GREMLIN Database
Q9HML2 - Uncharacterized protein
UniProt: Q9HML2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (238)
Sequences: 2451 (1829)
Seq/√Len: 118.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_T36_I4.8131.00
20_D47_D4.4961.00
175_T203_D4.1801.00
181_V203_D3.6501.00
175_T181_V3.1971.00
52_V58_V3.0771.00
17_L243_A2.9831.00
120_P136_H2.8661.00
174_L179_G2.8071.00
89_E173_L2.4851.00
142_D146_A2.4411.00
8_V22_V2.4111.00
213_R216_G2.3891.00
62_I90_C2.2251.00
103_R106_D2.1741.00
8_V34_V2.1351.00
37_T61_G2.1091.00
143_T146_A2.0451.00
114_V151_L2.0231.00
31_V34_V1.9771.00
112_L158_C1.9421.00
182_G238_T1.9371.00
120_P132_A1.9151.00
24_D51_T1.8871.00
227_A237_P1.8601.00
51_T54_D1.8501.00
166_D169_T1.8141.00
62_I77_G1.7871.00
207_A237_P1.7761.00
42_L87_T1.7511.00
91_D95_R1.7291.00
27_H56_I1.7221.00
141_Y146_A1.7011.00
81_H84_D1.6911.00
131_R144_M1.6731.00
182_G204_A1.6721.00
102_R118_L1.6521.00
141_Y147_V1.6431.00
23_P34_V1.5771.00
105_I118_L1.5631.00
17_L25_A1.5201.00
45_A60_H1.5191.00
169_T172_D1.5151.00
85_A88_A1.4981.00
132_A136_H1.4971.00
18_T21_A1.4801.00
145_D149_D1.4641.00
45_A58_V1.4581.00
187_L216_G1.4331.00
78_Y238_T1.4071.00
33_A57_T1.3751.00
174_L181_V1.3741.00
46_L83_T1.3611.00
212_D226_V1.3611.00
109_E115_S1.3571.00
103_R107_R1.3551.00
8_V26_A1.3461.00
42_L80_V1.3451.00
187_L212_D1.3441.00
27_H55_D1.3401.00
228_D232_T1.3331.00
104_I129_I1.3311.00
49_P60_H1.3241.00
26_A34_V1.3131.00
52_V56_I1.3111.00
25_A28_D1.3101.00
208_H227_A1.3071.00
102_R106_D1.2871.00
24_D28_D1.2861.00
77_G174_L1.2811.00
75_L174_L1.2761.00
117_P120_P1.2570.99
21_A24_D1.2510.99
101_G129_I1.2500.99
209_Y212_D1.2490.99
64_L170_G1.2370.99
120_P135_A1.2350.99
76_L238_T1.2340.99
66_V170_G1.2330.99
153_G156_G1.2320.99
209_Y239_G1.2290.99
34_V58_V1.2260.99
180_L203_D1.2150.99
49_P58_V1.2120.99
16_T245_D1.2030.99
207_A226_V1.1990.99
25_A29_A1.1970.99
168_E172_D1.1950.99
172_D176_D1.1910.99
49_P82_G1.1860.99
171_V200_A1.1810.99
101_G124_L1.1760.99
46_L82_G1.1650.99
105_I129_I1.1620.99
105_I109_E1.1610.99
75_L167_F1.1560.99
36_I44_P1.1480.99
208_H223_A1.1460.99
49_P53_R1.1410.99
141_Y152_I1.1280.99
95_R99_D1.1250.99
100_R148_F1.1240.99
97_R128_H1.1110.99
230_I237_P1.1070.99
50_V53_R1.0970.98
40_D97_R1.0950.98
16_T247_T1.0910.98
48_A58_V1.0900.98
4_A33_A1.0840.98
207_A227_A1.0820.98
20_D24_D1.0720.98
89_E92_R1.0710.98
19_I23_P1.0630.98
165_P170_G1.0600.98
187_L226_V1.0570.98
40_D65_R1.0560.98
27_H54_D1.0530.98
168_E200_A1.0510.98
154_N159_F1.0480.98
64_L90_C1.0450.98
