GREMLIN Database
Q9HML5 - Phosphate ABC transporter binding
UniProt: Q9HML5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (287)
Sequences: 537 (444)
Seq/√Len: 26.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_N227_D4.7391.00
203_T304_T3.5641.00
191_V273_I3.5221.00
204_I212_I3.0631.00
211_G216_E3.0361.00
205_T208_E2.9361.00
120_Y337_A2.7701.00
221_S227_D2.7611.00
208_E224_G2.6850.99
298_D306_Y2.6450.99
104_N154_V2.6330.99
107_D139_L2.6120.99
212_I230_I2.5970.99
228_R278_N2.5870.99
219_N225_G2.5820.99
218_T222_E2.5570.99
104_N148_G2.5270.99
368_E371_K2.5070.99
113_A342_L2.5050.99
190_I245_F2.4720.99
142_S159_A2.4410.99
219_N229_D2.4080.99
150_M171_D2.3770.99
212_I223_L2.3500.98
204_I209_L2.3300.98
300_E304_T2.2020.98
294_T301_I2.1530.97
161_A167_L2.1010.97
343_L372_V2.0450.96
103_A156_I2.0260.96
179_V329_Q2.0240.96
311_N314_A2.0150.96
159_A326_Y2.0060.96
110_M139_L1.9600.95
148_G154_V1.9490.95
160_S186_D1.9470.95
160_S323_L1.9440.95
113_A338_F1.9330.95
186_D321_R1.9240.94
189_P312_L1.9070.94
187_G312_L1.8910.94
231_L276_A1.8870.94
160_S321_R1.8800.94
138_A148_G1.8790.94
246_R250_F1.8750.94
219_N224_G1.8330.93
212_I215_Q1.8140.93
141_H241_T1.7930.92
209_L341_F1.7870.92
340_N369_R1.7770.92
146_I163_A1.7710.92
266_N287_F1.7600.91
362_E367_T1.7490.91
273_I281_G1.6640.89
102_W136_S1.6630.89
338_F342_L1.6630.89
308_Y311_N1.6590.89
155_D303_G1.5840.86
116_F347_G1.5710.86
297_L301_I1.5680.86
244_S321_R1.5600.85
166_E169_D1.5420.85
271_Q275_Q1.5350.84
286_A357_Y1.5100.83
263_Y269_L1.4710.82
294_T297_L1.4560.81
201_V204_I1.4390.80
236_A265_Q1.4250.80
106_Y109_E1.4170.79
213_Y266_N1.4120.79
186_D323_L1.4080.79
217_I221_S1.3980.78
142_S235_R1.3920.78
143_G241_T1.3900.78
188_Q244_S1.3730.77
105_E141_H1.3720.77
108_T186_D1.3720.77
81_E86_W1.3430.75
270_Q283_I1.3360.75
233_L269_L1.3290.75
369_R373_A1.3260.74
182_V368_E1.3160.74
110_M114_D1.3090.73
242_D282_Y1.3030.73
141_H240_G1.2970.73
86_W135_V1.2930.72
179_V330_D1.2870.72
117_A135_V1.2800.72
116_F342_L1.2780.72
108_T323_L1.2680.71
166_E310_E1.2480.70
210_R213_Y1.2460.70
108_T321_R1.2450.70
161_A243_T1.2260.68
170_A174_T1.2240.68
106_Y240_G1.2230.68
118_S284_A1.2140.68
166_E172_S1.1990.67
161_A186_D1.1980.67
206_I249_V1.1960.66
161_A175_L1.1920.66
172_S362_E1.1870.66
143_G240_G1.1830.66
78_I212_I1.1830.66
186_D284_A1.1810.65
161_A321_R1.1790.65
294_T305_T1.1720.65
142_S322_D1.1660.64
301_I304_T1.1620.64
207_E298_D1.1550.64
157_G324_H1.1490.63
142_S280_I1.1480.63
76_F79_T1.1260.62
107_D348_Q1.1220.61
367_T371_K1.1210.61
145_G149_V1.1150.61
193_S273_I1.1130.61
160_S234_G1.1010.60
87_N91_E1.1000.60
235_R282_Y1.0840.59
229_D335_E1.0800.58
367_T370_E1.0750.58
142_S282_Y1.0660.57
120_Y295_P1.0660.57
204_I308_Y1.0650.57
239_S266_N1.0630.57
203_T300_E1.0480.56
154_V157_G1.0390.55
179_V182_V1.0270.54
221_S224_G1.0100.53
78_I81_E1.0080.53
107_D145_G1.0050.53
90_P94_D0.9970.52
142_S241_T0.9810.51
362_E366_S0.9760.51
172_S216_E0.9750.51
108_T241_T0.9710.50
143_G286_A0.9670.50
80_N84_S0.9610.50
283_I287_F0.9520.49
206_I209_L0.9510.49
136_S355_N0.9460.48
263_Y283_I0.9460.48
294_T304_T0.9430.48
