GREMLIN Database
Q9HMP2 - Aminopeptidase homolog
UniProt: Q9HMP2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (347)
Sequences: 1689 (1167)
Seq/√Len: 62.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_G264_E4.8041.00
252_T260_S4.1791.00
349_E353_E3.8201.00
258_V315_L3.8131.00
200_S228_S3.7641.00
19_L25_V3.5741.00
43_K46_E3.5191.00
247_Q265_Q3.4571.00
29_L37_R3.3711.00
230_E255_D3.1691.00
267_E271_A3.1481.00
10_A43_K3.1341.00
236_D342_M3.0481.00
67_A110_V2.8761.00
186_E198_T2.8691.00
12_I137_T2.8051.00
275_D281_R2.8001.00
10_A14_D2.7741.00
346_S357_R2.6911.00
171_E212_S2.6741.00
6_R43_K2.5511.00
232_E252_T2.5351.00
13_V47_V2.4951.00
75_D117_A2.4181.00
13_V40_L2.3921.00
253_F283_L2.3581.00
354_I357_R2.3091.00
188_R196_D2.2131.00
14_D47_V2.2101.00
19_L94_A2.1591.00
261_F271_A2.1551.00
146_Q151_S2.1521.00
17_I96_V2.1331.00
250_A262_S2.0861.00
257_E281_R2.0331.00
175_Q179_D2.0311.00
105_T147_L2.0181.00
27_V40_L2.0151.00
63_T109_D2.0051.00
12_I96_V1.9931.00
274_L281_R1.9661.00
232_E250_A1.8541.00
83_E87_Q1.8401.00
41_Y61_I1.8391.00
161_D166_D1.8361.00
25_V96_V1.8201.00
199_M313_M1.8151.00
96_V135_C1.8061.00
271_A275_D1.7911.00
262_S267_E1.7701.00
71_L114_L1.7570.99
23_E94_A1.7520.99
179_D183_P1.7490.99
24_N50_N1.7430.99
226_P282_R1.7300.99
25_V44_I1.7280.99
234_V250_A1.6970.99
86_L90_E1.6810.99
26_V93_D1.6640.99
44_I49_A1.6630.99
198_T230_E1.6580.99
6_R39_A1.6550.99
229_V282_R1.6480.99
100_P141_A1.6210.99
203_D350_V1.6050.99
46_E68_R1.6050.99
66_A74_I1.6020.99
257_E282_R1.6020.99
6_R42_E1.5750.99
116_A120_E1.5720.99
200_S225_V1.5710.99
36_L40_L1.5710.99
296_R360_T1.5660.99
97_V136_L1.5640.99
261_F267_E1.5470.99
71_L75_D1.5300.99
163_V215_L1.5240.99
258_V274_L1.5190.98
241_H246_I1.5160.98
311_V340_V1.5120.98
180_I184_A1.5020.98
27_V37_R1.5000.98
223_A318_A1.4660.98
193_D344_E1.4580.98
138_Q303_F1.4580.98
225_V228_S1.4580.98
223_A322_T1.4470.98
171_E210_C1.4460.98
15_R168_D1.4310.98
233_V313_M1.4250.98
274_L280_A1.4150.98
69_A74_I1.4090.98
36_L139_Y1.4080.98
185_E204_M1.3870.97
254_E259_V1.3820.97
188_R198_T1.3780.97
63_T67_A1.3750.97
347_F357_R1.3580.97
99_R138_Q1.3560.97
65_R69_A1.3420.97
39_A42_E1.3310.96
40_L96_V1.3250.96
261_F274_L1.3240.96
127_N130_L1.3180.96
20_Q23_E1.2980.96
25_V135_C1.2720.95
142_P152_T1.2610.95
7_Q10_A1.2560.95
276_T333_A1.2500.95
71_L117_A1.2490.95
317_R331_D1.2480.95
13_V44_I1.2480.95
274_L315_L1.2320.95
86_L128_A1.2240.94
346_S354_I1.2170.94
98_G137_T1.2160.94
280_A334_K1.2110.94
39_A43_K1.2010.94
83_E86_L1.1940.94
19_L44_I1.1900.93
223_A319_Y1.1800.93
151_S154_A1.1700.93
197_V313_M1.1630.93
272_A275_D1.1620.93
171_E209_D1.1600.93
313_M340_V1.1580.93
187_V286_L1.1510.92
311_V345_D1.1450.92
192_G344_E1.1400.92
