PSTB2 - HALSA - GREMLIN Contacts

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PSTB2 - Phosphate import ATP-binding protein PstB 2

UniProt:	Q9HML8	Sequences: MSDTPQSEPRRSDDRSGADDATAAAAGSTDAAAAAVSSKTGGIAGPPGGPGEVDGDEPAVARTVGESDEQLQDAWTDYEFDGDAKVSVSDLDTYYGEERALESVSLDIPAESVTALIGPSGCGKSTFLRCLNRMNDRIRGARVEGRVALDDRDVYGDGVNLVELRRQVGMVFQEPNPFPKSIRDNISYGPRKHGDLETGLLARLLGRDDRDAERDLVERALRRAALWDEVNDRLGDNALGLSGGQQQRLCIARCLAVDPDVILMDEPASALDPVATAKIEDLIEELAEEYTVVVVTHNMQQAARISDQTAVFLTGGRLAEYDATDAIFQNPQSQRVEDYVAGKFG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	345 (267)
Sequences:	18508 (11723)
Seq/√Len:	717.4

ECOLI - YHES UUP ETTA PROV POTG GSIA POTA FBPC MALK CYSA YCJV YDCT UGPC METN ARAG MODC DPPF RBSA YEHX MACB MDLB MDLA OPPF YADG MSBA OPPD CYDC DPPD CYDD DDPD SAPD PSTB YOJI YTFR DDPF HISP MLAF FEPC LSRA SAPF YECC YPHE YBHF GLNQ YHDZ TAUB FHUC SSUB FECE NIKE GLTL XYLG LPTB PHNK LIVF SUFC ARTP ALSA LIVG YBIT PHNC MGLA FETA THIQ LOLD FTSE ZNUC BTUD MODF YBBA NIKD CCMA PHNL YEJF YDDA YNJD
BACSU - YDIF OPUAA OPUCA YVRA OPUBA YFMR YKPA YFMM MSMX YURJ YHEH TAGH METN OPPD SUNT PSTB2 YGAD DPPD RBSA YFIC YFIL YKFD PSTB1 YXLF BMRA EXPZ YDBJ APPF YKNV YHCH YFIB YCBN YHEI YWJA YVFR CYDC YKNU YHAQ APPD CYDD OPPF YUSV ECFA1 YTRB YKOD YFMF YJKB TCYN FHUC YCLP SUFC ARTM YLMA GLNQ YXDL ECSA TCYC YXEO SKFE FTSE ECFA2 YVCR BCEA NATA ALBC YVRO SSUB YTLC YKNY YHCG YUFO MNTB YTHP YYBJ ZNUC YCLH YYDI YTRE
HALSA - PSTB2 Q9HMX3 Q9HMW0 BTUDA Q9HR06 Q9HHQ5 Q9HNZ9 Q9HMT3 Q9HMX2 PSTB1 Q9HSQ7 Q9HRJ6 Q9HMU8 Q9HMG1 Q9HRH8 Q9HMG6 Q9HHM2 PHNC Y2317 Q9HRV7 Q9HNY3 Y1631 Q9HRZ9 Q9HHR7 Q9HR96 Q9HQA8 Q9HR21 Q9HT03 Q9HS04 Q9HMC1 Q9HMW1
SULSO - Q97UJ9 Q97UF2 Q97UY8 Q97YY4 Q7LX64 Q97VF5 Q97ZC0 Q97UH3 Q97VC1 Q97VK9 Q97VH6 Q97YP7 Q97YP3 Q97VK8 PSTB Q97YK2 Q97YP8 Q97X18 Q97VF4 Q97YQ7 Q97UD4 Q980W0 Y2030 Y1893 Q97U54 Q97UH4 Q97V01 Q97W42 Q97V00 Q97Z03 Q7LXM4 Q7LY07 Q97VM2 Q97VY4 Q7LX80 Q97UG5 Q97Z56 Q97Z96 Q97YP4 Q97UC2 Q97ZU0 Q980K5 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
112_S	308_Q	4.733	1.00
90_D	103_S	4.346	1.00
87_S	107_D	3.899	1.00
89_S	146_R	3.584	1.00
88_V	91_L	3.499	1.00
99_R	102_E	3.473	1.00
109_P	112_S	3.278	1.00
303_A	325_D	2.865	1.00
322_D	326_A	2.774	1.00
93_T	130_C	2.732	1.00
92_D	144_E	2.661	1.00
146_R	153_D	2.566	1.00
167_Q	260_D	2.544	1.00
