GREMLIN Database
Q9HMM2 - Uncharacterized protein
UniProt: Q9HMM2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (316)
Sequences: 940 (676)
Seq/√Len: 38.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_T222_R4.3131.00
245_R278_D3.7841.00
161_A226_E3.7681.00
149_T165_A3.2831.00
221_F225_A3.1751.00
107_P141_S3.1451.00
151_T162_L3.0071.00
284_L288_G2.9911.00
221_F239_T2.9251.00
97_I121_A2.8671.00
193_M244_C2.8421.00
191_L251_A2.8351.00
253_R291_H2.8281.00
142_V149_T2.8111.00
228_A237_L2.7881.00
194_F276_Y2.7401.00
228_A239_T2.6911.00
178_A182_D2.2580.99
201_A213_A2.2250.99
204_M255_V2.2250.99
91_A171_P2.2090.99
330_K338_H2.1970.99
96_V151_T2.1550.99
159_R230_L2.1540.99
166_A219_T2.1520.99
306_L310_R2.1390.99
307_S311_A2.1100.99
168_M173_N2.0950.99
122_D146_D2.0100.99
173_N257_G2.0060.99
12_D15_R1.9950.99
152_V161_A1.9530.98
126_D141_S1.9490.98
162_L223_F1.8870.98
192_D257_G1.8810.98
168_M172_G1.8790.98
188_E252_D1.8700.98
27_D30_R1.8700.98
226_E229_Q1.8630.98
308_R313_C1.8560.98
13_S40_V1.8120.97
152_V159_R1.7980.97
154_V159_R1.7970.97
150_E223_F1.7770.97
41_E45_T1.7530.97
188_E253_R1.7500.97
122_D148_D1.7380.97
205_A256_M1.7370.97
168_M257_G1.7270.97
210_T238_D1.7080.96
328_R337_F1.6910.96
291_H342_D1.6680.96
14_Q17_I1.6520.96
229_Q234_A1.6450.95
111_G144_A1.6300.95
256_M273_T1.6260.95
161_A230_L1.6180.95
222_R226_E1.6080.95
168_M199_Y1.6040.95
160_Y203_P1.5980.95
172_G199_Y1.5900.95
179_R340_V1.5880.94
173_N259_Y1.5750.94
183_A325_D1.5710.94
111_G143_V1.5630.94
97_I118_H1.5600.94
305_P308_R1.5430.94
301_L304_R1.5360.93
199_Y257_G1.5050.93
205_A237_L1.4870.92
195_A215_E1.4820.92
158_T202_L1.4730.92
192_D224_L1.4650.92
42_L45_T1.4590.92
72_R77_G1.4500.91
184_T255_V1.4470.91
173_N330_K1.4460.91
99_A143_V1.4300.91
177_R220_A1.4280.91
300_E303_E1.4210.90
35_H41_E1.4170.90
168_M259_Y1.4140.90
173_N199_Y1.4100.90
194_F292_A1.4090.90
123_T145_G1.4030.90
35_H38_D1.3990.90
63_D66_A1.3930.90
173_N215_E1.3860.89
184_T204_M1.3760.89
180_M184_T1.3760.89
226_E230_L1.3680.89
163_D166_A1.3660.89
115_L144_A1.3600.88
41_E47_E1.3590.88
172_G259_Y1.3570.88
274_P294_S1.3540.88
100_D127_R1.3530.88
331_S337_F1.3430.88
172_G257_G1.3410.88
190_V255_V1.3320.87
257_G338_H1.3200.87
173_N338_H1.3030.86
304_R308_R1.2890.85
125_L140_V1.2850.85
135_H216_K1.2780.85
184_T190_V1.2760.85
158_T206_R1.2730.85
17_I21_E1.2730.85
332_H336_V1.2660.84
134_E216_K1.2590.84
91_A172_G1.2460.83
46_A49_D1.2450.83
92_V119_R1.2220.82
256_M276_Y1.2200.82
289_V342_D1.2150.82
240_I247_V1.2150.82
