Q9HMM3 - HALSA - GREMLIN Contacts

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Q9HMM3 - Uncharacterized protein

UniProt:	Q9HMM3	Sequences: MTDAGSSFCPECGDPVDSVGGDGATRREQSLCDSCYFAAFDLVDAPDTIEVMVCARCGAVHRGNRWVDIGADDYVDVAVAETTEALGVHLEAEDVDWEVRPEKLDDNTVRMHATFTGVVRDTHRTEQVAVTVKVSRQTCQRCGRIAGESYASTVQVRAVGRDPTSEETDRAAELAHRIVADMEATGDREAFVTEIGDAESGTDIKLSTTKIGLKLARKLVEEFGGDFEDHETLITEDDDGNEVYRVTYAVRLPEFVPGDVVDIAADDGGPVLVQSNHGNLKGVRVTTGEPYEASFEDGDSPDARKLGAVADATEATVVTVEDDAAIQILDPDTYEAQTVARPDYVDPDASTVPALKSRAGLHVLPDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	367 (302)
Sequences:	486 (307)
Seq/√Len:	17.7

HALSA - Q9HMM3
SULSO - Q97W57

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
206_L	215_L	5.962	1.00
152_S	212_G	5.356	1.00
9_C	12_C	4.093	1.00
11_E	39_A	4.018	1.00
282_G	293_A	3.802	1.00
236_E	242_E	3.434	1.00
9_C	13_G	2.933	0.99
52_M	137_Q	2.718	0.98
114_T	125_T	2.704	0.98
255_F	273_V	2.698	0.98
233_L	244_Y	2.674	0.97
86_L	109_V	2.458	0.96
32_C	35_C	2.372	0.95
260_V	270_P	2.258	0.93
46_P	86_L	2.242	0.93
227_F	261_V	2.217	0.92
231_E	242_E	2.205	0.92
12_C	32_C	2.100	0.90
53_V	202_T	2.060	0.89
58_G	70_G	2.038	0.89
202_T	215_L	2.034	0.89
36_Y	320_V	1.998	0.88
54_C	57_C	1.991	0.88
168_T	256_V	1.991	0.88
17_D	26_R	1.970	0.87
259_D	305_K	1.970	0.87
160_G	259_D	1.949	0.86
140_Q	144_R	1.876	0.84
170_R	283_V	1.851	0.83
9_C	32_C	1.828	0.83
225_G	260_V	1.782	0.81
12_C	35_C	1.778	0.81
53_V	136_R	1.774	0.81
236_E	240_G	1.758	0.80
143_G	146_A	1.755	0.80
143_G	148_E	1.741	0.79
249_A	252_L	1.738	0.79
51_V	109_V	1.662	0.76
232_T	288_G	1.653	0.75
265_A	320_V	1.650	0.75
49_I	132_V	1.650	0.75
35_C	57_C	1.623	0.74
96_D	114_T	1.601	0.73
42_L	92_A	1.601	0.73
32_C	57_C	1.588	0.72
266_D	269_G	1.570	0.72
202_T	206_L	1.569	0.72
230_H	234_I	1.564	0.71
144_R	247_T	1.557	0.71
35_C	54_C	1.555	0.71
167_E	280_L	1.551	0.71
139_C	142_C	1.550	0.71
32_C	54_C	1.516	0.69
27_R	30_S	1.515	0.69
9_C	35_C	1.514	0.69
255_F	293_A	1.508	0.68
124_R	156_V	1.500	0.68
271_V	282_G	1.486	0.67
34_S	229_D	1.481	0.67
219_L	223_F	1.461	0.66
48_T	131_T	1.449	0.65
193_T	207_S	1.447	0.65
151_A	234_I	1.439	0.65
67_V	306_L	1.424	0.64
81_E	209_T	1.420	0.64
271_V	275_S	1.419	0.64
140_Q	310_A	1.419	0.64
190_A	273_V	1.419	0.64
31_L	156_V	1.392	0.62
92_A	130_V	1.384	0.62
55_A	136_R	1.382	0.61
