GREMLIN Database
Q9HML7 - Phosphate ABC transporter permease
UniProt: Q9HML7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 534 (431)
Sequences: 844 (631)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_I427_V6.6071.00
306_V423_V6.1301.00
396_S406_T5.3001.00
124_V128_V3.8781.00
342_I439_L3.7581.00
317_T386_L3.7001.00
274_T277_T3.3471.00
121_P125_V3.2201.00
121_P128_V3.2031.00
118_A121_P3.1021.00
319_Y404_W2.9041.00
349_L360_N2.6961.00
123_A128_V2.6631.00
119_W123_A2.4900.99
318_E393_R2.4460.99
515_G519_V2.3600.99
231_V235_G2.2190.99
271_P274_T2.1970.98
353_V360_N2.1680.98
170_A174_S2.1320.98
421_T424_I2.1170.98
193_L200_A2.1070.98
385_L411_V2.1060.98
112_A197_W2.0970.98
207_G210_G2.0880.98
197_W200_A2.0720.98
233_L236_F2.0710.98
269_T272_F2.0670.98
445_P476_S2.0130.97
123_A126_G2.0010.97
234_V239_S1.9920.97
121_P124_V1.9890.97
193_L197_W1.9670.97
363_L472_L1.9270.96
199_G206_F1.9110.96
83_T196_A1.8830.96
392_H422_G1.8740.96
214_G217_A1.8660.96
337_W376_L1.8510.96
231_V234_V1.8470.95
84_T87_R1.8330.95
230_L234_V1.8160.95
342_I353_V1.8080.95
277_T282_V1.8040.95
272_F439_L1.8020.95
234_V237_V1.7910.95
194_L206_F1.7640.94
296_W475_A1.7440.94
324_R327_Q1.7370.94
119_W122_V1.7260.93
170_A173_W1.7170.93
270_L273_V1.7070.93
386_L422_G1.6990.93
107_V222_V1.6800.92
206_F210_G1.6660.92
207_G214_G1.6570.92
396_S409_S1.6550.92
270_L274_T1.6550.92
201_S209_E1.6530.92
145_L159_A1.6520.92
287_V291_L1.6500.92
121_P130_G1.6460.92
353_V364_V1.6430.92
325_F329_V1.6420.92
302_I474_P1.6390.92
511_A515_G1.6150.91
478_L505_T1.6140.91
123_A130_G1.6050.91
386_L390_D1.5910.90
86_S89_T1.5810.90
177_V189_V1.5770.90
83_T86_S1.5650.90
193_L198_S1.5630.89
134_T137_P1.5420.89
360_N364_V1.5420.89
232_L237_V1.5410.89
216_Y239_S1.5350.89
321_E324_R1.5260.88
206_F209_E1.5230.88
519_V523_S1.5180.88
225_G519_V1.5050.88
195_A204_A1.5030.88
274_T283_T1.4880.87
359_G364_V1.4690.86
420_I523_S1.4620.86
232_L235_G1.4610.86
480_Y499_A1.4530.86
491_F499_A1.4450.85
79_E90_S1.4440.85
271_P497_T1.4400.85
207_G211_R1.4320.85
191_G209_E1.4320.85
226_T230_L1.4270.85
186_V190_G1.4260.85
353_V439_L1.4220.84
318_E413_P1.4200.84
443_G475_A1.4140.84
230_L233_L1.4120.84
224_V228_S1.4090.84
187_V190_G1.4070.84
182_E186_V1.4040.84
198_S201_S1.4040.84
118_A125_V1.4030.84
376_L425_L1.4020.84
438_L504_G1.3990.83
443_G484_T1.3980.83
233_L237_V1.3850.83
308_L358_G1.3660.82
194_L202_A1.3640.82
285_P501_F1.3610.82
229_V234_V1.3550.81
197_W201_S1.3500.81
120_L124_V1.3400.81
353_V384_A1.3350.80
295_L299_F1.3290.80
233_L240_K1.3170.79
273_V277_T1.3080.79
191_G194_L1.3050.79
83_T112_A1.3030.79
209_E212_Q1.2930.78
210_G215_A1.2910.78
193_L207_G1.2820.78
185_P190_G1.2810.77
272_F276_Q1.2810.77
508_V523_S1.2770.77
362_I366_Q1.2770.77
