GREMLIN Database
Q9HMK7 - Glutaryl-CoA dehydrogenase
UniProt: Q9HMK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (327)
Sequences: 32202 (17462)
Seq/√Len: 965.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_E172_R4.1851.00
244_Q282_D3.4081.00
106_N170_N3.3131.00
98_P175_A3.2321.00
68_A73_E2.9691.00
68_A74_A2.8041.00
148_T169_R2.7971.00
20_S23_A2.7431.00
59_E63_E2.6821.00
237_K286_V2.6641.00
108_S167_S2.5591.00
99_D172_R2.5451.00
208_R249_Q2.3121.00
216_E220_D2.2371.00
108_S165_E2.1171.00
136_R178_R2.1161.00
99_D104_V2.0861.00
121_A142_T2.0341.00
183_E186_K1.9851.00
298_T303_M1.9561.00
303_M307_A1.9181.00
233_M236_D1.8841.00
211_F245_I1.8741.00
227_P230_G1.8731.00
125_A138_F1.8581.00
150_N167_S1.8551.00
59_E62_K1.8431.00
148_T167_S1.8401.00
226_Q230_G1.8041.00
222_E227_P1.8001.00
33_A212_E1.7831.00
29_Q249_Q1.7731.00
77_C121_A1.7571.00
104_V170_N1.7461.00
58_S61_Q1.7451.00
104_V172_R1.7401.00
248_S276_N1.7361.00
258_L268_H1.7351.00
99_D102_E1.7271.00
278_R319_H1.7231.00
254_R258_L1.7161.00
115_S164_G1.6971.00
12_D18_N1.6901.00
213_T301_P1.6901.00
218_A290_M1.6701.00
282_D286_V1.6561.00
97_E106_N1.6421.00
103_Y138_F1.6411.00
257_G261_R1.6231.00
281_R313_Y1.6161.00
30_E33_A1.6051.00
208_R212_E1.5991.00
144_R171_V1.5941.00
116_P164_G1.5931.00
150_N165_E1.5911.00
64_R176_E1.5911.00
22_T257_G1.5811.00
64_R68_A1.5781.00
141_E177_S1.5621.00
210_C284_A1.5611.00
241_M283_Q1.5601.00
247_T275_N1.5451.00
63_E67_P1.5321.00
294_N300_Y1.5321.00
128_H131_D1.5301.00
215_R219_T1.5201.00
209_N213_T1.5031.00
213_T216_E1.4921.00
154_E298_T1.4751.00
101_D175_A1.4711.00
214_A287_A1.4651.00
218_A234_Q1.4611.00
98_P102_E1.4471.00
60_A64_R1.4441.00
141_E144_R1.4431.00
67_P71_A1.4371.00
68_A71_A1.4371.00
174_P177_S1.4361.00
242_A246_T1.4351.00
98_P182_V1.4291.00
33_A208_R1.4221.00
234_Q290_M1.4131.00
106_N169_R1.4131.00
56_F190_S1.3991.00
175_A178_R1.3951.00
207_A245_I1.3941.00
29_Q208_R1.3911.00
207_A283_Q1.3811.00
84_E93_E1.3751.00
241_M286_V1.3751.00
103_Y175_A1.3601.00
285_R310_E1.3531.00
223_Q231_F1.3481.00
74_A119_D1.3381.00
281_R285_R1.3371.00
178_R182_V1.3371.00
246_T254_R1.3221.00
14_Y62_K1.3221.00
226_Q231_F1.3221.00
21_E260_E1.3131.00
244_Q279_M1.3051.00
35_D38_L1.3031.00
98_P103_Y1.2961.00
254_R257_G1.2921.00
96_A138_F1.2881.00
19_V23_A1.2861.00
127_D136_R1.2851.00
144_R177_S1.2851.00
25_G256_A1.2741.00
124_W137_G1.2721.00
193_T266_P1.2701.00
79_G112_I1.2661.00
9_P27_L1.2631.00
55_A190_S1.2611.00
60_A176_E1.2611.00
280_A309_M1.2571.00
29_Q253_H1.2481.00
213_T291_L1.2431.00
102_E175_A1.2431.00
82_E109_K1.2391.00
142_T149_T1.2291.00
