GREMLIN Database
Q9HMK5 - Uncharacterized protein
UniProt: Q9HMK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (360)
Sequences: 1358 (973)
Seq/√Len: 51.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_A79_R4.0901.00
117_N135_A3.9981.00
160_L210_M3.8831.00
64_A154_V3.6331.00
28_Q31_R3.6131.00
230_A267_A3.4301.00
62_D79_R3.3621.00
21_L80_A3.2841.00
32_H249_T3.2371.00
84_L87_I3.1361.00
24_T123_V3.0631.00
265_D269_R2.9821.00
110_D114_L2.9211.00
183_L192_L2.8081.00
31_R51_F2.7951.00
7_S45_S2.7751.00
269_R274_D2.7331.00
233_R262_A2.6861.00
66_A75_A2.6071.00
178_R217_H2.5881.00
60_L154_V2.5561.00
39_I220_S2.4761.00
210_M215_Y2.4271.00
61_A82_A2.4221.00
61_A78_V2.3571.00
119_E123_V2.1761.00
25_E119_E2.1671.00
4_I14_A2.1211.00
263_T266_A2.0911.00
119_E124_L2.0761.00
223_A275_L1.9921.00
20_A126_A1.9721.00
18_A58_Y1.9641.00
210_M214_V1.9631.00
89_H109_D1.9210.99
90_G96_T1.9100.99
4_I44_P1.8610.99
241_D244_T1.8530.99
78_V144_L1.8480.99
230_A257_L1.8420.99
226_M276_Y1.8400.99
307_A311_G1.8320.99
178_R273_R1.8320.99
273_R277_K1.8150.99
21_L84_L1.7740.99
312_V319_I1.7600.99
121_G125_A1.7600.99
132_D136_A1.7200.99
92_Y254_L1.7020.99
120_P124_L1.6940.99
160_L206_G1.6920.99
7_S165_H1.6640.98
41_L223_A1.6640.98
226_M275_L1.6610.98
85_H155_D1.6390.98
85_H108_H1.6150.98
314_A319_I1.6080.98
8_V165_H1.5800.98
22_L27_V1.5770.98
84_L116_S1.5720.98
58_Y79_R1.5710.98
9_H161_V1.5480.97
196_N199_T1.5350.97
23_D31_R1.5300.97
120_P123_V1.5140.97
295_D299_V1.5040.97
192_L200_A1.5020.97
86_D155_D1.4930.97
5_K11_Y1.4850.97
315_T319_I1.4600.96
303_E307_A1.4580.96
24_T27_V1.4520.96
138_V143_K1.4520.96
64_A183_L1.4430.96
108_H155_D1.4350.96
57_V154_V1.4340.96
316_A319_I1.4340.96
134_V140_G1.4220.96
153_D156_R1.4200.96
2_R19_A1.4190.96
94_H155_D1.4120.95
8_V12_I1.4050.95
161_V176_H1.3950.95
125_A131_P1.3940.95
217_H273_R1.3890.95
28_Q92_Y1.3870.95
61_A147_L1.3740.95
171_Y210_M1.3720.95
109_D155_D1.3630.95
264_Q268_R1.3610.94
317_V323_G1.3550.94
135_A138_V1.3540.94
57_V82_A1.3390.94
130_D133_R1.3370.94
85_H109_D1.3060.93
3_A11_Y1.2990.93
78_V148_V1.2880.93
219_V273_R1.2810.92
261_P272_N1.2760.92
50_R53_H1.2650.92
140_G143_K1.2640.92
244_T247_R1.2630.92
134_V138_V1.2580.92
89_H108_H1.2520.92
46_A167_T1.2490.91
298_T302_L1.2480.91
355_A358_R1.2410.91
39_I43_Y1.2400.91
157_M174_I1.2350.91
87_I112_A1.2280.91
319_I322_P1.2280.91
221_R320_D1.2270.91
115_V246_A1.2230.91
14_A19_A1.2180.90
131_P135_A1.2060.90
28_Q51_F1.2050.90
167_T214_V1.2040.90
26_P118_G1.2040.90
134_V137_L1.2010.90
169_V172_G1.2000.90
109_D112_A1.2000.90
114_L118_G1.1910.89
317_V320_D1.1900.89
341_R346_Q1.1850.89
230_A270_I1.1790.89
136_A141_H1.1750.89
37_S93_G1.1740.89
40_R49_T1.1700.89
93_G156_R1.1690.89
281_W364_G1.1680.88
219_V277_K1.1660.88
65_L79_R1.1650.88
4_I8_V1.1600.88
5_K208_A1.1590.88