303_G360_L0.9420.48
284_A287_F0.9410.48
213_Y257_I0.9400.48
189_P285_L0.9340.48
185_V320_S0.9280.47
98_W133_F0.9230.47
227_D370_E0.9190.46
287_F357_Y0.9130.46
253_P347_G0.9120.46
79_T205_T0.9090.46
187_G321_R0.8990.45
301_I305_T0.8980.45
181_H224_G0.8950.45
184_G323_L0.8860.44
79_T311_N0.8840.44
182_V364_R0.8840.44
227_D308_Y0.8820.44
79_T207_E0.8800.44
162_S286_A0.8770.43
189_P213_Y0.8750.43
97_Y133_F0.8720.43
91_E354_S0.8680.43
85_Y275_Q0.8680.43
366_S370_E0.8660.43
107_D236_A0.8650.43
205_T300_E0.8630.42
300_E344_S0.8630.42
149_V356_D0.8600.42
241_T266_N0.8590.42
211_G255_A0.8590.42
311_N360_L0.8590.42
180_D326_Y0.8580.42
190_I209_L0.8550.42
274_G305_T0.8530.42
107_D143_G0.8510.41
207_E222_E0.8500.41
235_R266_N0.8490.41
161_A284_A0.8450.41
210_R215_Q0.8440.41
280_I347_G0.8430.41
343_L369_R0.8400.41
163_A322_D0.8370.40
82_G353_T0.8360.40
107_D149_V0.8350.40
108_T160_S0.8320.40
363_S366_S0.8320.40
116_F352_V0.8310.40
181_H339_I0.8310.40
266_N283_I0.8270.40
241_T284_A0.8240.40
294_T299_L0.8240.40
167_L186_D0.8180.39
172_S370_E0.8130.39
192_A201_V0.8130.39
129_S132_P0.8120.39
242_D246_R0.8110.39
213_Y280_I0.8060.38
86_W349_E0.8030.38
235_R239_S0.8030.38
143_G243_T0.7990.38
149_V213_Y0.7950.38
165_D309_G0.7950.38
108_T161_A0.7940.37
141_H145_G0.7930.37
235_R249_V0.7930.37
163_A326_Y0.7930.37
78_I86_W0.7920.37
88_S349_E0.7910.37
85_Y88_S0.7900.37
280_I297_L0.7880.37
85_Y310_E0.7880.37
219_N372_V0.7810.37
90_P310_E0.7800.36
345_E370_E0.7790.36
364_R367_T0.7760.36
242_D361_P0.7750.36
142_S146_I0.7740.36
235_R241_T0.7720.36
310_E363_S0.7710.36
89_N96_D0.7690.36
145_G240_G0.7660.36
161_A164_A0.7640.35
132_P153_R0.7610.35
108_T141_H0.7600.35
106_Y111_R0.7560.35
107_D235_R0.7550.35
83_S217_I0.7540.35
284_A321_R0.7520.35
79_T85_Y0.7510.35
280_I348_Q0.7480.34
106_Y326_Y0.7480.34
218_T367_T0.7470.34
237_Q265_Q0.7460.34
145_G226_P0.7440.34
323_L326_Y0.7410.34
82_G128_R0.7380.34
272_A275_Q0.7360.34
166_E311_N0.7350.33
111_R189_P0.7350.33
209_L299_L0.7310.33
136_S148_G0.7310.33
219_N261_Q0.7310.33
106_Y308_Y0.7290.33
91_E94_D0.7280.33
205_T317_Y0.7270.33
139_L238_G0.7260.33
173_D273_I0.7250.33
273_I296_P0.7230.33
157_G325_A0.7180.32
213_Y251_G0.7180.32
182_V318_P0.7170.32
232_A287_F0.7120.32
104_N140_S0.7120.32
83_S86_W0.7110.32
92_A96_D0.7090.32
191_V373_A0.7090.32
143_G317_Y0.7080.32
201_V225_G0.7080.32
108_T326_Y0.7060.32
77_P81_E0.7040.31
111_R114_D0.7030.31
270_Q284_A0.7010.31
88_S165_D0.6990.31
239_S282_Y0.6980.31
167_L180_D0.6970.31
194_R314_A0.6950.31
171_D176_D0.6910.31
170_A175_L0.6840.30
205_T366_S0.6840.30
264_G267_Q0.6810.30
86_W90_P0.6800.30
287_F331_T0.6790.30
164_A167_L0.6780.30
109_E112_L0.6750.30
296_P305_T0.6740.30
183_V307_A0.6740.30
116_F356_D0.6740.30
204_I225_G0.6730.29
164_A336_A0.6690.29
190_I296_P0.6660.29
155_D331_T0.6650.29
212_I217_I0.6640.29
289_Q294_T0.6620.29
121_G204_I0.6610.29
168_P178_F0.6610.29
206_I358_F0.6590.29
187_G313_G0.6570.28
118_S315_E0.6560.28
333_R337_A0.6550.28
140_S238_G0.6550.28
327_T339_I0.6550.28
227_D230_I0.6540.28
136_S183_V0.6510.28
277_D297_L0.6500.28
115_Y279_A0.6490.28
154_V269_L0.6490.28
