
311_V	356_Q	0.768	0.67
287_G	290_M	0.766	0.67
229_V	313_M	0.760	0.67
4_R	166_D	0.759	0.67
178_V	182_N	0.758	0.66
123_R	127_N	0.758	0.66
14_D	43_K	0.757	0.66
291_N	343_S	0.756	0.66
21_P	48_G	0.752	0.66
12_I	136_L	0.750	0.66
166_D	276_T	0.749	0.65
298_T	307_M	0.747	0.65
187_V	201_V	0.747	0.65
346_S	350_V	0.745	0.65
189_I	345_D	0.743	0.65
318_A	323_V	0.742	0.65
66_A	107_Q	0.740	0.65
234_V	248_G	0.735	0.64
246_I	273_I	0.734	0.64
249_A	270_L	0.730	0.63
219_E	224_P	0.729	0.63
192_G	311_V	0.728	0.63
192_G	340_V	0.727	0.63
45_G	51_P	0.726	0.63
179_D	182_N	0.722	0.63
17_I	25_V	0.722	0.63
219_E	312_H	0.721	0.63
28_S	97_V	0.720	0.62
305_E	312_H	0.712	0.62
101_H	143_A	0.709	0.61
122_H	126_L	0.707	0.61
8_H	137_T	0.707	0.61
317_R	320_P	0.703	0.61
193_D	342_M	0.703	0.61
181_L	220_V	0.702	0.60
136_L	223_A	0.701	0.60
219_E	335_H	0.700	0.60
112_T	116_A	0.699	0.60
4_R	157_D	0.698	0.60
314_A	335_H	0.697	0.60
214_N	302_L	0.697	0.60
168_D	172_D	0.695	0.60
3_S	7_Q	0.694	0.60
33_A	100_P	0.694	0.60
191_S	234_V	0.690	0.59
71_L	113_E	0.689	0.59
87_Q	90_E	0.685	0.59
218_G	306_K	0.683	0.58
81_T	84_H	0.682	0.58
184_A	355_V	0.680	0.58
281_R	315_L	0.678	0.58
158_F	297_F	0.677	0.58
241_H	334_K	0.677	0.58
349_E	354_I	0.675	0.57
140_P	160_Y	0.672	0.57
354_I	358_N	0.670	0.57
248_G	265_Q	0.669	0.57
70_Y	74_I	0.664	0.56
193_D	236_D	0.662	0.56
235_F	280_A	0.660	0.56
116_A	272_A	0.659	0.56
84_H	88_L	0.658	0.56
17_I	135_C	0.658	0.56
178_V	212_S	0.656	0.55
201_V	355_V	0.654	0.55
219_E	285_E	0.653	0.55
5_I	39_A	0.652	0.55
205_T	222_T	0.652	0.55
33_A	139_Y	0.652	0.55
61_I	64_D	0.650	0.55
349_E	352_G	0.647	0.54
63_T	110_V	0.646	0.54
305_E	335_H	0.646	0.54
110_V	115_G	0.646	0.54
230_E	254_E	0.643	0.54
318_A	331_D	0.643	0.54
53_M	84_H	0.642	0.54
99_R	136_L	0.640	0.54
89_Y	129_R	0.639	0.53
212_S	215_L	0.639	0.53
34_E	56_R	0.637	0.53
54_L	88_L	0.636	0.53
285_E	305_E	0.636	0.53
180_I	183_P	0.636	0.53
323_V	331_D	0.636	0.53
199_M	286_L	0.635	0.53
38_V	60_G	0.635	0.53
27_V	169_A	0.634	0.53
152_T	156_E	0.634	0.53
29_L	33_A	0.634	0.53
224_P	312_H	0.634	0.53
5_I	8_H	0.632	0.53
185_E	223_A	0.632	0.53
175_Q	209_D	0.632	0.53
162_A	303_F	0.631	0.52
103_N	147_L	0.631	0.52
166_D	215_L	0.629	0.52
200_S	230_E	0.629	0.52
268_D	272_A	0.628	0.52
55_A	61_I	0.626	0.52
132_T	135_C	0.621	0.51
347_F	352_G	0.619	0.51
304_D	307_M	0.619	0.51
251_L	338_M	0.619	0.51
156_E	160_Y	0.616	0.51
218_G	289_G	0.616	0.51
175_Q	211_G	0.615	0.51
227_D	282_R	0.614	0.51
121_A	125_V	0.614	0.51
68_R	114_L	0.613	0.50
42_E	67_A	0.612	0.50
184_A	350_V	0.612	0.50
50_N	76_A	0.611	0.50
62_G	118_F	0.610	0.50
11_V	215_L	0.608	0.50
16_C	215_L	0.607	0.50
81_T	85_L	0.607	0.50
29_L	98_G	0.606	0.50
219_E	305_E	0.604	0.49
314_A	337_D	0.604	0.49
312_H	337_D	0.602	0.49
282_R	347_F	0.601	0.49
169_A	173_H	0.598	0.49
36_L	98_G	0.597	0.49
301_M	338_M	0.597	0.49
115_G	242_Q	0.597	0.49
180_I	353_E	0.594	0.48
61_I	65_R	0.594	0.48
203_D	225_V	0.594	0.48
237_K	295_D	0.593	0.48
243_A	304_D	0.593	0.48
265_Q	268_D	0.592	0.48
273_I	276_T	0.591	0.48
42_E	352_G	0.590	0.48
241_H	273_I	0.589	0.48
252_T	255_D	0.589	0.48
248_G	271_A	0.588	0.48
3_S	143_A	0.588	0.48
138_Q	144_D	0.587	0.47
287_G	311_V	0.586	0.47