193_L201_S1.2760.77
353_V356_L1.2720.77
347_F351_F1.2570.76
484_T487_T1.2550.76
199_G207_G1.2440.75
125_V128_V1.2410.75
450_T473_A1.2330.75
270_L276_Q1.2250.74
214_G220_G1.2240.74
443_G498_T1.2210.74
223_V229_V1.2210.74
165_G170_A1.2200.74
193_L203_H1.2200.74
121_P126_G1.2170.74
107_V184_V1.2150.74
236_F240_K1.2120.73
397_A403_K1.2010.73
107_V407_I1.2000.73
481_Q493_K1.1980.73
318_E411_V1.1980.73
300_G366_Q1.1950.72
202_A206_F1.1910.72
231_V244_P1.1880.72
476_S499_A1.1840.72
386_L397_A1.1830.72
145_L150_V1.1830.72
364_V384_A1.1820.72
177_V182_E1.1800.71
230_L235_G1.1770.71
201_S219_V1.1760.71
197_W209_E1.1760.71
171_P174_S1.1740.71
192_A209_E1.1740.71
487_T508_V1.1730.71
215_A233_L1.1680.71
247_T363_L1.1620.70
392_H396_S1.1620.70
86_S112_A1.1620.70
392_H423_V1.1410.69
153_G170_A1.1370.68
95_C409_S1.1290.68
86_S218_L1.1270.68
195_A198_S1.1230.68
247_T490_V1.1190.67
82_E85_P1.1170.67
177_V181_T1.1140.67
223_V228_S1.1130.67
173_W314_V1.1090.67
364_V485_T1.1090.67
485_T498_T1.1090.67
213_A217_A1.0990.66
95_C99_M1.0960.66
228_S231_V1.0940.65
264_A288_F1.0920.65
271_P277_T1.0920.65
176_A179_P1.0910.65
120_L123_A1.0890.65
321_E325_F1.0880.65
106_G120_L1.0870.65
167_W170_A1.0750.64
88_A117_D1.0740.64
346_L484_T1.0730.64
133_A136_L1.0700.64
159_A162_G1.0660.63
396_S401_V1.0610.63
230_L237_V1.0600.63
200_A206_F1.0590.63
298_V317_T1.0520.62
204_A207_G1.0510.62
359_G363_L1.0450.62
272_F284_I1.0450.62
413_P532_H1.0410.62
156_G170_A1.0380.61
353_V359_G1.0380.61
247_T250_S1.0330.61
277_T283_T1.0330.61
194_L209_E1.0320.61
235_G239_S1.0270.60
272_F277_T1.0210.60
344_F508_V1.0190.60
77_R88_A1.0170.60
257_G261_V1.0150.60
213_A218_L1.0140.59
193_L210_G1.0130.59
302_I398_A1.0120.59
234_V394_D1.0120.59
146_P150_V1.0090.59
330_E383_E1.0080.59
319_Y408_R1.0040.59
195_A200_A1.0020.59
195_A206_F0.9990.58
126_G130_G0.9960.58
159_A423_V0.9950.58
272_F349_L0.9950.58
150_V154_W0.9920.58
199_G220_G0.9920.58
307_P370_G0.9900.58
337_W430_I0.9890.58
349_L364_V0.9880.57
206_F214_G0.9880.57
298_V329_V0.9860.57
201_S205_G0.9790.57
137_P511_A0.9700.56
208_A214_G0.9690.56
421_T501_F0.9680.56
311_G332_A0.9670.56
103_V222_V0.9660.56
349_L359_G0.9640.56
291_L393_R0.9620.55
206_F222_V0.9620.55
343_V413_P0.9580.55
118_A122_V0.9570.55
101_W196_A0.9570.55
308_L311_G0.9550.55
205_G219_V0.9550.55
191_G197_W0.9520.55
235_G240_K0.9510.55
180_G190_G0.9500.54
356_L367_L0.9500.54
157_A160_A0.9470.54
384_A530_K0.9470.54
194_L201_S0.9460.54
308_L312_A0.9450.54
177_V185_P0.9430.54
193_L209_E0.9420.54
269_T277_T0.9410.54
144_T155_G0.9400.54
238_V473_A0.9380.53
377_V408_R0.9370.53
149_A156_G0.9350.53
357_S480_Y0.9350.53
439_L481_Q0.9340.53
364_V438_L0.9330.53
215_A219_V0.9330.53
150_V163_G0.9330.53
450_T475_A0.9310.53
