GREMLIN Database
Q9HMM1 - Uncharacterized protein
UniProt: Q9HMM1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 543 (450)
Sequences: 4049 (3068)
Seq/√Len: 144.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
284_P287_N6.8831.00
417_G420_A4.5771.00
122_A252_L4.4911.00
308_P342_R4.4641.00
330_A339_L4.1871.00
318_M326_G4.1471.00
314_V396_V3.9911.00
102_F119_I3.8061.00
264_C276_L3.2951.00
317_V448_Y3.2071.00
321_H326_G3.0691.00
437_V445_G3.0491.00
374_E377_V2.9831.00
325_K393_R2.9291.00
314_V328_V2.9161.00
51_C80_C2.8061.00
365_E369_A2.7121.00
66_C69_E2.6621.00
119_I125_L2.4461.00
311_A342_R2.3941.00
343_L376_F2.3921.00
434_C447_T2.3791.00
334_D338_K2.3041.00
375_V378_A2.2891.00
382_E433_A2.2351.00
462_R470_A2.2331.00
449_I454_V2.1701.00
240_S245_D2.1581.00
333_Y378_A2.1441.00
41_K92_R2.0731.00
330_A376_F2.0701.00
239_L244_W2.0551.00
388_A440_A2.0501.00
154_L157_D2.0181.00
350_D355_H2.0171.00
217_T221_V2.0131.00
124_G383_E2.0031.00
456_D460_R1.9971.00
394_W448_Y1.9731.00
430_I449_I1.9451.00
317_V394_W1.9391.00
326_G394_W1.9381.00
313_T450_A1.9181.00
390_D393_R1.8951.00
263_F267_V1.8591.00
44_R47_S1.8521.00
27_Q30_D1.8331.00
74_C80_C1.8271.00
21_T99_L1.8181.00
157_D160_R1.8151.00
167_H171_V1.7901.00
258_L278_D1.7871.00
29_D33_A1.7871.00
321_H394_W1.7791.00
27_Q31_V1.7791.00
324_E390_D1.7671.00
45_G48_N1.7661.00
244_W252_L1.7631.00
136_D229_T1.7601.00
396_V450_A1.7531.00
20_Y31_V1.7301.00
198_E202_E1.7231.00
427_L461_A1.7211.00
170_G173_E1.7121.00
18_A118_V1.7111.00
311_A339_L1.6971.00
330_A336_A1.6741.00
247_A250_H1.6621.00
461_A466_P1.6601.00
171_V178_E1.6601.00
374_E378_A1.6471.00
45_G49_Y1.6461.00
200_I206_F1.6411.00
38_E41_K1.6391.00
74_C77_K1.6241.00
415_A419_W1.6181.00
317_V396_V1.6141.00
87_A90_S1.6091.00
379_V429_T1.6031.00
333_Y336_A1.6001.00
52_I81_P1.5931.00
153_G157_D1.5851.00
174_G177_D1.5801.00
340_A354_T1.5691.00
387_L391_L1.5581.00
43_I46_K1.5411.00
51_C74_C1.5361.00
159_E162_A1.5331.00
400_A426_A1.5321.00
333_Y337_E1.5271.00
300_Y303_R1.5171.00
462_R466_P1.5061.00
298_M301_E1.5051.00
270_D273_T1.5021.00
368_K391_L1.4981.00
154_L158_P1.4921.00
19_Y117_C1.4911.00
153_G156_G1.4901.00
213_P219_W1.4851.00
51_C69_E1.4631.00
19_Y114_R1.4601.00
459_E462_R1.4581.00
25_V28_L1.4581.00
308_P312_D1.4481.00
117_C247_A1.4481.00
171_V175_V1.4471.00
56_E76_V1.4401.00
22_T28_L1.4271.00
461_A465_M1.4111.00
69_E80_C1.4071.00
434_C449_I1.4051.00
461_A464_D1.3951.00
16_V115_D1.3941.00
173_E176_K1.3871.00
169_Q172_C1.3831.00
393_R444_Y1.3761.00
155_D158_P1.3721.00
160_R163_D1.3711.00
176_K180_L1.3561.00
360_R381_M1.3551.00
59_T62_D1.3531.00
351_R366_R1.3531.00
260_K276_L1.3381.00
397_L447_T1.3331.00
395_Q437_V1.3331.00
44_R48_N1.3321.00
430_I461_A1.3231.00
410_V414_L1.3191.00
414_L422_Y1.3151.00
108_S111_F1.3141.00
366_R369_A1.3091.00
168_L172_C1.3061.00
