GREMLIN Database
Q9HMN3 - Signal recognition particle receptor FtsY
UniProt: Q9HMN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (288)
Sequences: 6922 (3208)
Seq/√Len: 189.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_A232_C5.9901.00
251_Y255_N4.0801.00
121_E337_H3.3471.00
307_R311_E3.1171.00
179_F191_I3.1041.00
206_V257_V3.0271.00
198_L259_V3.0081.00
208_A248_A2.9051.00
276_S279_E2.7971.00
279_E312_A2.7341.00
204_S257_V2.5961.00
150_R365_D2.5601.00
222_E226_E2.5581.00
152_A155_S2.5031.00
222_E234_T2.5011.00
125_Q152_A2.4971.00
250_E254_A2.4541.00
99_E127_R2.4291.00
235_H247_D2.3801.00
197_Y201_E2.2771.00
219_Q222_E2.2501.00
207_L225_A2.2321.00
196_R200_S2.2291.00
291_V319_I2.2181.00
245_V262_G2.1401.00
310_D341_K2.1251.00
349_G354_D2.0771.00
308_E311_E2.0271.00
191_I261_L2.0141.00
359_D362_A1.9731.00
208_A260_V1.9711.00
289_V344_L1.9311.00
269_H301_D1.8871.00
228_L352_Y1.8851.00
307_R338_V1.8781.00
210_G245_V1.8681.00
282_D314_A1.8681.00
199_E229_G1.8041.00
190_T319_I1.8021.00
129_D152_A1.7961.00
231_K257_V1.7481.00
197_Y345_F1.7411.00
129_D151_E1.7221.00
199_E230_V1.7211.00
223_E226_E1.6921.00
192_A224_H1.6901.00
291_V317_G1.6531.00
306_A339_T1.6411.00
276_S280_K1.6301.00
251_Y254_A1.6201.00
272_D276_S1.6121.00
240_D243_A1.6091.00
320_L332_A1.5981.00
315_V341_K1.5711.00
197_Y357_P1.5691.00
170_S175_V1.5671.00
240_D280_K1.5611.00
206_V231_K1.5591.00
125_Q155_S1.5361.00
250_E253_D1.5291.00
195_A230_V1.5071.00
154_L361_D1.5031.00
121_E125_Q1.4931.00
289_V316_D1.4901.00
179_F261_L1.4891.00
191_I207_L1.4791.00
170_S173_K1.4791.00
242_T284_V1.4661.00
195_A207_L1.4481.00
243_A247_D1.4121.00
196_R353_E1.4051.00
233_I251_Y1.3871.00
177_I259_V1.3851.00
233_I247_D1.3821.00
296_A320_L1.3781.00
262_G285_V1.3741.00
207_L221_I1.3731.00
196_R352_Y1.3631.00
86_M90_R1.3521.00
222_E232_C1.3351.00
291_V344_L1.3241.00
114_V333_I1.3111.00
176_T249_V1.3001.00
323_A346_L1.2981.00
203_F258_D1.2931.00
310_D315_V1.2911.00
203_F259_V1.2901.00
249_V260_V1.2881.00
245_V285_V1.2661.00
137_F144_L1.2611.00
206_V251_Y1.2521.00
154_L364_V1.2431.00
356_E362_A1.2381.00
236_E239_G1.2291.00
247_D250_E1.2281.00
176_T262_G1.2231.00
251_Y257_V1.2161.00
207_L261_L1.2011.00
279_E283_R1.1921.00
242_T280_K1.1921.00
192_A228_L1.1921.00
179_F194_L1.1901.00
150_R154_L1.1891.00
231_K251_Y1.1871.00
248_A260_V1.1771.00
153_L333_I1.1641.00
304_N308_E1.1631.00
196_R199_E1.1591.00
153_L364_V1.1511.00
348_T356_E1.1511.00
175_V288_D1.1481.00
190_T347_G1.1471.00
224_H352_Y1.1461.00
79_F83_A1.1421.00
80_V83_A1.1411.00
205_S257_V1.1361.00
246_Y250_E1.1321.00
119_V123_L1.1251.00
212_T244_V1.1161.00
120_E124_D1.1061.00
206_V260_V1.1031.00
252_A260_V1.0951.00
218_N234_T1.0921.00
124_D127_R1.0921.00
180_T290_T1.0881.00
147_D151_E1.0871.00
219_Q237_Q1.0871.00
85_S89_G1.0861.00
110_L119_V1.0821.00
179_F319_I1.0821.00
178_V262_G1.0741.00
249_V285_V1.0681.00
190_T355_L1.0601.00
242_T281_L1.0591.00
304_N307_R1.0581.00
294_D320_L1.0551.00
185_V191_I1.0531.00
345_F357_P1.0451.00
282_D290_T1.0431.00
280_K284_V1.0401.00
282_D286_D1.0391.00
177_I261_L1.0381.00
171_T175_V1.0361.00
235_H243_A1.0361.00