168_T	259_D	1.378	0.61
106_D	177_R	1.375	0.61
123_H	302_D	1.372	0.61
108_T	257_P	1.366	0.60
97_W	101_P	1.359	0.60
213_L	229_D	1.356	0.60
144_R	213_L	1.356	0.60
209_T	246_V	1.349	0.59
31_L	39_A	1.335	0.59
81_E	137_Q	1.325	0.58
46_P	127_Q	1.324	0.58
41_D	171_A	1.318	0.58
169_D	256_V	1.317	0.58
92_A	182_M	1.316	0.58
103_K	106_D	1.313	0.57
12_C	57_C	1.313	0.57
49_I	280_L	1.304	0.57
13_G	32_C	1.297	0.56
144_R	250_V	1.286	0.56
160_G	168_T	1.277	0.55
208_T	211_I	1.273	0.55
142_C	157_R	1.267	0.55
139_C	157_R	1.267	0.55
155_Q	203_D	1.264	0.54
111_M	132_V	1.251	0.54
12_C	54_C	1.233	0.53
179_V	206_L	1.221	0.52
170_R	213_L	1.221	0.52
215_L	304_R	1.216	0.51
36_Y	125_T	1.203	0.51
34_S	261_V	1.200	0.51
294_S	316_T	1.197	0.50
102_E	105_D	1.193	0.50
144_R	149_S	1.187	0.50
199_E	217_R	1.183	0.49
82_T	179_V	1.182	0.49
157_R	203_D	1.182	0.49
53_V	232_T	1.174	0.49
17_D	308_A	1.169	0.49
208_T	273_V	1.166	0.48
260_V	272_L	1.160	0.48
226_D	251_R	1.156	0.48
293_A	306_L	1.146	0.47
206_L	246_V	1.146	0.47
80_A	141_R	1.143	0.47
220_V	227_F	1.135	0.47
275_S	322_D	1.127	0.46
140_Q	217_R	1.120	0.46
44_D	318_V	1.119	0.46
9_C	57_C	1.110	0.45
149_S	210_K	1.107	0.45
93_E	273_V	1.104	0.45
273_V	288_G	1.103	0.45
68_D	311_D	1.100	0.44
172_A	204_I	1.100	0.44
6_S	17_D	1.097	0.44
144_R	147_G	1.093	0.44
72_D	106_D	1.091	0.44
57_C	139_C	1.091	0.44
57_C	142_C	1.091	0.44
261_V	326_I	1.087	0.44
274_Q	281_K	1.080	0.43
198_A	227_F	1.079	0.43
70_G	318_V	1.068	0.43
57_C	66_W	1.059	0.42
219_L	282_G	1.054	0.42
256_V	259_D	1.053	0.42
144_R	152_S	1.045	0.41
95_V	125_T	1.040	0.41
31_L	36_Y	1.035	0.41
306_L	313_T	1.033	0.40
9_C	54_C	1.028	0.40
193_T	202_T	1.027	0.40
286_T	304_R	1.025	0.40
51_V	304_R	1.025	0.40
6_S	15_P	1.023	0.40
54_C	142_C	1.022	0.40
54_C	139_C	1.022	0.40
17_D	246_V	1.022	0.40
259_D	311_D	1.021	0.40
140_Q	199_E	1.013	0.39
13_G	35_C	1.012	0.39
131_T	249_A	1.008	0.39
69_I	81_E	1.003	0.39
225_G	229_D	1.001	0.39
187_D	233_L	0.999	0.38
207_S	270_P	0.994	0.38
92_A	115_F	0.988	0.38
179_V	215_L	0.987	0.38
67_V	115_F	0.987	0.38
274_Q	293_A	0.986	0.38
173_E	212_G	0.981	0.37
175_A	204_I	0.980	0.37
54_C	66_W	0.978	0.37
115_F	282_G	0.972	0.37
33_D	47_D	0.965	0.37
100_R	241_N	0.963	0.36
259_D	309_V	0.956	0.36
214_K	250_V	0.953	0.36
213_L	260_V	0.953	0.36
249_A	275_S	0.951	0.36
