Q9HMK5 - HALSA - GREMLIN Contacts

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Q9HMK5 - Uncharacterized protein

UniProt:	Q9HMK5	Sequences: MRAIKDSVHDYIEADGVAAALLDTEPVQRLRHIKQLSTIRLVYPSANHTRFEHSLGVYHLADRALAHLDISGTRADTVRAAALLHDIGHGPYGHQTEGIIQRRLDRHHDDVAHLVSNGEPGAVLAAHGLDPDRVAALVAGHGKLGQLVAGELDVDRMDYLVRDAHHTGVPYGTIDHGRLLRALTFRDGDLVLAEGNVATAESVLVGRALMNATVYRHHVSRIAGAMLDRASARLLDTTDLDAETFARFTDADLLAVLRDCPATQDAARRIRNRDLYKRAVWTERDAVPDDVATADYRTVRDLESQVADAAGVPATAVVIDTPGAPSMPESSVRVTVNGDTRRLDEQSPLVDGMLASQRAQWRFGVYTPDDHVPAVAAAAERTLGLGPIDDPPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	393 (360)
Sequences:	1358 (973)
Seq/√Len:	51.3

BACSU - YWFO YDHJ
HALSA - Q9HMK5 Q9HPP4 Q9HSK2
SULSO - Q97U95 Q97XC0 Q7LXZ1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_A	79_R	4.090	1.00
117_N	135_A	3.998	1.00
160_L	210_M	3.883	1.00
64_A	154_V	3.633	1.00
28_Q	31_R	3.613	1.00
230_A	267_A	3.430	1.00
62_D	79_R	3.362	1.00
21_L	80_A	3.284	1.00
32_H	249_T	3.237	1.00
84_L	87_I	3.136	1.00
24_T	123_V	3.063	1.00
265_D	269_R	2.982	1.00
110_D	114_L	2.921	1.00
183_L	192_L	2.808	1.00
31_R	51_F	2.795	1.00
7_S	45_S	2.775	1.00
269_R	274_D	2.733	1.00
233_R	262_A	2.686	1.00
66_A	75_A	2.607	1.00
178_R	217_H	2.588	1.00
60_L	154_V	2.556	1.00
39_I	220_S	2.476	1.00
210_M	215_Y	2.427	1.00
61_A	82_A	2.422	1.00
61_A	78_V	2.357	1.00
119_E	123_V	2.176	1.00
25_E	119_E	2.167	1.00
4_I	14_A	2.121	1.00
263_T	266_A	2.091	1.00
119_E	124_L	2.076	1.00
223_A	275_L	1.992	1.00
20_A	126_A	1.972	1.00
18_A	58_Y	1.964	1.00
210_M	214_V	1.963	1.00
89_H	109_D	1.921	0.99
90_G	96_T	1.910	0.99
4_I	44_P	1.861	0.99
241_D	244_T	1.853	0.99
78_V	144_L	1.848	0.99
230_A	257_L	1.842	0.99
226_M	276_Y	1.840	0.99
307_A	311_G	1.832	0.99
178_R	273_R	1.832	0.99
273_R	277_K	1.815	0.99
21_L	84_L	1.774	0.99
312_V	319_I	1.760	0.99
121_G	125_A	1.760	0.99
132_D	136_A	1.720	0.99
92_Y	254_L	1.702	0.99
120_P	124_L	1.694	0.99
160_L	206_G	1.692	0.99
7_S	165_H	1.664	0.98
41_L	223_A	1.664	0.98
226_M	275_L	1.661	0.98
85_H	155_D	1.639	0.98
85_H	108_H	1.615	0.98
314_A	319_I	1.608	0.98
8_V	165_H	1.580	0.98
22_L	27_V	1.577	0.98
84_L	116_S	1.572	0.98
58_Y	79_R	1.571	0.98
9_H	161_V	1.548	0.97
196_N	199_T	1.535	0.97
23_D	31_R	1.530	0.97
120_P	123_V	1.514	0.97
295_D	299_V	1.504	0.97
