GREMLIN Database
Q9HMM3 - Uncharacterized protein
UniProt: Q9HMM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (302)
Sequences: 486 (307)
Seq/√Len: 17.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_L215_L5.9621.00
152_S212_G5.3561.00
9_C12_C4.0931.00
11_E39_A4.0181.00
282_G293_A3.8021.00
236_E242_E3.4341.00
9_C13_G2.9330.99
52_M137_Q2.7180.98
114_T125_T2.7040.98
255_F273_V2.6980.98
233_L244_Y2.6740.97
86_L109_V2.4580.96
32_C35_C2.3720.95
260_V270_P2.2580.93
46_P86_L2.2420.93
227_F261_V2.2170.92
231_E242_E2.2050.92
12_C32_C2.1000.90
53_V202_T2.0600.89
58_G70_G2.0380.89
202_T215_L2.0340.89
36_Y320_V1.9980.88
54_C57_C1.9910.88
168_T256_V1.9910.88
17_D26_R1.9700.87
259_D305_K1.9700.87
160_G259_D1.9490.86
140_Q144_R1.8760.84
170_R283_V1.8510.83
9_C32_C1.8280.83
225_G260_V1.7820.81
12_C35_C1.7780.81
53_V136_R1.7740.81
236_E240_G1.7580.80
143_G146_A1.7550.80
143_G148_E1.7410.79
249_A252_L1.7380.79
51_V109_V1.6620.76
232_T288_G1.6530.75
265_A320_V1.6500.75
49_I132_V1.6500.75
35_C57_C1.6230.74
96_D114_T1.6010.73
42_L92_A1.6010.73
32_C57_C1.5880.72
266_D269_G1.5700.72
202_T206_L1.5690.72
230_H234_I1.5640.71
144_R247_T1.5570.71
35_C54_C1.5550.71
167_E280_L1.5510.71
139_C142_C1.5500.71
32_C54_C1.5160.69
27_R30_S1.5150.69
9_C35_C1.5140.69
255_F293_A1.5080.68
124_R156_V1.5000.68
271_V282_G1.4860.67
34_S229_D1.4810.67
219_L223_F1.4610.66
48_T131_T1.4490.65
193_T207_S1.4470.65
151_A234_I1.4390.65
67_V306_L1.4240.64
81_E209_T1.4200.64
271_V275_S1.4190.64
140_Q310_A1.4190.64
190_A273_V1.4190.64
31_L156_V1.3920.62
92_A130_V1.3840.62
55_A136_R1.3820.61
168_T259_D1.3780.61
106_D177_R1.3750.61
123_H302_D1.3720.61
108_T257_P1.3660.60
97_W101_P1.3590.60
213_L229_D1.3560.60
144_R213_L1.3560.60
209_T246_V1.3490.59
31_L39_A1.3350.59
81_E137_Q1.3250.58
46_P127_Q1.3240.58
41_D171_A1.3180.58
169_D256_V1.3170.58
92_A182_M1.3160.58
103_K106_D1.3130.57
12_C57_C1.3130.57
49_I280_L1.3040.57
13_G32_C1.2970.56
144_R250_V1.2860.56
160_G168_T1.2770.55
208_T211_I1.2730.55
142_C157_R1.2670.55
139_C157_R1.2670.55
155_Q203_D1.2640.54
111_M132_V1.2510.54
12_C54_C1.2330.53
179_V206_L1.2210.52
170_R213_L1.2210.52
215_L304_R1.2160.51
36_Y125_T1.2030.51
34_S261_V1.2000.51
294_S316_T1.1970.50
102_E105_D1.1930.50
144_R149_S1.1870.50
199_E217_R1.1830.49
82_T179_V1.1820.49
157_R203_D1.1820.49
53_V232_T1.1740.49
17_D308_A1.1690.49
208_T273_V1.1660.48
260_V272_L1.1600.48