344_A357_A1.3061.00
202_E206_F1.3011.00
62_D65_P1.2971.00
370_S373_P1.2971.00
126_A266_S1.2891.00
64_A68_R1.2801.00
195_R202_E1.2801.00
337_E341_A1.2791.00
127_E425_T1.2761.00
44_R49_Y1.2711.00
331_H399_K1.2501.00
116_V249_K1.2421.00
392_G437_V1.2421.00
168_L175_V1.2311.00
361_D365_E1.2291.00
329_H382_E1.2281.00
169_Q176_K1.2221.00
154_L159_E1.2141.00
307_L311_A1.2091.00
318_M375_V1.2041.00
189_A192_R1.2041.00
185_L190_V1.2031.00
176_K183_D1.1921.00
182_Q186_T1.1911.00
204_D208_E1.1751.00
374_E379_V1.1721.00
311_A343_L1.1721.00
325_K350_D1.1621.00
43_I89_A1.1561.00
25_V48_N1.1521.00
199_L206_F1.1490.99
119_I252_L1.1490.99
207_I210_Y1.1470.99
43_I95_A1.1460.99
336_A354_T1.1450.99
158_P162_A1.1450.99
107_G111_F1.1440.99
288_R438_V1.1400.99
376_F379_V1.1370.99
402_F423_Y1.1320.99
28_L32_A1.1270.99
145_W149_R1.1270.99
375_V379_V1.1220.99
202_E205_W1.1220.99
166_D169_Q1.1210.99
26_S30_D1.1200.99
205_W209_D1.1180.99
153_G158_P1.1160.99
351_R370_S1.1140.99
199_L205_W1.1100.99
71_G74_C1.1070.99
172_C176_K1.1050.99
172_C183_D1.1040.99
411_A415_A1.1040.99
166_D170_G1.1040.99
362_A365_E1.0980.99
392_G445_G1.0940.99
139_E143_P1.0910.99
199_L202_E1.0910.99
195_R199_L1.0900.99
154_L161_T1.0890.99
161_T164_F1.0880.99
21_T102_F1.0870.99
69_E74_C1.0720.99
411_A414_L1.0720.99
102_F117_C1.0700.99
340_A344_A1.0610.99
327_I395_Q1.0580.99
325_K371_D1.0580.99
310_L398_C1.0550.99
360_R380_K1.0530.99
252_L263_F1.0520.99
364_L387_L1.0490.99
126_A263_F1.0370.99
108_S112_R1.0370.99
436_R439_R1.0350.99
459_E466_P1.0310.99
173_E177_D1.0260.99
371_D390_D1.0240.99
177_D180_L1.0240.99
172_C177_D1.0210.99
97_M102_F1.0170.99
167_H175_V1.0150.99
342_R345_D1.0140.99
153_G163_D1.0140.99
153_G159_E1.0140.99
343_L377_V1.0080.99
299_T452_S1.0060.99
160_R164_F1.0060.99
176_K188_E1.0000.99
196_L204_D0.9960.99
103_M129_A0.9950.99
435_G439_R0.9940.99
46_K49_Y0.9940.99
32_A96_A0.9910.98
176_K181_G0.9910.98
171_V179_L0.9910.98
23_P124_G0.9900.98
169_Q173_E0.9900.98
103_M125_L0.9860.98
25_V32_A0.9830.98
161_T165_A0.9810.98
358_D366_R0.9800.98
156_G160_R0.9790.98
322_P325_K0.9790.98
155_D160_R0.9760.98
316_R319_A0.9760.98
117_C250_H0.9730.98
339_L342_R0.9730.98
147_D151_P0.9710.98
28_L98_T0.9660.98
312_D316_R0.9650.98
59_T66_C0.9620.98
183_D186_T0.9620.98
187_T191_A0.9600.98
25_V29_D0.9590.98
107_G110_V0.9530.98
23_P128_W0.9530.98
260_K263_F0.9530.98
335_I398_C0.9480.98
130_E413_R0.9450.98
196_L201_A0.9450.98
282_T389_H0.9440.98
401_P404_N0.9350.98
182_Q193_R0.9340.98
152_S156_G0.9330.98
178_E182_Q0.9310.98
340_A352_V0.9300.98
62_D66_C0.9260.98
53_L56_E0.9240.98
196_L206_F0.9230.98
97_M101_Y0.9210.98
156_G163_D0.9200.98
159_E163_D0.9170.98
50_T55_G0.9150.97
218_T222_D0.9140.97
59_T64_A0.9140.97
338_K341_A0.9140.97
63_R66_C0.9100.97
152_S158_P0.9090.97
397_L434_C0.9070.97
23_P27_Q0.9060.97