192_L	200_A	1.502	0.97
86_D	155_D	1.493	0.97
5_K	11_Y	1.485	0.97
315_T	319_I	1.460	0.96
303_E	307_A	1.458	0.96
24_T	27_V	1.452	0.96
138_V	143_K	1.452	0.96
64_A	183_L	1.443	0.96
108_H	155_D	1.435	0.96
57_V	154_V	1.434	0.96
316_A	319_I	1.434	0.96
134_V	140_G	1.422	0.96
153_D	156_R	1.420	0.96
2_R	19_A	1.419	0.96
94_H	155_D	1.412	0.95
8_V	12_I	1.405	0.95
161_V	176_H	1.395	0.95
125_A	131_P	1.394	0.95
217_H	273_R	1.389	0.95
28_Q	92_Y	1.387	0.95
61_A	147_L	1.374	0.95
171_Y	210_M	1.372	0.95
109_D	155_D	1.363	0.95
264_Q	268_R	1.361	0.94
317_V	323_G	1.355	0.94
135_A	138_V	1.354	0.94
57_V	82_A	1.339	0.94
130_D	133_R	1.337	0.94
85_H	109_D	1.306	0.93
3_A	11_Y	1.299	0.93
78_V	148_V	1.288	0.93
219_V	273_R	1.281	0.92
261_P	272_N	1.276	0.92
50_R	53_H	1.265	0.92
140_G	143_K	1.264	0.92
244_T	247_R	1.263	0.92
134_V	138_V	1.258	0.92
89_H	108_H	1.252	0.92
46_A	167_T	1.249	0.91
298_T	302_L	1.248	0.91
355_A	358_R	1.241	0.91
39_I	43_Y	1.240	0.91
157_M	174_I	1.235	0.91
87_I	112_A	1.228	0.91
319_I	322_P	1.228	0.91
221_R	320_D	1.227	0.91
115_V	246_A	1.223	0.91
14_A	19_A	1.218	0.90
131_P	135_A	1.206	0.90
28_Q	51_F	1.205	0.90
167_T	214_V	1.204	0.90
26_P	118_G	1.204	0.90
134_V	137_L	1.201	0.90
169_V	172_G	1.200	0.90
109_D	112_A	1.200	0.90
114_L	118_G	1.191	0.89
317_V	320_D	1.190	0.89
341_R	346_Q	1.185	0.89
230_A	270_I	1.179	0.89
136_A	141_H	1.175	0.89
37_S	93_G	1.174	0.89
40_R	49_T	1.170	0.89
93_G	156_R	1.169	0.89
281_W	364_G	1.168	0.88
219_V	277_K	1.166	0.88
65_L	79_R	1.165	0.88
4_I	8_V	1.160	0.88
5_K	208_A	1.159	0.88
16_G	20_A	1.155	0.88
316_A	322_P	1.151	0.88
174_I	204_L	1.151	0.88
229_R	232_A	1.146	0.88
59_H	63_R	1.144	0.87
47_N	52_E	1.131	0.87
299_V	303_E	1.131	0.87
88_G	93_G	1.130	0.87
145_G	148_V	1.123	0.86
113_H	139_A	1.122	0.86
10_D	177_G	1.122	0.86
51_F	178_R	1.119	0.86
118_G	122_A	1.116	0.86
15_D	76_D	1.116	0.86
230_A	266_A	1.110	0.86
169_V	210_M	1.104	0.85
226_M	230_A	1.099	0.85
206_G	210_M	1.094	0.85
348_P	357_Q	1.093	0.85
124_L	127_H	1.088	0.85
19_A	23_D	1.082	0.84
314_A	317_V	1.081	0.84
316_A	324_A	1.078	0.84
133_R	142_G	1.075	0.84
50_R	56_G	1.075	0.84
6_D	9_H	1.075	0.84
95_Q	220_S	1.071	0.84
67_H	176_H	1.070	0.84
149_A	153_D	1.070	0.84
327_M	330_S	1.064	0.83
23_D	28_Q	1.063	0.83
316_A	321_T	1.063	0.83
