Q9HML4 - HALSA - GREMLIN Contacts

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Q9HML4 - Uncharacterized protein

UniProt:	Q9HML4	Sequences: MGVLVTGATGFIGGRLTPALAGAGYDIRALVRDADGYDPDTSVDVAEGDLLDPASLAGVFDGIDTAYYLVHSMRAGDDFAERDRRAARNFAAAADAAGVDRVIYLGGLGEEGTDLSDHLESRREVEAVLAGAAFDLTTLRAAVVVGAGSASFELVFQLVDRLPVMITPKWVQTPCQPIAVADVIAYLRGVLETPATAGNTYEIGGPDVLSYKSMLERTATLAGQRLLLVPVPVLTPTLSTYWVDLVTDVPRSVAHPLIHGLKHPVVVTDDRIQDLVDVSLTPFDDAAANALRERGVAADE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	300 (249)
Sequences:	58296 (41853)
Seq/√Len:	2652.3

ECOLI - YBJS GM4D GALE RMLB1 RMLB2 YFCH YBJT HLDD RMLD QOR2 FCL YEEZ YRAR
BACSU - YTCB GALE YFNG RMLB YFHF SPSK YESF YHFK YHEG YWNB YTBQ EPSC
HALSA - Q9HML4 Q9HSV1 Q9HNV3 Q9HSU9 Q9HS50 Q9HRD1 Q9HSE7 Q9HR86 Q9HSQ3 Q9HPF1
SULSO - Q97VN5 Q980W1 Q7LXE8 Q97UM3 Q97XJ9 Q7LXG5 Q97XG1 Q7LX44

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_A	29_A	3.207	1.00
81_E	85_R	2.682	1.00
2_G	26_D	2.671	1.00
19_A	185_A	2.636	1.00
57_A	96_A	2.564	1.00
30_L	48_G	2.502	1.00
199_N	271_R	2.433	1.00
186_Y	203_I	2.390	1.00
19_A	23_A	2.327	1.00
65_T	191_L	2.301	1.00
52_D	55_S	2.262	1.00
48_G	55_S	2.253	1.00
53_P	92_A	2.252	1.00
4_L	63_I	2.127	1.00
19_A	188_R	2.107	1.00
101_R	135_D	2.103	1.00
28_R	46_A	2.076	1.00
129_L	136_L	2.014	1.00
212_K	216_E	1.978	1.00
28_R	63_I	1.965	1.00
270_D	274_D	1.954	1.00
141_A	187_L	1.953	1.00
105_L	187_L	1.948	1.00
28_R	44_D	1.926	1.00
57_A	93_A	1.906	1.00
6_T	68_Y	1.878	1.00
68_Y	104_Y	1.868	1.00
64_D	100_D	1.863	1.00
26_D	44_D	1.852	1.00
5_V	17_T	1.839	1.00
67_Y	191_L	1.839	1.00
139_L	190_V	1.800	1.00
87_A	125_V	1.752	1.00
53_P	57_A	1.743	1.00
51_L	81_E	1.733	1.00
185_A	189_G	1.726	1.00
2_G	28_R	1.717	1.00
88_R	92_A	1.707	1.00
55_S	58_G	1.707	1.00
210_S	213_S	1.681	1.00
36_G	39_P	1.667	1.00
88_R	128_V	1.667	1.00
123_R	127_A	1.630	1.00
19_A	22_G	1.619	1.00
188_R	192_E	1.600	1.00
33_D	45_V	1.596	1.00
53_P	89_N	1.592	1.00
23_A	188_R	1.566	1.00
85_R	88_R	1.566	1.00
16_L	67_Y	1.537	1.00
95_D	132_A	1.529	1.00
157_Q	161_R	1.514	1.00
217_R	220_T	1.499	1.00
269_D	273_Q	1.496	1.00
16_L	69_L	1.493	1.00
50_L	86_A	1.487	1.00
217_R	221_L	1.486	1.00
17_T	29_A	1.483	1.00
23_A	192_E	1.467	1.00
69_L	105_L	1.467	1.00
272_I	276_V	1.460	1.00
3_V	65_T	1.448	1.00
80_A	124_E	1.447	1.00
57_A	97_A	1.440	1.00
106_G	110_E	1.439	1.00
3_V	25_Y	1.433	1.00
66_A	94_A	1.433	1.00
206_P	273_Q	1.425	1.00
105_L	141_A	1.414	1.00
174_P	208_V	1.407	1.00
