GREMLIN Database
Q9HMK6 - Uncharacterized protein
UniProt: Q9HMK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (185)
Sequences: 11035 (7421)
Seq/√Len: 545.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_A139_V3.2921.00
101_E140_T3.0321.00
99_T141_E2.7921.00
92_L165_V2.6081.00
59_Y94_E2.5131.00
149_L160_R2.4501.00
93_A159_F2.4391.00
119_D160_R2.3921.00
148_L156_I2.3761.00
147_T160_R2.3401.00
99_T140_T2.2711.00
126_P178_A2.2411.00
23_R50_V2.2371.00
25_E180_R2.2341.00
69_C94_E2.1971.00
178_A181_I2.1851.00
112_T128_S2.1551.00
69_C95_A2.0701.00
73_E95_A1.9811.00
51_V68_L1.9721.00
150_A158_A1.9311.00
8_L20_R1.9131.00
147_T162_G1.9031.00
31_V46_F1.8351.00
148_L151_E1.8171.00
93_A98_G1.7841.00
116_V151_E1.7801.00
72_V91_V1.7751.00
161_V164_S1.7401.00
114_E128_S1.7361.00
139_V159_F1.7331.00
48_G188_S1.7111.00
89_H166_G1.6831.00
129_M178_A1.6751.00
112_T130_T1.6711.00
122_F158_A1.6391.00
130_T177_T1.6311.00
39_R42_G1.6291.00
70_D73_E1.6031.00
181_I184_E1.6031.00
114_E151_E1.5701.00
6_I48_G1.5691.00
19_A85_V1.5511.00
57_S60_W1.5181.00
73_E77_A1.5001.00
33_F38_G1.4851.00
54_S87_F1.4841.00
22_F180_R1.4741.00
93_A143_P1.4701.00
7_A33_F1.4361.00
125_L129_M1.4311.00
89_H139_V1.4141.00
142_L148_L1.4061.00
159_F166_G1.3951.00
5_R44_T1.3911.00
111_R132_F1.3841.00
119_D149_L1.3841.00
123_E186_D1.3191.00
34_H37_G1.3111.00
20_R24_R1.2941.00
89_H159_F1.2891.00
96_L165_V1.2841.00
49_V71_Y1.2791.00
74_D78_A1.2781.00
83_L167_V1.2641.00
92_L166_G1.2531.00
149_L158_A1.2451.00
117_A147_T1.2441.00
58_V94_E1.2391.00
146_A159_F1.2261.00
38_G43_H1.2151.00
142_L156_I1.2101.00
59_Y137_D1.2061.00
5_R31_V1.1931.00
70_D74_D1.1851.00
129_M182_A1.1771.00
5_R47_D1.1681.00
146_A161_V1.1661.00
85_V167_V1.1621.00
56_S60_W1.1571.00
11_A51_V1.1341.00
101_E138_V1.1251.00
151_E155_G1.1001.00
69_C73_E1.0901.00
31_V44_T1.0871.00
57_S137_D1.0851.00
120_P160_R1.0821.00
132_F175_T1.0791.00
106_F136_G1.0701.00
72_V82_V1.0691.00
38_G41_P1.0611.00
49_V80_V1.0601.00
19_A183_T1.0601.00
98_G143_P1.0581.00
145_A162_G1.0571.00
69_C91_V1.0521.00
145_A163_Q1.0321.00
122_F169_F1.0231.00
117_A149_L1.0081.00
126_P129_M1.0051.00
186_D189_E1.0021.00
38_G42_G1.0001.00
74_D77_A0.9861.00
40_V43_H0.9771.00
103_M138_V0.9761.00
145_A161_V0.9751.00
21_N24_R0.9721.00
107_E152_N0.9411.00
50_V83_L0.9391.00
11_A35_A0.9371.00
111_R130_T0.8941.00
12_A36_K0.8901.00
113_V130_T0.8881.00
102_D106_F0.8871.00
41_P74_D0.8831.00
22_F25_E0.8751.00
75_V80_V0.8711.00
46_F80_V0.8691.00
27_D30_L0.8481.00
48_G81_P0.8471.00
113_V150_A0.8421.00
118_D127_E0.8401.00
189_E193_D0.8301.00
38_G44_T0.8291.00
126_P177_T0.8241.00
86_C90_Q0.8181.00
119_D147_T0.8151.00
43_H46_F0.8131.00
82_V92_L0.8131.00
102_D105_G0.8111.00
98_G141_E0.8101.00
8_L23_R0.8081.00
8_L50_V0.8031.00
39_R43_H0.8011.00
49_V82_V0.8011.00
77_A165_V0.7941.00
5_R29_E0.7871.00
101_E141_E0.7861.00
17_E20_R0.7831.00
12_A34_H0.7821.00
16_G32_E0.7751.00
76_H96_L0.7751.00
169_F182_A0.7721.00
187_V190_A0.7701.00
96_L161_V0.7701.00
23_R28_A0.7641.00
186_D190_A0.7621.00