244_Q286_V1.2261.00
258_L263_D1.2221.00
173_V177_S1.2151.00
64_R177_S1.2111.00
209_N305_H1.2081.00
97_E104_V1.2061.00
248_S279_M1.2021.00
211_F215_R1.2011.00
81_T111_W1.2001.00
25_G201_W1.1971.00
142_T147_V1.1931.00
240_E323_T1.1901.00
65_W120_V1.1861.00
274_R319_H1.1811.00
287_A302_P1.1781.00
285_R313_Y1.1651.00
250_L254_R1.1651.00
76_G120_V1.1641.00
62_K66_L1.1631.00
79_G121_A1.1511.00
11_L70_G1.1471.00
201_W252_A1.1451.00
123_V140_V1.1441.00
69_L76_G1.1391.00
124_W135_V1.1391.00
219_T229_G1.1261.00
310_E313_Y1.1201.00
279_M282_D1.1201.00
20_S260_E1.1201.00
237_K320_D1.1181.00
105_L138_F1.1171.00
96_A125_A1.1061.00
274_R323_T1.0991.00
245_I283_Q1.0951.00
278_R282_D1.0951.00
49_V76_G1.0891.00
240_E244_Q1.0871.00
56_F187_G1.0731.00
215_R238_L1.0711.00
218_A229_G1.0681.00
270_S322_H1.0671.00
281_R306_M1.0601.00
61_Q65_W1.0571.00
95_T106_N1.0531.00
288_R306_M1.0531.00
10_N24_Y1.0511.00
147_V171_V1.0501.00
123_V168_L1.0491.00
26_L30_E1.0451.00
79_G168_L1.0401.00
120_V141_E1.0371.00
110_T165_E1.0371.00
57_G61_Q1.0361.00
60_A63_E1.0331.00
22_T260_E1.0331.00
88_N91_A1.0231.00
13_G63_E1.0201.00
203_A312_V1.0171.00
74_A120_V1.0161.00
195_A316_E1.0151.00
284_A309_M1.0121.00
22_T253_H1.0051.00
97_E170_N1.0001.00
26_L253_H0.9981.00
185_M189_L0.9961.00
121_A147_V0.9961.00
22_T26_L0.9931.00
11_L50_M0.9921.00
255_L272_A0.9901.00
240_E286_V0.9881.00
204_V252_A0.9861.00
204_V245_I0.9801.00
61_Q177_S0.9771.00
206_A280_A0.9741.00
242_A271_M0.9691.00
103_Y127_D0.9681.00
94_T105_L0.9661.00
32_E39_R0.9611.00
313_Y319_H0.9591.00
236_D240_E0.9591.00
267_Q329_D0.9551.00
122_V137_G0.9541.00
64_R141_E0.9531.00
102_E174_P0.9501.00
156_L306_M0.9301.00
146_G171_V0.9291.00
172_R175_A0.9291.00
105_L173_V0.9251.00
101_D172_R0.9221.00
138_F178_R0.9221.00
204_V248_S0.9211.00
206_A305_H0.9191.00
119_D143_D0.9171.00
136_R182_V0.9161.00
244_Q275_N0.9161.00
126_R135_V0.9081.00
218_A228_I0.9081.00
306_M310_E0.9031.00
145_D172_R0.9021.00
265_R268_H0.9001.00
121_A166_I0.8951.00
243_T271_M0.8951.00
237_K240_E0.8931.00
97_E128_H0.8881.00
311_T315_Y0.8871.00
237_K289_E0.8871.00
218_A238_L0.8861.00
149_T166_I0.8821.00
285_R306_M0.8791.00
37_G160_A0.8771.00
282_D285_R0.8741.00
105_L125_A0.8741.00
275_N279_M0.8681.00
158_L311_T0.8651.00
116_P162_I0.8651.00
312_V315_Y0.8621.00
159_R298_T0.8601.00
281_R310_E0.8601.00
278_R323_T0.8551.00
120_V139_L0.8551.00
236_D324_L0.8531.00
240_E282_D0.8531.00
277_V319_H0.8491.00
105_L123_V0.8481.00
49_V122_V0.8421.00
13_G59_E0.8411.00
168_L171_V0.8401.00
95_T128_H0.8311.00
115_S149_T0.8311.00
284_A305_H0.8301.00
251_L272_A0.8291.00