100_R126_R1.0440.98
35_A61_G1.0300.98
18_T22_V1.0250.98
126_R148_F1.0230.98
112_L157_P1.0120.97
33_A59_I1.0030.97
52_V55_D0.9920.97
133_I141_Y0.9880.97
89_E169_T0.9840.97
108_V158_C0.9840.97
192_P195_A0.9810.97
11_T18_T0.9760.97
224_A228_D0.9670.97
73_V189_Y0.9660.97
46_L50_V0.9640.97
96_D163_D0.9620.97
105_I116_L0.9540.96
134_T143_T0.9510.96
131_R135_A0.9510.96
205_V226_V0.9470.96
204_A236_I0.9400.96
77_G80_V0.9310.96
48_A52_V0.9300.96
207_A230_I0.9260.96
133_I138_D0.9210.96
49_P52_V0.9200.96
25_A243_A0.9190.96
114_V133_I0.9150.95
59_I79_G0.9110.95
180_L236_I0.9030.95
76_L204_A0.9030.95
107_R158_C0.9020.95
225_L229_A0.8990.95
23_P48_A0.8990.95
17_L21_A0.8980.95
89_E165_P0.8980.95
97_R100_R0.8930.95
98_R102_R0.8920.95
114_V138_D0.8880.95
183_L202_L0.8870.95
214_P224_A0.8850.95
66_V72_R0.8830.94
19_I51_T0.8830.94
116_L119_E0.8830.94
207_A223_A0.8780.94
20_D51_T0.8770.94
24_D27_H0.8670.94
60_H80_V0.8640.94
12_N47_D0.8520.93
66_V75_L0.8520.93
50_V54_D0.8510.93
116_L132_A0.8460.93
127_P130_A0.8460.93
100_R130_A0.8410.93
126_R152_I0.8300.92
45_A49_P0.8270.92
100_R104_I0.8250.92
138_D141_Y0.8210.92
146_A150_S0.8200.92
35_A45_A0.8200.92
99_D103_R0.8190.92
126_R130_A0.8170.92
205_V229_A0.8170.92
23_P51_T0.8170.92
115_S136_H0.8150.92
78_Y182_G0.8100.91
99_D102_R0.8100.91
84_D177_A0.8100.91
225_L228_D0.8100.91
60_H82_G0.8080.91
66_V167_F0.8070.91
188_R211_Y0.7940.91
92_R96_D0.7920.91
101_G118_L0.7900.90
23_P58_V0.7850.90
194_H198_L0.7830.90
197_A232_T0.7770.90
107_R112_L0.7750.90
45_A82_G0.7680.89
134_T144_M0.7670.89
86_L90_C0.7650.89
66_V93_I0.7640.89
62_I80_V0.7560.88
209_Y223_A0.7510.88
100_R125_G0.7500.88
104_I152_I0.7480.88
75_L181_V0.7470.88
31_V56_I0.7440.88
46_L49_P0.7340.87
77_G170_G0.7300.87
39_H244_H0.7300.87
192_P226_V0.7280.86
106_D111_R0.7270.86
79_G180_L0.7260.86
57_T79_G0.7230.86
212_D223_A0.7220.86
171_V201_A0.7210.86
36_I58_V0.7180.86
23_P52_V0.7130.85
199_C233_H0.7110.85
104_I126_R0.7070.85
141_Y151_L0.7050.85
12_N43_H0.7030.84
108_V114_V0.7010.84
175_T180_L0.7010.84
81_H87_T0.7010.84
32_T57_T0.7000.84
131_R247_T0.6980.84
216_G225_L0.6900.83
231_D237_P0.6890.83
134_T141_Y0.6870.83
106_D109_E0.6860.83
173_L177_A0.6820.83
129_I158_C0.6790.82
67_D164_V0.6770.82
185_H244_H0.6770.82
40_D100_R0.6760.82
130_A147_V0.6750.82
23_P30_G0.6730.82
76_L209_Y0.6710.82
86_L173_L0.6680.81
100_R128_H0.6650.81
130_A152_I0.6640.81
193_Q225_L0.6630.81
39_H242_D0.6620.81
117_P132_A0.6570.80
130_A148_F0.6550.80
228_D231_D0.6520.80
43_H94_Q0.6510.80
109_E117_P0.6470.79