323_A	326_A	2.522	1.00
128_L	295_V	2.502	1.00
114_T	310_A	2.491	1.00
92_D	103_S	2.485	1.00
89_S	148_A	2.457	1.00
128_L	263_L	2.431	1.00
88_V	106_L	2.430	1.00
87_S	148_A	2.378	1.00
115_A	306_S	2.311	1.00
169_G	259_P	2.305	1.00
108_I	114_T	2.301	1.00
102_E	317_R	2.282	1.00
93_T	138_I	2.258	1.00
94_Y	138_I	2.236	1.00
308_Q	321_Y	2.215	1.00
106_L	310_A	2.206	1.00
94_Y	99_R	2.178	1.00
233_R	236_D	2.138	1.00
92_D	99_R	2.137	1.00
91_L	137_R	2.135	1.00
185_N	253_R	2.125	1.00
90_D	105_S	2.002	1.00
183_R	187_S	1.954	1.00
284_E	304_R	1.950	1.00
294_V	306_S	1.879	1.00
33_A	37_S	1.864	1.00
28_S	31_A	1.844	1.00
218_E	222_R	1.816	1.00
93_T	135_N	1.794	1.00
132_N	263_L	1.789	1.00
115_A	302_A	1.715	1.00
181_S	184_D	1.704	1.00
258_D	290_Y	1.673	1.00
129_R	134_M	1.646	1.00
296_T	302_A	1.610	1.00
180_K	239_L	1.592	1.00
236_D	240_G	1.536	1.00
34_A	37_S	1.471	1.00
48_G	51_G	1.451	1.00
132_N	170_M	1.437	1.00
133_R	136_D	1.429	1.00
184_D	187_S	1.420	1.00
84_A	148_A	1.420	1.00
86_V	149_L	1.414	1.00
190_P	193_H	1.410	1.00
61_A	64_V	1.410	1.00
238_A	249_L	1.393	1.00
89_S	105_S	1.363	1.00
29_T	32_A	1.345	1.00
101_L	104_V	1.343	1.00
130_C	137_R	1.340	1.00
85_K	107_D	1.319	1.00
112_S	307_D	1.319	1.00
84_A	87_S	1.310	1.00
286_L	290_Y	1.306	1.00
39_K	42_G	1.303	1.00
185_N	238_A	1.290	1.00
56_D	59_A	1.286	1.00
310_A	321_Y	1.279	1.00
325_D	329_Q	1.264	1.00
237_N	240_G	1.260	1.00
50_P	53_V	1.256	1.00
129_R	135_N	1.246	1.00
108_I	291_T	1.232	1.00
114_T	308_Q	1.219	1.00
88_V	147_V	1.216	1.00
227_W	232_D	1.214	1.00
169_G	254_C	1.210	1.00
113_V	306_S	1.200	1.00
314_T	319_A	1.184	1.00
26_A	29_T	1.183	1.00
127_F	313_L	1.180	1.00
25_A	29_T	1.169	1.00
47_P	51_G	1.168	1.00
93_T	126_T	1.164	1.00
216_L	219_R	1.163	1.00
296_T	301_Q	1.150	1.00
43_I	46_P	1.149	1.00
280_E	304_R	1.147	1.00
85_K	110_A	1.146	1.00
28_S	32_A	1.143	1.00
243_G	248_R	1.142	1.00
29_T	33_A	1.136	1.00
55_G	59_A	1.136	1.00
326_A	329_Q	1.134	1.00
92_D	102_E	1.133	1.00
122_C	313_L	1.132	1.00
116_L	310_A	1.125	1.00
317_R	321_Y	1.088	1.00
138_I	144_E	1.086	1.00
116_L	127_F	1.085	1.00
35_A	39_K	1.073	1.00
180_K	184_D	1.073	1.00
322_D	327_I	1.072	1.00
168_V	261_V	1.063	1.00
215_D	219_R	1.056	1.00
271_L	279_I	1.054	1.00
185_N	188_Y	1.051	1.00
42_G	45_G	1.049	1.00
189_G	253_R	1.045	1.00
113_V	294_V	1.044	1.00