63_R	177_G	1.059	0.83
226_M	266_A	1.058	0.83
86_D	108_H	1.057	0.83
269_R	276_Y	1.051	0.83
85_H	89_H	1.050	0.82
134_V	143_K	1.043	0.82
160_L	214_V	1.042	0.82
268_R	274_D	1.033	0.81
132_D	268_R	1.031	0.81
52_E	166_H	1.031	0.81
66_A	73_T	1.028	0.81
115_V	242_A	1.025	0.81
87_I	120_P	1.023	0.81
172_G	210_M	1.022	0.81
99_I	115_V	1.021	0.81
171_Y	208_A	1.017	0.80
53_H	56_G	1.017	0.80
31_R	41_L	1.015	0.80
222_I	276_Y	1.013	0.80
7_S	168_G	1.011	0.80
172_G	201_E	1.011	0.80
141_H	274_D	1.009	0.80
35_Q	48_H	1.008	0.80
67_H	180_L	1.004	0.80
136_A	143_K	1.003	0.79
156_R	207_R	0.993	0.79
303_E	306_V	0.990	0.79
231_S	245_F	0.986	0.78
307_A	310_A	0.983	0.78
182_A	196_N	0.975	0.77
358_R	361_W	0.975	0.77
306_V	310_A	0.974	0.77
32_H	272_N	0.973	0.77
235_L	238_T	0.970	0.77
211_N	216_R	0.965	0.77
21_L	120_P	0.965	0.77
362_R	365_V	0.963	0.77
37_S	153_D	0.962	0.77
339_D	345_E	0.960	0.76
315_T	318_V	0.957	0.76
60_L	176_H	0.956	0.76
68_L	91_P	0.954	0.76
67_H	181_R	0.950	0.76
318_V	324_A	0.949	0.76
51_F	217_H	0.947	0.75
358_R	363_F	0.945	0.75
14_A	18_A	0.943	0.75
144_L	148_V	0.933	0.74
23_D	217_H	0.925	0.74
71_S	74_R	0.924	0.74
59_H	62_D	0.921	0.73
94_H	108_H	0.919	0.73
161_V	165_H	0.918	0.73
87_I	116_S	0.918	0.73
44_P	47_N	0.917	0.73
94_H	109_D	0.915	0.73
299_V	302_L	0.914	0.73
63_R	66_A	0.913	0.73
218_H	278_R	0.912	0.73
120_P	127_H	0.909	0.72
230_A	263_T	0.906	0.72
296_Y	299_V	0.906	0.72
156_R	205_V	0.906	0.72
298_T	301_D	0.903	0.72
43_Y	170_P	0.900	0.72
130_D	138_V	0.898	0.71
37_S	224_G	0.895	0.71
319_I	324_A	0.894	0.71
37_S	220_S	0.893	0.71
38_T	227_L	0.893	0.71
93_G	224_G	0.893	0.71
89_H	155_D	0.892	0.71
42_V	334_V	0.890	0.71
13_E	181_R	0.888	0.71
157_M	161_V	0.888	0.71
77_T	81_A	0.886	0.70
160_L	164_A	0.883	0.70
73_T	133_R	0.883	0.70
321_T	324_A	0.881	0.70
97_E	201_E	0.878	0.70
136_A	145_G	0.875	0.69
301_D	306_V	0.874	0.69
86_D	94_H	0.873	0.69
297_R	302_L	0.869	0.69
26_P	82_A	0.869	0.69
45_S	166_H	0.866	0.69
350_V	353_M	0.865	0.69
16_G	80_A	0.861	0.68
156_R	204_L	0.860	0.68
93_G	207_R	0.855	0.68
111_V	245_F	0.854	0.68
345_E	351_D	0.850	0.67
36_L	167_T	0.848	0.67
89_H	159_Y	0.845	0.67
7_S	166_H	0.842	0.66
37_S	159_Y	0.839	0.66
42_V	78_V	0.837	0.66
44_P	48_H	0.835	0.66
343_L	347_S	0.834	0.66
