GREMLIN Database
Q9HMN6 - Uncharacterized protein
UniProt: Q9HMN6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (180)
Sequences: 737 (528)
Seq/√Len: 39.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_A132_V3.6421.00
17_A21_S3.0231.00
13_E161_T2.8211.00
160_D165_P2.6761.00
64_G68_A2.6601.00
164_G175_G2.6581.00
74_G77_E2.4081.00
96_G108_V2.4021.00
141_L171_G2.3591.00
88_R132_V2.2951.00
14_A21_S2.2320.99
71_L153_Y2.2080.99
65_A173_L2.1330.99
56_R60_Y2.0400.99
60_Y149_V1.8940.98
157_Y163_V1.8850.98
45_L141_L1.8510.98
93_A97_N1.8250.98
54_A69_T1.8170.98
123_L127_V1.8090.98
63_F67_L1.7870.98
101_A119_P1.7840.97
56_R164_G1.7440.97
52_L58_N1.7420.97
60_Y167_V1.7070.97
23_L107_A1.6880.96
151_A154_R1.6750.96
56_R61_A1.6430.96
56_R59_V1.6250.96
21_S25_G1.6170.95
60_Y175_G1.5880.95
10_A14_A1.5570.94
17_A25_G1.5260.94
74_G156_G1.5230.94
7_A19_A1.4960.93
44_G47_V1.4760.93
104_F170_T1.4650.92
164_G168_T1.4550.92
52_L95_M1.4470.92
105_A149_V1.4430.92
146_V150_F1.4280.91
56_R175_G1.4050.91
59_V97_N1.3980.90
123_L132_V1.3770.90
48_V130_A1.3740.90
54_A168_T1.3660.89
39_L180_V1.3570.89
129_V154_R1.3570.89
135_L156_G1.3420.89
56_R62_S1.3410.89
152_G157_Y1.3200.88
90_A98_G1.3180.88
58_N171_G1.3130.87
51_A126_L1.2960.87
67_L144_A1.2900.87
91_V126_L1.2710.86
60_Y141_L1.2700.86
139_V185_L1.2680.86
23_L78_P1.2650.85
52_L61_A1.2600.85
125_T154_R1.2450.84
62_S164_G1.2450.84
171_G180_V1.2440.84
65_A160_D1.2270.84
154_R181_L1.2120.83
147_A185_L1.2100.83
151_A155_R1.2000.82
37_A111_G1.1980.82
67_L101_A1.1930.82
31_V101_A1.1850.81
24_G56_R1.1830.81
114_T118_R1.1790.81
148_V170_T1.1450.79
174_F177_A1.1440.79
18_L113_L1.1420.79
149_V158_N1.1410.79
144_A154_R1.1370.79
112_V181_L1.1210.78
149_V177_A1.1180.77
99_L103_G1.1090.77
80_V83_G1.1090.77
181_L185_L1.1020.76
106_A114_T1.0980.76
163_V174_F1.0780.75
131_L151_A1.0710.74
110_F133_A1.0640.74
21_S30_A1.0630.74
45_L183_V1.0620.74
60_Y63_F1.0550.73
59_V164_G1.0530.73
23_L119_P1.0520.73
40_E181_L1.0490.73
152_G163_V1.0450.72
146_V180_V1.0240.71
45_L176_L1.0140.70
120_V124_A1.0060.70
8_A12_R1.0010.69
42_V181_L0.9950.69
66_R72_H0.9870.68
13_E53_L0.9820.68
85_R157_Y0.9800.67
43_D180_V0.9740.67
133_A182_A0.9720.67
141_L149_V0.9700.67
168_T179_L0.9530.65
49_V111_G0.9480.65
48_V53_L0.9390.64
107_A134_G0.9350.64
99_L107_A0.9320.64
54_A137_S0.9310.63
166_L170_T0.9220.63
117_G144_A0.9210.63
31_V107_A0.9190.62
59_V98_G0.9070.61
80_V119_P0.8950.60
102_S106_A0.8930.60
119_P181_L0.8920.60
99_L135_L0.8880.60
125_T184_R0.8860.60
28_A92_G0.8810.59
65_A72_H0.8800.59
62_S72_H0.8780.59
168_T175_G0.8760.59
54_A66_R0.8720.58
58_N64_G0.8700.58
99_L131_L0.8690.58
148_V158_N0.8640.58
67_L182_A0.8640.58
26_L62_S0.8610.57
33_G51_A0.8610.57
13_E128_G0.8560.57
66_R69_T0.8550.57
156_G174_F0.8530.57
56_R137_S0.8520.57
70_G183_V0.8460.56
129_V182_A0.8440.56
17_A22_V0.8410.56
45_L73_Q0.8360.55
165_P169_T0.8360.55
48_V179_L0.8330.55
96_G111_G0.8330.55
68_A157_Y0.8250.54
