GREMLIN Database
Q9HML4 - Uncharacterized protein
UniProt: Q9HML4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (249)
Sequences: 58296 (41853)
Seq/√Len: 2652.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A29_A3.2071.00
81_E85_R2.6821.00
2_G26_D2.6711.00
19_A185_A2.6361.00
57_A96_A2.5641.00
30_L48_G2.5021.00
199_N271_R2.4331.00
186_Y203_I2.3901.00
19_A23_A2.3271.00
65_T191_L2.3011.00
52_D55_S2.2621.00
48_G55_S2.2531.00
53_P92_A2.2521.00
4_L63_I2.1271.00
19_A188_R2.1071.00
101_R135_D2.1031.00
28_R46_A2.0761.00
129_L136_L2.0141.00
212_K216_E1.9781.00
28_R63_I1.9651.00
270_D274_D1.9541.00
141_A187_L1.9531.00
105_L187_L1.9481.00
28_R44_D1.9261.00
57_A93_A1.9061.00
6_T68_Y1.8781.00
68_Y104_Y1.8681.00
64_D100_D1.8631.00
26_D44_D1.8521.00
5_V17_T1.8391.00
67_Y191_L1.8391.00
139_L190_V1.8001.00
87_A125_V1.7521.00
53_P57_A1.7431.00
51_L81_E1.7331.00
185_A189_G1.7261.00
2_G28_R1.7171.00
88_R92_A1.7071.00
55_S58_G1.7071.00
210_S213_S1.6811.00
36_G39_P1.6671.00
88_R128_V1.6671.00
123_R127_A1.6301.00
19_A22_G1.6191.00
188_R192_E1.6001.00
33_D45_V1.5961.00
53_P89_N1.5921.00
23_A188_R1.5661.00
85_R88_R1.5661.00
16_L67_Y1.5371.00
95_D132_A1.5291.00
157_Q161_R1.5141.00
217_R220_T1.4991.00
269_D273_Q1.4961.00
16_L69_L1.4931.00
50_L86_A1.4871.00
217_R221_L1.4861.00
17_T29_A1.4831.00
23_A192_E1.4671.00
69_L105_L1.4671.00
272_I276_V1.4601.00
3_V65_T1.4481.00
80_A124_E1.4471.00
57_A97_A1.4401.00
106_G110_E1.4391.00
3_V25_Y1.4331.00
66_A94_A1.4331.00
206_P273_Q1.4251.00
105_L141_A1.4141.00
174_P208_V1.4071.00
16_L184_I1.4001.00
77_D81_E1.3981.00
18_P148_G1.3901.00
65_T101_R1.3891.00
158_L163_P1.3671.00
101_R137_T1.3431.00
19_A184_I1.3291.00
12_I144_V1.3291.00
219_A225_R1.3181.00
104_Y129_L1.3161.00
92_A95_D1.3141.00
104_Y125_V1.3041.00
189_G193_T1.3031.00
29_A43_V1.3011.00
213_S216_E1.2931.00
61_D97_A1.2871.00
9_T31_V1.2671.00
8_A17_T1.2521.00
164_V229_V1.2491.00
142_A267_V1.2481.00
126_E140_R1.2481.00
118_H122_R1.2391.00
30_L59_V1.2381.00
94_A102_V1.2321.00
57_A61_D1.2011.00
21_A43_V1.1991.00
25_Y192_E1.1981.00
91_A102_V1.1971.00
56_L93_A1.1901.00
3_V20_L1.1871.00
4_L30_L1.1861.00
111_E202_E1.1761.00
104_Y138_T1.1701.00
212_K230_P1.1491.00
90_F102_V1.1421.00
120_E124_E1.1331.00
31_V45_V1.1321.00
60_F93_A1.1311.00
83_D121_S1.1261.00
172_Q210_S1.1241.00
58_G61_D1.1191.00
139_L187_L1.1141.00
18_P22_G1.1071.00
172_Q212_K1.1061.00
26_D42_S1.1061.00
68_Y87_A1.1021.00
6_T90_F1.0991.00
141_A183_V1.0931.00
151_S155_V1.0891.00
140_R200_T1.0801.00
72_S82_R1.0781.00
103_I139_L1.0751.00
67_Y187_L1.0741.00
89_N92_A1.0741.00
85_R89_N1.0731.00
50_L70_V1.0641.00
54_A58_G1.0641.00