100_V137_D0.7611.00
68_L91_V0.7601.00
143_P159_F0.7581.00
86_C170_H0.7571.00
189_E192_R0.7541.00
114_E153_D0.7541.00
125_L178_A0.7491.00
115_R127_E0.7451.00
188_S192_R0.7431.00
47_D190_A0.7361.00
131_A176_E0.7351.00
71_Y76_H0.7341.00
21_N25_E0.7311.00
114_E131_A0.7281.00
111_R133_T0.7271.00
59_Y69_C0.7201.00
26_L183_T0.7191.00
37_G40_V0.7181.00
56_S59_Y0.7171.00
179_E183_T0.7161.00
26_L180_R0.7141.00
108_L134_T0.7131.00
70_D95_A0.7101.00
110_Y132_F0.7061.00
72_V92_L0.7051.00
138_V155_G0.6961.00
7_A43_H0.6911.00
71_Y91_V0.6901.00
57_S102_D0.6881.00
72_V95_A0.6841.00
125_L181_I0.6811.00
90_Q168_Q0.6811.00
105_G154_Y0.6781.00
19_A52_T0.6781.00
133_T157_H0.6761.00
113_V128_S0.6761.00
6_I28_A0.6751.00
51_V82_V0.6751.00
107_E157_H0.6751.00
61_D69_C0.6731.00
167_V171_P0.6681.00
117_A160_R0.6661.00
76_H82_V0.6651.00
92_L164_S0.6611.00
108_L136_G0.6551.00
24_R30_L0.6511.00
98_G139_V0.6511.00
94_E99_T0.6501.00
141_E144_A0.6451.00
49_V75_V0.6411.00
177_T180_R0.6381.00
113_V153_D0.6361.00
188_S191_R0.6351.00
84_G88_G0.6311.00
187_V192_R0.6311.00
7_A10_N0.6281.00
6_I23_R0.6271.00
175_T179_E0.6251.00
20_R32_E0.6241.00
186_D191_R0.6231.00
115_R153_D0.6221.00
26_L184_E0.6211.00
180_R184_E0.6211.00
112_T115_R0.6201.00
115_R128_S0.6201.00
114_E127_E0.6181.00
36_K40_V0.6131.00
33_F42_G0.6131.00
94_E100_V0.6101.00
22_F183_T0.6061.00
10_N16_G0.6001.00
63_P70_D0.5961.00
77_A96_L0.5961.00
131_A169_F0.5911.00
96_L146_A0.5901.00
181_I185_K0.5881.00
19_A23_R0.5881.00
63_P71_Y0.5881.00
187_V191_R0.5871.00
116_V120_P0.5851.00
115_R151_E0.5830.99
89_H93_A0.5820.99
122_F150_A0.5820.99
37_G41_P0.5800.99
103_M106_F0.5770.99
76_H92_L0.5710.99
138_V156_I0.5690.99
7_A38_G0.5690.99
142_L146_A0.5640.99
36_K41_P0.5630.99
104_S138_V0.5600.99
91_V95_A0.5570.99
132_F173_Y0.5550.99
107_E110_Y0.5550.99
7_A46_F0.5510.99
107_E135_H0.5500.99
36_K39_R0.5490.99
118_D123_E0.5470.99
156_I159_F0.5440.99
35_A62_E0.5430.99
125_L185_K0.5420.99
44_T80_V0.5400.99
60_W63_P0.5390.99
33_F37_G0.5380.99
115_R129_M0.5350.99
57_S94_E0.5350.99
190_A193_D0.5340.99
113_V169_F0.5330.99
8_L16_G0.5330.99
84_G92_L0.5330.99
184_E192_R0.5320.99
74_D79_G0.5310.99
124_G181_I0.5310.99
16_G52_T0.5250.99
112_T116_V0.5220.99
113_V131_A0.5190.99
119_D122_F0.5160.99
178_A182_A0.5150.99
23_R183_T0.5150.99
28_A48_G0.5140.99
52_T136_G0.5110.99
5_R46_F0.5100.99
75_V82_V0.5080.99
116_V128_S0.5070.99
129_M177_T0.5040.99
117_A151_E0.5030.99
40_V63_P0.5030.99
20_R30_L0.5020.98
43_H71_Y0.5020.98
5_R45_E0.5000.98
120_P164_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m3pA 1 0.987 100 0.366 Contact Map
1o1yA 2 0.9524 100 0.377 Contact Map
3tqiA 3 0.9134 100 0.385 Contact Map
1gpmA 3 0.974 100 0.387 Contact Map
3l7nA 1 0.9524 100 0.393 Contact Map
3uowA 2 0.974 100 0.399 Contact Map
2ywbA 4 0.9351 100 0.406 Contact Map
2vxoA 2 0.9567 100 0.409 Contact Map
3r75A 2 0.8268 100 0.427 Contact Map
2vpiA 1 0.7706 100 0.445 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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