415_A418_Q0.9050.97
176_K186_T0.9050.97
25_V30_D0.9040.97
181_G184_E0.9040.97
161_T171_V0.9010.97
204_D207_I0.8990.97
163_D167_H0.8970.97
158_P163_D0.8950.97
412_A415_A0.8940.97
408_S415_A0.8930.97
197_Q201_A0.8910.97
373_P376_F0.8890.97
460_R466_P0.8880.97
421_W425_T0.8870.97
178_E183_D0.8860.97
155_D159_E0.8840.97
362_A366_R0.8820.97
428_Q431_I0.8780.97
201_A205_W0.8770.97
200_I210_Y0.8750.97
327_I433_A0.8730.97
43_I49_Y0.8730.97
334_D337_E0.8710.97
315_V319_A0.8690.97
316_R320_T0.8680.97
196_L202_E0.8670.97
197_Q203_L0.8650.96
196_L200_I0.8630.96
169_Q179_L0.8590.96
61_V66_C0.8580.96
397_L430_I0.8570.96
166_D183_D0.8570.96
63_R68_R0.8540.96
188_E191_A0.8530.96
338_K342_R0.8500.96
349_G355_H0.8500.96
22_T98_T0.8450.96
359_T362_A0.8440.96
306_T310_L0.8420.96
394_W446_A0.8410.96
202_E207_I0.8400.96
23_P26_S0.8380.96
171_V176_K0.8380.96
396_V448_Y0.8360.96
69_E77_K0.8350.96
240_S270_D0.8350.96
373_P377_V0.8340.96
244_W250_H0.8330.96
152_S157_D0.8330.96
26_S29_D0.8310.96
65_P68_R0.8290.95
401_P405_T0.8260.95
417_G421_W0.8220.95
186_T190_V0.8210.95
224_D227_G0.8200.95
178_E181_G0.8170.95
214_E217_T0.8150.95
181_G186_T0.8130.95
195_R200_I0.8110.95
180_L193_R0.8090.95
39_E42_L0.8090.95
406_N411_A0.8050.95
336_A376_F0.8050.95
100_A128_W0.8050.95
386_D445_G0.8020.95
123_H254_S0.8000.95
164_F174_G0.7980.94
449_I465_M0.7970.94
173_E178_E0.7940.94
167_H170_G0.7910.94
162_A166_D0.7900.94
155_D163_D0.7900.94
172_C189_A0.7890.94
154_L162_A0.7890.94
31_V34_D0.7890.94
408_S412_A0.7860.94
186_T189_A0.7840.94
307_L310_L0.7780.94
81_P84_A0.7770.94
171_V180_L0.7760.94
171_V182_Q0.7760.94
310_L314_V0.7750.94
153_G161_T0.7740.94
459_E464_D0.7730.93
154_L164_F0.7700.93
196_L203_L0.7690.93
172_C175_V0.7660.93
154_L165_A0.7650.93
182_Q185_L0.7640.93
432_Q435_G0.7640.93
203_L207_I0.7640.93
358_D362_A0.7620.93
157_D161_T0.7610.93
197_Q205_W0.7610.93
182_Q189_A0.7600.93
176_K187_T0.7580.93
341_A345_D0.7530.93
351_R372_D0.7510.92
309_K312_D0.7510.92
42_L96_A0.7510.92
195_R209_D0.7490.92
382_E431_I0.7480.92
315_V348_V0.7470.92
163_D166_D0.7410.92
157_D163_D0.7410.92
410_V422_Y0.7410.92
330_A377_V0.7390.92
138_D141_R0.7390.92
363_E375_V0.7390.92
310_L450_A0.7380.92
423_Y460_R0.7380.92
172_C188_E0.7370.92
307_L335_I0.7350.92
200_I203_L0.7350.92
402_F461_A0.7340.92
325_K394_W0.7330.92
315_V347_G0.7330.92
176_K193_R0.7320.92
45_G98_T0.7310.91
28_L31_V0.7300.91
72_Y77_K0.7290.91
183_D193_R0.7280.91
371_D391_L0.7270.91
173_E180_L0.7260.91
52_I56_E0.7260.91
130_E134_T0.7250.91
410_V421_W0.7250.91
434_C468_W0.7240.91
167_H172_C0.7240.91
127_E131_M0.7210.91
63_R69_E0.7200.91
321_H393_R0.7180.91
169_Q182_Q0.7180.91
403_L425_T0.7150.91
198_E204_D0.7140.90
293_V313_T0.7140.90
194_D198_E0.7130.90
182_Q192_R0.7120.90
307_L339_L0.7110.90
154_L160_R0.7110.90
170_G176_K0.7080.90
187_T190_V0.7080.90
