Q9HMM2 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HMM2 - Uncharacterized protein

UniProt:	Q9HMM2	Sequences: MRSLAVVVPKPDSQRAIDGLEDEGVYDDRRKVREHDADHVELPVTAEPDAVPFERAIAQADPDPRAPDLGDRLRERGWSAAERERAPSSWAVLGSVILADFTDCPRPGEVGAALLELHREADTVLDRGDGVAGEHRTPDVSVVAGDGDTETVHVEHGTRYALDLAAVMFSPGNKAERARMGDATGPGERVLDMFAGVGYFALPMARAGATVTAVEKNPTAFRFLAENAQLNDVAETLDTILGDCREVDAPADRIVMGYYDALGGGPVGDAASTPGYLDAALDNLVSGGVLHAHSAVPEAELWERPLSRLRAGCQRAGRPAPTVLDTRRVKSHSEGVFHVVIDARVP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	346 (316)
Sequences:	940 (676)
Seq/√Len:	38.0

HALSA - Q9HMM2 Q9HQK5
SULSO - Q97W08 Q97WJ4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
219_T	222_R	4.313	1.00
245_R	278_D	3.784	1.00
161_A	226_E	3.768	1.00
149_T	165_A	3.283	1.00
221_F	225_A	3.175	1.00
107_P	141_S	3.145	1.00
151_T	162_L	3.007	1.00
284_L	288_G	2.991	1.00
221_F	239_T	2.925	1.00
97_I	121_A	2.867	1.00
193_M	244_C	2.842	1.00
191_L	251_A	2.835	1.00
253_R	291_H	2.828	1.00
142_V	149_T	2.811	1.00
228_A	237_L	2.788	1.00
194_F	276_Y	2.740	1.00
228_A	239_T	2.691	1.00
178_A	182_D	2.258	0.99
201_A	213_A	2.225	0.99
204_M	255_V	2.225	0.99
91_A	171_P	2.209	0.99
330_K	338_H	2.197	0.99
96_V	151_T	2.155	0.99
159_R	230_L	2.154	0.99
166_A	219_T	2.152	0.99
306_L	310_R	2.139	0.99
307_S	311_A	2.110	0.99
168_M	173_N	2.095	0.99
122_D	146_D	2.010	0.99
173_N	257_G	2.006	0.99
12_D	15_R	1.995	0.99
152_V	161_A	1.953	0.98
126_D	141_S	1.949	0.98
162_L	223_F	1.887	0.98
192_D	257_G	1.881	0.98
168_M	172_G	1.879	0.98
188_E	252_D	1.870	0.98
27_D	30_R	1.870	0.98
226_E	229_Q	1.863	0.98
308_R	313_C	1.856	0.98
13_S	40_V	1.812	0.97
152_V	159_R	1.798	0.97
154_V	159_R	1.797	0.97
150_E	223_F	1.777	0.97
41_E	45_T	1.753	0.97
188_E	253_R	1.750	0.97
122_D	148_D	1.738	0.97
205_A	256_M	1.737	0.97
168_M	257_G	1.727	0.97
210_T	238_D	1.708	0.96
328_R	337_F	1.691	0.96
291_H	342_D	1.668	0.96
14_Q	17_I	1.652	0.96
229_Q	234_A	1.645	0.95
111_G	144_A	1.630	0.95
256_M	273_T	1.626	0.95
161_A	230_L	1.618	0.95
222_R	226_E	1.608	0.95
168_M	199_Y	1.604	0.95
160_Y	203_P	1.598	0.95
172_G	199_Y	1.590	0.95
179_R	340_V	1.588	0.94
173_N	259_Y	1.575	0.94
183_A	325_D	1.571	0.94
111_G	143_V	1.563	0.94
97_I	118_H	1.560	0.94
305_P	308_R	1.543	0.94
301_L	304_R	1.536	0.93
199_Y	257_G	1.505	0.93
205_A	237_L	1.487	0.92
195_A	215_E	1.482	0.92
158_T	202_L	1.473	0.92
192_D	224_L	1.465	0.92
42_L	45_T	1.459	0.92
72_R	77_G	1.450	0.91
