GREMLIN Database
Q9HML6 - Phosphate transporter permease
UniProt: Q9HML6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (283)
Sequences: 9555 (6447)
Seq/√Len: 383.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
262_Q266_S4.7151.00
109_S130_A4.6351.00
253_A263_T3.9071.00
152_I223_G3.9001.00
259_T262_Q3.8561.00
254_L263_T3.4331.00
261_W265_K3.2541.00
158_T280_V3.1481.00
170_E250_K3.1081.00
128_L131_A2.8901.00
103_A107_V2.5581.00
156_I227_G2.5311.00
250_K268_T2.5041.00
144_V148_I2.4721.00
128_L132_R2.2271.00
260_P263_T2.2121.00
120_L123_R2.1711.00
317_E325_F2.1421.00
166_V264_T2.0791.00
250_K263_T2.0741.00
238_S276_V2.0691.00
140_A144_V2.0621.00
307_P310_D1.9801.00
253_A258_S1.9001.00
179_V183_G1.8721.00
249_V271_A1.8701.00
291_T295_T1.8571.00
245_V271_A1.8371.00
262_Q265_K1.8151.00
162_I238_S1.8041.00
208_Y212_R1.7551.00
247_E251_S1.7521.00
92_V96_G1.7521.00
358_Y361_W1.7391.00
326_E334_H1.7251.00
239_E243_A1.6821.00
151_C155_V1.6701.00
322_V341_G1.6691.00
162_I264_T1.6691.00
241_A275_G1.6691.00
106_L343_V1.6501.00
218_S221_A1.6391.00
169_S243_A1.6341.00
253_A267_V1.6211.00
150_T284_V1.6171.00
322_V326_E1.6111.00
131_A135_G1.5771.00
269_L276_V1.5661.00
141_P144_V1.5561.00
165_A238_S1.5341.00
169_S239_E1.5251.00
81_A85_A1.5251.00
181_K239_E1.5191.00
160_V231_L1.5171.00
88_F92_V1.5151.00
141_P145_G1.5091.00
231_L235_V1.5071.00
278_A282_L1.4761.00
161_G234_V1.4721.00
242_L268_T1.4701.00
109_S343_V1.4651.00
83_G87_T1.4511.00
193_I296_V1.4491.00
351_A355_G1.4471.00
119_G122_G1.4391.00
355_G358_Y1.4271.00
258_S262_Q1.4271.00
169_S242_L1.4061.00
249_V267_V1.4061.00
147_A151_C1.3841.00
100_L104_F1.3791.00
298_L316_G1.3771.00
142_M322_V1.3651.00
116_M119_G1.3591.00
217_G220_L1.3541.00
241_A272_G1.3521.00
85_A88_F1.3471.00
152_I156_I1.3391.00
174_P177_R1.3311.00
354_V358_Y1.3261.00
130_A343_V1.3111.00
245_V272_G1.3101.00
148_I219_Y1.3071.00
323_I341_G1.3061.00
164_G235_V1.3001.00
78_E81_A1.2981.00
168_I235_V1.2981.00
149_T318_T1.2861.00
155_V159_P1.2851.00
245_V250_K1.2841.00
162_I272_G1.2841.00
154_T280_V1.2801.00
107_V111_P1.2761.00
317_E321_T1.2651.00
220_L224_A1.2581.00
218_S316_G1.2571.00
238_S279_G1.2431.00
129_W132_R1.2431.00
219_Y223_G1.2391.00
78_E82_T1.2391.00
222_A294_A1.2381.00
175_R178_D1.2141.00
173_P177_R1.2111.00
176_V179_V1.1981.00
234_V283_G1.1951.00
291_T324_A1.1931.00
139_L344_V1.1831.00
254_L260_P1.1821.00
234_V279_G1.1751.00
104_F108_R1.1741.00
131_A134_G1.1631.00
157_A283_G1.1561.00
161_G231_L1.1561.00
146_T319_L1.1531.00
299_T302_K1.1531.00
73_V77_R1.1511.00
152_I155_V1.1501.00
237_I279_G1.1441.00
132_R334_H1.1441.00
119_G123_R1.1401.00
154_T158_T1.1291.00
220_L223_G1.1271.00
85_A89_L1.1271.00
99_A103_A1.1241.00
177_R243_A1.1221.00
276_V279_G1.1171.00
308_V311_V1.1051.00
190_I195_Y1.1021.00
219_Y316_G1.0941.00
105_L342_G1.0941.00
242_L272_G1.0931.00
176_V180_V1.0921.00
162_I276_V1.0881.00
79_Q82_T1.0761.00
290_E294_A1.0731.00
185_E236_T1.0721.00
80_A83_G1.0701.00
206_Y212_R1.0671.00
298_L302_K1.0521.00
157_A234_V1.0511.00
75_W79_Q1.0491.00
