GREMLIN Database
Q9HMN8 - Uncharacterized protein
UniProt: Q9HMN8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (233)
Sequences: 212 (176)
Seq/√Len: 11.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_G222_G3.7000.99
40_L173_A3.0480.96
212_F215_G2.9970.95
218_G222_G2.9520.95
116_K120_P2.6790.91
155_P188_E2.6420.91
169_T172_G2.5390.89
147_P152_L2.5190.88
40_L129_V2.4430.87
82_S85_D2.4230.86
70_A74_V2.3980.86
180_V193_M2.2640.82
99_S150_S2.2570.82
44_L49_G2.0890.76
64_T179_H2.0870.76
58_A128_A2.0600.75
23_N34_T2.0570.75
148_L152_L2.0560.75
11_L157_V2.0420.75
125_V198_I2.0380.75
31_H64_T2.0050.73
119_V141_F1.9700.72
23_N31_H1.9510.71
35_F44_L1.9450.71
48_L186_A1.9320.70
13_D224_K1.8980.69
3_K57_A1.8940.69
27_G210_I1.8790.68
162_V188_E1.8580.67
177_A193_M1.8460.67
99_S148_L1.8200.66
44_L129_V1.8160.65
72_A110_K1.7760.64
118_L229_N1.7380.62
73_V101_R1.7360.62
129_V173_A1.7280.61
200_S215_G1.7200.61
68_V127_A1.7160.61
102_E127_A1.7140.61
15_A136_Y1.7120.61
23_N129_V1.6650.58
11_L218_G1.6420.57
69_L73_V1.6400.57
190_V239_A1.5560.53
118_L231_A1.5240.52
32_I48_L1.5080.51
49_G217_W1.5070.51
115_L155_P1.5050.51
9_G14_R1.5000.50
26_F213_Q1.4670.49
58_A132_L1.4550.48
66_A131_F1.4340.47
113_G162_V1.4340.47
119_V177_A1.3990.45
187_G195_V1.3700.44
39_V50_L1.3570.43
9_G231_A1.3550.43
190_V194_L1.3510.43
37_A169_T1.3450.43
160_P215_G1.3450.43
180_V188_E1.3430.43
31_H233_K1.3370.42
104_V108_V1.3350.42
176_I189_A1.3300.42
185_T188_E1.3290.42
77_E85_D1.3180.41
69_L154_L1.3140.41
2_L31_H1.3090.41
31_H59_V1.3010.41
133_T174_I1.2950.40
124_V233_K1.2880.40
41_L217_W1.2840.40
13_D221_F1.2820.40
31_H200_S1.2750.39
139_T145_A1.2710.39
141_F151_V1.2580.39
58_A159_V1.2410.38
41_L212_F1.2350.38
107_A186_A1.2210.37
192_T207_K1.2170.37
32_I56_R1.2050.36
31_H204_S1.2000.36
36_Y56_R1.2000.36
3_K201_F1.1950.36
8_A73_V1.1940.36
16_T217_W1.1940.36
35_F218_G1.1930.36
29_V32_I1.1920.36
202_A207_K1.1870.35
129_V212_F1.1870.35
121_R212_F1.1840.35
8_A199_V1.1790.35
30_Q172_G1.1760.35
56_R168_D1.1740.35
68_V95_A1.1730.35
111_T158_A1.1710.35
170_T174_I1.1670.34
143_A243_V1.1530.34
98_E141_F1.1490.34
158_A215_G1.1450.33
164_T175_F1.1390.33
176_I204_S1.1380.33
15_A60_S1.1330.33
34_T42_P1.1310.33
197_G204_S1.1300.33
196_G213_Q1.1220.32
126_Y215_G1.1210.32
172_G216_I1.1150.32
86_A185_T1.1130.32
17_L27_G1.1120.32
40_L212_F1.1100.32
101_R146_E1.1030.32
17_L228_V1.1000.32
52_Y60_S1.0970.31
189_A195_V1.0920.31
49_G155_P1.0920.31
74_V161_A1.0910.31
132_L143_A1.0900.31