184_T	255_V	1.447	0.91
173_N	330_K	1.446	0.91
99_A	143_V	1.430	0.91
177_R	220_A	1.428	0.91
300_E	303_E	1.421	0.90
35_H	41_E	1.417	0.90
168_M	259_Y	1.414	0.90
173_N	199_Y	1.410	0.90
194_F	292_A	1.409	0.90
123_T	145_G	1.403	0.90
35_H	38_D	1.399	0.90
63_D	66_A	1.393	0.90
173_N	215_E	1.386	0.89
184_T	204_M	1.376	0.89
180_M	184_T	1.376	0.89
226_E	230_L	1.368	0.89
163_D	166_A	1.366	0.89
115_L	144_A	1.360	0.88
41_E	47_E	1.359	0.88
172_G	259_Y	1.357	0.88
274_P	294_S	1.354	0.88
100_D	127_R	1.353	0.88
331_S	337_F	1.343	0.88
172_G	257_G	1.341	0.88
190_V	255_V	1.332	0.87
257_G	338_H	1.320	0.87
173_N	338_H	1.303	0.86
304_R	308_R	1.289	0.85
125_L	140_V	1.285	0.85
135_H	216_K	1.278	0.85
184_T	190_V	1.276	0.85
158_T	206_R	1.273	0.85
17_I	21_E	1.273	0.85
332_H	336_V	1.266	0.84
134_E	216_K	1.259	0.84
91_A	172_G	1.246	0.83
46_A	49_D	1.245	0.83
92_V	119_R	1.222	0.82
256_M	276_Y	1.220	0.82
289_V	342_D	1.215	0.82
240_I	247_V	1.215	0.82
260_D	273_T	1.209	0.82
213_A	224_L	1.183	0.80
215_E	221_F	1.178	0.80
273_T	276_Y	1.170	0.79
177_R	260_D	1.163	0.79
54_E	59_Q	1.158	0.79
168_M	338_H	1.155	0.78
198_G	224_L	1.144	0.78
160_Y	202_L	1.144	0.78
254_I	280_A	1.142	0.78
212_T	240_I	1.138	0.77
180_M	255_V	1.136	0.77
39_H	45_T	1.135	0.77
67_P	72_R	1.135	0.77
199_Y	259_Y	1.125	0.77
219_T	223_F	1.123	0.76
199_Y	338_H	1.123	0.76
97_I	114_L	1.121	0.76
215_E	257_G	1.101	0.75
143_V	245_R	1.094	0.75
193_M	280_A	1.091	0.74
289_V	344_R	1.090	0.74
308_R	311_A	1.088	0.74
40_V	43_P	1.081	0.74
218_P	241_L	1.076	0.73
114_L	121_A	1.075	0.73
13_S	17_I	1.064	0.72
176_E	179_R	1.063	0.72
170_S	177_R	1.060	0.72
125_L	131_V	1.048	0.71
189_R	251_A	1.042	0.71
326_T	341_I	1.025	0.70
220_A	293_H	1.025	0.70
192_D	338_H	1.022	0.69
253_R	342_D	1.020	0.69
14_Q	18_D	1.009	0.68
162_L	220_A	1.009	0.68
192_D	330_K	1.000	0.68
254_I	339_V	0.999	0.68
12_D	19_G	0.992	0.67
293_H	327_R	0.991	0.67
41_E	44_V	0.989	0.67
257_G	330_K	0.972	0.65
295_A	336_V	0.970	0.65
327_R	342_D	0.969	0.65
195_A	224_L	0.966	0.65
191_L	214_V	0.966	0.65
190_V	204_M	0.965	0.65
215_E	336_V	0.964	0.65
179_R	291_H	0.955	0.64
191_L	212_T	0.954	0.64
110_V	141_S	0.953	0.64
200_F	203_P	0.944	0.63
257_G	293_H	0.940	0.63
225_A	229_Q	0.939	0.63
202_L	227_N	0.938	0.63
133_G	155_E	0.938	0.63
162_L	167_V	0.932	0.62
332_H	338_H	0.931	0.62
118_H	121_A	0.928	0.62
245_R	275_G	0.923	0.61
42_L	47_E	0.921	0.61
11_P	38_D	0.919	0.61