234_L	260_C	0.828	0.65
2_R	10_D	0.824	0.65
301_D	307_A	0.823	0.65
336_V	341_R	0.821	0.64
38_T	224_G	0.820	0.64
292_A	301_D	0.819	0.64
32_H	251_A	0.817	0.64
359_A	362_R	0.814	0.64
262_A	265_D	0.812	0.64
90_G	245_F	0.801	0.63
42_V	111_V	0.800	0.62
205_V	209_L	0.800	0.62
90_G	248_F	0.800	0.62
14_A	58_Y	0.799	0.62
18_A	80_A	0.797	0.62
44_P	52_E	0.795	0.62
347_S	351_D	0.792	0.62
8_V	142_G	0.786	0.61
95_Q	224_G	0.783	0.61
184_T	191_V	0.782	0.61
354_L	361_W	0.777	0.60
52_E	178_R	0.777	0.60
231_S	317_V	0.774	0.60
61_A	154_V	0.774	0.60
15_D	18_A	0.773	0.60
303_E	308_D	0.772	0.60
268_R	272_N	0.769	0.59
18_A	62_D	0.765	0.59
336_V	339_D	0.763	0.59
314_A	318_V	0.762	0.59
314_A	322_P	0.757	0.58
194_E	336_V	0.750	0.57
3_A	181_R	0.749	0.57
212_A	249_T	0.749	0.57
135_A	175_D	0.746	0.57
158_D	162_R	0.746	0.57
206_G	334_V	0.741	0.57
65_L	75_A	0.741	0.57
342_R	345_E	0.739	0.56
109_D	159_Y	0.739	0.56
30_L	54_S	0.739	0.56
163_D	215_Y	0.739	0.56
87_I	283_E	0.739	0.56
223_A	229_R	0.738	0.56
307_A	322_P	0.735	0.56
252_D	256_V	0.735	0.56
184_T	269_R	0.735	0.56
166_H	220_S	0.735	0.56
140_G	149_A	0.734	0.56
157_M	203_V	0.731	0.56
300_R	303_E	0.730	0.55
28_Q	217_H	0.730	0.55
220_S	224_G	0.730	0.55
354_L	359_A	0.729	0.55
85_H	94_H	0.728	0.55
39_I	67_H	0.727	0.55
42_V	46_A	0.725	0.55
303_E	309_A	0.725	0.55
308_D	311_G	0.721	0.55
70_I	74_R	0.719	0.54
9_H	31_R	0.718	0.54
201_E	210_M	0.718	0.54
86_D	109_D	0.716	0.54
77_T	133_R	0.715	0.54
97_E	205_V	0.715	0.54
307_A	319_I	0.712	0.54
130_D	136_A	0.711	0.53
93_G	159_Y	0.709	0.53
90_G	215_Y	0.706	0.53
153_D	249_T	0.705	0.53
156_R	203_V	0.703	0.53
15_D	58_Y	0.700	0.52
261_P	264_Q	0.700	0.52
126_A	302_L	0.699	0.52
90_G	151_E	0.699	0.52
8_V	45_S	0.697	0.52
75_A	79_R	0.695	0.52
49_T	82_A	0.694	0.52
328_P	358_R	0.693	0.52
87_I	345_E	0.693	0.52
48_H	163_D	0.693	0.52
348_P	353_M	0.692	0.52
332_V	336_V	0.689	0.51
91_P	254_L	0.688	0.51
40_R	254_L	0.686	0.51
319_I	323_G	0.684	0.51
147_L	263_T	0.684	0.51
343_L	349_L	0.683	0.51
297_R	303_E	0.682	0.50
42_V	51_F	0.681	0.50
299_V	304_S	0.681	0.50
356_S	363_F	0.680	0.50
117_N	132_D	0.680	0.50
178_R	196_N	0.679	0.50
108_H	112_A	0.677	0.50
30_L	35_Q	0.676	0.50
150_G	204_L	0.675	0.50
9_H	77_T	0.673	0.50
36_L	46_A	0.673	0.50
302_L	309_A	0.671	0.49