226_D251_R1.1560.48
293_A306_L1.1460.47
206_L246_V1.1460.47
80_A141_R1.1430.47
220_V227_F1.1350.47
275_S322_D1.1270.46
140_Q217_R1.1200.46
44_D318_V1.1190.46
9_C57_C1.1100.45
149_S210_K1.1070.45
93_E273_V1.1040.45
273_V288_G1.1030.45
68_D311_D1.1000.44
172_A204_I1.1000.44
6_S17_D1.0970.44
144_R147_G1.0930.44
72_D106_D1.0910.44
57_C139_C1.0910.44
57_C142_C1.0910.44
261_V326_I1.0870.44
274_Q281_K1.0800.43
198_A227_F1.0790.43
70_G318_V1.0680.43
57_C66_W1.0590.42
219_L282_G1.0540.42
256_V259_D1.0530.42
144_R152_S1.0450.41
95_V125_T1.0400.41
31_L36_Y1.0350.41
306_L313_T1.0330.40
9_C54_C1.0280.40
193_T202_T1.0270.40
286_T304_R1.0250.40
51_V304_R1.0250.40
6_S15_P1.0230.40
54_C142_C1.0220.40
54_C139_C1.0220.40
17_D246_V1.0220.40
259_D311_D1.0210.40
140_Q199_E1.0130.39
13_G35_C1.0120.39
131_T249_A1.0080.39
69_I81_E1.0030.39
225_G229_D1.0010.39
187_D233_L0.9990.38
207_S270_P0.9940.38
92_A115_F0.9880.38
179_V215_L0.9870.38
67_V115_F0.9870.38
274_Q293_A0.9860.38
173_E212_G0.9810.37
175_A204_I0.9800.37
54_C66_W0.9780.37
115_F282_G0.9720.37
33_D47_D0.9650.37
100_R241_N0.9630.36
259_D309_V0.9560.36
214_K250_V0.9530.36
213_L260_V0.9530.36
249_A275_S0.9510.36
31_L62_R0.9500.36
227_F311_D0.9500.36
11_E272_L0.9490.36
59_A204_I0.9480.36
98_E119_V0.9440.35
138_T213_L0.9410.35
191_F208_T0.9350.35
281_K292_E0.9320.35
149_S260_V0.9310.35
191_F207_S0.9300.35
255_F294_S0.9290.35
96_D181_D0.9230.34
135_S198_A0.9230.34
50_E135_S0.9220.34
33_D113_A0.9220.34
187_D305_K0.9210.34
45_A92_A0.9180.34
87_G311_D0.9120.34
117_G225_G0.9110.34
116_T125_T0.9100.33
144_R312_A0.9050.33
119_V314_E0.9020.33
205_K219_L0.9010.33
149_S187_D0.9000.33
26_R98_E0.8950.33
73_D82_T0.8940.33
240_G305_K0.8830.32
208_T246_V0.8740.32
121_D231_E0.8660.31
10_P31_L0.8630.31
282_G305_K0.8630.31
32_C142_C0.8590.31
32_C139_C0.8590.31
36_Y153_T0.8540.31
72_D105_D0.8530.30
55_A221_E0.8500.30
16_V140_Q0.8500.30
65_R192_V0.8500.30
221_E279_N0.8490.30
62_R67_V0.8490.30
135_S216_A0.8460.30
252_L318_V0.8410.30
265_A316_T0.8360.30
39_A320_V0.8350.30
307_G313_T0.8330.29
35_C142_C0.8330.29
35_C139_C0.8330.29
26_R30_S0.8330.29
12_C142_C0.8300.29
12_C139_C0.8300.29
113_A130_V0.8290.29
153_T248_Y0.8280.29
67_V300_S0.8230.29
39_A187_D0.8230.29
7_S30_S0.8210.29
143_G190_A0.8180.29
149_S211_I0.8160.29
167_E190_A0.8150.29
42_L313_T0.8140.28
78_A105_D0.8120.28
138_T143_G0.8120.28
57_C157_R0.8090.28
93_E277_H0.8080.28