39_H	42_L	0.916	0.61
103_D	255_V	0.915	0.61
191_L	254_I	0.897	0.59
93_L	171_P	0.894	0.59
41_E	49_D	0.894	0.59
145_G	200_F	0.891	0.59
172_G	293_H	0.890	0.59
126_D	143_V	0.885	0.58
83_R	151_T	0.885	0.58
295_A	332_H	0.882	0.58
317_G	320_A	0.881	0.58
303_E	307_S	0.879	0.58
156_H	178_A	0.876	0.57
168_M	330_K	0.876	0.57
192_D	198_G	0.874	0.57
258_Y	273_T	0.874	0.57
172_G	330_K	0.874	0.57
132_A	139_D	0.871	0.57
177_R	194_F	0.870	0.57
101_F	110_V	0.870	0.57
189_R	212_T	0.867	0.57
123_T	148_D	0.866	0.56
143_V	232_D	0.863	0.56
221_F	224_L	0.856	0.56
45_T	48_P	0.855	0.55
286_S	307_S	0.855	0.55
171_P	204_M	0.853	0.55
172_G	338_H	0.852	0.55
163_D	207_A	0.851	0.55
41_E	46_A	0.851	0.55
173_N	293_H	0.847	0.55
177_R	200_F	0.847	0.55
133_G	137_T	0.844	0.54
138_P	330_K	0.844	0.54
41_E	48_P	0.842	0.54
150_E	163_D	0.840	0.54
153_H	169_F	0.837	0.54
64_P	116_E	0.836	0.54
159_R	323_V	0.834	0.54
150_E	194_F	0.832	0.53
127_R	295_A	0.832	0.53
138_P	203_P	0.831	0.53
168_M	215_E	0.829	0.53
168_M	293_H	0.827	0.53
89_S	212_T	0.827	0.53
22_D	25_V	0.818	0.52
16_A	20_L	0.817	0.52
91_A	223_F	0.816	0.52
203_P	224_L	0.816	0.52
227_N	243_D	0.813	0.52
192_D	215_E	0.809	0.51
138_P	199_Y	0.808	0.51
153_H	174_K	0.797	0.50
173_N	192_D	0.788	0.49
199_Y	330_K	0.788	0.49
107_P	115_L	0.784	0.49
70_G	74_R	0.782	0.49
125_L	164_L	0.782	0.49
322_T	344_R	0.780	0.49
95_S	200_F	0.775	0.48
155_E	163_D	0.775	0.48
193_M	197_V	0.774	0.48
202_L	233_V	0.770	0.48
190_V	228_A	0.769	0.48
45_T	49_D	0.764	0.47
138_P	200_F	0.764	0.47
140_V	203_P	0.762	0.47
91_A	138_P	0.760	0.47
40_V	45_T	0.758	0.47
178_A	197_V	0.757	0.47
205_A	233_V	0.753	0.46
32_V	42_L	0.752	0.46
200_F	261_A	0.751	0.46
78_W	106_R	0.751	0.46
305_P	341_I	0.747	0.46
23_E	26_Y	0.742	0.45
117_L	123_T	0.739	0.45
127_R	215_E	0.738	0.45
187_G	209_A	0.735	0.45
79_S	105_P	0.735	0.45
92_V	121_A	0.734	0.45
256_M	277_L	0.734	0.45
24_G	27_D	0.731	0.44
179_R	327_R	0.729	0.44
137_T	293_H	0.729	0.44
79_S	141_S	0.729	0.44
160_Y	171_P	0.725	0.44
305_P	313_C	0.724	0.44
116_E	241_L	0.724	0.44
40_V	46_A	0.721	0.44
187_G	252_D	0.719	0.43
138_P	173_N	0.717	0.43
155_E	177_R	0.715	0.43
256_M	290_L	0.714	0.43
113_A	117_L	0.713	0.43
16_A	23_E	0.713	0.43
122_D	154_V	0.713	0.43
338_H	342_D	0.711	0.43
225_A	239_T	0.710	0.43
260_D	295_A	0.710	0.43
181_G	253_R	0.709	0.42
66_A	180_M	0.709	0.42
215_E	258_Y	0.708	0.42
173_N	244_C	0.702	0.42
190_V	209_A	0.699	0.42
