GREMLIN Database
Q9HMM7 - Uncharacterized protein
UniProt: Q9HMM7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 102 (94)
Sequences: 156 (121)
Seq/√Len: 12.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_V63_A3.5370.99
71_D95_V3.2380.98
22_A56_V2.9770.96
68_V73_A2.8190.94
46_Y96_H2.6540.92
83_V97_A2.4170.88
51_A56_V2.3860.88
76_I80_A2.2420.84
7_L20_V2.1470.81
11_E30_E1.9920.76
22_A74_V1.8750.71
68_V93_G1.7590.66
45_F98_Q1.6660.62
21_A96_H1.5900.58
8_V21_A1.5350.55
31_T43_E1.5180.54
27_V87_N1.4720.52
63_A66_G1.3860.48
31_T40_T1.3760.47
23_C63_A1.3590.46
25_R74_V1.3530.46
7_L56_V1.3500.46
51_A75_G1.3220.44
14_T17_G1.3050.43
31_T38_E1.3000.43
19_L92_E1.2990.43
11_E79_D1.2800.42
55_A60_L1.2780.42
25_R50_A1.2550.41
84_E87_N1.2340.40
10_R32_Y1.1760.37
52_D56_V1.1600.36
24_D67_N1.1500.36
45_F77_A1.0980.33
7_L76_I1.0960.33
11_E14_T1.0900.33
26_D72_T1.0820.33
30_E92_E1.0390.31
18_L62_R1.0380.31
31_T60_L1.0370.31
24_D96_H1.0360.31
32_Y39_F1.0330.31
66_G84_E1.0310.30
23_C28_L1.0030.29
34_N37_T1.0000.29
56_V62_R0.9970.29
20_V23_C0.9760.28
41_V69_V0.9580.27
9_M21_A0.9470.27
12_R21_A0.9440.27
39_F69_V0.9430.27
37_T42_T0.9390.27
68_V86_A0.9340.26
10_R21_A0.9300.26
77_A98_Q0.9250.26
28_L81_G0.9250.26
54_D81_G0.9200.26
39_F71_D0.9170.26
16_R82_H0.9140.26
54_D58_A0.9100.25
71_D75_G0.9020.25
25_R72_T0.8940.25
25_R86_A0.8900.25
43_E47_D0.8870.25
12_R19_L0.8810.24
27_V95_V0.8770.24
32_Y80_A0.8740.24
51_A58_A0.8710.24
32_Y100_M0.8630.24
58_A74_V0.8570.23
86_A100_M0.8520.23
27_V88_V0.8490.23
26_D85_A0.8310.23
14_T65_I0.8300.23
40_T86_A0.8100.22
68_V77_A0.8030.22
57_R80_A0.7970.21
68_V75_G0.7930.21
7_L53_A0.7840.21
41_V89_L0.7830.21
50_A56_V0.7790.21
27_V65_I0.7730.21
67_N96_H0.7730.21
9_M56_V0.7720.20
9_M51_A0.7630.20
51_A55_A0.7610.20
17_G65_I0.7600.20
55_A58_A0.7590.20
28_L41_V0.7580.20
75_G93_G0.7540.20
12_R100_M0.7500.20
28_L69_V0.7480.20
24_D76_I0.7350.19
12_R65_I0.7330.19
21_A59_A0.7280.19
51_A91_L0.7220.19
56_V73_A0.7160.19
53_A76_I0.7130.19
51_A59_A0.7070.18
20_V56_V0.7000.18
21_A67_N0.6950.18
89_L96_H0.6920.18
47_D74_V0.6860.18
27_V36_G0.6760.17
44_S85_A0.6680.17
45_F63_A0.6620.17
7_L63_A0.6610.17
77_A97_A0.6590.17
32_Y41_V0.6570.17
10_R79_D0.6460.17
45_F96_H0.6460.17
45_F97_A0.6360.16
72_T88_V0.6360.16
49_E88_V0.6310.16
47_D55_A0.6230.16
29_G88_V0.6150.16
21_A45_F0.6130.16
10_R27_V0.6050.15
14_T19_L0.6050.15
34_N90_E0.5960.15
11_E35_G0.5800.15
37_T78_I0.5680.15
27_V86_A0.5660.14
9_M35_G0.5620.14
44_S51_A0.5520.14
9_M22_A0.5500.14
41_V100_M0.5410.14
49_E86_A0.5400.14
15_D52_D0.5390.14
83_V91_L0.5380.14
56_V74_V0.5320.14
11_E20_V0.5250.13
26_D35_G0.5240.13
54_D64_T0.5200.13
66_G99_F0.5150.13
55_A75_G0.5150.13
36_G71_D0.5100.13
60_L89_L0.5060.13
66_G98_Q0.5050.13
8_V85_A0.5000.13
13_H79_D0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qyaA 2 0.9608 100 0.13 Contact Map
2inpL 1 0.549 21.3 0.926 Contact Map
3r07C 1 0.8137 13.9 0.932 Contact Map
4wweA 1 0.4412 13.3 0.932 Contact Map
4wwtA 1 0.4412 12.6 0.933 Contact Map
1rm6B 1 0.6275 11.9 0.934 Contact Map
1rwhA 1 0.7745 11 0.935 Contact Map
3ge3E 1 0.6176 10.7 0.935 Contact Map
3h63A 1 0.6961 8.7 0.937 Contact Map
1t3qC 1 0.6176 7.9 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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