Q9HMN8 - HALSA - GREMLIN Contacts

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Q9HMN8 - Uncharacterized protein

UniProt:	Q9HMN8	Sequences: MLKEYRDAGVLSDRATLVAITINTFFGFVQHIFTFYAPVLLPILGLRLGLMYVGARAAVSLGITAAGVLAGAVVLSEDDVASASDAGVTMPGEDAADESTRETVAGAVTKTGGKLKTLVPRLAVVYAAVVFLTETYDVTAFTAAAEPLTSVLGLPGVAVPAVATFAVDTTTGAIFIAPHVPGEFTAGEAVATMLVGGIVSFAVSTFKRSIPFQYGIWGARFGSKVIAVNIAAKVVFISAAIAVLLV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	246 (233)
Sequences:	212 (176)
Seq/√Len:	11.5

HALSA - Q9HMN8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_G	222_G	3.700	0.99
40_L	173_A	3.048	0.96
212_F	215_G	2.997	0.95
218_G	222_G	2.952	0.95
116_K	120_P	2.679	0.91
155_P	188_E	2.642	0.91
169_T	172_G	2.539	0.89
147_P	152_L	2.519	0.88
40_L	129_V	2.443	0.87
82_S	85_D	2.423	0.86
70_A	74_V	2.398	0.86
180_V	193_M	2.264	0.82
99_S	150_S	2.257	0.82
44_L	49_G	2.089	0.76
64_T	179_H	2.087	0.76
58_A	128_A	2.060	0.75
23_N	34_T	2.057	0.75
148_L	152_L	2.056	0.75
11_L	157_V	2.042	0.75
125_V	198_I	2.038	0.75
31_H	64_T	2.005	0.73
119_V	141_F	1.970	0.72
23_N	31_H	1.951	0.71
35_F	44_L	1.945	0.71
48_L	186_A	1.932	0.70
13_D	224_K	1.898	0.69
3_K	57_A	1.894	0.69
27_G	210_I	1.879	0.68
162_V	188_E	1.858	0.67
177_A	193_M	1.846	0.67
99_S	148_L	1.820	0.66
44_L	129_V	1.816	0.65
72_A	110_K	1.776	0.64
118_L	229_N	1.738	0.62
73_V	101_R	1.736	0.62
129_V	173_A	1.728	0.61
200_S	215_G	1.720	0.61
68_V	127_A	1.716	0.61
102_E	127_A	1.714	0.61
15_A	136_Y	1.712	0.61
23_N	129_V	1.665	0.58
11_L	218_G	1.642	0.57
69_L	73_V	1.640	0.57
190_V	239_A	1.556	0.53
118_L	231_A	1.524	0.52
32_I	48_L	1.508	0.51
49_G	217_W	1.507	0.51
115_L	155_P	1.505	0.51
9_G	14_R	1.500	0.50
26_F	213_Q	1.467	0.49
58_A	132_L	1.455	0.48
66_A	131_F	1.434	0.47
113_G	162_V	1.434	0.47
119_V	177_A	1.399	0.45
187_G	195_V	1.370	0.44
39_V	50_L	1.357	0.43
9_G	231_A	1.355	0.43
190_V	194_L	1.351	0.43
37_A	169_T	1.345	0.43
160_P	215_G	1.345	0.43
180_V	188_E	1.343	0.43
31_H	233_K	1.337	0.42
104_V	108_V	1.335	0.42
176_I	189_A	1.330	0.42
185_T	188_E	1.329	0.42
77_E	85_D	1.318	0.41
69_L	154_L	1.314	0.41
2_L	31_H	1.309	0.41
31_H	59_V	1.301	0.41
133_T	174_I	1.295	0.40
124_V	233_K	1.288	0.40
41_L	217_W	1.284	0.40
13_D	221_F	1.282	0.40
31_H	200_S	1.275	0.39