172_G	258_Y	0.699	0.42
15_R	18_D	0.698	0.42
221_F	228_A	0.698	0.42
142_V	147_G	0.696	0.41
138_P	257_G	0.695	0.41
93_L	96_V	0.694	0.41
24_G	28_D	0.694	0.41
195_A	256_M	0.693	0.41
92_V	156_H	0.693	0.41
244_C	257_G	0.692	0.41
307_S	310_R	0.692	0.41
223_F	226_E	0.691	0.41
193_M	290_L	0.690	0.41
284_L	287_G	0.689	0.41
153_H	163_D	0.688	0.41
308_R	312_G	0.688	0.41
258_Y	295_A	0.687	0.41
259_Y	293_H	0.685	0.40
310_R	319_P	0.684	0.40
202_L	239_T	0.677	0.40
123_T	216_K	0.676	0.40
93_L	162_L	0.676	0.40
98_L	164_L	0.673	0.39
330_K	336_V	0.673	0.39
295_A	330_K	0.673	0.39
170_S	200_F	0.671	0.39
133_G	139_D	0.669	0.39
300_E	304_R	0.669	0.39
44_V	48_P	0.667	0.39
180_M	204_M	0.664	0.39
185_G	188_E	0.662	0.38
252_D	293_H	0.661	0.38
20_L	23_E	0.661	0.38
72_R	113_A	0.660	0.38
282_D	290_L	0.659	0.38
214_V	247_V	0.659	0.38
127_R	130_G	0.657	0.38
250_P	254_I	0.655	0.38
60_A	248_D	0.654	0.38
59_Q	139_D	0.653	0.38
52_P	62_P	0.653	0.38
138_P	338_H	0.652	0.38
12_D	16_A	0.652	0.38
112_A	116_E	0.651	0.38
324_L	341_I	0.650	0.37
149_T	163_D	0.650	0.37
283_N	287_G	0.649	0.37
98_L	169_F	0.647	0.37
177_R	203_P	0.646	0.37
257_G	273_T	0.644	0.37
257_G	295_A	0.643	0.37
310_R	313_C	0.642	0.37
156_H	172_G	0.641	0.37
244_C	259_Y	0.640	0.37
220_A	333_S	0.639	0.37
259_Y	273_T	0.639	0.37
19_G	31_K	0.637	0.36
107_P	110_V	0.637	0.36
200_F	220_A	0.634	0.36
177_R	330_K	0.633	0.36
92_V	171_P	0.633	0.36
21_E	31_K	0.632	0.36
129_D	154_V	0.631	0.36
173_N	295_A	0.630	0.36
132_A	311_A	0.628	0.36
71_D	283_N	0.628	0.36
199_Y	293_H	0.628	0.36
199_Y	295_A	0.627	0.36
138_P	177_R	0.627	0.36
38_D	42_L	0.625	0.35
215_E	330_K	0.624	0.35
179_R	187_G	0.623	0.35
110_V	127_R	0.622	0.35
293_H	330_K	0.622	0.35
296_V	304_R	0.620	0.35
125_L	227_N	0.619	0.35
69_L	309_L	0.616	0.35
129_D	139_D	0.616	0.35
177_R	199_Y	0.614	0.34
242_G	249_A	0.613	0.34
310_R	320_A	0.612	0.34
164_L	216_K	0.610	0.34
117_L	127_R	0.608	0.34
333_S	340_V	0.608	0.34
305_P	309_L	0.608	0.34
205_A	228_A	0.605	0.34
12_D	22_D	0.605	0.34
165_A	219_T	0.605	0.34
61_D	71_D	0.605	0.34
18_D	25_V	0.605	0.34
137_T	173_N	0.604	0.34
338_H	343_A	0.598	0.33
68_D	72_R	0.596	0.33
259_Y	295_A	0.595	0.33
172_G	340_V	0.594	0.33
173_N	177_R	0.592	0.33
11_P	19_G	0.591	0.33
299_A	303_E	0.590	0.33
51_V	157_G	0.590	0.33
64_P	72_R	0.588	0.32
153_H	260_D	0.587	0.32
93_L	155_E	0.587	0.32
199_Y	244_C	0.586	0.32
289_V	324_L	0.586	0.32
128_G	149_T	0.585	0.32