318_T335_V1.0341.00
79_F84_A1.0301.00
122_I126_I1.0251.00
235_H239_G1.0251.00
210_G262_G1.0231.00
269_H304_N1.0161.00
192_A352_Y1.0141.00
298_A302_A1.0091.00
178_V290_T1.0071.00
172_S175_V0.9920.99
155_S159_V0.9850.99
90_R97_D0.9830.99
76_S79_F0.9810.99
199_E228_L0.9780.99
176_T260_V0.9720.99
226_E229_G0.9710.99
129_D155_S0.9710.99
207_L232_C0.9630.99
317_G344_L0.9570.99
121_E124_D0.9540.99
323_A363_L0.9440.99
125_Q128_G0.9360.99
249_V253_D0.9340.99
360_P364_V0.9270.99
86_M91_V0.9200.99
132_G135_R0.9040.99
124_D128_G0.9030.99
208_A245_V0.9010.99
153_L368_L0.8990.99
104_E107_F0.8890.99
209_N218_N0.8860.99
117_S338_V0.8840.99
161_Q359_D0.8730.99
169_E259_V0.8730.99
94_D97_D0.8680.99
213_Y244_V0.8630.98
86_M89_G0.8620.98
303_V338_V0.8620.98
87_A91_V0.8600.98
206_V252_A0.8570.98
158_D360_P0.8560.98
218_N235_H0.8530.98
303_V334_S0.8510.98
87_A90_R0.8490.98
310_D314_A0.8470.98
196_R228_L0.8420.98
161_Q357_P0.8420.98
81_S85_S0.8420.98
99_E103_R0.8380.98
128_G132_G0.8380.98
238_G243_A0.8370.98
246_Y284_V0.8350.98
225_A228_L0.8290.98
148_A152_A0.8260.98
179_F190_T0.8260.98
222_E225_A0.8230.98
159_V340_G0.8220.98
205_S231_K0.8210.98
175_V289_V0.8190.98
273_D276_S0.8100.98
76_S84_A0.8070.98
260_V285_V0.8060.98
118_V337_H0.8040.98
185_V298_A0.8040.98
239_G243_A0.8030.98
224_H228_L0.7990.98
102_L127_R0.7960.97
173_K253_D0.7940.97
81_S84_A0.7870.97
208_A262_G0.7830.97
83_A86_M0.7810.97
76_S86_M0.7760.97
76_S80_V0.7730.97
123_L127_R0.7720.97
292_F318_T0.7720.97
93_I98_L0.7700.97
177_I345_F0.7700.97
308_E312_A0.7660.97
299_G302_A0.7630.97
209_N235_H0.7620.97
176_T288_D0.7610.97
84_A88_R0.7560.97
280_K283_R0.7560.97
129_D133_E0.7550.96
294_D335_V0.7540.96
102_L123_L0.7530.96
332_A343_I0.7500.96
253_D256_D0.7470.96
269_H305_R0.7430.96
78_G82_R0.7410.96
106_E119_V0.7410.96
208_A233_I0.7410.96
113_D301_D0.7380.96
245_V284_V0.7360.96
77_A81_S0.7360.96
82_R86_M0.7330.96
80_V84_A0.7320.96
207_L228_L0.7310.96
336_S340_G0.7260.96
108_A111_E0.7260.96
249_V284_V0.7250.96
301_D305_R0.7250.96
178_V281_L0.7230.96
231_K255_N0.7220.95
216_G265_A0.7210.95
179_F291_V0.7200.95
82_R85_S0.7190.95
279_E311_E0.7160.95
239_G247_D0.7140.95
197_Y200_S0.7110.95
120_E123_L0.7110.95
109_L114_V0.7090.95
146_E150_R0.7070.95
178_V282_D0.7060.95
125_Q337_H0.7050.95
169_E172_S0.7030.95
107_F111_E0.7020.95
160_G163_D0.7000.95
348_T355_L0.6980.95
303_V339_T0.6960.95
296_A323_A0.6950.94
133_E144_L0.6950.94
337_H340_G0.6900.94
267_R277_Q0.6860.94
269_H308_E0.6840.94
98_L131_V0.6830.94
84_A87_A0.6830.94
206_V255_N0.6830.94
185_V296_A0.6800.94
103_R107_F0.6800.94
243_A246_Y0.6780.94
276_S283_R0.6780.94
77_A85_S0.6760.94
228_L231_K0.6750.94
282_D313_S0.6680.93
361_D365_D0.6670.93
225_A231_K0.6660.93
198_L261_L0.6650.93
245_V249_V0.6650.93
159_V360_P0.6630.93
101_P142_D0.6630.93
182_V185_V0.6620.93
261_L355_L0.6580.93
290_T316_D0.6570.93
180_T230_V0.6550.93
218_N237_Q0.6540.92
200_S353_E0.6540.92
224_H227_A0.6500.92
151_E155_S0.6480.92
117_S120_E0.6470.92
163_D201_E0.6460.92
290_T313_S0.6450.92
109_L119_V0.6430.92
274_L278_L0.6420.92
216_G269_H0.6360.91
92_V95_E0.6360.91
152_A156_V0.6360.91
