GREMLIN Database
SYFA - Phenylalanine--tRNA ligase alpha subunit
UniProt: Q9HMK4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 502 (474)
Sequences: 603 (401)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_V137_E5.3521.00
432_R437_G4.8211.00
67_A71_D4.1631.00
206_L211_E3.9681.00
63_D66_H3.7441.00
196_T216_E3.7071.00
273_M283_W3.4831.00
182_T185_G3.0820.99
303_E306_E2.9160.99
68_Y74_P2.8840.99
308_A315_D2.7600.98
57_T171_V2.7600.98
412_D434_P2.7560.98
301_L456_L2.7520.98
299_D303_E2.7270.98
391_D461_D2.7170.98
324_W329_A2.6610.98
297_L302_V2.6200.97
283_W333_A2.4950.96
418_T430_F2.4770.96
412_D439_L2.4770.96
66_H149_T2.4740.96
493_G497_N2.4460.96
447_I453_L2.4200.96
410_I431_G2.4060.96
50_A182_T2.4020.96
93_E96_S2.3380.95
427_F445_S2.3040.94
119_G133_D2.2240.93
454_D460_G2.2230.93
394_V445_S2.2220.93
307_R311_E2.1680.92
431_G434_P2.1590.92
312_G319_G2.1570.92
365_K486_H2.1510.92
434_P437_G2.1430.92
486_H495_L2.1420.92
285_R370_D2.1310.92
390_D461_D2.1200.91
405_Y422_Y2.1160.91
443_G467_L2.1110.91
66_H70_T2.0790.91
420_N444_N2.0750.91
474_M482_I2.0500.90
264_D287_A2.0250.89
392_L463_M2.0130.89
151_G154_V1.9930.89
287_A370_D1.9830.88
237_L470_E1.9600.88
65_G69_A1.9450.87
310_R323_P1.9390.87
82_A121_G1.9330.87
251_M419_Y1.8840.86
268_N273_M1.8720.85
318_D321_H1.7900.83
237_L362_S1.7890.82
422_Y470_E1.7690.82
248_L434_P1.7670.82
282_H287_A1.7650.82
169_V391_D1.7590.81
40_A51_V1.7520.81
237_L477_T1.7470.81
429_L443_G1.7280.80
362_S384_E1.7270.80
414_Q439_L1.7190.80
243_R476_M1.7130.80
125_S128_L1.7070.79
179_V383_I1.6980.79
187_T193_V1.6840.78
94_M391_D1.6680.78
115_Y120_Y1.6660.78
114_N117_R1.6520.77
67_A77_R1.6490.77
391_D418_T1.6470.77
204_P208_A1.6360.76
223_A491_D1.6350.76
74_P121_G1.6330.76
234_T239_Q1.6300.76
221_N375_T1.6220.76
401_F429_L1.6190.76
250_G407_Q1.6160.75
416_K430_F1.6070.75
328_F331_A1.6020.75
387_V455_P1.5990.75
264_D331_A1.5890.74
473_L485_V1.5870.74
264_D333_A1.5870.74
64_E168_L1.5840.74
401_F408_F1.5840.74
423_T426_S1.5500.72
210_G213_A1.5320.71
293_R330_R1.5240.71
10_V69_A1.5210.71
357_P389_A1.5200.71
112_L116_A1.5120.70
78_L111_A1.5080.70
37_A41_L1.5000.70
312_G317_G1.4940.69
384_E422_Y1.4900.69
96_S326_E1.4890.69
420_N428_E1.4840.69
416_K420_N1.4760.68
59_V160_V1.4750.68
237_L377_L1.4710.68
115_Y121_G1.4670.68
412_D432_R1.4640.68
470_E477_T1.4610.68
212_W217_F1.4580.67
257_A345_H1.4500.67
199_V215_V1.4420.67
336_G370_D1.4410.66
144_A147_T1.4380.66
116_A123_I1.4360.66
393_S396_D1.4350.66
285_R336_G1.4340.66
354_V383_I1.4300.66
422_Y443_G1.4230.65