220_A	256_A	1.037	1.00
172_F	175_P	1.037	1.00
95_Y	100_A	1.036	1.00
32_A	35_A	1.032	1.00
95_Y	126_T	1.026	1.00
311_V	327_I	1.025	1.00
276_T	298_N	1.025	1.00
228_D	232_D	1.023	1.00
111_E	291_T	1.018	1.00
85_K	109_P	1.012	1.00
62_R	65_G	1.009	1.00
40_T	53_V	1.007	1.00
49_G	53_V	1.003	1.00
35_A	43_I	1.000	1.00
181_S	185_N	0.996	1.00
248_R	271_L	0.991	1.00
277_A	281_D	0.987	1.00
51_G	54_D	0.986	1.00
35_A	42_G	0.979	1.00
310_A	318_L	0.978	1.00
309_T	324_T	0.977	1.00
182_I	185_N	0.977	1.00
56_D	60_V	0.966	1.00
50_P	54_D	0.965	1.00
110_A	260_D	0.965	1.00
113_V	292_V	0.961	1.00
47_P	50_P	0.961	1.00
320_E	330_N	0.959	1.00
27_G	30_D	0.957	1.00
314_T	317_R	0.954	1.00
214_R	218_E	0.948	1.00
85_K	150_D	0.947	1.00
326_A	330_N	0.936	1.00
47_P	52_E	0.932	1.00
324_T	328_F	0.923	1.00
262_I	290_Y	0.921	1.00
308_Q	320_E	0.915	1.00
108_I	293_V	0.909	1.00
39_K	43_I	0.906	1.00
114_T	293_V	0.898	1.00
190_P	194_G	0.893	1.00
106_L	127_F	0.889	1.00
132_N	168_V	0.889	1.00
55_G	58_P	0.888	1.00
320_E	331_P	0.882	1.00
281_D	285_E	0.878	1.00
130_C	147_V	0.877	1.00
39_K	45_G	0.875	1.00
37_S	40_T	0.870	1.00
42_G	46_P	0.868	1.00
91_L	130_C	0.867	1.00
35_A	41_G	0.863	1.00
38_S	41_G	0.863	1.00
30_D	34_A	0.861	1.00
53_V	57_E	0.859	1.00
35_A	48_G	0.859	1.00
283_I	305_I	0.858	1.00
40_T	43_I	0.853	1.00
125_S	129_R	0.853	1.00
44_A	49_G	0.850	1.00
117_I	311_V	0.842	1.00
37_S	41_G	0.839	1.00
92_D	101_L	0.839	1.00
109_P	308_Q	0.838	1.00
124_K	266_E	0.834	1.00
57_E	60_V	0.821	1.00
46_P	51_G	0.821	1.00
40_T	44_A	0.821	1.00
46_P	49_G	0.821	1.00
130_C	138_I	0.818	1.00
45_G	48_G	0.812	1.00
26_A	30_D	0.811	1.00
224_A	252_A	0.810	1.00
41_G	46_P	0.806	1.00
59_A	62_R	0.805	1.00
86_V	261_V	0.802	1.00
36_V	40_T	0.801	1.00
119_P	122_C	0.801	1.00
63_T	66_E	0.800	1.00
263_L	293_V	0.799	1.00
33_A	36_V	0.795	1.00
54_D	57_E	0.789	1.00
219_R	222_R	0.788	1.00
264_M	283_I	0.787	1.00
40_T	46_P	0.785	1.00
83_D	109_P	0.784	1.00
101_L	130_C	0.780	1.00
149_L	261_V	0.780	1.00
34_A	38_S	0.775	1.00
103_S	317_R	0.772	1.00
185_N	189_G	0.772	1.00
145_G	150_D	0.767	1.00
178_F	185_N	0.764	1.00
61_A	65_G	0.764	1.00
317_R	320_E	0.763	1.00
66_E	69_E	0.762	1.00
88_V	131_L	0.754	1.00
91_L	147_V	0.753	1.00
65_G	68_D	0.750	1.00
83_D	110_A	0.748	1.00
69_E	72_Q	0.747	1.00
190_P	256_A	0.746	1.00
72_Q	75_W	0.744	1.00