139_T	145_A	1.271	0.39
141_F	151_V	1.258	0.39
58_A	159_V	1.241	0.38
41_L	212_F	1.235	0.38
107_A	186_A	1.221	0.37
192_T	207_K	1.217	0.37
32_I	56_R	1.205	0.36
31_H	204_S	1.200	0.36
36_Y	56_R	1.200	0.36
3_K	201_F	1.195	0.36
8_A	73_V	1.194	0.36
16_T	217_W	1.194	0.36
35_F	218_G	1.193	0.36
29_V	32_I	1.192	0.36
202_A	207_K	1.187	0.35
129_V	212_F	1.187	0.35
121_R	212_F	1.184	0.35
8_A	199_V	1.179	0.35
30_Q	172_G	1.176	0.35
56_R	168_D	1.174	0.35
68_V	95_A	1.173	0.35
111_T	158_A	1.171	0.35
170_T	174_I	1.167	0.34
143_A	243_V	1.153	0.34
98_E	141_F	1.149	0.34
158_A	215_G	1.145	0.33
164_T	175_F	1.139	0.33
176_I	204_S	1.138	0.33
15_A	60_S	1.133	0.33
34_T	42_P	1.131	0.33
197_G	204_S	1.130	0.33
196_G	213_Q	1.122	0.32
126_Y	215_G	1.121	0.32
172_G	216_I	1.115	0.32
86_A	185_T	1.113	0.32
17_L	27_G	1.112	0.32
40_L	212_F	1.110	0.32
101_R	146_E	1.103	0.32
17_L	228_V	1.100	0.32
52_Y	60_S	1.097	0.31
189_A	195_V	1.092	0.31
49_G	155_P	1.092	0.31
74_V	161_A	1.091	0.31
132_L	143_A	1.090	0.31
28_F	61_L	1.087	0.31
28_F	57_A	1.077	0.31
57_A	216_I	1.075	0.30
35_F	152_L	1.066	0.30
41_L	216_I	1.066	0.30
17_L	218_G	1.060	0.30
11_L	206_F	1.055	0.30
44_L	228_V	1.046	0.29
101_R	224_K	1.044	0.29
136_Y	240_A	1.041	0.29
20_I	23_N	1.038	0.29
37_A	60_S	1.037	0.29
34_T	196_G	1.036	0.29
101_R	220_R	1.033	0.29
40_L	211_P	1.030	0.29
69_L	185_T	1.016	0.28
31_H	208_R	1.015	0.28
65_A	86_A	1.003	0.28
72_A	224_K	0.998	0.27
105_A	231_A	0.984	0.27
172_G	188_E	0.968	0.26
33_F	124_V	0.967	0.26
198_I	201_F	0.955	0.26
118_L	179_H	0.955	0.26
5_Y	222_G	0.952	0.26
43_I	67_G	0.945	0.25
62_G	220_R	0.944	0.25
167_V	207_K	0.944	0.25
3_K	29_V	0.943	0.25
177_A	221_F	0.937	0.25
11_L	154_L	0.931	0.25
67_G	229_N	0.928	0.25
63_I	225_V	0.923	0.25
166_A	193_M	0.923	0.25
104_V	239_A	0.917	0.24
176_I	184_F	0.911	0.24
123_A	220_R	0.908	0.24
35_F	174_I	0.906	0.24
66_A	232_A	0.905	0.24
204_S	208_R	0.905	0.24
189_A	197_G	0.904	0.24
184_F	224_K	0.904	0.24
3_K	229_N	0.894	0.23
18_V	195_V	0.892	0.23
67_G	221_F	0.892	0.23
77_E	240_A	0.884	0.23
12_S	127_A	0.880	0.23
86_A	106_G	0.875	0.23
159_V	194_L	0.874	0.23
152_L	182_G	0.870	0.23
210_I	214_Y	0.848	0.22
154_L	220_R	0.848	0.22
11_L	79_D	0.845	0.22
44_L	218_G	0.843	0.22
127_A	215_G	0.839	0.22
69_L	177_A	0.830	0.21