160_S242_D0.6490.28
113_A265_Q0.6480.28
213_Y232_A0.6480.28
290_P362_E0.6460.28
233_L279_A0.6460.28
267_Q270_Q0.6430.28
285_L289_Q0.6430.28
241_T269_L0.6420.28
142_S240_G0.6420.28
87_N302_D0.6400.27
142_S239_S0.6370.27
184_G192_A0.6370.27
182_V193_S0.6350.27
213_Y259_P0.6350.27
182_V360_L0.6330.27
207_E229_D0.6320.27
100_E136_S0.6310.27
192_A223_L0.6270.27
235_R240_G0.6250.27
233_L273_I0.6240.27
140_S239_S0.6240.27
105_E108_T0.6220.26
235_R265_Q0.6220.26
365_L369_R0.6180.26
163_A178_F0.6140.26
220_W317_Y0.6140.26
287_F303_G0.6140.26
113_A325_A0.6120.26
296_P299_L0.6120.26
370_E373_A0.6110.26
158_D325_A0.6100.26
153_R329_Q0.6070.26
94_D299_L0.6060.26
171_D264_G0.6060.26
219_N222_E0.6040.25
255_A366_S0.6030.25
93_G97_Y0.6020.25
325_A342_L0.5990.25
109_E328_W0.5960.25
104_N138_A0.5940.25
330_D333_R0.5930.25
209_L349_E0.5930.25
170_A193_S0.5920.25
120_Y341_F0.5910.25
138_A153_R0.5860.24
149_V317_Y0.5850.24
362_E369_R0.5850.24
216_E302_D0.5850.24
148_G234_G0.5840.24
193_S335_E0.5840.24
84_S183_V0.5840.24
102_W218_T0.5830.24
241_T321_R0.5810.24
189_P259_P0.5800.24
83_S173_D0.5780.24
231_L269_L0.5780.24
284_A324_H0.5770.24
92_A310_E0.5760.24
366_S369_R0.5750.24
253_P256_A0.5740.24
82_G88_S0.5720.24
173_D366_S0.5690.23
208_E249_V0.5680.23
234_G321_R0.5630.23
109_E322_D0.5620.23
227_D258_S0.5600.23
312_L320_S0.5590.23
76_F81_E0.5580.23
109_E113_A0.5580.23
154_V236_A0.5570.23
321_R324_H0.5570.23
107_D141_H0.5550.23
113_A150_M0.5540.23
230_I278_N0.5490.22
202_E298_D0.5480.22
295_P354_S0.5470.22
310_E314_A0.5470.22
120_Y309_G0.5460.22
91_E349_E0.5460.22
332_S335_E0.5460.22
141_H266_N0.5450.22
166_E275_Q0.5440.22
213_Y235_R0.5440.22
331_T335_E0.5420.22
121_G287_F0.5420.22
186_D266_N0.5420.22
90_P95_E0.5400.22
362_E365_L0.5390.22
252_D255_A0.5390.22
94_D165_D0.5390.22
82_G89_N0.5380.22
142_S145_G0.5380.22
152_D359_A0.5370.22
151_E262_R0.5370.22
193_S237_Q0.5360.22
80_N94_D0.5340.22
343_L360_L0.5330.22
303_G357_Y0.5330.22
192_A319_L0.5330.22
309_G313_G0.5320.22
137_I140_S0.5310.22
187_G336_A0.5280.21
105_E145_G0.5280.21
230_I339_I0.5250.21
109_E321_R0.5250.21
107_D263_Y0.5230.21
302_D349_E0.5220.21
82_G336_A0.5220.21
94_D366_S0.5210.21
266_N326_Y0.5210.21
173_D367_T0.5200.21
236_A242_D0.5200.21
300_E320_S0.5180.21
163_A167_L0.5180.21
117_A188_Q0.5170.21
79_T275_Q0.5170.21
96_D100_E0.5170.21
181_H285_L0.5160.21
108_T244_S0.5160.21
132_P337_A0.5160.21
232_A260_D0.5160.21
115_Y335_E0.5140.21
88_S151_E0.5080.20
250_F257_I0.5060.20
80_N305_T0.5060.20
117_A338_F0.5050.20
206_I252_D0.5030.20
111_R161_A0.5020.20
218_T227_D0.5010.20
205_T222_E0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f1vA 1 0.7018 100 0.404 Contact Map
4n13A 1 0.6438 100 0.563 Contact Map
1ixhA 1 0.6966 100 0.612 Contact Map
1pc3A 1 0.7203 100 0.615 Contact Map
4lvqA 1 0.6939 100 0.654 Contact Map
4jwoA 1 0.7177 100 0.656 Contact Map
4ombA 1 0.7335 100 0.658 Contact Map
4ecfA 1 0.6834 100 0.688 Contact Map
4exlA 1 0.6939 100 0.689 Contact Map
4q8rA 1 0.6332 100 0.697 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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