217_V	220_A	0.743	1.00
53_V	56_D	0.743	1.00
35_A	40_T	0.735	1.00
187_S	190_P	0.734	1.00
52_E	55_G	0.734	1.00
49_G	52_E	0.732	1.00
241_L	249_L	0.732	1.00
118_G	124_K	0.728	1.00
46_P	50_P	0.727	1.00
311_V	314_T	0.725	1.00
43_I	58_P	0.723	1.00
187_S	191_R	0.722	1.00
183_R	234_L	0.722	1.00
68_D	71_L	0.719	1.00
36_V	42_G	0.718	1.00
120_S	275_A	0.714	1.00
90_D	144_E	0.714	1.00
287_A	292_V	0.714	1.00
46_P	54_D	0.712	1.00
71_L	75_W	0.709	1.00
77_D	287_A	0.706	1.00
108_I	112_S	0.702	1.00
186_I	189_G	0.702	1.00
49_G	54_D	0.701	1.00
218_E	234_L	0.698	1.00
94_Y	100_A	0.696	1.00
64_V	67_S	0.695	1.00
42_G	47_P	0.695	1.00
234_L	241_L	0.691	1.00
84_A	109_P	0.690	1.00
130_C	135_N	0.688	1.00
219_R	223_R	0.687	1.00
25_A	32_A	0.687	1.00
280_E	301_Q	0.683	1.00
318_L	321_Y	0.678	1.00
234_L	238_A	0.676	1.00
294_V	302_A	0.674	1.00
35_A	38_S	0.673	1.00
36_V	39_K	0.671	1.00
135_N	138_I	0.670	1.00
43_I	47_P	0.669	1.00
171_V	247_Q	0.665	1.00
183_R	186_I	0.665	1.00
300_Q	304_R	0.663	1.00
31_A	34_A	0.662	1.00
71_L	74_A	0.661	1.00
222_R	227_W	0.660	1.00
137_R	144_E	0.658	1.00
177_P	246_Q	0.653	1.00
47_P	53_V	0.653	1.00
137_R	147_V	0.653	1.00
68_D	72_Q	0.650	1.00
76_T	79_E	0.650	1.00
131_L	293_V	0.649	1.00
46_P	53_V	0.649	1.00
32_A	36_V	0.647	1.00
116_L	293_V	0.646	1.00
183_R	235_G	0.645	1.00
94_Y	98_E	0.645	1.00
222_R	228_D	0.644	1.00
175_P	250_C	0.643	1.00
36_V	45_G	0.643	1.00
119_P	314_T	0.643	1.00
294_V	301_Q	0.642	1.00
179_P	239_L	0.642	1.00
45_G	49_G	0.641	1.00
171_V	264_M	0.640	1.00
38_S	42_G	0.639	1.00
294_V	305_I	0.637	1.00
302_A	306_S	0.636	1.00
67_S	70_Q	0.635	1.00
44_A	48_G	0.635	1.00
84_A	107_D	0.633	1.00
180_K	237_N	0.630	1.00
48_G	52_E	0.629	1.00
259_P	286_L	0.628	1.00
45_G	52_E	0.627	1.00
89_S	107_D	0.626	1.00
32_A	55_G	0.626	1.00
54_D	58_P	0.625	1.00
43_I	49_G	0.624	1.00
45_G	51_G	0.623	1.00
313_L	318_L	0.623	1.00
232_D	235_G	0.623	1.00
104_V	318_L	0.621	1.00
316_G	319_A	0.619	1.00
41_G	53_V	0.618	1.00
85_K	291_T	0.617	1.00
36_V	53_V	0.613	1.00
31_A	35_A	0.613	1.00
95_Y	135_N	0.611	1.00
37_S	42_G	0.609	1.00
44_A	50_P	0.609	1.00
64_V	68_D	0.606	1.00
183_R	217_V	0.606	1.00
121_G	266_E	0.605	1.00
182_I	188_Y	0.604	1.00
102_E	316_G	0.602	1.00
84_A	150_D	0.602	1.00
185_N	190_P	0.601	1.00
68_D	74_A	0.599	1.00
93_T	96_G	0.596	1.00
