GREMLIN Database
Q9HMM8 - Uncharacterized protein
UniProt: Q9HMM8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 263 (209)
Sequences: 4993 (4389)
Seq/√Len: 303.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
237_R240_E4.9601.00
203_R206_Q4.5601.00
95_R98_Q4.3521.00
169_E172_Q3.9891.00
132_E135_A3.9301.00
124_G140_H2.9051.00
161_A177_A2.8521.00
229_T245_A2.8301.00
87_G103_F2.6421.00
195_G211_L2.4641.00
120_W139_A2.1531.00
103_F122_N2.1291.00
225_Y244_V2.1171.00
157_H176_H2.1061.00
160_L176_H2.0831.00
228_K232_L2.0591.00
191_W210_A2.0321.00
194_L210_A1.9891.00
232_L237_R1.9601.00
178_E194_L1.9291.00
212_D228_K1.9281.00
141_R160_L1.9241.00
194_L198_E1.8611.00
123_K139_A1.8401.00
211_L227_E1.7971.00
228_K244_V1.7931.00
127_H135_A1.7811.00
160_L164_L1.7551.00
127_H132_E1.7401.00
140_H159_N1.7391.00
104_E123_K1.7381.00
208_L228_K1.7151.00
232_L240_E1.6981.00
174_Y178_E1.6481.00
242_A246_E1.6201.00
164_L172_Q1.6011.00
83_L102_T1.5731.00
86_V90_Y1.5661.00
195_G214_A1.5441.00
97_E130_L1.5221.00
87_G106_A1.4991.00
177_A193_N1.4881.00
90_Y98_Q1.4851.00
123_K127_H1.4801.00
240_E243_K1.4781.00
208_L231_A1.4701.00
164_L169_E1.4621.00
84_I88_L1.4581.00
100_V127_H1.4461.00
100_V104_E1.4441.00
172_Q175_E1.4381.00
198_E206_Q1.4281.00
137_V160_L1.4041.00
215_I224_V1.3891.00
229_T248_A1.3881.00
124_G143_A1.3771.00
113_D116_E1.3541.00
134_D167_F1.3181.00
180_A190_A1.3181.00
161_A173_A1.3131.00
174_Y197_I1.3131.00
188_P214_A1.2951.00
154_A180_A1.2821.00
174_Y194_L1.2671.00
171_E201_R1.2641.00
100_V123_K1.2561.00
208_L212_D1.2431.00
198_E203_R1.2191.00
90_Y95_R1.2151.00
86_V102_T1.2131.00
221_Q224_V1.2071.00
227_E230_R1.2011.00
137_V141_R1.1961.00
158_T193_N1.1931.00
161_A180_A1.1671.00
205_E235_L1.1641.00
147_A153_E1.1561.00
184_D187_L1.1531.00
106_A119_A1.1531.00
142_E145_F1.1491.00
137_V163_A1.1421.00
100_V126_A1.1351.00
162_Y177_A1.1311.00
206_Q209_D1.1271.00
215_I225_Y1.1241.00
213_N216_R1.1231.00
80_A106_A1.1101.00
90_Y102_T1.1091.00
222_A248_A1.0991.00
107_A119_A1.0821.00
196_F211_L1.0751.00
153_E156_A1.0651.00
142_E146_V1.0641.00
246_E250_E1.0541.00
120_W143_A1.0531.00
157_H191_W1.0481.00
157_H179_E1.0431.00
137_V164_L1.0411.00
195_G210_A1.0381.00
195_G207_A1.0371.00
144_L157_H1.0341.00
208_L235_L1.0301.00
98_Q101_D1.0291.00
121_V159_N1.0251.00
232_L244_V1.0191.00
192_Y227_E1.0181.00
124_G139_A1.0171.00
143_A156_A1.0141.00
100_V130_L1.0081.00
163_A167_F1.0081.00
165_W197_I0.9971.00
208_L232_L0.9921.00
135_A138_G0.9911.00
218_G221_Q0.9881.00
198_E210_A0.9811.00
107_A120_W0.9801.00
141_R145_F0.9771.00
60_D63_V0.9611.00
91_M103_F0.9551.00
88_L122_N0.9551.00
197_I201_R0.9501.00
120_W157_H0.9471.00
121_V156_A0.9431.00
181_V190_A0.9421.00
120_W191_W0.9271.00
106_A109_Y0.9171.00
120_W142_E0.9131.00
89_S93_I0.9121.00
116_E120_W0.9121.00
137_V167_F0.9071.00
157_H225_Y0.9031.00
238_D242_A0.8891.00
91_M96_N0.8891.00
174_Y201_R0.8851.00
214_A224_V0.8831.00
125_I159_N0.8821.00
126_A130_L0.8771.00
174_Y208_L0.8751.00
157_H180_A0.8701.00
174_Y198_E0.8681.00
181_V191_W0.8641.00
124_G136_A0.8621.00
164_L176_H0.8551.00
83_L106_A0.8531.00
191_W214_A0.8481.00
198_E232_L0.8421.00
187_L190_A0.8371.00
123_K160_L0.8361.00
170_D197_I0.8351.00
199_N204_P0.8261.00
139_A210_A0.8231.00
76_D79_D0.8121.00
171_E205_E0.8071.00
61_S64_V0.8051.00
145_F182_R0.8031.00
192_Y224_V0.7951.00
193_N196_F0.7941.00
225_Y247_Q0.7941.00
144_L156_A0.7911.00
192_Y214_A0.7901.00
127_H139_A0.7881.00
247_Q250_E0.7870.99
213_N217_L0.7840.99