16_L	184_I	1.400	1.00
77_D	81_E	1.398	1.00
18_P	148_G	1.390	1.00
65_T	101_R	1.389	1.00
158_L	163_P	1.367	1.00
101_R	137_T	1.343	1.00
19_A	184_I	1.329	1.00
12_I	144_V	1.329	1.00
219_A	225_R	1.318	1.00
104_Y	129_L	1.316	1.00
92_A	95_D	1.314	1.00
104_Y	125_V	1.304	1.00
189_G	193_T	1.303	1.00
29_A	43_V	1.301	1.00
213_S	216_E	1.293	1.00
61_D	97_A	1.287	1.00
9_T	31_V	1.267	1.00
8_A	17_T	1.252	1.00
164_V	229_V	1.249	1.00
142_A	267_V	1.248	1.00
126_E	140_R	1.248	1.00
118_H	122_R	1.239	1.00
30_L	59_V	1.238	1.00
94_A	102_V	1.232	1.00
57_A	61_D	1.201	1.00
21_A	43_V	1.199	1.00
25_Y	192_E	1.198	1.00
91_A	102_V	1.197	1.00
56_L	93_A	1.190	1.00
3_V	20_L	1.187	1.00
4_L	30_L	1.186	1.00
111_E	202_E	1.176	1.00
104_Y	138_T	1.170	1.00
212_K	230_P	1.149	1.00
90_F	102_V	1.142	1.00
120_E	124_E	1.133	1.00
31_V	45_V	1.132	1.00
60_F	93_A	1.131	1.00
83_D	121_S	1.126	1.00
172_Q	210_S	1.124	1.00
58_G	61_D	1.119	1.00
139_L	187_L	1.114	1.00
18_P	22_G	1.107	1.00
172_Q	212_K	1.106	1.00
26_D	42_S	1.106	1.00
68_Y	87_A	1.102	1.00
6_T	90_F	1.099	1.00
141_A	183_V	1.093	1.00
151_S	155_V	1.089	1.00
140_R	200_T	1.080	1.00
72_S	82_R	1.078	1.00
103_I	139_L	1.075	1.00
67_Y	187_L	1.074	1.00
89_N	92_A	1.074	1.00
85_R	89_N	1.073	1.00
50_L	70_V	1.064	1.00
54_A	58_G	1.064	1.00
94_A	99_V	1.064	1.00
145_V	179_A	1.059	1.00
82_R	86_A	1.055	1.00
21_A	42_S	1.050	1.00
46_A	59_V	1.048	1.00
92_A	96_A	1.046	1.00
180_V	184_I	1.043	1.00
19_A	181_A	1.042	1.00
56_L	89_N	1.026	1.00
189_G	192_E	1.022	1.00
11_F	146_G	1.020	1.00
93_A	96_A	1.016	1.00
140_R	202_E	1.014	1.00
60_F	63_I	1.007	1.00
54_A	57_A	1.004	1.00
53_P	96_A	1.000	1.00
95_D	134_F	0.996	1.00
30_L	56_L	0.978	1.00
135_D	197_A	0.978	1.00
60_F	94_A	0.974	1.00
32_R	49_D	0.973	1.00
216_E	219_A	0.973	1.00
34_A	47_E	0.969	1.00
55_S	59_V	0.966	1.00
176_Q	206_P	0.965	1.00
91_A	128_V	0.959	1.00
66_A	90_F	0.950	1.00
2_G	25_Y	0.944	1.00
84_R	124_E	0.943	1.00
2_G	64_D	0.942	1.00
270_D	273_Q	0.935	1.00
88_R	124_E	0.930	1.00
234_L	237_T	0.929	1.00
16_L	105_L	0.923	1.00
184_I	188_R	0.923	1.00
14_G	148_G	0.918	1.00
15_R	18_P	0.917	1.00
17_T	27_I	0.914	1.00
102_V	129_L	0.910	1.00
30_L	55_S	0.909	1.00
93_A	97_A	0.901	1.00
219_A	224_Q	0.901	1.00
204_G	267_V	0.901	1.00
166_I	229_V	0.899	1.00
156_F	160_D	0.899	1.00
69_L	187_L	0.897	1.00
60_F	66_A	0.895	1.00
80_A	85_R	0.893	1.00
28_R	62_G	0.890	1.00
2_G	63_I	0.887	1.00
80_A	84_R	0.880	1.00
20_L	188_R	0.880	1.00
33_D	47_E	0.879	1.00