96_A	131_F	0.829	0.21
174_I	178_P	0.827	0.21
71_G	194_L	0.826	0.21
123_A	194_L	0.823	0.21
60_S	126_Y	0.821	0.21
22_I	222_G	0.821	0.21
68_V	242_A	0.820	0.21
60_S	138_V	0.816	0.21
53_V	166_A	0.811	0.21
185_T	231_A	0.808	0.21
152_L	188_E	0.808	0.21
145_A	232_A	0.805	0.20
184_F	217_W	0.805	0.20
45_G	224_K	0.803	0.20
115_L	119_V	0.802	0.20
105_A	109_T	0.798	0.20
42_P	169_T	0.795	0.20
16_T	32_I	0.793	0.20
81_A	219_A	0.791	0.20
116_K	224_K	0.783	0.20
69_L	79_D	0.782	0.20
108_V	143_A	0.774	0.20
78_D	84_S	0.771	0.19
3_K	171_T	0.769	0.19
83_A	195_V	0.765	0.19
173_A	212_F	0.764	0.19
14_R	182_G	0.760	0.19
83_A	194_L	0.757	0.19
198_I	234_V	0.751	0.19
36_Y	50_L	0.751	0.19
117_T	180_V	0.750	0.19
28_F	31_H	0.743	0.19
16_T	233_K	0.742	0.19
49_G	161_A	0.741	0.19
101_R	140_A	0.741	0.19
108_V	118_L	0.737	0.18
126_Y	170_T	0.737	0.18
143_A	238_S	0.733	0.18
132_L	137_D	0.723	0.18
65_A	242_A	0.723	0.18
28_F	126_Y	0.716	0.18
66_A	112_G	0.716	0.18
21_T	26_F	0.713	0.18
19_A	179_H	0.713	0.18
36_Y	59_V	0.712	0.18
44_L	189_A	0.711	0.18
57_A	177_A	0.709	0.18
30_Q	209_S	0.708	0.18
84_S	131_F	0.707	0.18
115_L	127_A	0.702	0.17
178_P	205_T	0.701	0.17
29_V	216_I	0.700	0.17
58_A	94_D	0.696	0.17
36_Y	210_I	0.696	0.17
28_F	63_I	0.691	0.17
31_H	138_V	0.688	0.17
123_A	142_T	0.687	0.17
193_M	217_W	0.676	0.17
126_Y	168_D	0.669	0.16
19_A	39_V	0.669	0.16
19_A	198_I	0.669	0.16
79_D	150_S	0.668	0.16
207_K	233_K	0.665	0.16
35_F	122_L	0.665	0.16
198_I	241_I	0.655	0.16
72_A	140_A	0.654	0.16
196_G	215_G	0.654	0.16
18_V	172_G	0.652	0.16
233_K	237_I	0.652	0.16
56_R	209_S	0.651	0.16
99_S	149_T	0.650	0.16
25_F	49_G	0.650	0.16
105_A	128_A	0.641	0.16
31_H	190_V	0.639	0.16
31_H	207_K	0.639	0.16
37_A	240_A	0.639	0.16
43_I	53_V	0.639	0.16
40_L	217_W	0.633	0.16
71_G	198_I	0.632	0.15
26_F	193_M	0.632	0.15
132_L	149_T	0.632	0.15
33_F	233_K	0.630	0.15
109_T	144_A	0.630	0.15
131_F	135_T	0.629	0.15
169_T	197_G	0.625	0.15
156_G	171_T	0.623	0.15
83_A	242_A	0.621	0.15
215_G	218_G	0.619	0.15
168_D	208_R	0.613	0.15
113_G	181_P	0.612	0.15
23_N	226_I	0.612	0.15
70_A	102_E	0.609	0.15
176_I	192_T	0.607	0.15
42_P	198_I	0.607	0.15
61_L	123_A	0.602	0.15
21_T	225_V	0.601	0.15
197_G	229_N	0.599	0.15
15_A	26_F	0.599	0.15
129_V	153_G	0.599	0.15