333_A401_F1.4150.65
411_H434_P1.4090.65
436_T440_I1.4080.65
145_L151_G1.3990.64
453_L482_I1.3870.63
82_A127_A1.3840.63
264_D332_L1.3810.63
210_G478_G1.3780.63
81_A98_I1.3770.63
265_F305_V1.3620.62
258_G341_L1.3530.61
439_L485_V1.3490.61
396_D399_G1.3460.61
240_A473_L1.3430.61
343_A452_M1.3400.61
416_K428_E1.3360.60
64_E68_Y1.3350.60
389_A393_S1.3330.60
372_L378_L1.3250.60
337_H422_Y1.3190.59
52_T180_T1.3170.59
268_N364_E1.3120.59
264_D422_Y1.2960.58
264_D285_R1.2950.58
302_V324_W1.2900.58
60_S172_S1.2890.58
473_L479_F1.2870.57
283_W287_A1.2830.57
237_L369_N1.2820.57
125_S129_A1.2790.57
70_T143_D1.2710.56
398_M429_L1.2610.56
299_D326_E1.2600.56
256_M342_T1.2600.56
7_Q74_P1.2600.56
77_R107_Q1.2570.56
378_L416_K1.2530.55
399_G439_L1.2530.55
244_V468_A1.2500.55
369_N487_G1.2490.55
59_V171_V1.2480.55
480_E486_H1.2470.55
285_R328_F1.2440.55
377_L470_E1.2320.54
467_L490_C1.2300.54
41_L287_A1.2270.54
256_M420_N1.2270.54
401_F418_T1.2160.53
302_V326_E1.2120.53
273_M282_H1.2080.53
283_W337_H1.2070.53
344_R348_G1.2060.52
444_N487_G1.2020.52
359_R497_N1.2010.52
147_T152_D1.1980.52
362_S470_E1.1980.52
381_F470_E1.1980.52
256_M362_S1.1950.52
146_A150_D1.1930.52
70_T155_D1.1880.51
211_E214_D1.1870.51
422_Y467_L1.1680.50
329_A464_A1.1670.50
444_N461_D1.1640.50
455_P467_L1.1630.50
10_V39_A1.1630.50
420_N487_G1.1600.50
237_L383_I1.1590.50
481_D484_D1.1530.49
266_Y370_D1.1510.49
149_T155_D1.1510.49
143_D147_T1.1490.49
236_V384_E1.1420.48
181_L219_D1.1390.48
237_L427_F1.1390.48
181_L227_A1.1370.48
122_T325_D1.1360.48
273_M341_L1.1360.48
320_Y490_C1.1350.48
278_P425_P1.1310.48
248_L342_T1.1310.48
8_V12_D1.1160.47
65_G331_A1.1140.47
274_P404_F1.1120.47
142_A146_A1.1110.47
291_P342_T1.1110.47
413_L477_T1.1070.46
65_G154_V1.1070.46
248_L422_Y1.1060.46
447_I463_M1.1030.46
212_W279_A1.1030.46
32_P35_T1.1000.46
236_V274_P1.0990.46
283_W370_D1.0990.46
273_M329_A1.0950.46
147_T155_D1.0940.46
117_R130_A1.0860.45
387_V463_M1.0780.45
325_D330_R1.0780.45
143_D150_D1.0700.44
272_F455_P1.0670.44
82_A281_N1.0620.44
81_A85_A1.0580.43
109_D113_S1.0570.43
218_A367_Y1.0560.43
396_D463_M1.0550.43
83_L87_A1.0480.43
109_D442_I1.0470.43
78_L113_S1.0420.42
470_E487_G1.0400.42
118_K288_L1.0360.42
162_Q165_S1.0340.42
12_D16_T1.0290.42
337_H369_N1.0280.41
123_I126_G1.0200.41
92_V96_S1.0200.41
459_D473_L1.0190.41
264_D328_F1.0170.41
43_L195_A1.0150.41
49_V124_D1.0140.41
422_Y487_G1.0130.41
450_P482_I1.0100.40
278_P465_W1.0080.40
14_A243_R1.0050.40
69_A146_A1.0020.40
283_W336_G0.9960.40
77_R288_L0.9960.40
114_N118_K0.9950.40
431_G440_I0.9900.39