94_A99_V1.0641.00
145_V179_A1.0591.00
82_R86_A1.0551.00
21_A42_S1.0501.00
46_A59_V1.0481.00
92_A96_A1.0461.00
180_V184_I1.0431.00
19_A181_A1.0421.00
56_L89_N1.0261.00
189_G192_E1.0221.00
11_F146_G1.0201.00
93_A96_A1.0161.00
140_R202_E1.0141.00
60_F63_I1.0071.00
54_A57_A1.0041.00
53_P96_A1.0001.00
95_D134_F0.9961.00
30_L56_L0.9781.00
135_D197_A0.9781.00
60_F94_A0.9741.00
32_R49_D0.9731.00
216_E219_A0.9731.00
34_A47_E0.9691.00
55_S59_V0.9661.00
176_Q206_P0.9651.00
91_A128_V0.9591.00
66_A90_F0.9501.00
2_G25_Y0.9441.00
84_R124_E0.9431.00
2_G64_D0.9421.00
270_D273_Q0.9351.00
88_R124_E0.9301.00
234_L237_T0.9291.00
16_L105_L0.9231.00
184_I188_R0.9231.00
14_G148_G0.9181.00
15_R18_P0.9171.00
17_T27_I0.9141.00
102_V129_L0.9101.00
30_L55_S0.9091.00
93_A97_A0.9011.00
219_A224_Q0.9011.00
204_G267_V0.9011.00
166_I229_V0.8991.00
156_F160_D0.8991.00
69_L187_L0.8971.00
60_F66_A0.8951.00
80_A85_R0.8931.00
28_R62_G0.8901.00
2_G63_I0.8871.00
80_A84_R0.8801.00
20_L188_R0.8801.00
33_D47_E0.8791.00
60_F97_A0.8781.00
219_A226_L0.8771.00
141_A144_V0.8761.00
21_A27_I0.8651.00
209_L213_S0.8621.00
53_P93_A0.8621.00
91_A129_L0.8561.00
15_R19_A0.8541.00
108_L142_A0.8371.00
182_D205_G0.8351.00
89_N93_A0.8321.00
157_Q160_D0.8301.00
100_D135_D0.8291.00
15_R181_A0.8291.00
144_V183_V0.8211.00
213_S217_R0.8211.00
91_A95_D0.8211.00
51_L82_R0.8201.00
106_G126_E0.8201.00
110_E140_R0.8201.00
72_S78_D0.8191.00
186_Y272_I0.8151.00
271_R274_D0.8141.00
164_V227_L0.8121.00
125_V129_L0.8021.00
136_L198_G0.7961.00
154_L157_Q0.7881.00
66_A102_V0.7881.00
95_D133_A0.7871.00
87_A129_L0.7791.00
68_Y90_F0.7791.00
79_F121_S0.7771.00
208_V266_V0.7761.00
201_Y271_R0.7761.00
72_S79_F0.7711.00
188_R191_L0.7691.00
6_T70_V0.7651.00
16_L20_L0.7641.00
178_I183_V0.7631.00
154_L158_L0.7591.00
171_V212_K0.7561.00
120_E127_A0.7541.00
116_S119_L0.7541.00
3_V67_Y0.7461.00
237_T240_T0.7421.00
185_A188_R0.7401.00
88_R91_A0.7381.00
126_E138_T0.7371.00
124_E128_V0.7341.00
25_Y64_D0.7341.00
147_A179_A0.7321.00
139_L203_I0.7301.00
40_D43_V0.7231.00
78_D81_E0.7191.00
124_E127_A0.7181.00
209_L214_M0.7171.00
11_F180_V0.7161.00
137_T190_V0.7121.00
107_G110_E0.7031.00
216_E220_T0.7021.00
174_P210_S0.7021.00
138_T200_T0.7011.00
185_A278_V0.7001.00
190_V272_I0.7001.00
179_A182_D0.6991.00
225_R228_L0.6991.00
87_A91_A0.6951.00
166_I231_V0.6951.00
238_L241_Y0.6931.00
74_R78_D0.6921.00
94_A97_A0.6911.00
108_L267_V0.6901.00
101_R194_P0.6901.00
150_A153_E0.6881.00
52_D56_L0.6831.00
144_V178_I0.6801.00
33_D36_G0.6791.00
65_T100_D0.6761.00
215_L219_A0.6751.00
109_G119_L0.6721.00
15_R180_V0.6721.00
80_A120_E0.6721.00
31_V35_D0.6711.00
219_A222_A0.6701.00