180_A285_V0.8050.28
13_G255_F0.8040.28
146_A307_G0.8030.28
17_D39_A0.8030.28
138_T259_D0.8020.28
143_G199_E0.7980.28
66_W139_C0.7970.28
66_W142_C0.7970.28
142_C155_Q0.7940.27
139_C155_Q0.7940.27
118_V123_H0.7850.27
257_P308_A0.7850.27
116_T168_T0.7830.27
80_A310_A0.7810.27
55_A114_T0.7780.27
56_R192_V0.7780.27
195_I246_V0.7770.27
35_C201_G0.7740.27
71_A269_G0.7740.27
287_T293_A0.7740.27
223_F252_L0.7730.26
264_A298_G0.7690.26
107_N315_A0.7680.26
192_V225_G0.7660.26
82_T309_V0.7630.26
220_V229_D0.7610.26
160_G256_V0.7590.26
204_I230_H0.7560.26
43_V117_G0.7550.26
259_D283_V0.7550.26
231_E243_V0.7550.26
134_V257_P0.7520.26
85_A151_A0.7510.25
32_C201_G0.7510.25
214_K296_E0.7500.25
139_C201_G0.7460.25
142_C201_G0.7460.25
70_G239_D0.7450.25
155_Q201_G0.7450.25
141_R206_L0.7450.25
194_E316_T0.7410.25
54_C157_R0.7390.25
68_D194_E0.7390.25
257_P271_V0.7360.25
179_V189_E0.7360.25
46_P132_V0.7350.25
159_V260_V0.7340.25
11_E213_L0.7340.25
168_T172_A0.7310.25
176_H204_I0.7280.24
222_E253_P0.7280.24
144_R244_Y0.7270.24
46_P240_G0.7240.24
93_E210_K0.7230.24
116_T256_V0.7200.24
53_V215_L0.7140.24
28_E60_V0.7140.24
7_S10_P0.7100.24
52_M170_R0.7100.24
290_P294_S0.7070.23
247_T324_A0.7040.23
35_C66_W0.7040.23
168_T223_F0.7010.23
140_Q167_E0.7010.23
82_T101_P0.7000.23
275_S300_S0.7000.23
110_R202_T0.6980.23
84_E117_G0.6980.23
82_T111_M0.6960.23
173_E258_G0.6950.23
95_V283_V0.6950.23
115_F202_T0.6950.23
318_V326_I0.6900.23
121_D262_D0.6870.23
67_V286_T0.6840.22
142_C203_D0.6810.22
139_C203_D0.6810.22
97_W102_E0.6810.22
316_T320_V0.6800.22
32_C66_W0.6770.22
48_T148_E0.6760.22
59_A96_D0.6750.22
73_D108_T0.6740.22
231_E240_G0.6730.22
33_D122_T0.6710.22
229_D243_V0.6700.22
113_A320_V0.6680.22
195_I248_Y0.6670.22
151_A207_S0.6660.22
43_V46_P0.6660.22
9_C142_C0.6650.22
9_C139_C0.6650.22
131_T276_N0.6620.22
44_D87_G0.6620.22
261_V290_P0.6600.21
47_D117_G0.6560.21
106_D206_L0.6520.21
36_Y123_H0.6490.21
140_Q212_G0.6460.21
191_F240_G0.6450.21
10_P137_Q0.6440.21
52_M292_E0.6420.21
230_H317_V0.6360.21
10_P28_E0.6350.20
143_G247_T0.6330.20
34_S221_E0.6330.20
219_L309_V0.6320.20
149_S231_E0.6320.20
167_E208_T0.6320.20
149_S190_A0.6300.20
93_E269_G0.6300.20
81_E107_N0.6300.20
38_A239_D0.6270.20
71_A286_T0.6250.20
133_K263_I0.6240.20
136_R198_A0.6220.20
120_R143_G0.6190.20
7_S56_R0.6170.20
109_V276_N0.6160.20
10_P140_Q0.6130.20
86_L278_G0.6120.20
141_R212_G0.6090.19