31_L	62_R	0.950	0.36
227_F	311_D	0.950	0.36
11_E	272_L	0.949	0.36
59_A	204_I	0.948	0.36
98_E	119_V	0.944	0.35
138_T	213_L	0.941	0.35
191_F	208_T	0.935	0.35
281_K	292_E	0.932	0.35
149_S	260_V	0.931	0.35
191_F	207_S	0.930	0.35
255_F	294_S	0.929	0.35
96_D	181_D	0.923	0.34
135_S	198_A	0.923	0.34
50_E	135_S	0.922	0.34
33_D	113_A	0.922	0.34
187_D	305_K	0.921	0.34
45_A	92_A	0.918	0.34
87_G	311_D	0.912	0.34
117_G	225_G	0.911	0.34
116_T	125_T	0.910	0.33
144_R	312_A	0.905	0.33
119_V	314_E	0.902	0.33
205_K	219_L	0.901	0.33
149_S	187_D	0.900	0.33
26_R	98_E	0.895	0.33
73_D	82_T	0.894	0.33
240_G	305_K	0.883	0.32
208_T	246_V	0.874	0.32
121_D	231_E	0.866	0.31
10_P	31_L	0.863	0.31
282_G	305_K	0.863	0.31
32_C	142_C	0.859	0.31
32_C	139_C	0.859	0.31
36_Y	153_T	0.854	0.31
72_D	105_D	0.853	0.30
55_A	221_E	0.850	0.30
16_V	140_Q	0.850	0.30
65_R	192_V	0.850	0.30
221_E	279_N	0.849	0.30
62_R	67_V	0.849	0.30
135_S	216_A	0.846	0.30
252_L	318_V	0.841	0.30
265_A	316_T	0.836	0.30
39_A	320_V	0.835	0.30
307_G	313_T	0.833	0.29
35_C	142_C	0.833	0.29
35_C	139_C	0.833	0.29
26_R	30_S	0.833	0.29
12_C	142_C	0.830	0.29
12_C	139_C	0.830	0.29
113_A	130_V	0.829	0.29
153_T	248_Y	0.828	0.29
67_V	300_S	0.823	0.29
39_A	187_D	0.823	0.29
7_S	30_S	0.821	0.29
143_G	190_A	0.818	0.29
149_S	211_I	0.816	0.29
167_E	190_A	0.815	0.29
42_L	313_T	0.814	0.28
78_A	105_D	0.812	0.28
138_T	143_G	0.812	0.28
57_C	157_R	0.809	0.28
93_E	277_H	0.808	0.28
180_A	285_V	0.805	0.28
13_G	255_F	0.804	0.28
146_A	307_G	0.803	0.28
17_D	39_A	0.803	0.28
138_T	259_D	0.802	0.28
143_G	199_E	0.798	0.28
66_W	139_C	0.797	0.28
66_W	142_C	0.797	0.28
142_C	155_Q	0.794	0.27
139_C	155_Q	0.794	0.27
118_V	123_H	0.785	0.27
257_P	308_A	0.785	0.27
116_T	168_T	0.783	0.27
80_A	310_A	0.781	0.27
55_A	114_T	0.778	0.27
56_R	192_V	0.778	0.27
195_I	246_V	0.777	0.27
35_C	201_G	0.774	0.27
71_A	269_G	0.774	0.27
287_T	293_A	0.774	0.27
223_F	252_L	0.773	0.26
264_A	298_G	0.769	0.26
107_N	315_A	0.768	0.26
192_V	225_G	0.766	0.26
82_T	309_V	0.763	0.26
220_V	229_D	0.761	0.26
160_G	256_V	0.759	0.26
204_I	230_H	0.756	0.26
43_V	117_G	0.755	0.26
259_D	283_V	0.755	0.26
231_E	243_V	0.755	0.26
134_V	257_P	0.752	0.26
85_A	151_A	0.751	0.25
32_C	201_G	0.751	0.25
214_K	296_E	0.750	0.25
139_C	201_G	0.746	0.25
142_C	201_G	0.746	0.25
70_G	239_D	0.745	0.25
