GREMLIN Database
Q9HMN9 - UPF0201 protein VNG_2454C
UniProt: Q9HMN9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (125)
Sequences: 160 (123)
Seq/√Len: 11.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_R125_L2.6000.89
11_V28_I2.5490.88
117_A120_Q2.4010.84
36_T66_T2.0620.74
63_I67_A2.0510.73
67_A96_F2.0370.73
129_T132_G2.0260.72
65_D96_F2.0180.72
97_A106_D1.9750.70
24_V27_A1.9590.70
59_F64_L1.9500.69
25_A91_N1.9410.69
82_F109_V1.9110.68
54_F94_V1.9090.68
58_L64_L1.9010.67
102_D106_D1.8170.64
13_A28_I1.7910.62
82_F96_F1.7680.61
16_Y57_Q1.7650.61
48_T52_A1.6520.56
9_V94_V1.6330.55
28_I58_L1.6020.53
58_L67_A1.5920.53
18_T95_N1.5620.52
44_A109_V1.5600.51
9_V15_V1.5520.51
64_L132_G1.5210.50
92_G125_L1.5190.50
38_T77_D1.4710.47
94_V126_A1.4450.46
85_K109_V1.4370.46
68_R127_P1.4300.45
84_L94_V1.4000.44
65_D129_T1.3990.44
63_I68_R1.3960.44
29_L94_V1.3950.44
28_I111_V1.3780.43
32_F109_V1.3460.41
63_I96_F1.3260.40
9_V76_T1.3140.40
51_T104_L1.2960.39
31_L118_V1.2800.38
29_L34_D1.2580.37
22_D26_D1.2430.37
47_E125_L1.2360.36
127_P132_G1.2280.36
24_V89_A1.2160.35
55_R124_H1.1980.35
50_T84_L1.1950.34
15_V92_G1.1910.34
64_L127_P1.1650.33
88_A105_G1.1610.33
72_Q123_D1.1420.32
97_A102_D1.1360.32
64_L134_P1.1220.31
15_V24_V1.1120.31
75_Q121_F1.1120.31
61_Q94_V1.1010.30
76_T79_G1.0910.30
37_V40_E1.0890.30
44_A93_T1.0880.30
13_A54_F1.0700.29
20_P23_R1.0560.29
105_G111_V1.0480.28
31_L131_G1.0380.28
61_Q64_L1.0290.28
65_D132_G1.0240.27
12_T72_Q1.0020.27
49_D54_F0.9970.26
80_F118_V0.9850.26
83_D108_H0.9850.26
100_N106_D0.9790.26
47_E102_D0.9740.26
90_F94_V0.9630.25
41_D114_A0.9500.25
31_L97_A0.9310.24
88_A102_D0.9300.24
92_G105_G0.8970.23
57_Q60_D0.8910.23
32_F89_A0.8880.23
10_R45_V0.8860.22
66_T95_N0.8820.22
70_Q92_G0.8820.22
38_T74_S0.8770.22
66_T109_V0.8770.22
25_A29_L0.8740.22
74_S96_F0.8690.22
44_A73_A0.8680.22
63_I95_N0.8650.22
78_A114_A0.8640.22
40_E45_V0.8550.21
13_A18_T0.8500.21
55_R59_F0.8470.21
82_F105_G0.8450.21
10_R116_P0.8420.21
51_T103_E0.8400.21
46_A73_A0.8390.21
10_R77_D0.8330.21
27_A32_F0.8290.21
24_V107_L0.8250.20
31_L60_D0.8140.20
75_Q124_H0.8110.20
30_R125_L0.8050.20
96_F127_P0.8040.20
9_V40_E0.7950.20
58_L63_I0.7940.20
22_D69_E0.7910.19
59_F68_R0.7860.19
32_F82_F0.7780.19
48_T61_Q0.7780.19
114_A117_A0.7710.19
61_Q93_T0.7700.19
17_P41_D0.7690.19
89_A107_L0.7670.19
102_D124_H0.7650.19
51_T124_H0.7650.19
28_I33_P0.7440.18
34_D75_Q0.7370.18
68_R129_T0.7340.18
73_A91_N0.7340.18
59_F98_V0.7330.18
72_Q119_Q0.7320.18
16_Y50_T0.7290.18
18_T22_D0.7270.18
27_A89_A0.7260.18
65_D74_S0.7260.18
64_L129_T0.7170.17
100_N121_F0.7120.17
47_E88_A0.7120.17
53_S56_E0.7120.17
103_E124_H0.7030.17
120_Q130_D0.6990.17
8_T114_A0.6970.17
32_F88_A0.6970.17
100_N104_L0.6940.17
60_D72_Q0.6930.17
62_R99_G0.6890.17
115_E121_F0.6870.16
51_T107_L0.6800.16
33_P66_T0.6720.16
8_T54_F0.6640.16
38_T56_E0.6610.16
49_D71_F0.6580.16
75_Q78_A0.6570.16
43_R131_G0.6570.16
57_Q61_Q0.6540.16
51_T79_G0.6520.16
52_A94_V0.6510.16
11_V70_Q0.6480.15
88_A93_T0.6450.15
46_A95_N0.6450.15
123_D133_E0.6370.15
63_I129_T0.6360.15
56_E62_R0.6330.15
21_D109_V0.6270.15
46_A131_G0.6240.15
55_R134_P0.6190.15
53_S75_Q0.6190.15
45_V80_F0.6150.15
16_Y31_L0.6140.15
30_R83_D0.6120.15
95_N106_D0.6120.15
48_T54_F0.6080.14
18_T63_I0.6070.14
68_R123_D0.6020.14
49_D52_A0.5990.14
28_I83_D0.5930.14
109_V119_Q0.5910.14
31_L134_P0.5870.14
20_P25_A0.5840.14
30_R88_A0.5830.14
31_L125_L0.5720.14
85_K102_D0.5680.14
67_A129_T0.5610.13
64_L116_P0.5600.13
129_T134_P0.5560.13
67_A126_A0.5560.13
25_A33_P0.5500.13
62_R120_Q0.5490.13
88_A91_N0.5390.13
24_V54_F0.5390.13
94_V133_E0.5330.13
37_V73_A0.5330.13
58_L134_P0.5100.12
82_F111_V0.5090.12
83_D97_A0.5080.12
35_A115_E0.5050.12
55_R123_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c9gA 2 0.9348 100 0.283 Contact Map
3d7aA 2 0.942 100 0.295 Contact Map
2nwuA 2 0.8841 100 0.296 Contact Map
2pzzA 2 0.9203 100 0.302 Contact Map
2ogkA 4 0.8841 100 0.495 Contact Map
2nrqA 1 0.8043 100 0.52 Contact Map
2wnyA 1 0.8623 99.9 0.54 Contact Map
1gkmA 4 0.4855 12.4 0.951 Contact Map
2qveA 3 0.4928 8.5 0.955 Contact Map
4g9iA 1 0.529 6.7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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