420_N468_A0.9860.39
365_K414_Q0.9860.39
298_P455_P0.9830.39
268_N285_R0.9820.39
243_R383_I0.9790.39
109_D251_M0.9780.39
444_N453_L0.9770.38
362_S422_Y0.9760.38
209_S215_V0.9760.38
394_V398_M0.9740.38
47_G393_S0.9730.38
74_P109_D0.9720.38
418_T453_L0.9710.38
264_D370_D0.9670.38
369_N420_N0.9670.38
283_W422_Y0.9650.38
420_N445_S0.9570.37
112_L123_I0.9560.37
331_A438_E0.9550.37
80_R136_P0.9540.37
233_K283_W0.9510.37
371_T463_M0.9470.37
74_P114_N0.9430.36
427_F470_E0.9400.36
11_L43_L0.9370.36
445_S470_E0.9370.36
27_A85_A0.9370.36
416_K445_S0.9360.36
63_D180_T0.9350.36
13_A17_D0.9330.36
369_N398_M0.9330.36
65_G157_D0.9310.36
405_Y470_E0.9280.36
364_E370_D0.9250.35
117_R229_H0.9250.35
198_E390_D0.9240.35
49_V347_A0.9230.35
241_A405_Y0.9220.35
57_T157_D0.9220.35
273_M427_F0.9200.35
316_D319_G0.9190.35
163_L181_L0.9170.35
62_T172_S0.9170.35
22_I40_A0.9150.35
64_E111_A0.9140.35
236_V404_F0.9120.35
330_R462_V0.9090.35
282_H336_G0.9090.35
158_A165_S0.9080.34
237_L384_E0.9050.34
149_T390_D0.9030.34
85_A329_A0.9020.34
240_A422_Y0.9000.34
139_D184_A0.8980.34
472_L495_L0.8960.34
345_H465_W0.8880.33
264_D337_H0.8870.33
383_I470_E0.8870.33
74_P78_L0.8860.33
254_Q360_Y0.8820.33
80_R84_D0.8740.33
355_E462_V0.8730.33
268_N432_R0.8720.32
248_L283_W0.8720.32
26_A33_P0.8720.32
148_L169_V0.8700.32
410_I416_K0.8690.32
394_V427_F0.8660.32
268_N369_N0.8650.32
221_N226_A0.8630.32
16_T214_D0.8610.32
236_V336_G0.8600.32
81_A307_R0.8590.32
113_S116_A0.8590.32
147_T151_G0.8540.31
475_L482_I0.8530.31
41_L44_E0.8500.31
369_N377_L0.8500.31
240_A405_Y0.8490.31
219_D401_F0.8440.31
237_L422_Y0.8430.31
427_F469_L0.8420.31
312_G316_D0.8420.31
442_I464_A0.8420.31
234_T395_R0.8410.31
369_N477_T0.8390.31
383_I422_Y0.8350.30
237_L469_L0.8330.30
392_L481_D0.8320.30
63_D211_E0.8310.30
433_H444_N0.8300.30
442_I479_F0.8240.30
398_M427_F0.8230.30
119_G399_G0.8230.30
464_A500_V0.8230.30
259_P442_I0.8220.30
384_E404_F0.8200.30
369_N422_Y0.8190.30
278_P424_E0.8160.29
115_Y440_I0.8140.29
55_T175_T0.8140.29
304_R455_P0.8110.29
54_T180_T0.8110.29
113_S324_W0.8080.29
225_D242_E0.8080.29
78_L94_M0.8010.29
88_D128_L0.8010.29
267_I273_M0.8000.29
94_M97_V0.7970.29
416_K444_N0.7960.28
16_T143_D0.7950.28
108_V250_G0.7950.28
398_M445_S0.7930.28
273_M340_S0.7910.28
82_A105_G0.7880.28
310_R318_D0.7860.28
227_A491_D0.7860.28
392_L431_G0.7850.28
96_S146_A0.7840.28
262_D344_R0.7820.28
260_H365_K0.7820.28
17_D47_G0.7790.28
482_I492_V0.7770.28
93_E97_V0.7750.27
233_K464_A0.7720.27
435_E440_I0.7680.27
149_T153_S0.7670.27
355_E359_R0.7650.27