91_E252_L0.6090.19
143_G315_A0.6080.19
56_R147_G0.6040.19
141_R245_R0.6040.19
214_K262_D0.6020.19
179_V291_Y0.6020.19
68_D246_V0.6020.19
42_L45_A0.6000.19
39_A311_D0.5990.19
94_D247_T0.5980.19
31_L65_R0.5970.19
235_T243_V0.5970.19
131_T312_A0.5960.19
156_V194_E0.5950.19
234_I248_Y0.5940.19
117_G200_S0.5930.19
252_L258_G0.5930.19
82_T314_E0.5930.19
262_D269_G0.5910.19
123_H317_V0.5890.19
71_A308_A0.5890.19
265_A286_T0.5880.19
80_A83_T0.5870.19
138_T199_E0.5870.19
127_Q309_V0.5860.19
68_D220_V0.5860.19
196_G202_T0.5850.19
231_E304_R0.5830.18
30_S87_G0.5820.18
52_M136_R0.5790.18
205_K323_D0.5790.18
276_N280_L0.5780.18
153_T295_F0.5770.18
11_E31_L0.5770.18
32_C157_R0.5760.18
13_G57_C0.5740.18
42_L124_R0.5710.18
168_T209_T0.5670.18
207_S266_D0.5660.18
231_E244_Y0.5650.18
167_E265_A0.5650.18
263_I283_V0.5650.18
68_D199_E0.5600.18
177_R263_I0.5600.18
102_E106_D0.5580.18
211_I294_S0.5580.18
138_T200_S0.5570.18
190_A194_E0.5550.17
61_H244_Y0.5550.17
235_T270_P0.5530.17
213_L231_E0.5520.17
35_C157_R0.5520.17
208_T301_P0.5510.17
115_F196_G0.5500.17
16_V115_F0.5500.17
93_E270_P0.5490.17
68_D227_F0.5440.17
84_E223_F0.5440.17
114_T315_A0.5420.17
12_C157_R0.5410.17
167_E223_F0.5400.17
45_A128_V0.5380.17
229_D266_D0.5370.17
60_V156_V0.5370.17
46_P225_G0.5350.17
153_T229_D0.5330.17
160_G287_T0.5320.17
14_D294_S0.5320.17
46_P148_E0.5300.17
149_S225_G0.5300.17
17_D261_V0.5300.17
107_N223_F0.5300.17
149_S271_V0.5280.17
277_H307_G0.5270.17
173_E323_D0.5270.17
110_R129_A0.5250.16
12_C201_G0.5240.16
177_R317_V0.5210.16
78_A110_R0.5200.16
212_G304_R0.5200.16
190_A316_T0.5160.16
60_V149_S0.5150.16
114_T287_T0.5150.16
6_S301_P0.5130.16
140_Q156_V0.5110.16
226_D234_I0.5100.16
223_F266_D0.5070.16
45_A289_E0.5060.16
222_E257_P0.5060.16
11_E260_V0.5050.16
153_T216_A0.5030.16
96_D103_K0.5030.16
179_V218_K0.5020.16
109_V250_V0.5010.16
98_E112_H0.5000.16
80_A250_V0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ybyA 2 0.3025 99.2 0.877 Contact Map
1iz6A 1 0.3134 98.7 0.901 Contact Map
1bkbA 3 0.3188 98.5 0.904 Contact Map
2eifA 1 0.3215 98.4 0.908 Contact Map
1uebA 1 0.3025 98.3 0.911 Contact Map
3treA 1 0.3025 98.3 0.911 Contact Map
3a5zB 1 0.3025 98.2 0.915 Contact Map
3oyyA 1 0.3079 97.6 0.925 Contact Map
3hksA 1 0.3161 97.1 0.931 Contact Map
1x6oA 1 0.3079 96.9 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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