192_A195_A0.9270.53
270_L277_T0.9270.53
331_V437_L0.9250.52
187_V303_V0.9250.52
354_P370_G0.9250.52
216_Y240_K0.9230.52
359_G474_P0.9180.52
119_W125_V0.9160.52
240_K243_T0.9150.52
152_V156_G0.9150.52
144_T149_A0.9140.52
517_Y520_G0.9130.52
485_T493_K0.9130.52
480_Y490_V0.9120.51
218_L221_A0.9120.51
277_T280_L0.9100.51
172_A299_F0.9070.51
350_A490_V0.9050.51
199_G212_Q0.9030.51
325_F530_K0.9010.51
295_L519_V0.8980.50
298_V526_Y0.8950.50
214_G219_V0.8950.50
326_T348_G0.8920.50
200_A203_H0.8910.50
93_A203_H0.8890.50
120_L125_V0.8880.50
85_P88_A0.8880.50
138_R160_A0.8850.49
204_A208_A0.8850.49
201_S207_G0.8810.49
91_L214_G0.8790.49
199_G203_H0.8780.49
203_H238_V0.8750.48
317_T392_H0.8730.48
118_A131_A0.8680.48
301_A334_N0.8680.48
168_T238_V0.8660.48
233_L251_L0.8650.48
246_L249_A0.8630.48
181_T188_A0.8620.47
100_L218_L0.8590.47
204_A212_Q0.8590.47
226_T229_V0.8570.47
106_G109_T0.8550.47
481_Q485_T0.8550.47
172_A181_T0.8550.47
372_M502_G0.8540.47
172_A190_G0.8540.47
117_D317_T0.8520.47
481_Q498_T0.8520.47
211_R217_A0.8520.47
205_G208_A0.8480.46
333_T362_I0.8470.46
215_A220_G0.8470.46
295_L508_V0.8460.46
304_A425_L0.8460.46
139_E143_A0.8440.46
198_S210_G0.8420.46
297_L365_G0.8400.46
202_A210_G0.8400.46
271_P439_L0.8400.46
443_G446_Y0.8390.46
248_G497_T0.8380.46
89_T150_V0.8370.45
343_V385_L0.8350.45
105_G198_S0.8340.45
89_T204_A0.8340.45
493_K498_T0.8320.45
118_A123_A0.8320.45
234_V240_K0.8320.45
430_I517_Y0.8290.45
118_A126_G0.8290.45
235_G238_V0.8280.45
317_T422_G0.8280.45
87_R308_L0.8280.45
199_G210_G0.8280.45
227_L230_L0.8260.45
250_S480_Y0.8250.44
173_W221_A0.8240.44
99_M478_L0.8240.44
178_F182_E0.8230.44
392_H409_S0.8210.44
269_T274_T0.8210.44
272_F498_T0.8210.44
156_G160_A0.8210.44
186_V189_V0.8190.44
508_V530_K0.8180.44
364_V508_V0.8170.44
277_T284_I0.8150.44
425_L529_R0.8140.44
443_G501_F0.8140.44
132_L137_P0.8140.44
104_S205_G0.8130.44
128_V287_V0.8120.43
480_Y484_T0.8080.43
164_G167_W0.8040.43
276_Q281_Y0.8030.43
110_T425_L0.7960.42
101_W295_L0.7950.42
129_A143_A0.7940.42
163_G172_A0.7920.42
82_E199_G0.7890.42
347_F414_A0.7880.42
525_R530_K0.7880.42
325_F413_P0.7870.42
115_G119_W0.7860.41
118_A134_T0.7830.41
201_S214_G0.7830.41
99_M398_A0.7820.41
112_A512_V0.7810.41
445_P451_P0.7810.41
290_A299_F0.7770.41
272_F490_V0.7770.41
301_A354_P0.7760.41
185_P188_A0.7730.40
296_W472_L0.7710.40
203_H409_S0.7710.40
398_A427_V0.7700.40
398_A403_K0.7650.40
218_L222_V0.7650.40
192_A199_G0.7640.40
268_P272_F0.7590.39
493_K501_F0.7580.39
162_G166_G0.7570.39
295_L523_S0.7560.39
149_A171_P0.7550.39
294_T395_A0.7550.39
206_F212_Q0.7540.39
353_V485_T0.7540.39
160_A168_T0.7510.39
289_P370_G0.7500.39
173_W212_Q0.7490.39
223_V230_L0.7470.38
443_G481_Q0.7410.38
319_Y385_L0.7390.38
300_G362_I0.7380.38