319_H323_T0.8251.00
138_F173_V0.8241.00
211_F242_A0.8231.00
235_Q324_L0.8231.00
216_E219_T0.8221.00
210_C287_A0.8201.00
147_V166_I0.8181.00
210_C305_H0.8161.00
103_Y182_V0.8151.00
212_E216_E0.8151.00
61_Q139_L0.8111.00
213_T305_H0.8091.00
119_D142_T0.8071.00
77_C118_A0.8071.00
92_M124_W0.8061.00
200_A272_A0.8031.00
9_P19_V0.8031.00
214_A290_M0.8021.00
156_L303_M0.8021.00
246_T249_Q0.7951.00
50_M69_L0.7921.00
178_R181_G0.7881.00
207_A279_M0.7861.00
217_Y294_N0.7841.00
199_I316_E0.7811.00
14_Y59_E0.7811.00
246_T250_L0.7811.00
278_R313_Y0.7801.00
58_S62_K0.7791.00
96_A127_D0.7761.00
103_Y178_R0.7721.00
243_T275_N0.7721.00
111_W297_T0.7711.00
214_A291_L0.7701.00
111_W294_N0.7691.00
243_T274_R0.7671.00
144_R147_V0.7641.00
96_A103_Y0.7631.00
117_I162_I0.7631.00
211_F330_L0.7591.00
232_Q236_D0.7581.00
284_A306_M0.7531.00
208_R242_A0.7531.00
100_G172_R0.7531.00
247_T251_L0.7521.00
11_L14_Y0.7511.00
13_G62_K0.7501.00
80_L192_L0.7481.00
207_A248_S0.7461.00
237_K290_M0.7441.00
254_R268_H0.7421.00
235_Q327_G0.7421.00
241_M287_A0.7411.00
288_R302_P0.7401.00
51_Y55_A0.7401.00
126_R129_G0.7331.00
244_Q247_T0.7321.00
200_A252_A0.7291.00
249_Q253_H0.7281.00
33_A209_N0.7221.00
64_R67_P0.7221.00
251_L271_M0.7181.00
51_Y54_H0.7151.00
231_F235_Q0.7151.00
209_N212_E0.7141.00
200_A276_N0.7141.00
126_R134_P0.7131.00
95_T129_G0.7111.00
108_S150_N0.7111.00
65_W139_L0.7101.00
183_E187_G0.7081.00
127_D134_P0.7051.00
94_T109_K0.7021.00
79_G166_I0.7001.00
322_H325_I0.7001.00
158_L315_Y0.6961.00
26_L29_Q0.6941.00
128_H134_P0.6921.00
186_K190_S0.6901.00
54_H62_K0.6901.00
79_G123_V0.6901.00
92_M135_V0.6901.00
208_R245_I0.6901.00
244_Q278_R0.6891.00
288_R295_G0.6891.00
112_I166_I0.6871.00
203_A277_V0.6871.00
65_W177_S0.6871.00
57_G62_K0.6861.00
324_L328_E0.6851.00
8_A17_P0.6821.00
251_L275_N0.6811.00
206_A309_M0.6811.00
228_I231_F0.6751.00
279_M283_Q0.6721.00
87_S321_I0.6721.00
140_V168_L0.6701.00
13_G18_N0.6701.00
248_S275_N0.6691.00
102_E176_E0.6681.00
281_R309_M0.6671.00
126_R131_D0.6671.00
52_P56_F0.6661.00
256_A260_E0.6651.00
304_R308_N0.6641.00
252_A276_N0.6641.00
83_P108_S0.6631.00
214_A241_M0.6611.00
214_A218_A0.6581.00
291_L302_P0.6551.00
154_E159_R0.6531.00
8_A70_G0.6521.00
52_P191_C0.6501.00
318_T321_I0.6481.00
77_C142_T0.6451.00
149_T164_G0.6441.00
21_E259_K0.6431.00
128_H132_G0.6431.00
124_W188_P0.6431.00
30_E34_C0.6421.00
94_T107_G0.6411.00
246_T251_L0.6381.00
284_A302_P0.6321.00
78_F188_P0.6291.00
204_V208_R0.6271.00
24_Y198_G0.6221.00
301_P305_H0.6221.00
12_D15_G0.6211.00
143_D147_V0.6191.00
82_E94_T0.6161.00
101_D176_E0.6141.00
194_Q259_K0.6131.00