41_G45_D0.7840.99
233_E245_A0.7710.99
43_D47_P0.7690.99
229_T244_V0.7660.99
178_E182_R0.7650.99
212_D246_E0.7560.99
132_E203_R0.7520.99
214_A248_A0.7520.99
170_D238_D0.7470.99
107_A123_K0.7460.99
191_W225_Y0.7460.99
207_A231_A0.7420.99
61_S65_A0.7330.99
88_L91_M0.7330.99
73_L77_A0.7250.99
196_F227_E0.7230.99
205_E239_E0.7230.99
46_P49_L0.7130.99
81_D85_D0.7110.99
39_Y43_D0.7100.99
40_A43_D0.7070.99
73_L79_D0.7010.99
132_E169_E0.6990.99
50_D54_D0.6980.99
204_P231_A0.6980.99
179_E182_R0.6980.99
231_A235_L0.6960.99
158_T190_A0.6920.99
122_N125_I0.6900.99
204_P208_L0.6860.99
52_D55_T0.6840.99
159_N162_Y0.6820.99
55_T58_P0.6730.98
192_Y195_G0.6710.98
180_A214_A0.6700.98
165_W170_D0.6670.98
191_W213_N0.6670.98
209_D243_K0.6660.98
182_R216_R0.6640.98
143_A146_V0.6640.98
72_T76_D0.6600.98
83_L105_R0.6600.98
181_V194_L0.6590.98
80_A87_G0.6570.98
101_D105_R0.6560.98
176_H179_E0.6510.98
160_L194_L0.6500.98
202_D234_A0.6460.98
128_G140_H0.6450.98
225_Y248_A0.6440.98
165_W193_N0.6430.98
73_L76_D0.6420.98
80_A84_I0.6380.98
197_I231_A0.6380.98
243_K247_Q0.6370.98
165_W177_A0.6350.98
162_Y193_N0.6350.98
121_V125_I0.6290.98
216_R250_E0.6280.98
117_Q143_A0.6220.97
53_P57_D0.6210.97
199_N211_L0.6190.97
243_K246_E0.6180.97
230_R233_E0.6160.97
192_Y196_F0.6130.97
42_F46_P0.6130.97
137_V174_Y0.6130.97
203_R237_R0.6120.97
128_G159_N0.6110.97
136_A163_A0.6100.97
58_P61_S0.6100.97
241_A245_A0.6060.97
99_A126_A0.6040.97
208_L237_R0.6030.97
103_F126_A0.6030.97
214_A217_L0.5990.97
45_D48_E0.5970.97
162_Y196_F0.5930.97
148_D153_E0.5920.96
84_I87_G0.5920.96
139_A143_A0.5910.96
87_G102_T0.5890.96
101_D104_E0.5880.96
133_W137_V0.5870.96
96_N130_L0.5860.96
122_N159_N0.5860.96
175_E209_D0.5850.96
88_L103_F0.5830.96
138_G142_E0.5810.96
147_A156_A0.5800.96
62_R65_A0.5800.96
161_A195_G0.5750.96
248_A251_I0.5740.96
104_E127_H0.5710.96
96_N100_V0.5680.96
158_T192_Y0.5680.96
143_A147_A0.5670.96
141_R212_D0.5660.95
59_V64_V0.5660.95
86_V89_S0.5630.95
179_E183_V0.5600.95
99_A103_F0.5590.95
42_F52_D0.5590.95
194_L228_K0.5580.95
123_K228_K0.5570.95
91_M126_A0.5550.95
41_G44_L0.5530.95
140_H144_L0.5520.95
117_Q124_G0.5520.95
210_A244_V0.5520.95
166_E234_A0.5520.95
226_E248_A0.5520.95
164_L198_E0.5510.95
176_H180_A0.5500.95
163_A197_I0.5500.95
105_R109_Y0.5460.95
226_E230_R0.5450.94
176_H210_A0.5440.94
155_A189_Q0.5440.94
215_I228_K0.5400.94
178_E212_D0.5390.94
71_R74_D0.5340.94
121_V143_A0.5330.94
217_L251_I0.5330.94
153_E221_Q0.5320.94
43_D46_P0.5320.94
100_V103_F0.5310.94
145_F250_E0.5280.94
80_A83_L0.5280.94
63_V66_D0.5260.93
46_P50_D0.5250.93
39_Y45_D0.5230.93
84_I122_N0.5220.93
182_R250_E0.5210.93
83_L87_G0.5200.93
105_R108_Q0.5200.93
213_N247_Q0.5170.93
154_A184_D0.5170.93
104_E108_Q0.5160.93
54_D57_D0.5150.93
180_A248_A0.5130.93
102_T106_A0.5110.92
199_N233_E0.5110.92
247_Q251_I0.5100.92
116_E153_E0.5100.92
39_Y44_L0.5090.92
137_V208_L0.5060.92
125_I129_E0.5040.92
166_E200_E0.5040.92
190_A193_N0.5030.92
73_L78_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l9pA 1 0.8175 99.9 0.277 Contact Map
1dceA 1 0.9125 99.9 0.277 Contact Map
3dssA 1 0.7376 99.9 0.286 Contact Map
3q7aA 1 0.8023 99.9 0.293 Contact Map
1w3bA 2 0.8973 99.9 0.308 Contact Map
2h6fA 1 0.7909 99.9 0.31 Contact Map
5aioA 1 0.6654 99.9 0.319 Contact Map
4gywA 2 0.6882 99.9 0.321 Contact Map
3qkyA 1 0.7148 99.9 0.327 Contact Map
3draA 1 0.7871 99.9 0.33 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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