425_L429_R0.7350.38
132_L403_K0.7330.37
276_Q480_Y0.7330.37
229_V232_L0.7320.37
103_V129_A0.7320.37
199_G328_L0.7310.37
402_T430_I0.7310.37
443_G485_T0.7300.37
135_V140_D0.7280.37
197_W332_A0.7250.37
247_T251_L0.7240.37
282_V490_V0.7220.37
176_A180_G0.7210.37
298_V530_K0.7190.36
147_A151_I0.7170.36
436_P513_V0.7160.36
221_A324_R0.7150.36
326_T379_L0.7130.36
219_V222_V0.7120.36
182_E189_V0.7100.36
352_L367_L0.7080.36
342_I481_Q0.7080.36
121_P136_L0.7060.35
384_A422_G0.7050.35
133_A137_P0.7030.35
424_I525_R0.7030.35
490_V498_T0.7030.35
156_G159_A0.7030.35
330_E334_N0.7000.35
97_V298_V0.6980.35
102_A114_G0.6960.35
274_T278_G0.6950.35
392_H411_V0.6920.34
485_T501_F0.6910.34
258_L262_D0.6870.34
336_L393_R0.6870.34
165_G174_S0.6860.34
338_S426_G0.6860.34
126_G142_G0.6850.34
424_I483_Y0.6850.34
192_A212_Q0.6830.34
161_S165_G0.6820.34
416_M514_I0.6810.34
439_L474_P0.6800.34
202_A217_A0.6800.34
348_G435_A0.6790.33
86_S328_L0.6780.33
125_V130_G0.6780.33
193_L212_Q0.6760.33
270_L514_I0.6760.33
192_A198_S0.6760.33
97_V101_W0.6760.33
233_L239_S0.6740.33
357_S361_S0.6730.33
323_G328_L0.6720.33
318_E380_T0.6710.33
94_G98_G0.6710.33
398_A487_T0.6700.33
154_W285_P0.6690.33
197_W207_G0.6690.33
301_A370_G0.6680.33
119_W127_G0.6680.33
238_V242_I0.6670.33
435_A513_V0.6670.33
191_G206_F0.6660.33
171_P178_F0.6660.33
194_L204_A0.6650.32
348_G383_E0.6650.32
138_R225_G0.6630.32
478_L499_A0.6630.32
137_P403_K0.6620.32
141_A329_V0.6590.32
155_G185_P0.6570.32
184_V188_A0.6570.32
165_G172_A0.6570.32
227_L231_V0.6560.32
137_P169_W0.6560.32
207_G215_A0.6560.32
200_A511_A0.6550.32
272_F342_I0.6540.32
342_I485_T0.6540.32
128_V131_A0.6540.32
216_Y235_G0.6520.32
286_G481_Q0.6510.31
443_G490_V0.6510.31
354_P503_W0.6500.31
296_W443_G0.6490.31
331_V435_A0.6450.31
332_A423_V0.6440.31
181_T185_P0.6420.31
179_P188_A0.6420.31
123_A127_G0.6410.31
119_W124_V0.6390.31
176_A190_G0.6390.31
445_P503_W0.6390.31
191_G202_A0.6370.31
184_V191_G0.6370.31
306_V398_A0.6360.30
194_L210_G0.6350.30
265_V411_V0.6310.30
349_L353_V0.6290.30
348_G436_P0.6280.30
335_G352_L0.6280.30
277_T475_A0.6280.30
243_T251_L0.6260.30
209_E222_V0.6250.30
321_E403_K0.6240.30
215_A232_L0.6230.30
343_V380_T0.6230.30
388_V418_G0.6210.29
488_A502_G0.6190.29
135_V200_A0.6170.29
216_Y226_T0.6160.29
99_M200_A0.6140.29
364_V498_T0.6140.29
80_Y165_G0.6130.29
228_S412_V0.6130.29
105_G332_A0.6130.29
330_E348_G0.6120.29
306_V377_V0.6100.29
360_N384_A0.6100.29
296_W497_T0.6090.29
311_G507_L0.6090.29
404_W428_G0.6070.29
192_A197_W0.6070.29
103_V106_G0.6050.28
143_A147_A0.6030.28
403_K519_V0.6010.28
237_V240_K0.5980.28
223_V227_L0.5980.28
111_V325_F0.5970.28
201_S216_Y0.5970.28
118_A128_V0.5940.28
135_V184_V0.5930.28
318_E337_W0.5920.28
217_A236_F0.5910.28