77_E	80_V	0.598	0.15
208_R	230_I	0.598	0.15
79_D	85_D	0.595	0.15
5_Y	234_V	0.588	0.14
158_A	229_N	0.588	0.14
98_E	128_A	0.588	0.14
159_V	219_A	0.586	0.14
15_A	117_T	0.583	0.14
9_G	207_K	0.583	0.14
70_A	131_F	0.581	0.14
75_L	177_A	0.580	0.14
28_F	200_S	0.580	0.14
17_L	28_F	0.578	0.14
152_L	195_V	0.577	0.14
205_T	209_S	0.574	0.14
79_D	109_T	0.572	0.14
108_V	119_V	0.570	0.14
204_S	209_S	0.570	0.14
56_R	230_I	0.569	0.14
65_A	182_G	0.569	0.14
64_T	138_V	0.568	0.14
43_I	134_E	0.568	0.14
164_T	169_T	0.566	0.14
154_L	157_V	0.560	0.14
158_A	198_I	0.559	0.14
20_I	175_F	0.555	0.14
162_V	192_T	0.554	0.14
52_Y	136_Y	0.554	0.14
197_G	203_V	0.553	0.14
138_V	208_R	0.552	0.14
12_S	185_T	0.550	0.13
2_L	182_G	0.550	0.13
176_I	202_A	0.550	0.13
63_I	213_Q	0.550	0.13
46_L	162_V	0.546	0.13
40_L	166_A	0.546	0.13
179_H	220_R	0.545	0.13
2_L	16_T	0.545	0.13
145_A	195_V	0.544	0.13
64_T	200_S	0.543	0.13
101_R	105_A	0.543	0.13
222_G	234_V	0.543	0.13
94_D	109_T	0.542	0.13
172_G	202_A	0.542	0.13
10_V	174_I	0.541	0.13
124_V	207_K	0.540	0.13
203_V	229_N	0.539	0.13
168_D	209_S	0.539	0.13
40_L	139_T	0.538	0.13
151_V	195_V	0.536	0.13
25_F	128_A	0.536	0.13
23_N	211_P	0.535	0.13
79_D	132_L	0.534	0.13
30_Q	63_I	0.533	0.13
40_L	215_G	0.532	0.13
61_L	179_H	0.529	0.13
230_I	241_I	0.529	0.13
150_S	227_A	0.520	0.13
196_G	200_S	0.520	0.13
39_V	118_L	0.519	0.13
55_A	118_L	0.519	0.13
45_G	57_A	0.518	0.13
59_V	208_R	0.518	0.13
26_F	217_W	0.516	0.13
82_S	86_A	0.516	0.13
56_R	169_T	0.515	0.13
57_A	158_A	0.513	0.13
30_Q	37_A	0.511	0.13
66_A	96_A	0.511	0.13
198_I	229_N	0.510	0.13
4_E	58_A	0.505	0.12
199_V	203_V	0.504	0.12
133_T	141_F	0.504	0.12
6_R	13_D	0.502	0.12
197_G	201_F	0.502	0.12
120_P	229_N	0.500	0.12
23_N	237_I	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pd6A	3	0.8821	95.2	0.909	Contact Map
4r1iA	2	0.8415	33.6	0.951	Contact Map
2jlnA	1	0.3049	28.9	0.953	Contact Map
4dx5A	3	0.3374	20	0.956	Contact Map
4lz6A	1	0.8211	16	0.958	Contact Map
1pw4A	1	0.874	10.7	0.961	Contact Map
4kjrA	3	0.7195	9.5	0.962	Contact Map
3qe7A	2	0.2358	9.3	0.962	Contact Map
3w4tA	1	0.8293	8.5	0.963	Contact Map
4r0cA	3	0.8455	8	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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