155_Q	201_G	0.745	0.25
141_R	206_L	0.745	0.25
194_E	316_T	0.741	0.25
54_C	157_R	0.739	0.25
68_D	194_E	0.739	0.25
257_P	271_V	0.736	0.25
179_V	189_E	0.736	0.25
46_P	132_V	0.735	0.25
159_V	260_V	0.734	0.25
11_E	213_L	0.734	0.25
168_T	172_A	0.731	0.25
176_H	204_I	0.728	0.24
222_E	253_P	0.728	0.24
144_R	244_Y	0.727	0.24
46_P	240_G	0.724	0.24
93_E	210_K	0.723	0.24
116_T	256_V	0.720	0.24
53_V	215_L	0.714	0.24
28_E	60_V	0.714	0.24
7_S	10_P	0.710	0.24
52_M	170_R	0.710	0.24
290_P	294_S	0.707	0.23
247_T	324_A	0.704	0.23
35_C	66_W	0.704	0.23
168_T	223_F	0.701	0.23
140_Q	167_E	0.701	0.23
82_T	101_P	0.700	0.23
275_S	300_S	0.700	0.23
110_R	202_T	0.698	0.23
84_E	117_G	0.698	0.23
82_T	111_M	0.696	0.23
173_E	258_G	0.695	0.23
95_V	283_V	0.695	0.23
115_F	202_T	0.695	0.23
318_V	326_I	0.690	0.23
121_D	262_D	0.687	0.23
67_V	286_T	0.684	0.22
142_C	203_D	0.681	0.22
139_C	203_D	0.681	0.22
97_W	102_E	0.681	0.22
316_T	320_V	0.680	0.22
32_C	66_W	0.677	0.22
48_T	148_E	0.676	0.22
59_A	96_D	0.675	0.22
73_D	108_T	0.674	0.22
231_E	240_G	0.673	0.22
33_D	122_T	0.671	0.22
229_D	243_V	0.670	0.22
113_A	320_V	0.668	0.22
195_I	248_Y	0.667	0.22
151_A	207_S	0.666	0.22
43_V	46_P	0.666	0.22
9_C	142_C	0.665	0.22
9_C	139_C	0.665	0.22
131_T	276_N	0.662	0.22
44_D	87_G	0.662	0.22
261_V	290_P	0.660	0.21
47_D	117_G	0.656	0.21
106_D	206_L	0.652	0.21
36_Y	123_H	0.649	0.21
140_Q	212_G	0.646	0.21
191_F	240_G	0.645	0.21
10_P	137_Q	0.644	0.21
52_M	292_E	0.642	0.21
230_H	317_V	0.636	0.21
10_P	28_E	0.635	0.20
143_G	247_T	0.633	0.20
34_S	221_E	0.633	0.20
219_L	309_V	0.632	0.20
149_S	231_E	0.632	0.20
167_E	208_T	0.632	0.20
149_S	190_A	0.630	0.20
93_E	269_G	0.630	0.20
81_E	107_N	0.630	0.20
38_A	239_D	0.627	0.20
71_A	286_T	0.625	0.20
133_K	263_I	0.624	0.20
136_R	198_A	0.622	0.20
120_R	143_G	0.619	0.20
7_S	56_R	0.617	0.20
109_V	276_N	0.616	0.20
10_P	140_Q	0.613	0.20
86_L	278_G	0.612	0.20
141_R	212_G	0.609	0.19
91_E	252_L	0.609	0.19
143_G	315_A	0.608	0.19
56_R	147_G	0.604	0.19
141_R	245_R	0.604	0.19
214_K	262_D	0.602	0.19
179_V	291_Y	0.602	0.19
68_D	246_V	0.602	0.19
42_L	45_A	0.600	0.19
39_A	311_D	0.599	0.19
94_D	247_T	0.598	0.19
31_L	65_R	0.597	0.19
235_T	243_V	0.597	0.19
131_T	312_A	0.596	0.19
156_V	194_E	0.595	0.19
234_I	248_Y	0.594	0.19
117_G	200_S	0.593	0.19
252_L	258_G	0.593	0.19
82_T	314_E	0.593	0.19
