GREMLIN Database
PFDA - Prefoldin subunit alpha
UniProt: Q9HMN2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (131)
Sequences: 478 (348)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_L131_A5.5771.00
91_D94_A5.4221.00
82_L88_A4.2351.00
50_D96_A3.0401.00
90_Q94_A2.9641.00
104_A108_G2.9291.00
104_A107_D2.3850.99
18_I22_E2.2370.99
11_L49_L2.2240.99
68_V117_I2.2070.99
97_S101_E2.1690.98
21_I127_L2.0930.98
77_E89_E2.0870.98
72_V78_V2.0730.98
45_A99_L1.9910.97
50_D100_D1.9470.97
108_G112_D1.9160.96
42_I98_V1.8470.95
130_Q134_A1.7880.95
62_L134_A1.7830.94
32_V110_I1.7120.93
20_A42_I1.6280.91
55_G71_E1.5980.90
19_Q94_A1.5330.89
49_L92_S1.5190.88
44_E133_Q1.5090.88
58_V69_R1.5080.88
100_D104_A1.4300.85
11_L47_E1.4200.84
99_L102_K1.4060.84
54_T73_K1.3990.83
74_D77_E1.3880.83
35_L85_G1.3820.83
46_K49_L1.3620.82
72_V75_M1.3440.81
35_L42_I1.3080.79
38_E70_A1.3040.79
28_L32_V1.2930.78
20_A84_G1.2680.77
27_E45_A1.2160.74
16_Q19_Q1.1910.72
40_T129_Q1.1870.72
18_I65_D1.1380.69
49_L96_A1.1350.68
28_L117_I1.1340.68
86_Y105_T1.1130.67
81_S84_G1.0940.65
60_V68_V1.0840.65
131_A135_Q1.0780.64
66_A113_V1.0540.62
44_E59_Q1.0450.62
45_A82_L1.0340.61
100_D103_K1.0030.59
29_E55_G0.9840.57
65_D84_G0.9820.57
24_E67_Y0.9710.56
23_E96_A0.9560.55
36_R114_Q0.9430.54
41_E84_G0.9370.53
36_R107_D0.9290.53
26_E30_A0.9270.53
89_E133_Q0.9200.52
63_G134_A0.9090.51
17_E101_E0.9070.51
24_E134_A0.9020.51
41_E118_A0.8990.50
46_K98_V0.8990.50
119_D123_E0.8980.50
41_E65_D0.8970.50
54_T91_D0.8890.50
89_E98_V0.8800.49
46_K99_L0.8790.49
63_G130_Q0.8780.49
55_G136_Q0.8780.49
36_R39_Q0.8710.48
22_E58_V0.8640.48
31_D84_G0.8620.47
30_A62_L0.8620.47
13_Q106_I0.8600.47
111_D135_Q0.8520.47
63_G120_L0.8470.46
18_I70_A0.8460.46
119_D122_E0.8430.46
15_S40_T0.8390.46
31_D120_L0.8370.45
18_I107_D0.8370.45
14_L21_I0.8330.45
93_D115_A0.8300.45
28_L109_R0.8270.45
102_K132_Q0.8220.44
66_A87_A0.8210.44
50_D91_D0.8210.44
74_D113_V0.8130.44
51_V106_I0.7970.42
16_Q69_R0.7970.42
57_T71_E0.7960.42
95_A99_L0.7930.42
96_A104_A0.7750.41
118_A137_Q0.7620.40
92_S106_I0.7610.40
82_L105_T0.7550.39
58_V74_D0.7480.39
34_S72_V0.7470.38
38_E62_L0.7450.38
28_L35_L0.7350.38
52_L125_E0.7310.37
72_V111_D0.7270.37
76_D140_Q0.7200.36
32_V38_E0.7120.36
132_Q136_Q0.7120.36
16_Q44_E0.7080.36
104_A115_A0.7050.35
12_Q139_M0.7030.35
59_Q72_V0.7030.35
31_D66_A0.6970.35
37_Q40_T0.6950.35
42_I84_G0.6910.34
54_T115_A0.6850.34
48_A58_V0.6840.34
62_L74_D0.6830.34
77_E90_Q0.6810.34
63_G66_A0.6780.33
11_L15_S0.6760.33
66_A120_L0.6740.33
46_K80_V0.6730.33
79_V89_E0.6730.33
36_R53_E0.6720.33
45_A101_E0.6710.33
72_V126_Q0.6670.33
35_L106_I0.6640.32
12_Q89_E0.6570.32
28_L138_M0.6560.32
16_Q64_G0.6560.32
15_S25_V0.6520.32
23_E108_G0.6510.31
41_E87_A0.6490.31
30_A50_D0.6480.31
31_D102_K0.6460.31
67_Y132_Q0.6460.31
94_A97_S0.6450.31
11_L130_Q0.6440.31
48_A62_L0.6440.31
32_V117_I0.6430.31
45_A66_A0.6380.31
84_G120_L0.6320.30
64_G81_S0.6290.30
50_D54_T0.6280.30
48_A57_T0.6230.30
128_E135_Q0.6160.29
37_Q60_V0.6100.29
62_L68_V0.6090.29
21_I129_Q0.6050.28
11_L36_R0.6030.28
20_A78_V0.6020.28
17_E41_E0.6020.28
24_E120_L0.6010.28
77_E87_A0.5990.28
105_T139_M0.5970.28
99_L110_I0.5960.28
28_L116_E0.5950.28
35_L81_S0.5930.28
53_E59_Q0.5920.28
30_A97_S0.5910.27
47_E96_A0.5860.27
67_Y86_Y0.5800.27
90_Q139_M0.5790.27
17_E63_G0.5750.26
51_V91_D0.5730.26
14_L102_K0.5720.26
108_G111_D0.5700.26
20_A24_E0.5650.26
27_E46_K0.5650.26
10_Q22_E0.5610.26
109_R124_A0.5600.26
18_I84_G0.5590.26
10_Q87_A0.5580.25
57_T74_D0.5570.25
27_E31_D0.5450.25
33_A72_V0.5440.25
82_L121_S0.5440.25
39_Q44_E0.5430.25
91_D138_M0.5410.24
55_G137_Q0.5370.24
11_L128_E0.5360.24
25_V117_I0.5350.24
16_Q137_Q0.5230.23
93_D137_Q0.5220.23
40_T115_A0.5180.23
41_E120_L0.5170.23
46_K96_A0.5140.23
11_L118_A0.5120.23
33_A117_I0.5120.23
108_G121_S0.5100.23
57_T133_Q0.5080.23
14_L80_V0.5060.22
93_D135_Q0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zdiC 2 0.9286 100 0.393 Contact Map
1fxkC 2 0.8506 99.9 0.416 Contact Map
2zqmA 5 0.7403 98.6 0.761 Contact Map
1fxkA 2 0.6948 98.5 0.772 Contact Map
3aeiA 3 0.6104 96.4 0.846 Contact Map
4q4gX 1 0 51.6 0.916 Contact Map
4cgkA 3 0.9026 47.4 0.918 Contact Map
1i84S 2 0.0649 39.1 0.922 Contact Map
3trtA 2 0.474 38 0.922 Contact Map
3vkgA 2 0.9351 36.6 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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