186_E348_I1.1400.92
126_L130_L1.1390.92
23_E133_K1.1380.92
37_R96_V1.1340.92
103_N143_A1.1320.92
3_S6_R1.1310.92
258_V281_R1.1300.92
260_S271_A1.1300.92
251_L274_L1.1300.92
193_D234_V1.1260.91
12_I135_C1.0990.90
67_A109_D1.0770.90
25_V94_A1.0760.89
19_L47_V1.0760.89
171_E211_G1.0720.89
42_E46_E1.0710.89
240_Y245_E1.0630.89
30_P100_P1.0620.89
209_D217_A1.0610.89
87_Q91_H1.0580.89
64_D67_A1.0460.88
344_E358_N1.0450.88
225_V282_R1.0440.88
251_L258_V1.0430.88
111_S114_L1.0410.88
233_V340_V1.0380.88
185_E350_V1.0370.88
43_K47_V1.0250.87
199_M229_V1.0230.87
172_D176_Q1.0190.87
184_A347_F1.0180.87
185_E202_A1.0160.87
221_F321_E1.0090.86
186_E352_G1.0090.86
288_I348_I1.0070.86
42_E64_D1.0060.86
95_A132_T1.0030.86
28_S55_A0.9970.86
261_F275_D0.9960.85
271_A281_R0.9950.85
13_V25_V0.9940.85
119_A242_Q0.9920.85
4_R7_Q0.9750.84
55_A84_H0.9750.84
112_T272_A0.9660.84
291_N360_T0.9630.84
97_V319_Y0.9600.83
136_L319_Y0.9580.83
201_V222_T0.9560.83
258_V280_A0.9540.83
15_R212_S0.9470.82
24_N91_H0.9460.82
276_T334_K0.9440.82
32_V141_A0.9390.82
42_E68_R0.9330.82
162_A297_F0.9320.81
270_L273_I0.9320.81
197_V283_L0.9220.81
126_L129_R0.9140.80
239_V336_V0.9110.80
209_D212_S0.9090.80
17_I94_A0.9080.80
189_I197_V0.9070.80
118_F122_H0.9030.79
147_L299_Y0.9020.79
197_V229_V0.8990.79
24_N93_D0.8970.79
315_L334_K0.8970.79
189_I199_M0.8970.79
140_P156_E0.8950.79
70_Y73_A0.8940.79
177_M355_V0.8930.79
164_N170_V0.8870.78
18_D212_S0.8860.78
249_A301_M0.8850.78
184_A349_E0.8830.78
36_L39_A0.8750.77
194_T250_A0.8750.77
285_E312_H0.8750.77
120_E124_D0.8750.77
239_V301_M0.8710.77
204_M323_V0.8680.77
113_E272_A0.8660.76
62_G107_Q0.8630.76
280_A315_L0.8620.76
138_Q141_A0.8600.76
42_E60_G0.8590.76
246_I270_L0.8570.76
178_V210_C0.8560.76
194_T234_V0.8530.75
139_Y156_E0.8530.75
350_V353_E0.8500.75
250_A260_S0.8500.75
312_H335_H0.8470.75
13_V19_L0.8440.75
176_Q180_I0.8440.75
100_P138_Q0.8430.74
90_E128_A0.8400.74
103_N146_Q0.8390.74
157_D166_D0.8370.74
69_A114_L0.8330.74
40_L98_G0.8330.74
168_D171_E0.8320.74
224_P283_L0.8310.73
249_A338_M0.8310.73
175_Q208_N0.8260.73
142_P146_Q0.8190.72
257_E278_D0.8180.72
4_R160_Y0.8170.72
28_S95_A0.8170.72
285_E335_H0.8120.72
178_V209_D0.8120.72
189_I286_L0.8110.72
35_D60_G0.8070.71
34_E38_V0.8060.71
260_S267_E0.8030.71
69_A73_A0.8020.71
186_E200_S0.7970.70
244_R269_V0.7970.70
11_V164_N0.7960.70
171_E178_V0.7930.70
117_A121_A0.7930.70
154_A157_D0.7890.70
177_M362_V0.7890.70
171_E175_Q0.7880.69
30_P33_A0.7860.69
163_V303_F0.7830.69
258_V261_F0.7820.69
174_Q220_V0.7780.68
158_F162_A0.7750.68
113_E117_A0.7710.68
279_G332_S0.7700.68
54_L61_I0.7690.68
311_V356_Q0.7680.67
287_G290_M0.7660.67
229_V313_M0.7600.67
4_R166_D0.7590.67
178_V182_N0.7580.66
123_R127_N0.7580.66