136_L	213_N	0.583	0.47
298_T	341_D	0.578	0.46
238_P	245_E	0.577	0.46
295_D	343_S	0.576	0.46
32_V	100_P	0.576	0.46
261_F	281_R	0.576	0.46
126_L	136_L	0.571	0.46
86_L	129_R	0.571	0.46
67_A	111_S	0.569	0.45
108_S	265_Q	0.569	0.45
305_E	337_D	0.568	0.45
167_W	238_P	0.567	0.45
35_D	39_A	0.566	0.45
256_G	316_G	0.566	0.45
51_P	65_R	0.566	0.45
355_V	362_V	0.566	0.45
22_D	72_Q	0.565	0.45
94_A	133_K	0.565	0.45
157_D	161_D	0.565	0.45
356_Q	360_T	0.564	0.45
239_V	338_M	0.564	0.45
289_G	306_K	0.563	0.45
258_V	282_R	0.562	0.45
273_I	334_K	0.561	0.44
252_T	262_S	0.560	0.44
4_R	165_K	0.560	0.44
27_V	44_I	0.557	0.44
188_R	191_S	0.556	0.44
202_A	205_T	0.555	0.44
204_M	226_P	0.553	0.44
161_D	255_D	0.552	0.43
36_L	251_L	0.552	0.43
274_L	283_L	0.552	0.43
227_D	255_D	0.552	0.43
109_D	154_A	0.550	0.43
236_D	310_T	0.549	0.43
13_V	43_K	0.549	0.43
60_G	154_A	0.549	0.43
123_R	333_A	0.547	0.43
104_V	147_L	0.547	0.43
101_H	240_Y	0.546	0.43
204_M	322_T	0.546	0.43
19_L	91_H	0.546	0.43
26_V	89_Y	0.546	0.43
174_Q	208_N	0.545	0.43
245_E	299_Y	0.544	0.43
201_V	205_T	0.544	0.43
210_C	217_A	0.543	0.42
45_G	50_N	0.543	0.42
12_I	98_G	0.543	0.42
144_D	155_Y	0.542	0.42
241_H	336_V	0.541	0.42
191_S	342_M	0.541	0.42
271_A	274_L	0.540	0.42
159_V	303_F	0.539	0.42
11_V	43_K	0.539	0.42
7_Q	11_V	0.538	0.42
224_P	335_H	0.535	0.42
26_V	95_A	0.535	0.42
60_G	64_D	0.534	0.41
12_I	36_L	0.534	0.41
85_L	122_H	0.533	0.41
217_A	304_D	0.532	0.41
73_A	165_K	0.530	0.41
214_N	314_A	0.529	0.41
233_V	355_V	0.528	0.41
41_Y	54_L	0.527	0.41
233_V	311_V	0.527	0.41
163_V	223_A	0.526	0.41
234_V	247_Q	0.525	0.40
47_V	153_A	0.524	0.40
206_T	323_V	0.522	0.40
196_D	352_G	0.522	0.40
148_A	155_Y	0.522	0.40
183_P	188_R	0.521	0.40
35_D	199_M	0.521	0.40
50_N	70_Y	0.521	0.40
246_I	263_A	0.520	0.40
240_Y	301_M	0.519	0.40
163_V	286_L	0.519	0.40
14_D	46_E	0.518	0.40
208_N	321_E	0.513	0.39
229_V	240_Y	0.513	0.39
101_H	108_S	0.513	0.39
285_E	314_A	0.512	0.39
119_A	213_N	0.512	0.39
178_V	208_N	0.512	0.39
19_L	23_E	0.511	0.39
222_T	322_T	0.511	0.39
182_N	206_T	0.510	0.39
189_I	340_V	0.509	0.39
199_M	228_S	0.509	0.39
4_R	161_D	0.508	0.39
288_I	311_V	0.508	0.39
14_D	182_N	0.508	0.39
30_P	99_R	0.508	0.39
183_P	353_E	0.507	0.38
169_A	172_D	0.507	0.38
291_N	295_D	0.507	0.38
247_Q	264_E	0.507	0.38
50_N	73_A	0.507	0.38
243_A	246_I	0.506	0.38
146_Q	154_A	0.506	0.38
178_V	211_G	0.506	0.38
160_Y	163_V	0.505	0.38
343_S	358_N	0.505	0.38
302_L	312_H	0.505	0.38
107_Q	114_L	0.505	0.38
60_G	103_N	0.504	0.38
192_G	234_V	0.504	0.38
163_V	166_D	0.504	0.38
19_L	49_A	0.503	0.38
195_T	302_L	0.503	0.38
197_V	230_E	0.502	0.38
89_Y	95_A	0.502	0.38
310_T	315_L	0.501	0.38
213_N	319_Y	0.501	0.38
9_A	43_K	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4icsA	2	0.9729	100	0.214	Contact Map
2ayiA	2	0.9621	100	0.217	Contact Map
1zjcA	2	0.9783	100	0.221	Contact Map
3lygA	2	0.3117	44.3	0.969	Contact Map
3bchA	1	0.3631	15.4	0.976	Contact Map
3shoA	4	0.3279	13.9	0.976	Contact Map
4ivnA	2	0.3388	13	0.976	Contact Map
3er7A	2	0.2873	12.6	0.976	Contact Map
5aihA	1	0.3062	12.3	0.977	Contact Map
4eo7A	1	0.3713	11.8	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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