262_D	269_G	0.591	0.19
123_H	317_V	0.589	0.19
71_A	308_A	0.589	0.19
265_A	286_T	0.588	0.19
80_A	83_T	0.587	0.19
138_T	199_E	0.587	0.19
127_Q	309_V	0.586	0.19
68_D	220_V	0.586	0.19
196_G	202_T	0.585	0.19
231_E	304_R	0.583	0.18
30_S	87_G	0.582	0.18
52_M	136_R	0.579	0.18
205_K	323_D	0.579	0.18
276_N	280_L	0.578	0.18
153_T	295_F	0.577	0.18
11_E	31_L	0.577	0.18
32_C	157_R	0.576	0.18
13_G	57_C	0.574	0.18
42_L	124_R	0.571	0.18
168_T	209_T	0.567	0.18
207_S	266_D	0.566	0.18
231_E	244_Y	0.565	0.18
167_E	265_A	0.565	0.18
263_I	283_V	0.565	0.18
68_D	199_E	0.560	0.18
177_R	263_I	0.560	0.18
102_E	106_D	0.558	0.18
211_I	294_S	0.558	0.18
138_T	200_S	0.557	0.18
190_A	194_E	0.555	0.17
61_H	244_Y	0.555	0.17
235_T	270_P	0.553	0.17
213_L	231_E	0.552	0.17
35_C	157_R	0.552	0.17
208_T	301_P	0.551	0.17
115_F	196_G	0.550	0.17
16_V	115_F	0.550	0.17
93_E	270_P	0.549	0.17
68_D	227_F	0.544	0.17
84_E	223_F	0.544	0.17
114_T	315_A	0.542	0.17
12_C	157_R	0.541	0.17
167_E	223_F	0.540	0.17
45_A	128_V	0.538	0.17
229_D	266_D	0.537	0.17
60_V	156_V	0.537	0.17
46_P	225_G	0.535	0.17
153_T	229_D	0.533	0.17
160_G	287_T	0.532	0.17
14_D	294_S	0.532	0.17
46_P	148_E	0.530	0.17
149_S	225_G	0.530	0.17
17_D	261_V	0.530	0.17
107_N	223_F	0.530	0.17
149_S	271_V	0.528	0.17
277_H	307_G	0.527	0.17
173_E	323_D	0.527	0.17
110_R	129_A	0.525	0.16
12_C	201_G	0.524	0.16
177_R	317_V	0.521	0.16
78_A	110_R	0.520	0.16
212_G	304_R	0.520	0.16
190_A	316_T	0.516	0.16
60_V	149_S	0.515	0.16
114_T	287_T	0.515	0.16
6_S	301_P	0.513	0.16
140_Q	156_V	0.511	0.16
226_D	234_I	0.510	0.16
223_F	266_D	0.507	0.16
45_A	289_E	0.506	0.16
222_E	257_P	0.506	0.16
11_E	260_V	0.505	0.16
153_T	216_A	0.503	0.16
96_D	103_K	0.503	0.16
179_V	218_K	0.502	0.16
109_V	250_V	0.501	0.16
98_E	112_H	0.500	0.16
80_A	250_V	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ybyA	2	0.3025	99.2	0.877	Contact Map
1iz6A	1	0.3134	98.7	0.901	Contact Map
1bkbA	3	0.3188	98.5	0.904	Contact Map
2eifA	1	0.3215	98.4	0.908	Contact Map
1uebA	1	0.3025	98.3	0.911	Contact Map
3treA	1	0.3025	98.3	0.911	Contact Map
3a5zB	1	0.3025	98.2	0.915	Contact Map
3oyyA	1	0.3079	97.6	0.925	Contact Map
3hksA	1	0.3161	97.1	0.931	Contact Map
1x6oA	1	0.3079	96.9	0.933	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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