170_S174_P0.6350.91
222_E236_E0.6350.91
126_I152_A0.6350.91
196_R355_L0.6340.91
102_L130_L0.6320.91
84_A91_V0.6300.91
154_L158_D0.6300.91
294_D302_A0.6290.91
210_G281_L0.6270.91
164_L177_I0.6270.91
154_L365_D0.6260.91
347_G355_L0.6250.91
289_V317_G0.6250.91
198_L201_E0.6230.91
83_A90_R0.6230.91
102_L126_I0.6210.90
310_D313_S0.6200.90
169_E175_V0.6200.90
182_V270_T0.6190.90
154_L157_I0.6190.90
151_E154_L0.6180.90
218_N236_E0.6170.90
225_A230_V0.6160.90
93_I97_D0.6160.90
144_L147_D0.6140.90
209_N234_T0.6140.90
218_N222_E0.6130.90
205_S258_D0.6110.90
235_H244_V0.6090.90
87_A101_P0.6080.89
154_L360_P0.6060.89
85_S88_R0.6060.89
225_A234_T0.6050.89
318_T341_K0.6040.89
314_A341_K0.6030.89
283_R286_D0.6030.89
129_D148_A0.6020.89
301_D304_N0.6010.89
96_A99_E0.6010.89
204_S256_D0.5990.89
180_T315_V0.5980.89
321_T326_D0.5970.89
242_T245_V0.5970.89
76_S91_V0.5950.88
212_T241_P0.5930.88
102_L145_I0.5900.88
85_S90_R0.5890.88
241_P281_L0.5880.88
169_E173_K0.5870.88
227_A354_D0.5830.87
174_P260_V0.5800.87
164_L357_P0.5770.87
178_V333_I0.5770.87
297_V326_D0.5760.87
158_D361_D0.5760.87
162_F165_V0.5760.87
269_H278_L0.5760.87
115_E334_S0.5750.87
279_E313_S0.5750.87
235_H251_Y0.5750.87
129_D134_E0.5740.87
117_S337_H0.5730.87
76_S87_A0.5720.86
106_E123_L0.5710.86
122_I153_L0.5700.86
218_N239_G0.5690.86
247_D251_Y0.5680.86
331_A334_S0.5680.86
281_L285_V0.5660.86
164_L198_L0.5650.86
199_E204_S0.5640.86
126_I149_L0.5640.86
302_A331_A0.5630.86
290_T314_A0.5630.86
153_L367_L0.5590.85
227_A351_A0.5580.85
195_A228_L0.5580.85
194_L198_L0.5570.85
274_L347_G0.5560.85
113_D116_M0.5560.85
180_T313_S0.5550.85
78_G81_S0.5540.85
130_L148_A0.5520.84
319_I345_F0.5510.84
150_R368_L0.5480.84
272_D312_A0.5450.84
207_L230_V0.5440.84
219_Q236_E0.5400.83
92_V97_D0.5380.83
174_P258_D0.5370.83
174_P252_A0.5360.83
161_Q164_L0.5360.83
94_D98_L0.5350.83
183_N268_L0.5350.83
325_A350_Q0.5340.83
133_E151_E0.5340.83
150_R364_V0.5340.83
215_A224_H0.5330.82
227_A352_Y0.5330.82
95_E131_V0.5320.82
79_F91_V0.5310.82
213_Y277_Q0.5300.82
321_T325_A0.5290.82
116_M120_E0.5290.82
183_N213_Y0.5270.82
75_S78_G0.5270.82
290_T315_V0.5250.81
103_R120_E0.5230.81
98_L102_L0.5230.81
189_T347_G0.5230.81
213_Y241_P0.5220.81
269_H275_M0.5220.81
245_V281_L0.5210.81
204_S231_K0.5180.81
205_S208_A0.5160.80
183_N350_Q0.5160.80
267_R275_M0.5150.80
282_D310_D0.5150.80
235_H254_A0.5140.80
265_A275_M0.5130.80
107_F110_L0.5130.80
171_T288_D0.5120.80
195_A352_Y0.5090.79
198_L203_F0.5070.79
130_L145_I0.5070.79
88_R91_V0.5060.79
257_V260_V0.5060.79
219_Q234_T0.5050.79
95_E98_L0.5030.79
179_F293_V0.5020.79
204_S258_D0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yhsA 1 0.7828 100 0.472 Contact Map
1vmaA 1 0.7453 100 0.482 Contact Map
2px0A 4 0.6863 100 0.484 Contact Map
4c7oA 1 0.7936 100 0.485 Contact Map
2og2A 1 0.7614 100 0.487 Contact Map
2v3cC 1 0.7936 100 0.496 Contact Map
1ls1A 1 0.7748 100 0.502 Contact Map
3b9qA 1 0.7641 100 0.509 Contact Map
2j37W 1 0.7802 100 0.51 Contact Map
2xxaA 1 0.7936 100 0.515 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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