295_T321_T1.0451.00
74_G77_R1.0441.00
133_D337_A1.0421.00
307_P311_V1.0361.00
283_G286_R1.0351.00
188_A233_T1.0351.00
358_Y362_R1.0291.00
165_A242_L1.0281.00
217_G221_A1.0281.00
196_G296_V1.0071.00
319_L341_G1.0061.00
250_K254_L1.0051.00
168_I180_V1.0021.00
248_S251_S0.9921.00
153_A226_I0.9911.00
159_P163_A0.9881.00
82_T86_V0.9861.00
238_S242_L0.9751.00
77_R81_A0.9721.00
166_V242_L0.9701.00
317_E322_V0.9661.00
264_T269_L0.9621.00
89_L93_G0.9561.00
323_I342_G0.9541.00
153_A223_G0.9531.00
203_L221_A0.9521.00
163_A261_W0.9321.00
234_V238_S0.9241.00
190_I194_T0.9201.00
86_V90_M0.9151.00
245_V268_T0.9101.00
139_L143_L0.9051.00
324_A328_G0.8981.00
82_T85_A0.8901.00
154_T284_V0.8891.00
179_V182_P0.8881.00
220_L309_F0.8791.00
174_P178_D0.8781.00
95_V99_A0.8741.00
165_A169_S0.8721.00
171_I260_P0.8711.00
140_A143_L0.8691.00
146_T320_T0.8691.00
214_P217_G0.8651.00
222_A298_L0.8561.00
265_K269_L0.8531.00
271_A274_S0.8521.00
72_V75_W0.8521.00
337_A341_G0.8461.00
149_T219_Y0.8421.00
258_S263_T0.8391.00
123_R131_A0.8381.00
216_I220_L0.8371.00
136_V337_A0.8371.00
223_G227_G0.8361.00
214_P218_S0.8331.00
95_V100_L0.8291.00
334_H337_A0.8271.00
139_L341_G0.8231.00
144_V147_A0.8211.00
104_F107_V0.8201.00
221_A297_M0.8121.00
291_T294_A0.8111.00
272_G276_V0.8101.00
199_G225_M0.8071.00
142_M319_L0.8061.00
279_G283_G0.8051.00
158_T238_S0.8041.00
292_M296_V0.8021.00
175_R179_V0.8001.00
77_R80_A0.7981.00
107_V110_V0.7971.00
118_V122_G0.7921.00
157_A230_A0.7881.00
153_A287_A0.7871.00
247_E254_L0.7871.00
327_G338_L0.7871.00
163_A167_F0.7861.00
173_P176_V0.7851.00
68_L71_T0.7831.00
67_F70_T0.7821.00
225_M297_M0.7821.00
161_G238_S0.7821.00
259_T263_T0.7801.00
199_G297_M0.7731.00
266_S271_A0.7721.00
320_T345_L0.7721.00
158_T276_V0.7701.00
263_T266_S0.7621.00
318_T321_T0.7621.00
260_P264_T0.7611.00
166_V269_L0.7581.00
138_S141_P0.7571.00
161_G235_V0.7551.00
69_A72_V0.7471.00
225_M293_A0.7451.00
70_T74_G0.7421.00
143_L319_L0.7391.00
91_T95_V0.7381.00
285_G352_L0.7381.00
192_S229_M0.7341.00
252_G267_V0.7331.00
188_A232_P0.7321.00
204_N221_A0.7311.00
118_V123_R0.7301.00
288_M349_V0.7291.00
74_G81_A0.7291.00
72_V76_R0.7281.00
252_G255_A0.7251.00
132_R136_V0.7231.00
76_R80_A0.7201.00
156_I160_V0.7161.00
80_A84_K0.7161.00
69_A73_V0.7051.00
273_L277_S0.7031.00
81_A84_K0.7031.00
129_W133_D0.7011.00
115_H333_V0.7001.00
73_V76_R0.6990.99
233_T237_I0.6990.99
157_A226_I0.6900.99
347_V351_A0.6900.99
79_Q83_G0.6890.99
247_E250_K0.6890.99
222_A226_I0.6880.99
65_G69_A0.6880.99
218_S222_A0.6870.99
66_V70_T0.6830.99
264_T268_T0.6810.99
93_G97_V0.6800.99
199_G203_L0.6800.99
87_T91_T0.6800.99
157_A227_G0.6800.99
72_V77_R0.6790.99
300_H316_G0.6780.99
130_A133_D0.6710.99
109_S340_A0.6710.99
149_T153_A0.6700.99
132_R337_A0.6680.99
265_K273_L0.6680.99
233_T282_L0.6640.99
293_A297_M0.6630.99
267_V271_A0.6600.99
153_A157_A0.6600.99
111_P115_H0.6570.99
216_I219_Y0.6570.99
351_A354_V0.6560.99
273_L276_V0.6550.99
301_T316_G0.6550.99
145_G219_Y0.6540.99
100_L103_A0.6520.99
105_L346_F0.6520.99
275_G279_G0.6520.99
129_W336_S0.6510.99
263_T267_V0.6500.99