228_I234_Q0.6121.00
94_T123_V0.6121.00
136_R180_P0.6091.00
197_Y252_A0.6081.00
69_L120_V0.6081.00
242_A330_L0.6081.00
80_L89_P0.6061.00
240_E278_R0.6051.00
152_I165_E0.6051.00
223_Q228_I0.6041.00
233_M237_K0.6021.00
40_S158_L0.6011.00
85_H93_E0.5991.00
140_V171_V0.5951.00
24_Y47_A0.5941.00
80_L124_W0.5931.00
61_Q64_R0.5931.00
122_V179_L0.5921.00
157_S308_N0.5921.00
151_E164_G0.5881.00
207_A280_A0.5861.00
243_T247_T0.5851.00
251_L255_L0.5851.00
147_V168_L0.5831.00
92_M126_R0.5821.00
207_A210_C0.5821.00
127_D182_V0.5811.00
11_L54_H0.5811.00
193_T269_V0.5811.00
13_G16_L0.5791.00
143_D146_G0.5791.00
197_Y256_A0.5781.00
94_T125_A0.5771.00
231_F234_Q0.5721.00
209_N301_P0.5711.00
53_I57_G0.5711.00
234_Q237_K0.5691.00
294_N297_T0.5691.00
36_S206_A0.5671.00
271_M326_L0.5671.00
211_F241_M0.5661.00
25_G253_H0.5591.00
130_E134_P0.5581.00
75_V117_I0.5571.00
55_A194_Q0.5551.00
49_V52_P0.5551.00
224_F231_F0.5541.00
156_L307_A0.5541.00
247_T250_L0.5541.00
180_P183_E0.5541.00
234_Q238_L0.5531.00
50_M66_L0.5531.00
65_W68_A0.5521.00
280_A284_A0.5521.00
120_V177_S0.5501.00
221_R224_F0.5471.00
98_P101_D0.5471.00
197_Y259_K0.5471.00
175_A182_V0.5461.00
65_W74_A0.5431.00
105_L140_V0.5421.00
94_T168_L0.5421.00
98_P104_V0.5401.00
274_R278_R0.5371.00
301_P304_R0.5351.00
266_P329_D0.5341.00
274_R322_H0.5331.00
240_E243_T0.5321.00
244_Q283_Q0.5321.00
201_W205_G0.5311.00
14_Y63_E0.5311.00
155_K163_T0.5311.00
293_G296_I0.5301.00
277_V312_V0.5301.00
27_L31_L0.5271.00
127_D138_F0.5251.00
246_T271_M0.5251.00
289_E310_E0.5251.00
244_Q248_S0.5251.00
116_P149_T0.5241.00
100_G104_V0.5221.00
211_F238_L0.5211.00
210_C214_A0.5201.00
115_S166_I0.5201.00
99_D175_A0.5181.00
310_E314_T0.5161.00
213_T302_P0.5151.00
6_F27_L0.5131.00
222_E230_G0.5121.00
41_M44_V0.5091.00
25_G197_Y0.5091.00
129_G132_G0.5091.00
125_A136_R0.5091.00
285_R289_E0.5081.00
270_S325_I0.5081.00
25_G252_A0.5081.00
14_Y66_L0.5071.00
28_M32_E0.5051.00
24_Y28_M0.5051.00
89_P92_M0.5041.00
83_P110_T0.5041.00
79_G109_K0.5041.00
217_Y220_D0.5031.00
217_Y300_Y0.5031.00
192_L196_R0.5021.00
222_E225_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ix5A 4 0.9941 100 0.095 Contact Map
3sf6A 4 0.9881 100 0.107 Contact Map
3swoA 4 0.9881 100 0.109 Contact Map
3ii9A 4 0.997 100 0.11 Contact Map
1siqA 4 0.9911 100 0.113 Contact Map
4w9uA 4 0.9763 100 0.116 Contact Map
2ebaA 4 0.9733 100 0.116 Contact Map
1ivhA 4 0.9881 100 0.121 Contact Map
2jifA 4 0.9881 100 0.123 Contact Map
2d29A 4 0.9911 100 0.124 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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