GREMLIN Database
Y2452 - UPF0200 protein VNG_2452C
UniProt: Q9HMP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (170)
Sequences: 6221 (3861)
Seq/√Len: 296.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_A59_D3.8471.00
115_R144_R3.3851.00
51_G55_Q2.8081.00
23_N173_R2.7291.00
35_I66_I2.6341.00
112_S158_R2.5621.00
53_I62_G2.5171.00
163_D171_A2.4471.00
37_Q41_D2.4191.00
141_D145_G2.1981.00
67_A89_I2.1471.00
38_E72_P2.1451.00
99_R155_A2.1441.00
153_D158_R2.1221.00
163_D167_A1.9901.00
110_H158_R1.9841.00
49_H52_R1.9061.00
122_I136_L1.9001.00
114_P162_T1.8631.00
117_L120_A1.8511.00
129_G132_D1.8241.00
39_C54_A1.8191.00
111_V161_N1.7851.00
124_D127_R1.7751.00
67_A97_T1.7741.00
23_N169_H1.7691.00
133_G137_D1.7611.00
164_S167_A1.7541.00
107_T157_V1.7501.00
43_G48_Q1.7221.00
157_V175_L1.7061.00
138_A141_D1.6931.00
119_K137_D1.6911.00
73_I79_T1.6901.00
52_R56_A1.6831.00
24_A173_R1.6621.00
45_D49_H1.6531.00
45_D48_Q1.6421.00
117_L162_T1.6161.00
73_I76_D1.5741.00
169_H173_R1.5171.00
146_F150_D1.5021.00
49_H68_H1.4621.00
59_D138_A1.4081.00
12_S113_A1.3971.00
17_A172_V1.3511.00
110_H149_D1.3311.00
150_D154_L1.3131.00
124_D128_P1.3091.00
123_E133_G1.3041.00
132_D135_P1.2971.00
77_H81_A1.2841.00
38_E44_L1.2801.00
71_L75_E1.2801.00
6_T18_A1.2641.00
113_A161_N1.2431.00
115_R137_D1.2191.00
19_T22_A1.2001.00
53_I59_D1.1981.00
38_E41_D1.1771.00
38_E69_Q1.1751.00
170_D174_D1.1621.00
7_V149_D1.1541.00
150_D153_D1.1311.00
171_A174_D1.1221.00
167_A171_A1.1211.00
140_E144_R1.1191.00
93_V96_T1.1181.00
111_V172_V1.1181.00
138_A142_R1.1151.00
99_R152_I1.1141.00
68_H71_L1.1141.00
163_D168_F1.0931.00
151_A155_A1.0821.00
97_T100_D1.0821.00
9_M143_E1.0721.00
99_R151_A1.0711.00
62_G65_A1.0651.00
170_D173_R1.0631.00
160_E163_D1.0631.00
32_G36_R1.0531.00
27_P73_I1.0521.00
43_G51_G1.0471.00
11_G122_I1.0451.00
41_D44_L1.0351.00
71_L101_A1.0291.00
123_E126_D1.0081.00
96_T99_R1.0031.00
115_R141_D0.9851.00
50_H53_I0.9831.00
49_H64_G0.9811.00
99_R102_F0.9771.00
50_H54_A0.9761.00
5_G105_D0.9751.00
119_K133_G0.9731.00
92_D96_T0.9721.00
29_L73_I0.9711.00
37_Q73_I0.9691.00
52_R55_Q0.9631.00
116_E120_A0.9501.00
115_R140_E0.9491.00
7_V108_L0.9361.00
72_P76_D0.9361.00
63_P94_E0.9351.00
6_T20_V0.9331.00
17_A169_H0.9231.00
15_S87_D0.9191.00
63_P91_S0.9181.00
167_A170_D0.9171.00
123_E132_D0.9101.00
27_P80_D0.9061.00
44_L47_A0.9051.00
109_V172_V0.8991.00
46_P68_H0.8671.00
67_A70_S0.8661.00
26_I84_V0.8651.00
95_V151_A0.8541.00
65_A68_H0.8531.00
96_T100_D0.8461.00
48_Q51_G0.8431.00
48_Q52_R0.8411.00
112_S149_D0.8391.00
98_F102_F0.8371.00
19_T28_V0.8331.00
160_E168_F0.8311.00
34_V69_Q0.8281.00
77_H80_D0.8181.00
63_P93_V0.8131.00
49_H53_I0.8081.00
165_L169_H0.8061.00
37_Q76_D0.7970.99
135_P138_A0.7960.99
21_A28_V0.7950.99
9_M118_R0.7920.99
119_K123_E0.7900.99