198_E205_W0.7080.90
254_S386_D0.7020.90
254_S327_I0.7000.90
59_T65_P0.6990.90
304_A338_K0.6990.90
347_G350_D0.6980.89
419_W423_Y0.6970.89
101_Y105_T0.6970.89
283_F288_R0.6950.89
155_D161_T0.6950.89
195_R203_L0.6950.89
432_Q439_R0.6940.89
38_E42_L0.6940.89
280_E467_P0.6940.89
427_L430_I0.6940.89
200_I207_I0.6930.89
155_D162_A0.6930.89
194_D203_L0.6920.89
317_V450_A0.6870.89
198_E207_I0.6860.89
198_E210_Y0.6840.89
24_Q30_D0.6840.89
255_A283_F0.6830.88
29_D32_A0.6820.88
39_E93_A0.6820.88
27_Q329_H0.6810.88
180_L186_T0.6800.88
351_R354_T0.6800.88
31_V96_A0.6780.88
156_G162_A0.6760.88
459_E465_M0.6750.88
24_Q34_D0.6740.88
297_K313_T0.6720.88
197_Q206_F0.6710.88
331_H382_E0.6700.87
26_S31_V0.6690.87
242_T245_D0.6680.87
187_T192_R0.6680.87
153_G170_G0.6680.87
170_G208_E0.6660.87
204_D209_D0.6650.87
76_V79_R0.6650.87
348_V351_R0.6630.87
212_D215_S0.6620.87
167_H181_G0.6570.86
407_D410_V0.6550.86
159_E164_F0.6550.86
409_R413_R0.6530.86
327_I387_L0.6520.86
27_Q98_T0.6500.86
44_R52_I0.6500.86
178_E187_T0.6490.86
289_P295_Q0.6490.86
176_K182_Q0.6490.86
389_H440_A0.6470.86
260_K264_C0.6430.85
121_E436_R0.6420.85
169_Q183_D0.6420.85
185_L191_A0.6410.85
121_E432_Q0.6410.85
206_F210_Y0.6400.85
52_I55_G0.6390.85
194_D200_I0.6360.85
24_Q28_L0.6350.85
200_I205_W0.6340.84
430_I454_V0.6340.84
315_V343_L0.6330.84
59_T69_E0.6320.84
427_L464_D0.6300.84
292_D448_Y0.6300.84
153_G160_R0.6280.84
254_S257_I0.6270.84
155_D164_F0.6270.84
319_A347_G0.6260.84
371_D374_E0.6240.84
297_K300_Y0.6230.83
133_A238_Y0.6230.83
408_S411_A0.6220.83
432_Q436_R0.6220.83
198_E201_A0.6210.83
349_G353_R0.6200.83
43_I47_S0.6200.83
195_R210_Y0.6180.83
126_A250_H0.6130.82
184_E190_V0.6110.82
152_S162_A0.6110.82
167_H185_L0.6110.82
152_S155_D0.6110.82
137_L273_T0.6090.82
196_L199_L0.6070.82
341_A344_A0.6060.82
167_H186_T0.6040.82
161_T175_V0.6040.82
361_D390_D0.6030.81
313_T316_R0.6030.81
156_G164_F0.6030.81
68_R71_G0.6020.81
188_E193_R0.6010.81
121_E439_R0.6010.81
409_R412_A0.6000.81
350_D353_R0.6000.81
319_A349_G0.5990.81
162_A165_A0.5970.81
190_V193_R0.5970.81
353_R373_P0.5950.81
344_A349_G0.5940.80
66_C78_H0.5940.80
447_T468_W0.5930.80
178_E184_E0.5920.80
103_M230_I0.5920.80
128_W131_M0.5920.80
206_F209_D0.5910.80
325_K444_Y0.5880.80
177_D182_Q0.5880.80
143_P146_E0.5870.80
169_Q178_E0.5870.80
304_A308_P0.5870.80
185_L192_R0.5860.80
141_R202_E0.5860.80
180_L189_A0.5860.80
297_K301_E0.5840.79
385_L438_V0.5830.79
179_L183_D0.5830.79
100_A132_Y0.5820.79
44_R402_F0.5810.79
256_T439_R0.5810.79
194_D201_A0.5810.79
364_L385_L0.5800.79
24_Q27_Q0.5800.79
148_V213_P0.5800.79
407_D414_L0.5770.79
180_L187_T0.5760.78
157_D165_A0.5760.78
454_V465_M0.5760.78
353_R370_S0.5760.78
169_Q181_G0.5760.78
208_E212_D0.5760.78
58_A62_D0.5750.78
158_P161_T0.5750.78
462_R465_M0.5740.78
289_P434_C0.5740.78
183_D192_R0.5740.78