11_F15_R0.6691.00
91_A132_A0.6661.00
3_V191_L0.6641.00
50_L56_L0.6621.00
204_G269_D0.6621.00
152_F156_F0.6601.00
78_D82_R0.6581.00
230_P233_V0.6581.00
114_D119_L0.6571.00
237_T241_Y0.6521.00
5_V20_L0.6501.00
106_G140_R0.6481.00
232_P235_T0.6481.00
21_A41_T0.6421.00
80_A121_S0.6411.00
219_A228_L0.6401.00
4_L60_F0.6371.00
110_E126_E0.6351.00
236_P239_S0.6341.00
153_E156_F0.6311.00
231_V234_L0.6301.00
14_G18_P0.6241.00
65_T103_I0.6221.00
156_F218_T0.6151.00
186_Y278_V0.6141.00
86_A89_N0.6121.00
11_F148_G0.6081.00
206_P269_D0.6071.00
150_A154_L0.6001.00
16_L187_L0.5971.00
117_D121_S0.5941.00
49_D52_D0.5931.00
269_D278_V0.5931.00
209_L217_R0.5931.00
176_Q205_G0.5921.00
15_R184_I0.5901.00
190_V276_V0.5901.00
46_A55_S0.5861.00
123_R126_E0.5861.00
4_L48_G0.5821.00
149_S152_F0.5801.00
11_F147_A0.5771.00
189_G277_D0.5761.00
149_S153_E0.5761.00
29_A45_V0.5751.00
231_V236_P0.5741.00
203_I272_I0.5721.00
28_R59_V0.5661.00
9_T33_D0.5661.00
21_A40_D0.5651.00
111_E140_R0.5641.00
183_V188_R0.5641.00
4_L66_A0.5601.00
114_D123_R0.5591.00
94_A134_F0.5581.00
235_T238_L0.5581.00
153_E157_Q0.5581.00
48_G59_V0.5581.00
87_A104_Y0.5581.00
142_A204_G0.5561.00
163_P166_I0.5521.00
20_L25_Y0.5511.00
122_R125_V0.5501.00
120_E123_R0.5471.00
232_P241_Y0.5471.00
5_V29_A0.5461.00
229_V232_P0.5461.00
91_A134_F0.5401.00
25_Y65_T0.5371.00
187_L191_L0.5371.00
20_L191_L0.5341.00
233_V236_P0.5331.00
272_I278_V0.5331.00
4_L59_V0.5331.00
162_L224_Q0.5311.00
5_V8_A0.5301.00
56_L60_F0.5291.00
87_A128_V0.5291.00
12_I105_L0.5291.00
48_G56_L0.5281.00
232_P237_T0.5251.00
62_G97_A0.5241.00
155_V159_V0.5231.00
23_A185_A0.5221.00
71_H83_D0.5221.00
158_L166_I0.5211.00
60_F90_F0.5211.00
186_Y189_G0.5211.00
130_A136_L0.5191.00
189_G278_V0.5181.00
122_R126_E0.5161.00
63_I94_A0.5161.00
68_Y102_V0.5141.00
201_Y272_I0.5091.00
230_P234_L0.5091.00
2_G62_G0.5071.00
31_V34_A0.5071.00
91_A94_A0.5061.00
155_V158_L0.5061.00
189_G276_V0.5061.00
108_L112_G0.5061.00
102_V136_L0.5041.00
103_I137_T0.5041.00
17_T21_A0.5031.00
72_S83_D0.5031.00
125_V128_V0.5021.00
187_L190_V0.5021.00
232_P236_P0.5021.00
176_Q208_V0.5021.00
135_D195_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x4gA 2 0.9 100 0.234 Contact Map
1sb8A 2 0.9333 100 0.246 Contact Map
3m2pA 2 0.9 100 0.249 Contact Map
3slgA 4 0.9267 100 0.25 Contact Map
3rufA 2 0.9167 100 0.252 Contact Map
1orrA 3 0.91 100 0.254 Contact Map
2q1sA 2 0.8967 100 0.255 Contact Map
2pzmA 2 0.9067 100 0.257 Contact Map
2bllA 2 0.9267 100 0.259 Contact Map
4wkgA 5 0.9667 100 0.26 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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