28_F61_L1.0870.31
28_F57_A1.0770.31
57_A216_I1.0750.30
35_F152_L1.0660.30
41_L216_I1.0660.30
17_L218_G1.0600.30
11_L206_F1.0550.30
44_L228_V1.0460.29
101_R224_K1.0440.29
136_Y240_A1.0410.29
20_I23_N1.0380.29
37_A60_S1.0370.29
34_T196_G1.0360.29
101_R220_R1.0330.29
40_L211_P1.0300.29
69_L185_T1.0160.28
31_H208_R1.0150.28
65_A86_A1.0030.28
72_A224_K0.9980.27
105_A231_A0.9840.27
172_G188_E0.9680.26
33_F124_V0.9670.26
198_I201_F0.9550.26
118_L179_H0.9550.26
5_Y222_G0.9520.26
43_I67_G0.9450.25
62_G220_R0.9440.25
167_V207_K0.9440.25
3_K29_V0.9430.25
177_A221_F0.9370.25
11_L154_L0.9310.25
67_G229_N0.9280.25
63_I225_V0.9230.25
166_A193_M0.9230.25
104_V239_A0.9170.24
176_I184_F0.9110.24
123_A220_R0.9080.24
35_F174_I0.9060.24
66_A232_A0.9050.24
204_S208_R0.9050.24
189_A197_G0.9040.24
184_F224_K0.9040.24
3_K229_N0.8940.23
18_V195_V0.8920.23
67_G221_F0.8920.23
77_E240_A0.8840.23
12_S127_A0.8800.23
86_A106_G0.8750.23
159_V194_L0.8740.23
152_L182_G0.8700.23
210_I214_Y0.8480.22
154_L220_R0.8480.22
11_L79_D0.8450.22
44_L218_G0.8430.22
127_A215_G0.8390.22
69_L177_A0.8300.21
96_A131_F0.8290.21
174_I178_P0.8270.21
71_G194_L0.8260.21
123_A194_L0.8230.21
60_S126_Y0.8210.21
22_I222_G0.8210.21
68_V242_A0.8200.21
60_S138_V0.8160.21
53_V166_A0.8110.21
185_T231_A0.8080.21
152_L188_E0.8080.21
145_A232_A0.8050.20
184_F217_W0.8050.20
45_G224_K0.8030.20
115_L119_V0.8020.20
105_A109_T0.7980.20
42_P169_T0.7950.20
16_T32_I0.7930.20
81_A219_A0.7910.20
116_K224_K0.7830.20
69_L79_D0.7820.20
108_V143_A0.7740.20
78_D84_S0.7710.19
3_K171_T0.7690.19
83_A195_V0.7650.19
173_A212_F0.7640.19
14_R182_G0.7600.19
83_A194_L0.7570.19
198_I234_V0.7510.19
36_Y50_L0.7510.19
117_T180_V0.7500.19
28_F31_H0.7430.19
16_T233_K0.7420.19
49_G161_A0.7410.19
101_R140_A0.7410.19
108_V118_L0.7370.18
126_Y170_T0.7370.18
143_A238_S0.7330.18
132_L137_D0.7230.18
65_A242_A0.7230.18
28_F126_Y0.7160.18
66_A112_G0.7160.18
21_T26_F0.7130.18
19_A179_H0.7130.18
36_Y59_V0.7120.18
44_L189_A0.7110.18
57_A177_A0.7090.18
30_Q209_S0.7080.18
84_S131_F0.7070.18
115_L127_A0.7020.17
178_P205_T0.7010.17
29_V216_I0.7000.17
58_A94_D0.6960.17
36_Y210_I0.6960.17
28_F63_I0.6910.17
31_H138_V0.6880.17
123_A142_T0.6870.17
193_M217_W0.6760.17
126_Y168_D0.6690.16
19_A39_V0.6690.16
19_A198_I0.6690.16
79_D150_S0.6680.16
207_K233_K0.6650.16
35_F122_L0.6650.16
198_I241_I0.6550.16
72_A140_A0.6540.16
196_G215_G0.6540.16
18_V172_G0.6520.16
233_K237_I0.6520.16
56_R209_S0.6510.16
99_S149_T0.6500.16
25_F49_G0.6500.16
105_A128_A0.6410.16