260_D273_T1.2090.82
213_A224_L1.1830.80
215_E221_F1.1780.80
273_T276_Y1.1700.79
177_R260_D1.1630.79
54_E59_Q1.1580.79
168_M338_H1.1550.78
198_G224_L1.1440.78
160_Y202_L1.1440.78
254_I280_A1.1420.78
212_T240_I1.1380.77
180_M255_V1.1360.77
39_H45_T1.1350.77
67_P72_R1.1350.77
199_Y259_Y1.1250.77
219_T223_F1.1230.76
199_Y338_H1.1230.76
97_I114_L1.1210.76
215_E257_G1.1010.75
143_V245_R1.0940.75
193_M280_A1.0910.74
289_V344_R1.0900.74
308_R311_A1.0880.74
40_V43_P1.0810.74
218_P241_L1.0760.73
114_L121_A1.0750.73
13_S17_I1.0640.72
176_E179_R1.0630.72
170_S177_R1.0600.72
125_L131_V1.0480.71
189_R251_A1.0420.71
326_T341_I1.0250.70
220_A293_H1.0250.70
192_D338_H1.0220.69
253_R342_D1.0200.69
14_Q18_D1.0090.68
162_L220_A1.0090.68
192_D330_K1.0000.68
254_I339_V0.9990.68
12_D19_G0.9920.67
293_H327_R0.9910.67
41_E44_V0.9890.67
257_G330_K0.9720.65
295_A336_V0.9700.65
327_R342_D0.9690.65
195_A224_L0.9660.65
191_L214_V0.9660.65
190_V204_M0.9650.65
215_E336_V0.9640.65
179_R291_H0.9550.64
191_L212_T0.9540.64
110_V141_S0.9530.64
200_F203_P0.9440.63
257_G293_H0.9400.63
225_A229_Q0.9390.63
202_L227_N0.9380.63
133_G155_E0.9380.63
162_L167_V0.9320.62
332_H338_H0.9310.62
118_H121_A0.9280.62
245_R275_G0.9230.61
42_L47_E0.9210.61
11_P38_D0.9190.61
39_H42_L0.9160.61
103_D255_V0.9150.61
191_L254_I0.8970.59
93_L171_P0.8940.59
41_E49_D0.8940.59
145_G200_F0.8910.59
172_G293_H0.8900.59
126_D143_V0.8850.58
83_R151_T0.8850.58
295_A332_H0.8820.58
317_G320_A0.8810.58
303_E307_S0.8790.58
156_H178_A0.8760.57
168_M330_K0.8760.57
192_D198_G0.8740.57
258_Y273_T0.8740.57
172_G330_K0.8740.57
132_A139_D0.8710.57
177_R194_F0.8700.57
101_F110_V0.8700.57
189_R212_T0.8670.57
123_T148_D0.8660.56
143_V232_D0.8630.56
221_F224_L0.8560.56
45_T48_P0.8550.55
286_S307_S0.8550.55
171_P204_M0.8530.55
172_G338_H0.8520.55
163_D207_A0.8510.55
41_E46_A0.8510.55
173_N293_H0.8470.55
177_R200_F0.8470.55
133_G137_T0.8440.54
138_P330_K0.8440.54
41_E48_P0.8420.54
150_E163_D0.8400.54
153_H169_F0.8370.54
64_P116_E0.8360.54
159_R323_V0.8340.54
150_E194_F0.8320.53
127_R295_A0.8320.53
138_P203_P0.8310.53
168_M215_E0.8290.53
168_M293_H0.8270.53
89_S212_T0.8270.53
22_D25_V0.8180.52
16_A20_L0.8170.52
91_A223_F0.8160.52
203_P224_L0.8160.52
227_N243_D0.8130.52
192_D215_E0.8090.51
138_P199_Y0.8080.51
153_H174_K0.7970.50
173_N192_D0.7880.49
199_Y330_K0.7880.49
107_P115_L0.7840.49
70_G74_R0.7820.49
125_L164_L0.7820.49
322_T344_R0.7800.49
95_S200_F0.7750.48
155_E163_D0.7750.48
193_M197_V0.7740.48
202_L233_V0.7700.48
190_V228_A0.7690.48
45_T49_D0.7640.47