14_D43_K0.7570.66
291_N343_S0.7560.66
21_P48_G0.7520.66
12_I136_L0.7500.66
166_D276_T0.7490.65
298_T307_M0.7470.65
187_V201_V0.7470.65
346_S350_V0.7450.65
189_I345_D0.7430.65
318_A323_V0.7420.65
66_A107_Q0.7400.65
234_V248_G0.7350.64
246_I273_I0.7340.64
249_A270_L0.7300.63
219_E224_P0.7290.63
192_G311_V0.7280.63
192_G340_V0.7270.63
45_G51_P0.7260.63
179_D182_N0.7220.63
17_I25_V0.7220.63
219_E312_H0.7210.63
28_S97_V0.7200.62
305_E312_H0.7120.62
101_H143_A0.7090.61
122_H126_L0.7070.61
8_H137_T0.7070.61
317_R320_P0.7030.61
193_D342_M0.7030.61
181_L220_V0.7020.60
136_L223_A0.7010.60
219_E335_H0.7000.60
112_T116_A0.6990.60
4_R157_D0.6980.60
314_A335_H0.6970.60
214_N302_L0.6970.60
168_D172_D0.6950.60
3_S7_Q0.6940.60
33_A100_P0.6940.60
191_S234_V0.6900.59
71_L113_E0.6890.59
87_Q90_E0.6850.59
218_G306_K0.6830.58
81_T84_H0.6820.58
184_A355_V0.6800.58
281_R315_L0.6780.58
158_F297_F0.6770.58
241_H334_K0.6770.58
349_E354_I0.6750.57
140_P160_Y0.6720.57
354_I358_N0.6700.57
248_G265_Q0.6690.57
70_Y74_I0.6640.56
193_D236_D0.6620.56
235_F280_A0.6600.56
116_A272_A0.6590.56
84_H88_L0.6580.56
17_I135_C0.6580.56
178_V212_S0.6560.55
201_V355_V0.6540.55
219_E285_E0.6530.55
5_I39_A0.6520.55
205_T222_T0.6520.55
33_A139_Y0.6520.55
61_I64_D0.6500.55
349_E352_G0.6470.54
63_T110_V0.6460.54
305_E335_H0.6460.54
110_V115_G0.6460.54
230_E254_E0.6430.54
318_A331_D0.6430.54
53_M84_H0.6420.54
99_R136_L0.6400.54
89_Y129_R0.6390.53
212_S215_L0.6390.53
34_E56_R0.6370.53
54_L88_L0.6360.53
285_E305_E0.6360.53
180_I183_P0.6360.53
323_V331_D0.6360.53
199_M286_L0.6350.53
38_V60_G0.6350.53
27_V169_A0.6340.53
152_T156_E0.6340.53
29_L33_A0.6340.53
224_P312_H0.6340.53
5_I8_H0.6320.53
185_E223_A0.6320.53
175_Q209_D0.6320.53
162_A303_F0.6310.52
103_N147_L0.6310.52
166_D215_L0.6290.52
200_S230_E0.6290.52
268_D272_A0.6280.52
55_A61_I0.6260.52
132_T135_C0.6210.51
347_F352_G0.6190.51
304_D307_M0.6190.51
251_L338_M0.6190.51
156_E160_Y0.6160.51
218_G289_G0.6160.51
175_Q211_G0.6150.51
227_D282_R0.6140.51
121_A125_V0.6140.51
68_R114_L0.6130.50
42_E67_A0.6120.50
184_A350_V0.6120.50
50_N76_A0.6110.50
62_G118_F0.6100.50
11_V215_L0.6080.50
16_C215_L0.6070.50
81_T85_L0.6070.50
29_L98_G0.6060.50
219_E305_E0.6040.49
314_A337_D0.6040.49
312_H337_D0.6020.49
282_R347_F0.6010.49
169_A173_H0.5980.49
36_L98_G0.5970.49
301_M338_M0.5970.49
115_G242_Q0.5970.49
180_I353_E0.5940.48
61_I65_R0.5940.48
203_D225_V0.5940.48
237_K295_D0.5930.48
243_A304_D0.5930.48
265_Q268_D0.5920.48
273_I276_T0.5910.48
42_E352_G0.5900.48
241_H273_I0.5890.48
252_T255_D0.5890.48
248_G271_A0.5880.48
3_S143_A0.5880.48
138_Q144_D0.5870.47
287_G311_V0.5860.47
136_L213_N0.5830.47
298_T341_D0.5780.46
238_P245_E0.5770.46
295_D343_S0.5760.46
32_V100_P0.5760.46