349_L443_G0.5910.28
177_V186_V0.5910.28
185_P189_V0.5900.27
180_G184_V0.5900.27
199_G216_Y0.5870.27
148_A159_A0.5860.27
326_T513_V0.5850.27
187_V515_G0.5850.27
191_G201_S0.5840.27
220_G226_T0.5830.27
342_I525_R0.5830.27
195_A213_A0.5830.27
364_V481_Q0.5820.27
195_A202_A0.5810.27
219_V234_V0.5770.27
396_S410_V0.5760.27
212_Q218_L0.5760.27
196_A212_Q0.5750.26
342_I349_L0.5750.26
408_R413_P0.5740.26
331_V334_N0.5740.26
221_A224_V0.5730.26
114_G121_P0.5720.26
360_N490_V0.5720.26
244_P247_T0.5670.26
217_A222_V0.5670.26
165_G189_V0.5650.26
445_P499_A0.5640.26
192_A200_A0.5620.26
174_S190_G0.5620.26
362_I477_A0.5600.26
421_T435_A0.5600.26
202_A218_L0.5600.26
445_P480_Y0.5570.25
437_L442_G0.5570.25
334_N380_T0.5560.25
341_S395_A0.5560.25
357_S499_A0.5560.25
343_V414_A0.5540.25
148_A156_G0.5530.25
272_F485_T0.5530.25
144_T163_G0.5520.25
203_H210_G0.5520.25
277_T281_Y0.5510.25
213_A216_Y0.5500.25
273_V278_G0.5470.25
200_A204_A0.5470.25
192_A201_S0.5460.25
201_S408_R0.5450.25
89_T328_L0.5440.25
331_V436_P0.5440.25
395_A398_A0.5420.24
387_A445_P0.5410.24
134_T202_A0.5400.24
507_L516_L0.5400.24
330_E435_A0.5380.24
204_A224_V0.5380.24
285_P440_V0.5370.24
122_V321_E0.5360.24
285_P479_P0.5340.24
360_N426_G0.5340.24
206_F211_R0.5330.24
83_T171_P0.5300.24
342_I484_T0.5300.24
85_P171_P0.5290.24
194_L207_G0.5290.24
200_A214_G0.5290.24
330_E513_V0.5280.24
214_G227_L0.5280.24
274_T333_T0.5270.24
326_T436_P0.5250.24
99_M103_V0.5240.23
156_G161_S0.5240.23
171_P324_R0.5240.23
117_D120_L0.5230.23
331_V348_G0.5230.23
276_Q284_I0.5220.23
162_G165_G0.5220.23
270_L485_T0.5210.23
342_I372_M0.5210.23
285_P443_G0.5200.23
143_A174_S0.5200.23
174_S186_V0.5190.23
412_V423_V0.5190.23
439_L484_T0.5190.23
111_V411_V0.5180.23
275_N281_Y0.5180.23
148_A152_V0.5170.23
201_S215_A0.5160.23
197_W203_H0.5150.23
162_G299_F0.5150.23
125_V151_I0.5150.23
317_T333_T0.5130.23
334_N436_P0.5120.23
353_V440_V0.5110.23
247_T361_S0.5100.23
216_Y234_V0.5100.23
168_T172_A0.5100.23
508_V511_A0.5090.23
398_A474_P0.5080.23
361_S480_Y0.5070.22
337_W473_A0.5060.22
271_P285_P0.5060.22
344_F502_G0.5060.22
201_S204_A0.5060.22
162_G174_S0.5040.22
348_G440_V0.5040.22
80_Y242_I0.5040.22
191_G198_S0.5030.22
244_P252_T0.5030.22
360_N487_T0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.4551 99.9 0.847 Contact Map
3tuiA 2 0.3951 99.9 0.853 Contact Map
3d31C 2 0.4438 99.9 0.853 Contact Map
3rlfF 1 0.8146 99.9 0.856 Contact Map
4ymuD 2 0.4007 99.9 0.857 Contact Map
4tquM 1 0.4925 99.8 0.86 Contact Map
4tquN 1 0.515 99.8 0.87 Contact Map
3rlfG 1 0.5019 99.8 0.874 Contact Map
4gxbB 1 0.0019 8.8 0.983 Contact Map
2yevB 1 0.0993 6.4 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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