18_A	154_V	0.671	0.49
149_A	156_R	0.671	0.49
314_A	321_T	0.671	0.49
167_T	202_S	0.667	0.49
312_V	316_A	0.666	0.49
36_L	39_I	0.664	0.49
186_R	191_V	0.662	0.48
243_E	295_D	0.659	0.48
111_V	220_S	0.653	0.47
65_L	78_V	0.653	0.47
13_E	265_D	0.653	0.47
195_G	217_H	0.652	0.47
22_L	25_E	0.652	0.47
16_G	76_D	0.649	0.47
170_P	173_T	0.649	0.47
258_R	271_R	0.649	0.47
89_H	163_D	0.646	0.47
152_L	203_V	0.646	0.47
206_G	354_L	0.645	0.47
312_V	315_T	0.642	0.46
300_R	304_S	0.642	0.46
7_S	12_I	0.641	0.46
152_L	174_I	0.641	0.46
203_V	263_T	0.641	0.46
23_D	273_R	0.638	0.46
312_V	322_P	0.637	0.46
27_V	184_T	0.637	0.46
203_V	245_F	0.636	0.46
121_G	306_V	0.634	0.46
71_S	115_V	0.633	0.45
261_P	271_R	0.632	0.45
27_V	87_I	0.629	0.45
95_Q	172_G	0.628	0.45
58_Y	62_D	0.626	0.45
306_V	315_T	0.626	0.45
71_S	140_G	0.623	0.44
9_H	207_R	0.623	0.44
150_G	196_N	0.623	0.44
203_V	218_H	0.623	0.44
34_K	116_S	0.621	0.44
318_V	322_P	0.621	0.44
355_A	363_F	0.620	0.44
97_E	343_L	0.616	0.44
97_E	266_A	0.616	0.44
112_A	119_E	0.615	0.44
222_I	275_L	0.614	0.43
231_S	252_D	0.613	0.43
8_V	128_G	0.612	0.43
151_E	233_R	0.609	0.43
4_I	22_L	0.607	0.43
11_Y	253_L	0.606	0.43
75_A	80_A	0.606	0.43
303_E	319_I	0.605	0.43
178_R	182_A	0.605	0.43
5_K	164_A	0.605	0.43
291_V	295_D	0.603	0.42
43_Y	317_V	0.603	0.42
170_P	179_L	0.602	0.42
148_V	173_T	0.602	0.42
186_R	189_D	0.602	0.42
301_D	308_D	0.601	0.42
14_A	27_V	0.601	0.42
22_L	51_F	0.601	0.42
159_Y	163_D	0.600	0.42
198_A	213_T	0.597	0.42
123_V	127_H	0.596	0.42
198_A	208_A	0.595	0.42
241_D	289_D	0.593	0.41
201_E	205_V	0.593	0.41
283_E	288_P	0.593	0.41
172_G	196_N	0.593	0.41
14_A	55_L	0.592	0.41
304_S	308_D	0.589	0.41
94_H	159_Y	0.589	0.41
43_Y	275_L	0.588	0.41
87_I	351_D	0.587	0.41
222_I	270_I	0.584	0.40
215_Y	221_R	0.584	0.40
358_R	364_G	0.581	0.40
223_A	266_A	0.581	0.40
307_A	312_V	0.581	0.40
231_S	248_F	0.578	0.40
343_L	353_M	0.576	0.40
126_A	289_D	0.575	0.40
199_T	213_T	0.575	0.40
35_Q	163_D	0.574	0.39
160_L	169_V	0.574	0.39
44_P	82_A	0.573	0.39
315_T	325_P	0.572	0.39
23_D	277_K	0.572	0.39
11_Y	55_L	0.572	0.39
137_L	141_H	0.571	0.39
249_T	254_L	0.568	0.39
43_Y	217_H	0.567	0.39
21_L	47_N	0.566	0.39
70_I	195_G	0.565	0.39
96_T	215_Y	0.562	0.38
172_G	206_G	0.562	0.38
257_L	271_R	0.561	0.38