290_E293_A0.6490.99
96_G100_L0.6480.99
253_A266_S0.6470.99
66_V69_A0.6470.99
171_I174_P0.6460.99
349_V353_S0.6430.99
143_L344_V0.6400.99
178_D181_K0.6390.99
150_T154_T0.6380.99
286_R289_G0.6370.99
76_R79_Q0.6350.99
298_L301_T0.6340.99
156_I223_G0.6330.99
261_W264_T0.6310.99
226_I290_E0.6300.99
290_E318_T0.6290.99
149_T226_I0.6290.99
141_P317_E0.6290.99
292_M297_M0.6270.99
189_G195_Y0.6250.99
215_T218_S0.6220.99
90_M93_G0.6220.99
132_R135_G0.6210.99
84_K87_T0.6190.99
277_S360_E0.6170.99
95_V98_L0.6160.99
184_I235_V0.6160.99
229_M293_A0.6130.99
66_V71_T0.6100.99
326_E332_G0.6100.99
263_T268_T0.6080.99
216_I221_A0.6060.99
158_T161_G0.6050.99
196_G293_A0.6030.99
232_P275_G0.6000.98
84_K88_F0.5990.98
168_I239_E0.5980.98
200_L204_N0.5960.98
177_R181_K0.5940.98
223_G226_I0.5930.98
86_V89_L0.5910.98
326_E337_A0.5890.98
241_A268_T0.5880.98
104_F113_V0.5860.98
110_V114_E0.5850.98
134_G137_Y0.5850.98
154_T287_A0.5850.98
213_T217_G0.5840.98
188_A229_M0.5800.98
170_E268_T0.5780.98
102_V106_L0.5780.98
152_I308_V0.5780.98
337_A344_V0.5750.98
282_L286_R0.5740.98
196_G199_G0.5730.98
74_G78_E0.5720.98
319_L345_L0.5720.98
355_G359_V0.5710.98
321_T325_F0.5710.98
272_G275_G0.5700.98
207_F212_R0.5700.98
112_A340_A0.5680.98
117_G123_R0.5680.98
156_I159_P0.5670.98
133_D341_G0.5660.98
88_F91_T0.5650.98
146_T288_M0.5630.98
332_G335_M0.5590.98
197_F200_L0.5590.98
192_S292_M0.5560.98
71_T75_W0.5560.98
300_H317_E0.5550.97
123_R128_L0.5550.97
226_I293_A0.5540.97
221_A225_M0.5540.97
164_G231_L0.5520.97
185_E188_A0.5520.97
168_I181_K0.5490.97
344_V348_T0.5480.97
191_P292_M0.5480.97
300_H325_F0.5460.97
195_Y228_V0.5450.97
111_P120_L0.5450.97
111_P114_E0.5450.97
230_A286_R0.5440.97
130_A136_V0.5410.97
321_T324_A0.5410.97
133_D344_V0.5390.97
170_E173_P0.5380.97
105_L343_V0.5380.97
106_L110_V0.5380.97
232_P238_S0.5360.97
73_V78_E0.5360.97
188_A230_A0.5350.97
89_L92_V0.5330.97
152_I219_Y0.5310.97
241_A271_A0.5310.97
339_F342_G0.5310.97
230_A283_G0.5290.97
167_F171_I0.5280.97
241_A245_V0.5280.97
123_R129_W0.5270.97
178_D243_A0.5250.96
320_T323_I0.5240.96
250_K260_P0.5230.96
293_A296_V0.5220.96
325_F331_S0.5220.96
356_S360_E0.5210.96
246_P251_S0.5200.96
238_S275_G0.5170.96
76_R81_A0.5150.96
203_L225_M0.5150.96
71_T77_R0.5140.96
323_I338_L0.5140.96
164_G184_I0.5140.96
118_V121_L0.5140.96
195_Y229_M0.5130.96
232_P290_E0.5110.96
160_V227_G0.5100.96
161_G232_P0.5100.96
130_A340_A0.5080.96
104_F109_S0.5070.96
72_V81_A0.5060.96
354_V357_Q0.5040.96
188_A191_P0.5010.95
190_I293_A0.5000.95
294_A298_L0.5000.95
101_I109_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.6685 100 0.448 Contact Map
4tquM 1 0.7251 100 0.465 Contact Map
3rlfG 1 0.7332 100 0.474 Contact Map
3d31C 2 0.6523 100 0.476 Contact Map
4tquN 1 0.717 100 0.481 Contact Map
3rlfF 1 0.9137 100 0.498 Contact Map
4ymuD 2 0.5768 100 0.591 Contact Map
3tuiA 2 0.5633 100 0.611 Contact Map
2kogA 1 0.2426 31.4 0.954 Contact Map
3hd7A 1 0.2426 17.7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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