138_P200_F0.7640.47
140_V203_P0.7620.47
91_A138_P0.7600.47
40_V45_T0.7580.47
178_A197_V0.7570.47
205_A233_V0.7530.46
32_V42_L0.7520.46
200_F261_A0.7510.46
78_W106_R0.7510.46
305_P341_I0.7470.46
23_E26_Y0.7420.45
117_L123_T0.7390.45
127_R215_E0.7380.45
187_G209_A0.7350.45
79_S105_P0.7350.45
92_V121_A0.7340.45
256_M277_L0.7340.45
24_G27_D0.7310.44
179_R327_R0.7290.44
137_T293_H0.7290.44
79_S141_S0.7290.44
160_Y171_P0.7250.44
305_P313_C0.7240.44
116_E241_L0.7240.44
40_V46_A0.7210.44
187_G252_D0.7190.43
138_P173_N0.7170.43
155_E177_R0.7150.43
256_M290_L0.7140.43
113_A117_L0.7130.43
16_A23_E0.7130.43
122_D154_V0.7130.43
338_H342_D0.7110.43
225_A239_T0.7100.43
260_D295_A0.7100.43
181_G253_R0.7090.42
66_A180_M0.7090.42
215_E258_Y0.7080.42
173_N244_C0.7020.42
190_V209_A0.6990.42
172_G258_Y0.6990.42
15_R18_D0.6980.42
221_F228_A0.6980.42
142_V147_G0.6960.41
138_P257_G0.6950.41
93_L96_V0.6940.41
24_G28_D0.6940.41
195_A256_M0.6930.41
92_V156_H0.6930.41
244_C257_G0.6920.41
307_S310_R0.6920.41
223_F226_E0.6910.41
193_M290_L0.6900.41
284_L287_G0.6890.41
153_H163_D0.6880.41
308_R312_G0.6880.41
258_Y295_A0.6870.41
259_Y293_H0.6850.40
310_R319_P0.6840.40
202_L239_T0.6770.40
123_T216_K0.6760.40
93_L162_L0.6760.40
98_L164_L0.6730.39
330_K336_V0.6730.39
295_A330_K0.6730.39
170_S200_F0.6710.39
133_G139_D0.6690.39
300_E304_R0.6690.39
44_V48_P0.6670.39
180_M204_M0.6640.39
185_G188_E0.6620.38
252_D293_H0.6610.38
20_L23_E0.6610.38
72_R113_A0.6600.38
282_D290_L0.6590.38
214_V247_V0.6590.38
127_R130_G0.6570.38
250_P254_I0.6550.38
60_A248_D0.6540.38
59_Q139_D0.6530.38
52_P62_P0.6530.38
138_P338_H0.6520.38
12_D16_A0.6520.38
112_A116_E0.6510.38
324_L341_I0.6500.37
149_T163_D0.6500.37
283_N287_G0.6490.37
98_L169_F0.6470.37
177_R203_P0.6460.37
257_G273_T0.6440.37
257_G295_A0.6430.37
310_R313_C0.6420.37
156_H172_G0.6410.37
244_C259_Y0.6400.37
220_A333_S0.6390.37
259_Y273_T0.6390.37
19_G31_K0.6370.36
107_P110_V0.6370.36
200_F220_A0.6340.36
177_R330_K0.6330.36
92_V171_P0.6330.36
21_E31_K0.6320.36
129_D154_V0.6310.36
173_N295_A0.6300.36
132_A311_A0.6280.36
71_D283_N0.6280.36
199_Y293_H0.6280.36
199_Y295_A0.6270.36
138_P177_R0.6270.36
38_D42_L0.6250.35
215_E330_K0.6240.35
179_R187_G0.6230.35
110_V127_R0.6220.35
293_H330_K0.6220.35
296_V304_R0.6200.35
125_L227_N0.6190.35
69_L309_L0.6160.35
129_D139_D0.6160.35
177_R199_Y0.6140.34
242_G249_A0.6130.34
310_R320_A0.6120.34
164_L216_K0.6100.34
117_L127_R0.6080.34
333_S340_V0.6080.34
305_P309_L0.6080.34
205_A228_A0.6050.34
12_D22_D0.6050.34