64_G68_H0.7890.99
39_C51_G0.7830.99
34_V38_E0.7820.99
148_M152_I0.7800.99
6_T85_L0.7780.99
159_I168_F0.7750.99
84_V105_D0.7690.99
6_T111_V0.7630.99
32_G90_R0.7610.99
160_E171_A0.7590.99
123_E127_R0.7520.99
35_I70_S0.7490.99
26_I83_T0.7480.99
27_P79_T0.7420.99
13_G16_E0.7410.99
66_I70_S0.7370.99
35_I39_C0.7320.99
171_A175_L0.7260.99
18_A28_V0.7110.99
73_I77_H0.7060.99
30_V33_D0.7030.99
95_V152_I0.7000.99
20_V85_L0.6950.99
38_E47_A0.6910.99
153_D156_D0.6860.98
159_I175_L0.6850.98
137_D141_D0.6780.98
123_E128_P0.6760.98
10_P135_P0.6730.98
6_T109_V0.6720.98
4_I107_T0.6670.98
38_E50_H0.6650.98
125_R139_R0.6560.98
142_R145_G0.6560.98
114_P117_L0.6550.98
35_I54_A0.6540.98
13_G121_R0.6520.98
24_A169_H0.6500.98
31_M70_S0.6500.98
166_D169_H0.6490.98
25_G82_T0.6480.98
125_R131_T0.6480.98
116_E137_D0.6450.98
41_D76_D0.6390.98
39_C47_A0.6380.98
5_G108_L0.6380.98
96_T151_A0.6350.98
8_G11_G0.6320.97
9_M12_S0.6320.97
102_F105_D0.6300.97
120_A124_D0.6300.97
138_A145_G0.6280.97
46_P72_P0.6230.97
50_H68_H0.6230.97
17_A168_F0.6230.97
107_T176_L0.6230.97
113_A118_R0.6150.97
50_H56_A0.6140.97
33_D37_Q0.6140.97
72_P75_E0.6130.97
116_E119_K0.6100.97
36_R90_R0.6090.97
92_D151_A0.6080.97
162_T168_F0.6080.97
8_G12_S0.6070.97
35_I50_H0.6050.97
50_H69_Q0.6050.97
6_T21_A0.6050.97
63_P97_T0.6010.97
11_G136_L0.6000.97
49_H65_A0.5960.96
17_A165_L0.5950.96
141_D144_R0.5930.96
29_L34_V0.5910.96
21_A24_A0.5900.96
20_V172_V0.5860.96
22_A25_G0.5850.96
60_E90_R0.5830.96
34_V73_I0.5830.96
94_E98_F0.5820.96
98_F105_D0.5800.96
84_V102_F0.5770.96
73_I80_D0.5750.96
133_G136_L0.5740.96
28_V33_D0.5740.96
20_V169_H0.5740.96
21_A85_L0.5720.95
35_I61_H0.5650.95
17_A121_R0.5620.95
38_E68_H0.5620.95
74_I80_D0.5530.95
99_R104_D0.5510.94
21_A27_P0.5410.94
27_P77_H0.5400.94
172_V175_L0.5390.94
91_S98_F0.5370.94
107_T175_L0.5360.94
161_N168_F0.5300.93
7_V110_H0.5290.93
16_E121_R0.5280.93
119_K136_L0.5270.93
10_P118_R0.5250.93
47_A50_H0.5240.93
73_I83_T0.5230.93
39_C43_G0.5230.93
74_I84_V0.5230.93
83_T106_F0.5210.93
43_G47_A0.5190.92
4_I176_L0.5180.92
166_D170_D0.5170.92
118_R136_L0.5160.92
147_G150_D0.5150.92
93_V97_T0.5110.92
46_P49_H0.5100.92
61_H66_I0.5080.92
162_T171_A0.5050.91
115_R119_K0.5030.91
92_D148_M0.5030.91
112_S160_E0.5010.91
92_D95_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qbgB 1 0.9316 99.9 0.426 Contact Map
1ukzA 1 0.9421 99.9 0.434 Contact Map
3gmtA 1 0.8211 99.9 0.437 Contact Map
4pzlA 2 0.9263 99.9 0.439 Contact Map
4jzkA 1 0.9105 99.9 0.44 Contact Map
4nu0A 1 0.9316 99.9 0.443 Contact Map
2c95A 1 0.9421 99.9 0.443 Contact Map
1zakA 2 0.9895 99.9 0.446 Contact Map
3be4A 1 0.9 99.9 0.447 Contact Map
1akyA 1 0.9316 99.9 0.454 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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