77_T	134_V	0.561	0.38
352_G	357_Q	0.561	0.38
122_A	125_A	0.560	0.38
302_L	307_A	0.560	0.38
54_S	79_R	0.560	0.38
165_H	169_V	0.560	0.38
209_L	213_T	0.558	0.38
63_R	176_H	0.557	0.38
114_L	117_N	0.556	0.38
214_V	273_R	0.554	0.37
45_S	193_A	0.553	0.37
154_V	216_R	0.552	0.37
147_L	267_A	0.549	0.37
27_V	83_L	0.549	0.37
115_V	245_F	0.548	0.37
22_L	214_V	0.547	0.37
284_R	288_P	0.546	0.37
59_H	123_V	0.545	0.37
303_E	350_V	0.545	0.37
27_V	276_Y	0.545	0.37
109_D	149_A	0.544	0.36
313_P	323_G	0.543	0.36
201_E	347_S	0.543	0.36
165_H	180_L	0.541	0.36
74_R	182_A	0.541	0.36
110_D	139_A	0.541	0.36
325_P	330_S	0.540	0.36
12_I	302_L	0.539	0.36
353_M	356_S	0.539	0.36
34_K	250_D	0.538	0.36
262_A	272_N	0.538	0.36
169_V	206_G	0.536	0.36
96_T	151_E	0.536	0.36
17_V	76_D	0.536	0.36
317_V	324_A	0.535	0.36
263_T	267_A	0.532	0.35
35_Q	155_D	0.531	0.35
66_A	338_G	0.531	0.35
361_W	365_V	0.531	0.35
25_E	272_N	0.530	0.35
341_R	345_E	0.530	0.35
327_M	336_V	0.530	0.35
318_V	336_V	0.529	0.35
203_V	213_T	0.528	0.35
203_V	230_A	0.527	0.35
192_L	196_N	0.527	0.35
307_A	314_A	0.525	0.35
341_R	344_D	0.523	0.34
171_Y	175_D	0.523	0.34
53_H	86_D	0.522	0.34
154_V	207_R	0.521	0.34
5_K	220_S	0.521	0.34
165_H	211_N	0.521	0.34
167_T	174_I	0.521	0.34
203_V	212_A	0.520	0.34
88_G	163_D	0.519	0.34
21_L	124_L	0.518	0.34
15_D	79_R	0.517	0.34
157_M	196_N	0.516	0.34
344_D	357_Q	0.515	0.34
44_P	218_H	0.514	0.34
78_V	154_V	0.511	0.33
311_G	314_A	0.510	0.33
25_E	243_E	0.510	0.33
193_A	250_D	0.510	0.33
198_A	212_A	0.509	0.33
329_E	332_V	0.508	0.33
183_L	196_N	0.508	0.33
43_Y	223_A	0.507	0.33
55_L	200_A	0.504	0.33
77_T	129_L	0.503	0.33
286_A	289_D	0.502	0.33
139_A	143_K	0.501	0.32
80_A	253_L	0.501	0.32
205_V	349_L	0.500	0.32
109_D	156_R	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mz7A	4	0.9873	100	0.251	Contact Map
4lrlA	4	0.9618	100	0.288	Contact Map
2hekA	4	0.9084	100	0.292	Contact Map
2q14A	4	0.8957	100	0.333	Contact Map
3bg2A	4	0.6768	100	0.732	Contact Map
2pgsA	4	0.6412	100	0.737	Contact Map
2dqbA	4	0.6718	100	0.739	Contact Map
4x9eA	4	0.6819	100	0.743	Contact Map
2pq7A	2	0.4326	98.5	0.909	Contact Map
3gw7A	2	0.4962	98.5	0.91	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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