60_F	97_A	0.878	1.00
219_A	226_L	0.877	1.00
141_A	144_V	0.876	1.00
21_A	27_I	0.865	1.00
209_L	213_S	0.862	1.00
53_P	93_A	0.862	1.00
91_A	129_L	0.856	1.00
15_R	19_A	0.854	1.00
108_L	142_A	0.837	1.00
182_D	205_G	0.835	1.00
89_N	93_A	0.832	1.00
157_Q	160_D	0.830	1.00
100_D	135_D	0.829	1.00
15_R	181_A	0.829	1.00
144_V	183_V	0.821	1.00
213_S	217_R	0.821	1.00
91_A	95_D	0.821	1.00
51_L	82_R	0.820	1.00
106_G	126_E	0.820	1.00
110_E	140_R	0.820	1.00
72_S	78_D	0.819	1.00
186_Y	272_I	0.815	1.00
271_R	274_D	0.814	1.00
164_V	227_L	0.812	1.00
125_V	129_L	0.802	1.00
136_L	198_G	0.796	1.00
154_L	157_Q	0.788	1.00
66_A	102_V	0.788	1.00
95_D	133_A	0.787	1.00
87_A	129_L	0.779	1.00
68_Y	90_F	0.779	1.00
79_F	121_S	0.777	1.00
208_V	266_V	0.776	1.00
201_Y	271_R	0.776	1.00
72_S	79_F	0.771	1.00
188_R	191_L	0.769	1.00
6_T	70_V	0.765	1.00
16_L	20_L	0.764	1.00
178_I	183_V	0.763	1.00
154_L	158_L	0.759	1.00
171_V	212_K	0.756	1.00
120_E	127_A	0.754	1.00
116_S	119_L	0.754	1.00
3_V	67_Y	0.746	1.00
237_T	240_T	0.742	1.00
185_A	188_R	0.740	1.00
88_R	91_A	0.738	1.00
126_E	138_T	0.737	1.00
124_E	128_V	0.734	1.00
25_Y	64_D	0.734	1.00
147_A	179_A	0.732	1.00
139_L	203_I	0.730	1.00
40_D	43_V	0.723	1.00
78_D	81_E	0.719	1.00
124_E	127_A	0.718	1.00
209_L	214_M	0.717	1.00
11_F	180_V	0.716	1.00
137_T	190_V	0.712	1.00
107_G	110_E	0.703	1.00
216_E	220_T	0.702	1.00
174_P	210_S	0.702	1.00
138_T	200_T	0.701	1.00
185_A	278_V	0.700	1.00
190_V	272_I	0.700	1.00
179_A	182_D	0.699	1.00
225_R	228_L	0.699	1.00
87_A	91_A	0.695	1.00
166_I	231_V	0.695	1.00
238_L	241_Y	0.693	1.00
74_R	78_D	0.692	1.00
94_A	97_A	0.691	1.00
108_L	267_V	0.690	1.00
101_R	194_P	0.690	1.00
150_A	153_E	0.688	1.00
52_D	56_L	0.683	1.00
144_V	178_I	0.680	1.00
33_D	36_G	0.679	1.00
65_T	100_D	0.676	1.00
215_L	219_A	0.675	1.00
109_G	119_L	0.672	1.00
15_R	180_V	0.672	1.00
80_A	120_E	0.672	1.00
31_V	35_D	0.671	1.00
219_A	222_A	0.670	1.00
11_F	15_R	0.669	1.00
91_A	132_A	0.666	1.00
3_V	191_L	0.664	1.00
50_L	56_L	0.662	1.00
204_G	269_D	0.662	1.00
152_F	156_F	0.660	1.00
78_D	82_R	0.658	1.00
230_P	233_V	0.658	1.00
114_D	119_L	0.657	1.00
237_T	241_Y	0.652	1.00
5_V	20_L	0.650	1.00
106_G	140_R	0.648	1.00
232_P	235_T	0.648	1.00
21_A	41_T	0.642	1.00
80_A	121_S	0.641	1.00
219_A	228_L	0.640	1.00
4_L	60_F	0.637	1.00
110_E	126_E	0.635	1.00
236_P	239_S	0.634	1.00
153_E	156_F	0.631	1.00
231_V	234_L	0.630	1.00
14_G	18_P	0.624	1.00
65_T	103_I	0.622	1.00
156_F	218_T	0.615	1.00