289_P468_W0.5730.78
27_Q32_A0.5710.78
181_G192_R0.5710.78
205_W210_Y0.5700.78
382_E385_L0.5700.78
156_G159_E0.5700.78
366_R370_S0.5700.78
88_I92_R0.5700.78
158_P167_H0.5690.78
115_D118_V0.5680.77
34_D255_A0.5680.77
361_D364_L0.5670.77
163_D174_G0.5670.77
183_D187_T0.5660.77
298_M302_N0.5660.77
423_Y465_M0.5650.77
183_D188_E0.5650.77
201_A204_D0.5650.77
61_V67_A0.5630.77
131_M134_T0.5620.77
416_D420_A0.5620.77
81_P399_K0.5590.76
153_G162_A0.5590.76
126_A130_E0.5590.76
172_C184_E0.5590.76
235_P259_N0.5580.76
59_T63_R0.5580.76
174_G181_G0.5580.76
168_L176_K0.5570.76
291_Y449_I0.5560.76
170_G174_G0.5560.76
307_L342_R0.5550.76
167_H182_Q0.5550.76
262_A266_S0.5530.76
158_P165_A0.5530.76
179_L187_T0.5520.75
194_D204_D0.5520.75
188_E192_R0.5520.75
166_D174_G0.5520.75
64_A69_E0.5510.75
289_P294_T0.5500.75
200_I209_D0.5500.75
66_C74_C0.5500.75
199_L209_D0.5500.75
172_C178_E0.5490.75
297_K302_N0.5490.75
53_L57_E0.5480.75
195_R204_D0.5450.75
99_L329_H0.5440.74
101_Y104_R0.5430.74
438_V443_D0.5430.74
171_V174_G0.5430.74
311_A347_G0.5420.74
41_K85_D0.5420.74
194_D197_Q0.5420.74
40_F92_R0.5420.74
163_D170_G0.5410.74
32_A40_F0.5390.74
121_E435_G0.5370.73
303_R308_P0.5370.73
172_C179_L0.5370.73
156_G302_N0.5360.73
66_C71_G0.5350.73
160_R167_H0.5350.73
403_L414_L0.5350.73
209_D212_D0.5340.73
32_A42_L0.5340.73
81_P382_E0.5330.73
179_L189_A0.5330.73
232_P235_P0.5320.73
183_D191_A0.5320.73
46_K105_T0.5310.73
28_L33_A0.5310.73
184_E189_A0.5310.73
175_V183_D0.5260.72
166_D186_T0.5260.72
181_G191_A0.5260.72
116_V251_A0.5260.72
389_H392_G0.5240.72
308_P338_K0.5240.72
174_G186_T0.5230.72
439_R443_D0.5230.72
176_K185_L0.5200.71
414_L418_Q0.5200.71
217_T222_D0.5190.71
346_A349_G0.5180.71
203_L206_F0.5180.71
200_I211_R0.5170.71
248_N463_G0.5170.71
467_P470_A0.5170.71
39_E88_I0.5160.71
80_C399_K0.5160.71
67_A100_A0.5150.70
71_G77_K0.5150.70
410_V413_R0.5140.70
106_A243_V0.5130.70
130_E231_K0.5130.70
365_E368_K0.5130.70
82_Y86_R0.5120.70
26_S33_A0.5110.70
126_A244_W0.5110.70
99_L105_T0.5110.70
156_G161_T0.5110.70
285_V288_R0.5100.70
162_A169_Q0.5090.69
170_G178_E0.5090.69
43_I48_N0.5080.69
200_I204_D0.5070.69
290_L446_A0.5060.69
166_D175_V0.5050.69
197_Q202_E0.5050.69
85_D426_A0.5030.69
83_F86_R0.5020.68
353_R366_R0.5020.68
367_W373_P0.5020.68
140_Q396_V0.5010.68
45_G101_Y0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a15A 1 0.8398 100 0.4 Contact Map
3crvA 1 0.8103 100 0.437 Contact Map
2vl7A 1 0.7201 100 0.471 Contact Map
1gkuB 1 0.6869 99.9 0.804 Contact Map
3fhoA 2 0.4954 99.9 0.817 Contact Map
4dduA 1 0.7182 99.8 0.834 Contact Map
4d25A 1 0.5764 99.8 0.838 Contact Map
4kbfA 2 0.558 99.8 0.84 Contact Map
3oiyA 1 0.639 99.8 0.841 Contact Map
2db3A 1 0.5691 99.8 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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