127_R	142_V	0.584	0.32
127_R	214_V	0.584	0.32
44_V	47_E	0.583	0.32
142_V	154_V	0.583	0.32
208_G	333_S	0.581	0.32
125_L	216_K	0.579	0.32
214_V	244_C	0.578	0.32
19_G	22_D	0.576	0.31
205_A	227_N	0.572	0.31
44_V	252_D	0.569	0.31
168_M	244_C	0.567	0.31
94_G	163_D	0.566	0.31
260_D	332_H	0.565	0.31
168_M	336_V	0.564	0.31
201_A	244_C	0.563	0.30
131_V	137_T	0.562	0.30
62_P	66_A	0.562	0.30
103_D	142_V	0.561	0.30
293_H	338_H	0.559	0.30
135_H	218_P	0.556	0.30
25_V	34_E	0.554	0.30
89_S	124_V	0.553	0.30
162_L	203_P	0.553	0.30
254_I	284_L	0.552	0.30
68_D	89_S	0.552	0.30
182_D	210_T	0.551	0.30
124_V	224_L	0.550	0.29
175_A	329_V	0.549	0.29
306_L	317_G	0.549	0.29
79_S	106_R	0.548	0.29
150_E	161_A	0.548	0.29
52_P	55_R	0.547	0.29
16_A	30_R	0.546	0.29
180_M	183_A	0.546	0.29
138_P	258_Y	0.545	0.29
93_L	251_A	0.543	0.29
205_A	236_T	0.543	0.29
244_C	273_T	0.542	0.29
75_E	91_A	0.538	0.29
67_P	282_D	0.538	0.29
88_S	111_G	0.538	0.29
15_R	19_G	0.538	0.29
88_S	224_L	0.537	0.29
283_N	333_S	0.537	0.29
123_T	149_T	0.535	0.28
223_F	227_N	0.535	0.28
136_R	217_N	0.535	0.28
138_P	172_G	0.533	0.28
155_E	204_M	0.531	0.28
131_V	173_N	0.529	0.28
21_E	26_Y	0.528	0.28
156_H	174_K	0.528	0.28
200_F	256_M	0.527	0.28
84_E	153_H	0.527	0.28
98_L	167_V	0.527	0.28
96_V	224_L	0.526	0.28
29_R	33_R	0.525	0.28
173_N	336_V	0.525	0.28
42_L	48_P	0.524	0.28
257_G	260_D	0.524	0.28
202_L	301_L	0.523	0.28
30_R	35_H	0.522	0.27
121_A	127_R	0.519	0.27
188_E	341_I	0.519	0.27
259_Y	330_K	0.519	0.27
62_P	67_P	0.519	0.27
15_R	159_R	0.518	0.27
40_V	44_V	0.516	0.27
180_M	284_L	0.516	0.27
192_D	203_P	0.514	0.27
51_V	54_E	0.512	0.27
96_V	310_R	0.512	0.27
150_E	162_L	0.511	0.27
140_V	333_S	0.511	0.27
193_M	256_M	0.508	0.26
14_Q	32_V	0.508	0.26
191_L	237_L	0.507	0.26
200_F	277_L	0.506	0.26
201_A	229_Q	0.506	0.26
251_A	294_S	0.506	0.26
91_A	212_T	0.505	0.26
244_C	330_K	0.504	0.26
259_Y	338_H	0.502	0.26
292_A	309_L	0.501	0.26
221_F	241_L	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yx1A	2	0.896	100	0.512	Contact Map
3k6rA	1	0.737	100	0.599	Contact Map
3a27A	1	0.6156	100	0.624	Contact Map
3vseA	1	0.9711	99.9	0.758	Contact Map
2b78A	1	0.9335	99.9	0.758	Contact Map
2as0A	2	0.9711	99.9	0.764	Contact Map
3v97A	1	0.8671	99.9	0.771	Contact Map
4dmgA	2	0.9653	99.9	0.772	Contact Map
1wxxA	2	0.9335	99.9	0.777	Contact Map
3c0kA	2	0.9682	99.9	0.78	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.