261_F281_R0.5760.46
126_L136_L0.5710.46
86_L129_R0.5710.46
67_A111_S0.5690.45
108_S265_Q0.5690.45
305_E337_D0.5680.45
167_W238_P0.5670.45
35_D39_A0.5660.45
256_G316_G0.5660.45
51_P65_R0.5660.45
355_V362_V0.5660.45
22_D72_Q0.5650.45
94_A133_K0.5650.45
157_D161_D0.5650.45
356_Q360_T0.5640.45
239_V338_M0.5640.45
289_G306_K0.5630.45
258_V282_R0.5620.45
273_I334_K0.5610.44
252_T262_S0.5600.44
4_R165_K0.5600.44
27_V44_I0.5570.44
188_R191_S0.5560.44
202_A205_T0.5550.44
204_M226_P0.5530.44
161_D255_D0.5520.43
36_L251_L0.5520.43
274_L283_L0.5520.43
227_D255_D0.5520.43
109_D154_A0.5500.43
236_D310_T0.5490.43
13_V43_K0.5490.43
60_G154_A0.5490.43
123_R333_A0.5470.43
104_V147_L0.5470.43
101_H240_Y0.5460.43
204_M322_T0.5460.43
19_L91_H0.5460.43
26_V89_Y0.5460.43
174_Q208_N0.5450.43
245_E299_Y0.5440.43
201_V205_T0.5440.43
210_C217_A0.5430.42
45_G50_N0.5430.42
12_I98_G0.5430.42
144_D155_Y0.5420.42
241_H336_V0.5410.42
191_S342_M0.5410.42
271_A274_L0.5400.42
159_V303_F0.5390.42
11_V43_K0.5390.42
7_Q11_V0.5380.42
224_P335_H0.5350.42
26_V95_A0.5350.42
60_G64_D0.5340.41
12_I36_L0.5340.41
85_L122_H0.5330.41
217_A304_D0.5320.41
73_A165_K0.5300.41
214_N314_A0.5290.41
233_V355_V0.5280.41
41_Y54_L0.5270.41
233_V311_V0.5270.41
163_V223_A0.5260.41
234_V247_Q0.5250.40
47_V153_A0.5240.40
206_T323_V0.5220.40
196_D352_G0.5220.40
148_A155_Y0.5220.40
183_P188_R0.5210.40
35_D199_M0.5210.40
50_N70_Y0.5210.40
246_I263_A0.5200.40
240_Y301_M0.5190.40
163_V286_L0.5190.40
14_D46_E0.5180.40
208_N321_E0.5130.39
229_V240_Y0.5130.39
101_H108_S0.5130.39
285_E314_A0.5120.39
119_A213_N0.5120.39
178_V208_N0.5120.39
19_L23_E0.5110.39
222_T322_T0.5110.39
182_N206_T0.5100.39
189_I340_V0.5090.39
199_M228_S0.5090.39
4_R161_D0.5080.39
288_I311_V0.5080.39
14_D182_N0.5080.39
30_P99_R0.5080.39
183_P353_E0.5070.38
169_A172_D0.5070.38
291_N295_D0.5070.38
247_Q264_E0.5070.38
50_N73_A0.5070.38
243_A246_I0.5060.38
146_Q154_A0.5060.38
178_V211_G0.5060.38
160_Y163_V0.5050.38
343_S358_N0.5050.38
302_L312_H0.5050.38
107_Q114_L0.5050.38
60_G103_N0.5040.38
192_G234_V0.5040.38
163_V166_D0.5040.38
19_L49_A0.5030.38
195_T302_L0.5030.38
197_V230_E0.5020.38
89_Y95_A0.5020.38
310_T315_L0.5010.38
213_N319_Y0.5010.38
9_A43_K0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4icsA 2 0.9729 100 0.214 Contact Map
2ayiA 2 0.9621 100 0.217 Contact Map
1zjcA 2 0.9783 100 0.221 Contact Map
3lygA 2 0.3117 44.3 0.969 Contact Map
3bchA 1 0.3631 15.4 0.976 Contact Map
3shoA 4 0.3279 13.9 0.976 Contact Map
4ivnA 2 0.3388 13 0.976 Contact Map
3er7A 2 0.2873 12.6 0.976 Contact Map
5aihA 1 0.3062 12.3 0.977 Contact Map
4eo7A 1 0.3713 11.8 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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