16_G20_A1.1550.88
316_A322_P1.1510.88
174_I204_L1.1510.88
229_R232_A1.1460.88
59_H63_R1.1440.87
47_N52_E1.1310.87
299_V303_E1.1310.87
88_G93_G1.1300.87
145_G148_V1.1230.86
113_H139_A1.1220.86
10_D177_G1.1220.86
51_F178_R1.1190.86
118_G122_A1.1160.86
15_D76_D1.1160.86
230_A266_A1.1100.86
169_V210_M1.1040.85
226_M230_A1.0990.85
206_G210_M1.0940.85
348_P357_Q1.0930.85
124_L127_H1.0880.85
19_A23_D1.0820.84
314_A317_V1.0810.84
316_A324_A1.0780.84
133_R142_G1.0750.84
50_R56_G1.0750.84
6_D9_H1.0750.84
95_Q220_S1.0710.84
67_H176_H1.0700.84
149_A153_D1.0700.84
327_M330_S1.0640.83
23_D28_Q1.0630.83
316_A321_T1.0630.83
63_R177_G1.0590.83
226_M266_A1.0580.83
86_D108_H1.0570.83
269_R276_Y1.0510.83
85_H89_H1.0500.82
134_V143_K1.0430.82
160_L214_V1.0420.82
268_R274_D1.0330.81
132_D268_R1.0310.81
52_E166_H1.0310.81
66_A73_T1.0280.81
115_V242_A1.0250.81
87_I120_P1.0230.81
172_G210_M1.0220.81
99_I115_V1.0210.81
171_Y208_A1.0170.80
53_H56_G1.0170.80
31_R41_L1.0150.80
222_I276_Y1.0130.80
7_S168_G1.0110.80
172_G201_E1.0110.80
141_H274_D1.0090.80
35_Q48_H1.0080.80
67_H180_L1.0040.80
136_A143_K1.0030.79
156_R207_R0.9930.79
303_E306_V0.9900.79
231_S245_F0.9860.78
307_A310_A0.9830.78
182_A196_N0.9750.77
358_R361_W0.9750.77
306_V310_A0.9740.77
32_H272_N0.9730.77
235_L238_T0.9700.77
211_N216_R0.9650.77
21_L120_P0.9650.77
362_R365_V0.9630.77
37_S153_D0.9620.77
339_D345_E0.9600.76
315_T318_V0.9570.76
60_L176_H0.9560.76
68_L91_P0.9540.76
67_H181_R0.9500.76
318_V324_A0.9490.76
51_F217_H0.9470.75
358_R363_F0.9450.75
14_A18_A0.9430.75
144_L148_V0.9330.74
23_D217_H0.9250.74
71_S74_R0.9240.74
59_H62_D0.9210.73
94_H108_H0.9190.73
161_V165_H0.9180.73
87_I116_S0.9180.73
44_P47_N0.9170.73
94_H109_D0.9150.73
299_V302_L0.9140.73
63_R66_A0.9130.73
218_H278_R0.9120.73
120_P127_H0.9090.72
230_A263_T0.9060.72
296_Y299_V0.9060.72
156_R205_V0.9060.72
298_T301_D0.9030.72
43_Y170_P0.9000.72
130_D138_V0.8980.71
37_S224_G0.8950.71
319_I324_A0.8940.71
37_S220_S0.8930.71
38_T227_L0.8930.71
93_G224_G0.8930.71
89_H155_D0.8920.71
42_V334_V0.8900.71
13_E181_R0.8880.71
157_M161_V0.8880.71
77_T81_A0.8860.70
160_L164_A0.8830.70
73_T133_R0.8830.70
321_T324_A0.8810.70
97_E201_E0.8780.70
136_A145_G0.8750.69
301_D306_V0.8740.69
86_D94_H0.8730.69
297_R302_L0.8690.69
26_P82_A0.8690.69
45_S166_H0.8660.69
350_V353_M0.8650.69
16_G80_A0.8610.68
156_R204_L0.8600.68
93_G207_R0.8550.68
111_V245_F0.8540.68
345_E351_D0.8500.67
36_L167_T0.8480.67
89_H159_Y0.8450.67
7_S166_H0.8420.66
37_S159_Y0.8390.66
42_V78_V0.8370.66
44_P48_H0.8350.66
343_L347_S0.8340.66
234_L260_C0.8280.65
2_R10_D0.8240.65
301_D307_A0.8230.65
336_V341_R0.8210.64
38_T224_G0.8200.64
292_A301_D0.8190.64
32_H251_A0.8170.64
359_A362_R0.8140.64
262_A265_D0.8120.64
90_G245_F0.8010.63
42_V111_V0.8000.62
205_V209_L0.8000.62
90_G248_F0.8000.62
14_A58_Y0.7990.62