31_H190_V0.6390.16
31_H207_K0.6390.16
37_A240_A0.6390.16
43_I53_V0.6390.16
40_L217_W0.6330.16
71_G198_I0.6320.15
26_F193_M0.6320.15
132_L149_T0.6320.15
33_F233_K0.6300.15
109_T144_A0.6300.15
131_F135_T0.6290.15
169_T197_G0.6250.15
156_G171_T0.6230.15
83_A242_A0.6210.15
215_G218_G0.6190.15
168_D208_R0.6130.15
113_G181_P0.6120.15
23_N226_I0.6120.15
70_A102_E0.6090.15
176_I192_T0.6070.15
42_P198_I0.6070.15
61_L123_A0.6020.15
21_T225_V0.6010.15
197_G229_N0.5990.15
15_A26_F0.5990.15
129_V153_G0.5990.15
77_E80_V0.5980.15
208_R230_I0.5980.15
79_D85_D0.5950.15
5_Y234_V0.5880.14
158_A229_N0.5880.14
98_E128_A0.5880.14
159_V219_A0.5860.14
15_A117_T0.5830.14
9_G207_K0.5830.14
70_A131_F0.5810.14
75_L177_A0.5800.14
28_F200_S0.5800.14
17_L28_F0.5780.14
152_L195_V0.5770.14
205_T209_S0.5740.14
79_D109_T0.5720.14
108_V119_V0.5700.14
204_S209_S0.5700.14
56_R230_I0.5690.14
65_A182_G0.5690.14
64_T138_V0.5680.14
43_I134_E0.5680.14
164_T169_T0.5660.14
154_L157_V0.5600.14
158_A198_I0.5590.14
20_I175_F0.5550.14
162_V192_T0.5540.14
52_Y136_Y0.5540.14
197_G203_V0.5530.14
138_V208_R0.5520.14
12_S185_T0.5500.13
2_L182_G0.5500.13
176_I202_A0.5500.13
63_I213_Q0.5500.13
46_L162_V0.5460.13
40_L166_A0.5460.13
179_H220_R0.5450.13
2_L16_T0.5450.13
145_A195_V0.5440.13
64_T200_S0.5430.13
101_R105_A0.5430.13
222_G234_V0.5430.13
94_D109_T0.5420.13
172_G202_A0.5420.13
10_V174_I0.5410.13
124_V207_K0.5400.13
203_V229_N0.5390.13
168_D209_S0.5390.13
40_L139_T0.5380.13
151_V195_V0.5360.13
25_F128_A0.5360.13
23_N211_P0.5350.13
79_D132_L0.5340.13
30_Q63_I0.5330.13
40_L215_G0.5320.13
61_L179_H0.5290.13
230_I241_I0.5290.13
150_S227_A0.5200.13
196_G200_S0.5200.13
39_V118_L0.5190.13
55_A118_L0.5190.13
45_G57_A0.5180.13
59_V208_R0.5180.13
26_F217_W0.5160.13
82_S86_A0.5160.13
56_R169_T0.5150.13
57_A158_A0.5130.13
30_Q37_A0.5110.13
66_A96_A0.5110.13
198_I229_N0.5100.13
4_E58_A0.5050.12
199_V203_V0.5040.12
133_T141_F0.5040.12
6_R13_D0.5020.12
197_G201_F0.5020.12
120_P229_N0.5000.12
23_N237_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.8821 95.2 0.909 Contact Map
4r1iA 2 0.8415 33.6 0.951 Contact Map
2jlnA 1 0.3049 28.9 0.953 Contact Map
4dx5A 3 0.3374 20 0.956 Contact Map
4lz6A 1 0.8211 16 0.958 Contact Map
1pw4A 1 0.874 10.7 0.961 Contact Map
4kjrA 3 0.7195 9.5 0.962 Contact Map
3qe7A 2 0.2358 9.3 0.962 Contact Map
3w4tA 1 0.8293 8.5 0.963 Contact Map
4r0cA 3 0.8455 8 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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