186_Y	278_V	0.614	1.00
86_A	89_N	0.612	1.00
11_F	148_G	0.608	1.00
206_P	269_D	0.607	1.00
150_A	154_L	0.600	1.00
16_L	187_L	0.597	1.00
117_D	121_S	0.594	1.00
49_D	52_D	0.593	1.00
269_D	278_V	0.593	1.00
209_L	217_R	0.593	1.00
176_Q	205_G	0.592	1.00
15_R	184_I	0.590	1.00
190_V	276_V	0.590	1.00
46_A	55_S	0.586	1.00
123_R	126_E	0.586	1.00
4_L	48_G	0.582	1.00
149_S	152_F	0.580	1.00
11_F	147_A	0.577	1.00
189_G	277_D	0.576	1.00
149_S	153_E	0.576	1.00
29_A	45_V	0.575	1.00
231_V	236_P	0.574	1.00
203_I	272_I	0.572	1.00
28_R	59_V	0.566	1.00
9_T	33_D	0.566	1.00
21_A	40_D	0.565	1.00
111_E	140_R	0.564	1.00
183_V	188_R	0.564	1.00
4_L	66_A	0.560	1.00
114_D	123_R	0.559	1.00
94_A	134_F	0.558	1.00
235_T	238_L	0.558	1.00
153_E	157_Q	0.558	1.00
48_G	59_V	0.558	1.00
87_A	104_Y	0.558	1.00
142_A	204_G	0.556	1.00
163_P	166_I	0.552	1.00
20_L	25_Y	0.551	1.00
122_R	125_V	0.550	1.00
120_E	123_R	0.547	1.00
232_P	241_Y	0.547	1.00
5_V	29_A	0.546	1.00
229_V	232_P	0.546	1.00
91_A	134_F	0.540	1.00
25_Y	65_T	0.537	1.00
187_L	191_L	0.537	1.00
20_L	191_L	0.534	1.00
233_V	236_P	0.533	1.00
272_I	278_V	0.533	1.00
4_L	59_V	0.533	1.00
162_L	224_Q	0.531	1.00
5_V	8_A	0.530	1.00
56_L	60_F	0.529	1.00
87_A	128_V	0.529	1.00
12_I	105_L	0.529	1.00
48_G	56_L	0.528	1.00
232_P	237_T	0.525	1.00
62_G	97_A	0.524	1.00
155_V	159_V	0.523	1.00
23_A	185_A	0.522	1.00
71_H	83_D	0.522	1.00
158_L	166_I	0.521	1.00
60_F	90_F	0.521	1.00
186_Y	189_G	0.521	1.00
130_A	136_L	0.519	1.00
189_G	278_V	0.518	1.00
122_R	126_E	0.516	1.00
63_I	94_A	0.516	1.00
68_Y	102_V	0.514	1.00
201_Y	272_I	0.509	1.00
230_P	234_L	0.509	1.00
2_G	62_G	0.507	1.00
31_V	34_A	0.507	1.00
91_A	94_A	0.506	1.00
155_V	158_L	0.506	1.00
189_G	276_V	0.506	1.00
108_L	112_G	0.506	1.00
102_V	136_L	0.504	1.00
103_I	137_T	0.504	1.00
17_T	21_A	0.503	1.00
72_S	83_D	0.503	1.00
125_V	128_V	0.502	1.00
187_L	190_V	0.502	1.00
232_P	236_P	0.502	1.00
176_Q	208_V	0.502	1.00
135_D	195_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2x4gA	2	0.9	100	0.234	Contact Map
1sb8A	2	0.9333	100	0.246	Contact Map
3m2pA	2	0.9	100	0.249	Contact Map
3slgA	4	0.9267	100	0.25	Contact Map
3rufA	2	0.9167	100	0.252	Contact Map
1orrA	3	0.91	100	0.254	Contact Map
2q1sA	2	0.8967	100	0.255	Contact Map
2pzmA	2	0.9067	100	0.257	Contact Map
2bllA	2	0.9267	100	0.259	Contact Map
4wkgA	5	0.9667	100	0.26	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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