18_A80_A0.7970.62
44_P52_E0.7950.62
347_S351_D0.7920.62
8_V142_G0.7860.61
95_Q224_G0.7830.61
184_T191_V0.7820.61
354_L361_W0.7770.60
52_E178_R0.7770.60
231_S317_V0.7740.60
61_A154_V0.7740.60
15_D18_A0.7730.60
303_E308_D0.7720.60
268_R272_N0.7690.59
18_A62_D0.7650.59
336_V339_D0.7630.59
314_A318_V0.7620.59
314_A322_P0.7570.58
194_E336_V0.7500.57
3_A181_R0.7490.57
212_A249_T0.7490.57
135_A175_D0.7460.57
158_D162_R0.7460.57
206_G334_V0.7410.57
65_L75_A0.7410.57
342_R345_E0.7390.56
109_D159_Y0.7390.56
30_L54_S0.7390.56
163_D215_Y0.7390.56
87_I283_E0.7390.56
223_A229_R0.7380.56
307_A322_P0.7350.56
252_D256_V0.7350.56
184_T269_R0.7350.56
166_H220_S0.7350.56
140_G149_A0.7340.56
157_M203_V0.7310.56
300_R303_E0.7300.55
28_Q217_H0.7300.55
220_S224_G0.7300.55
354_L359_A0.7290.55
85_H94_H0.7280.55
39_I67_H0.7270.55
42_V46_A0.7250.55
303_E309_A0.7250.55
308_D311_G0.7210.55
70_I74_R0.7190.54
9_H31_R0.7180.54
201_E210_M0.7180.54
86_D109_D0.7160.54
77_T133_R0.7150.54
97_E205_V0.7150.54
307_A319_I0.7120.54
130_D136_A0.7110.53
93_G159_Y0.7090.53
90_G215_Y0.7060.53
153_D249_T0.7050.53
156_R203_V0.7030.53
15_D58_Y0.7000.52
261_P264_Q0.7000.52
126_A302_L0.6990.52
90_G151_E0.6990.52
8_V45_S0.6970.52
75_A79_R0.6950.52
49_T82_A0.6940.52
328_P358_R0.6930.52
87_I345_E0.6930.52
48_H163_D0.6930.52
348_P353_M0.6920.52
332_V336_V0.6890.51
91_P254_L0.6880.51
40_R254_L0.6860.51
319_I323_G0.6840.51
147_L263_T0.6840.51
343_L349_L0.6830.51
297_R303_E0.6820.50
42_V51_F0.6810.50
299_V304_S0.6810.50
356_S363_F0.6800.50
117_N132_D0.6800.50
178_R196_N0.6790.50
108_H112_A0.6770.50
30_L35_Q0.6760.50
150_G204_L0.6750.50
9_H77_T0.6730.50
36_L46_A0.6730.50
302_L309_A0.6710.49
18_A154_V0.6710.49
149_A156_R0.6710.49
314_A321_T0.6710.49
167_T202_S0.6670.49
312_V316_A0.6660.49
36_L39_I0.6640.49
186_R191_V0.6620.48
243_E295_D0.6590.48
111_V220_S0.6530.47
65_L78_V0.6530.47
13_E265_D0.6530.47
195_G217_H0.6520.47
22_L25_E0.6520.47
16_G76_D0.6490.47
170_P173_T0.6490.47
258_R271_R0.6490.47
89_H163_D0.6460.47
152_L203_V0.6460.47
206_G354_L0.6450.47
312_V315_T0.6420.46
300_R304_S0.6420.46
7_S12_I0.6410.46
152_L174_I0.6410.46
203_V263_T0.6410.46
23_D273_R0.6380.46
312_V322_P0.6370.46
27_V184_T0.6370.46
203_V245_F0.6360.46
121_G306_V0.6340.46
71_S115_V0.6330.45
261_P271_R0.6320.45
27_V87_I0.6290.45
95_Q172_G0.6280.45
58_Y62_D0.6260.45
306_V315_T0.6260.45
71_S140_G0.6230.44
9_H207_R0.6230.44
150_G196_N0.6230.44
203_V218_H0.6230.44
34_K116_S0.6210.44
318_V322_P0.6210.44
355_A363_F0.6200.44
97_E343_L0.6160.44
97_E266_A0.6160.44
112_A119_E0.6150.44
222_I275_L0.6140.43
231_S252_D0.6130.43
8_V128_G0.6120.43
151_E233_R0.6090.43
4_I22_L0.6070.43
11_Y253_L0.6060.43
75_A80_A0.6060.43
303_E319_I0.6050.43
178_R182_A0.6050.43
5_K164_A0.6050.43
291_V295_D0.6030.42
43_Y317_V0.6030.42
170_P179_L0.6020.42