23_P56_I0.6430.79
9_H13_S0.6420.79
76_L182_G0.6410.79
124_L129_I0.6360.78
146_A149_D0.6340.78
108_V129_I0.6300.77
174_L177_A0.6280.77
41_R44_P0.6270.77
171_V175_T0.6250.77
213_R223_A0.6240.77
205_V230_I0.6230.77
132_A138_D0.6200.76
75_L166_D0.6190.76
42_L45_A0.6190.76
118_L124_L0.6190.76
12_N19_I0.6170.76
207_A212_D0.6120.75
133_I152_I0.6090.75
7_H13_S0.6080.75
191_D195_A0.6080.75
100_R152_I0.6070.75
192_P198_L0.6070.75
215_V224_A0.6060.75
100_R127_P0.6060.75
172_D200_A0.6010.74
223_A227_A0.5990.74
173_L176_D0.5970.74
97_R126_R0.5960.73
74_D185_H0.5950.73
179_G182_G0.5910.73
83_T87_T0.5910.73
103_R161_A0.5900.73
44_P51_T0.5890.73
75_L183_L0.5840.72
150_S157_P0.5830.72
126_R147_V0.5810.72
167_F202_L0.5810.72
12_N41_R0.5770.71
125_G148_F0.5740.71
92_R169_T0.5740.71
234_D237_P0.5720.70
5_D8_V0.5710.70
36_I45_A0.5700.70
107_R160_V0.5700.70
99_D224_A0.5690.70
95_R98_R0.5680.70
40_D128_H0.5680.70
153_G160_V0.5670.70
202_L239_G0.5670.70
26_A31_V0.5660.70
14_D185_H0.5630.69
98_R118_L0.5630.69
97_R125_G0.5620.69
93_I162_R0.5610.69
60_H79_G0.5600.69
19_I44_P0.5560.68
100_R147_V0.5540.68
44_P48_A0.5540.68
203_D236_I0.5520.68
86_L186_P0.5490.67
33_A79_G0.5490.67
74_D184_A0.5460.67
84_D176_D0.5450.67
9_H14_D0.5440.67
125_G130_A0.5420.66
83_T175_T0.5410.66
165_P173_L0.5400.66
73_V171_V0.5400.66
100_R160_V0.5380.66
127_P148_F0.5370.66
229_A233_H0.5360.65
239_G245_D0.5350.65
172_D175_T0.5350.65
81_H179_G0.5350.65
80_V86_L0.5350.65
126_R159_F0.5340.65
163_D176_D0.5330.65
64_L174_L0.5330.65
245_D248_L0.5330.65
111_R115_S0.5320.65
20_D54_D0.5320.65
65_R74_D0.5310.65
113_G212_D0.5270.64
88_A91_D0.5260.64
211_Y248_L0.5260.64
35_A78_Y0.5250.64
74_D244_H0.5240.64
87_T91_D0.5240.64
174_L182_G0.5230.64
28_D224_A0.5210.63
107_R161_A0.5210.63
92_R99_D0.5210.63
65_R162_R0.5200.63
96_D162_R0.5200.63
205_V212_D0.5190.63
143_T149_D0.5190.63
16_T246_H0.5150.62
95_R228_D0.5140.62
10_T22_V0.5140.62
77_G181_V0.5140.62
76_L239_G0.5130.62
5_D241_T0.5080.61
227_A230_I0.5080.61
40_D126_R0.5040.61
88_A92_R0.5020.60
143_T152_I0.5020.60
112_L156_G0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yb1A 1 0.9513 100 0.352 Contact Map
3o0fA 1 0.9588 100 0.372 Contact Map
3e38A 4 0.6742 100 0.641 Contact Map
4gc3A 1 0.7416 100 0.663 Contact Map
2anuA 5 0.6367 100 0.663 Contact Map
1m65A 3 0.6891 100 0.666 Contact Map
2yxoA 3 0.7865 99.9 0.683 Contact Map
2wjeA 1 0.7715 99.9 0.685 Contact Map
3qy7A 1 0.7191 99.9 0.691 Contact Map
2w9mA 1 0.7154 99.9 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.