69_T99_L0.8190.54
9_T41_A0.8180.54
85_R88_R0.8140.53
119_P122_G0.8140.53
150_F154_R0.8080.53
11_Y14_A0.8070.53
161_T167_V0.8050.52
103_G116_L0.8050.52
111_G180_V0.8050.52
8_A30_A0.7930.51
13_E20_A0.7870.51
89_A94_A0.7870.51
45_L74_G0.7870.51
53_L137_S0.7860.51
57_G69_T0.7840.50
167_V171_G0.7810.50
100_L104_F0.7810.50
130_A134_G0.7780.50
45_L116_L0.7770.50
69_T105_A0.7740.50
99_L110_F0.7720.49
150_F169_T0.7660.49
132_V136_L0.7620.48
61_A65_A0.7620.48
120_V166_L0.7580.48
129_V177_A0.7550.48
90_A95_M0.7490.47
38_Q42_V0.7470.47
50_P127_V0.7430.47
144_A166_L0.7410.47
96_G112_V0.7400.46
54_A65_A0.7400.46
141_L170_T0.7370.46
13_E24_G0.7330.46
111_G147_A0.7330.46
90_A97_N0.7330.46
23_L83_G0.7300.46
94_A150_F0.7280.45
17_A54_A0.7280.45
24_G60_Y0.7250.45
49_V53_L0.7150.44
25_G60_Y0.7020.43
49_V143_G0.6980.43
64_G163_V0.6980.43
165_P172_D0.6970.43
14_A22_V0.6970.43
95_M105_A0.6930.42
125_T144_A0.6920.42
46_L130_A0.6860.42
19_A123_L0.6810.41
12_R99_L0.6770.41
8_A108_V0.6750.41
11_Y22_V0.6710.40
142_T153_Y0.6700.40
52_L158_N0.6630.40
21_S28_A0.6620.39
105_A109_A0.6610.39
68_A108_V0.6590.39
63_F173_L0.6530.39
57_G160_D0.6530.39
53_L138_G0.6510.39
48_V109_A0.6490.38
55_T164_G0.6470.38
100_L116_L0.6450.38
26_L88_R0.6400.38
45_L118_R0.6400.38
67_L70_G0.6370.37
27_F136_L0.6270.36
37_A184_R0.6250.36
107_A130_A0.6210.36
86_R89_A0.6190.36
98_G102_S0.6170.36
79_H111_G0.6130.35
49_V73_Q0.6110.35
113_L117_G0.6110.35
28_A50_P0.6060.35
77_E153_Y0.6030.34
55_T97_N0.6010.34
17_A65_A0.5980.34
60_Y145_V0.5920.34
21_S24_G0.5910.34
28_A173_L0.5900.33
55_T129_V0.5900.33
166_L169_T0.5900.33
58_N161_T0.5890.33
20_A71_L0.5850.33
54_A62_S0.5830.33
28_A69_T0.5770.32
128_G156_G0.5720.32
50_P74_G0.5720.32
159_P165_P0.5710.32
173_L183_V0.5710.32
124_A170_T0.5710.32
157_Y170_T0.5680.32
8_A115_A0.5650.31
90_A139_V0.5650.31
65_A145_V0.5640.31
108_V173_L0.5550.31
46_L61_A0.5540.31
27_F144_A0.5520.30
51_A158_N0.5520.30
78_P132_V0.5500.30
88_R119_P0.5480.30
75_I185_L0.5480.30
94_A110_F0.5480.30
11_Y15_A0.5470.30
9_T155_R0.5400.30
137_S178_F0.5380.29
18_L62_S0.5350.29
60_Y72_H0.5270.29
114_T139_V0.5230.28
61_A71_L0.5220.28
14_A46_L0.5210.28
93_A129_V0.5200.28
62_S78_P0.5140.28
81_A85_R0.5120.27
18_L25_G0.5120.27
7_A11_Y0.5110.27
79_H82_A0.5110.27
126_L169_T0.5080.27
11_Y113_L0.5080.27
72_H153_Y0.5040.27
45_L76_I0.5030.27
140_A174_F0.5020.27
39_L46_L0.5010.27
62_S175_G0.5000.27
55_T175_G0.5000.27
22_V62_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u9nA 2 0.9316 99.9 0.447 Contact Map
2zy9A 2 0.9368 99.6 0.636 Contact Map
3j1zP 8 0.8947 5.1 0.95 Contact Map
1f8vD 3 0.1421 4.9 0.95 Contact Map
4ftbD 1 0.1053 4.5 0.951 Contact Map
2mofA 1 0.1789 3.2 0.955 Contact Map
1novD 1 0.1053 3.2 0.955 Contact Map
4lz6A 1 0.9684 2.9 0.956 Contact Map
4mt1A 3 0.3158 2.6 0.957 Contact Map
3ne5A 3 0.4 1.8 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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