148_V173_T0.6020.42
186_R189_D0.6020.42
301_D308_D0.6010.42
14_A27_V0.6010.42
22_L51_F0.6010.42
159_Y163_D0.6000.42
198_A213_T0.5970.42
123_V127_H0.5960.42
198_A208_A0.5950.42
241_D289_D0.5930.41
201_E205_V0.5930.41
283_E288_P0.5930.41
172_G196_N0.5930.41
14_A55_L0.5920.41
304_S308_D0.5890.41
94_H159_Y0.5890.41
43_Y275_L0.5880.41
87_I351_D0.5870.41
222_I270_I0.5840.40
215_Y221_R0.5840.40
358_R364_G0.5810.40
223_A266_A0.5810.40
307_A312_V0.5810.40
231_S248_F0.5780.40
343_L353_M0.5760.40
126_A289_D0.5750.40
199_T213_T0.5750.40
35_Q163_D0.5740.39
160_L169_V0.5740.39
44_P82_A0.5730.39
315_T325_P0.5720.39
23_D277_K0.5720.39
11_Y55_L0.5720.39
137_L141_H0.5710.39
249_T254_L0.5680.39
43_Y217_H0.5670.39
21_L47_N0.5660.39
70_I195_G0.5650.39
96_T215_Y0.5620.38
172_G206_G0.5620.38
257_L271_R0.5610.38
77_T134_V0.5610.38
352_G357_Q0.5610.38
122_A125_A0.5600.38
302_L307_A0.5600.38
54_S79_R0.5600.38
165_H169_V0.5600.38
209_L213_T0.5580.38
63_R176_H0.5570.38
114_L117_N0.5560.38
214_V273_R0.5540.37
45_S193_A0.5530.37
154_V216_R0.5520.37
147_L267_A0.5490.37
27_V83_L0.5490.37
115_V245_F0.5480.37
22_L214_V0.5470.37
284_R288_P0.5460.37
59_H123_V0.5450.37
303_E350_V0.5450.37
27_V276_Y0.5450.37
109_D149_A0.5440.36
313_P323_G0.5430.36
201_E347_S0.5430.36
165_H180_L0.5410.36
74_R182_A0.5410.36
110_D139_A0.5410.36
325_P330_S0.5400.36
12_I302_L0.5390.36
353_M356_S0.5390.36
34_K250_D0.5380.36
262_A272_N0.5380.36
169_V206_G0.5360.36
96_T151_E0.5360.36
17_V76_D0.5360.36
317_V324_A0.5350.36
263_T267_A0.5320.35
35_Q155_D0.5310.35
66_A338_G0.5310.35
361_W365_V0.5310.35
25_E272_N0.5300.35
341_R345_E0.5300.35
327_M336_V0.5300.35
318_V336_V0.5290.35
203_V213_T0.5280.35
203_V230_A0.5270.35
192_L196_N0.5270.35
307_A314_A0.5250.35
341_R344_D0.5230.34
171_Y175_D0.5230.34
53_H86_D0.5220.34
154_V207_R0.5210.34
5_K220_S0.5210.34
165_H211_N0.5210.34
167_T174_I0.5210.34
203_V212_A0.5200.34
88_G163_D0.5190.34
21_L124_L0.5180.34
15_D79_R0.5170.34
157_M196_N0.5160.34
344_D357_Q0.5150.34
44_P218_H0.5140.34
78_V154_V0.5110.33
311_G314_A0.5100.33
25_E243_E0.5100.33
193_A250_D0.5100.33
198_A212_A0.5090.33
329_E332_V0.5080.33
183_L196_N0.5080.33
43_Y223_A0.5070.33
55_L200_A0.5040.33
77_T129_L0.5030.33
286_A289_D0.5020.33
139_A143_K0.5010.32
80_A253_L0.5010.32
205_V349_L0.5000.32
109_D156_R0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz7A 4 0.9873 100 0.251 Contact Map
4lrlA 4 0.9618 100 0.288 Contact Map
2hekA 4 0.9084 100 0.292 Contact Map
2q14A 4 0.8957 100 0.333 Contact Map
3bg2A 4 0.6768 100 0.732 Contact Map
2pgsA 4 0.6412 100 0.737 Contact Map
2dqbA 4 0.6718 100 0.739 Contact Map
4x9eA 4 0.6819 100 0.743 Contact Map
2pq7A 2 0.4326 98.5 0.909 Contact Map
3gw7A 2 0.4962 98.5 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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