165_A219_T0.6050.34
61_D71_D0.6050.34
18_D25_V0.6050.34
137_T173_N0.6040.34
338_H343_A0.5980.33
68_D72_R0.5960.33
259_Y295_A0.5950.33
172_G340_V0.5940.33
173_N177_R0.5920.33
11_P19_G0.5910.33
299_A303_E0.5900.33
51_V157_G0.5900.33
64_P72_R0.5880.32
153_H260_D0.5870.32
93_L155_E0.5870.32
199_Y244_C0.5860.32
289_V324_L0.5860.32
128_G149_T0.5850.32
127_R142_V0.5840.32
127_R214_V0.5840.32
44_V47_E0.5830.32
142_V154_V0.5830.32
208_G333_S0.5810.32
125_L216_K0.5790.32
214_V244_C0.5780.32
19_G22_D0.5760.31
205_A227_N0.5720.31
44_V252_D0.5690.31
168_M244_C0.5670.31
94_G163_D0.5660.31
260_D332_H0.5650.31
168_M336_V0.5640.31
201_A244_C0.5630.30
131_V137_T0.5620.30
62_P66_A0.5620.30
103_D142_V0.5610.30
293_H338_H0.5590.30
135_H218_P0.5560.30
25_V34_E0.5540.30
89_S124_V0.5530.30
162_L203_P0.5530.30
254_I284_L0.5520.30
68_D89_S0.5520.30
182_D210_T0.5510.30
124_V224_L0.5500.29
175_A329_V0.5490.29
306_L317_G0.5490.29
79_S106_R0.5480.29
150_E161_A0.5480.29
52_P55_R0.5470.29
16_A30_R0.5460.29
180_M183_A0.5460.29
138_P258_Y0.5450.29
93_L251_A0.5430.29
205_A236_T0.5430.29
244_C273_T0.5420.29
75_E91_A0.5380.29
67_P282_D0.5380.29
88_S111_G0.5380.29
15_R19_G0.5380.29
88_S224_L0.5370.29
283_N333_S0.5370.29
123_T149_T0.5350.28
223_F227_N0.5350.28
136_R217_N0.5350.28
138_P172_G0.5330.28
155_E204_M0.5310.28
131_V173_N0.5290.28
21_E26_Y0.5280.28
156_H174_K0.5280.28
200_F256_M0.5270.28
84_E153_H0.5270.28
98_L167_V0.5270.28
96_V224_L0.5260.28
29_R33_R0.5250.28
173_N336_V0.5250.28
42_L48_P0.5240.28
257_G260_D0.5240.28
202_L301_L0.5230.28
30_R35_H0.5220.27
121_A127_R0.5190.27
188_E341_I0.5190.27
259_Y330_K0.5190.27
62_P67_P0.5190.27
15_R159_R0.5180.27
40_V44_V0.5160.27
180_M284_L0.5160.27
192_D203_P0.5140.27
51_V54_E0.5120.27
96_V310_R0.5120.27
150_E162_L0.5110.27
140_V333_S0.5110.27
193_M256_M0.5080.26
14_Q32_V0.5080.26
191_L237_L0.5070.26
200_F277_L0.5060.26
201_A229_Q0.5060.26
251_A294_S0.5060.26
91_A212_T0.5050.26
244_C330_K0.5040.26
259_Y338_H0.5020.26
292_A309_L0.5010.26
221_F241_L0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yx1A 2 0.896 100 0.512 Contact Map
3k6rA 1 0.737 100 0.599 Contact Map
3a27A 1 0.6156 100 0.624 Contact Map
3vseA 1 0.9711 99.9 0.758 Contact Map
2b78A 1 0.9335 99.9 0.758 Contact Map
2as0A 2 0.9711 99.9 0.764 Contact Map
3v97A 1 0.8671 99.9 0.771 Contact Map
4dmgA 2 0.9653 99.9 0.772 Contact Map
1wxxA 2 0.9335 99.9 0.777 Contact Map
3c0kA 2 0.9682 99.9 0.78 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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