113_V	287_A	0.595	1.00
120_S	248_R	0.592	1.00
25_A	28_S	0.591	1.00
120_S	266_E	0.587	1.00
44_A	52_E	0.586	1.00
40_T	45_G	0.585	1.00
99_R	138_I	0.584	1.00
115_A	309_T	0.583	1.00
136_D	155_Y	0.582	1.00
44_A	47_P	0.579	1.00
51_G	55_G	0.579	1.00
131_L	263_L	0.578	1.00
182_I	226_L	0.577	1.00
84_A	110_A	0.577	1.00
184_D	188_Y	0.576	1.00
29_T	35_A	0.572	1.00
128_L	132_N	0.571	1.00
41_G	45_G	0.569	1.00
117_I	302_A	0.569	1.00
25_A	59_A	0.566	1.00
92_D	138_I	0.564	1.00
171_V	175_P	0.563	1.00
93_T	101_L	0.560	1.00
194_G	216_L	0.558	1.00
32_A	43_I	0.558	1.00
94_Y	97_E	0.556	1.00
31_A	36_V	0.556	1.00
28_S	55_G	0.556	1.00
278_K	281_D	0.555	1.00
42_G	48_G	0.555	1.00
218_E	221_L	0.553	1.00
183_R	188_Y	0.551	1.00
177_P	185_N	0.551	1.00
37_S	43_I	0.550	1.00
43_I	50_P	0.549	1.00
39_K	48_G	0.548	1.00
66_E	71_L	0.545	1.00
97_E	100_A	0.544	1.00
69_E	73_D	0.544	1.00
46_P	52_E	0.543	1.00
63_T	70_Q	0.543	1.00
30_D	33_A	0.543	1.00
36_V	43_I	0.542	1.00
42_G	53_V	0.542	1.00
113_V	283_I	0.539	1.00
43_I	48_G	0.537	1.00
90_D	93_T	0.536	1.00
86_V	131_L	0.535	1.00
64_V	69_E	0.535	1.00
39_K	44_A	0.531	1.00
52_E	56_D	0.529	1.00
283_I	292_V	0.528	1.00
169_G	173_Q	0.527	1.00
284_E	305_I	0.526	1.00
63_T	68_D	0.526	1.00
32_A	37_S	0.526	1.00
315_G	318_L	0.526	1.00
243_G	270_A	0.525	1.00
35_A	45_G	0.524	1.00
48_G	53_V	0.522	1.00
60_V	64_V	0.522	1.00
39_K	46_P	0.522	1.00
38_S	45_G	0.522	1.00
228_D	233_R	0.521	1.00
186_I	190_P	0.520	1.00
280_E	300_Q	0.518	1.00
39_K	47_P	0.517	1.00
66_E	70_Q	0.517	1.00
32_A	42_G	0.515	1.00
61_A	67_S	0.515	1.00
76_T	258_D	0.514	1.00
172_F	176_N	0.512	1.00
280_E	296_T	0.511	1.00
35_A	52_E	0.511	1.00
187_S	217_V	0.511	1.00
303_A	328_F	0.509	1.00
52_E	57_E	0.506	0.99
188_Y	192_K	0.506	0.99
220_A	252_A	0.505	0.99
25_A	33_A	0.503	0.99
113_V	284_E	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4f4cA	1	0.7797	100	0.248	Contact Map
4ry2A	2	0.7768	100	0.25	Contact Map
3tuiC	2	0.6899	100	0.266	Contact Map
4q9hA	1	0.8174	100	0.266	Contact Map
4a82A	2	0.8087	100	0.274	Contact Map
3nh6A	1	0.7884	100	0.277	Contact Map
4mrsA	2	0.8087	100	0.279	Contact Map
2yyzA	1	0.6812	100	0.281	Contact Map
3zdqA	2	0.7855	100	0.281	Contact Map
1g291	4	0.6957	100	0.282	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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