404_F448_F0.7650.27
369_N470_E0.7650.27
257_A364_E0.7620.27
247_V370_D0.7610.27
453_L470_E0.7580.27
411_H414_Q0.7560.26
50_A71_D0.7550.26
139_D142_A0.7530.26
246_D465_W0.7530.26
262_D273_M0.7490.26
370_D422_Y0.7480.26
67_A200_G0.7470.26
52_T142_A0.7410.26
71_D216_E0.7400.26
62_T105_G0.7360.26
283_W344_R0.7360.26
363_V469_L0.7360.26
198_E216_E0.7350.25
450_P470_E0.7350.25
80_R142_A0.7340.25
73_L394_V0.7340.25
7_Q114_N0.7340.25
373_D376_H0.7320.25
337_H362_S0.7310.25
42_A343_A0.7310.25
337_H379_E0.7300.25
455_P484_D0.7300.25
237_L248_L0.7290.25
219_D484_D0.7270.25
443_G448_F0.7240.25
408_F429_L0.7240.25
143_D155_D0.7240.25
122_T186_V0.7230.25
247_V338_T0.7230.25
276_D473_L0.7220.25
429_L445_S0.7220.25
213_A304_R0.7210.25
369_N444_N0.7210.25
110_I168_L0.7200.25
154_V213_A0.7190.25
244_V469_L0.7190.25
201_E413_L0.7150.25
241_A320_Y0.7140.25
180_T289_S0.7130.24
272_F314_G0.7100.24
18_D58_T0.7090.24
298_P478_G0.7090.24
418_T428_E0.7080.24
337_H404_F0.7070.24
283_W341_L0.7060.24
161_D407_Q0.7060.24
435_E491_D0.7050.24
69_A142_A0.7050.24
294_I330_R0.7030.24
77_R82_A0.7030.24
147_T154_V0.7020.24
237_L241_A0.7000.24
386_W420_N0.7000.24
418_T482_I0.6990.24
287_A463_M0.6970.24
256_M443_G0.6970.24
263_A294_I0.6970.24
416_K487_G0.6960.24
5_T396_D0.6940.24
104_D108_V0.6930.24
311_E315_D0.6920.24
466_G471_R0.6920.24
107_Q205_E0.6920.24
243_R333_A0.6920.24
232_G343_A0.6910.23
431_G494_F0.6910.23
226_A237_L0.6900.23
80_R216_E0.6900.23
387_V400_T0.6900.23
118_K163_L0.6890.23
406_S411_H0.6880.23
76_V80_R0.6860.23
63_D214_D0.6850.23
378_L394_V0.6840.23
379_E474_M0.6840.23
86_G89_D0.6820.23
140_P153_S0.6820.23
444_N468_A0.6810.23
151_G161_D0.6800.23
30_D67_A0.6800.23
227_A411_H0.6790.23
33_P41_L0.6790.23
138_N143_D0.6780.23
369_N378_L0.6760.23
369_N469_L0.6760.23
164_A306_E0.6750.23
397_L483_R0.6750.23
285_R333_A0.6730.23
341_L344_R0.6720.23
12_D154_V0.6710.23
404_F422_Y0.6710.23
33_P332_L0.6710.23
138_N153_S0.6700.23
329_A401_F0.6670.22
38_G59_V0.6670.22
431_G461_D0.6670.22
108_V118_K0.6650.22
14_A20_Q0.6640.22
422_Y444_N0.6640.22
424_E465_W0.6630.22
327_D330_R0.6630.22
445_S477_T0.6620.22
184_A241_A0.6620.22
68_Y464_A0.6620.22
21_R70_T0.6620.22
359_R432_R0.6620.22
207_L212_W0.6590.22
256_M422_Y0.6580.22
433_H487_G0.6580.22
14_A18_D0.6560.22
146_A211_E0.6560.22
78_L198_E0.6550.22
381_F475_L0.6550.22
44_E49_V0.6540.22
262_D267_I0.6530.22
94_M307_R0.6510.22
36_I410_I0.6510.22
248_L370_D0.6500.22
62_T143_D0.6500.22
387_V496_R0.6490.22
369_N416_K0.6480.22
336_G422_Y0.6480.22
274_P337_H0.6470.22
341_L390_D0.6460.22
394_V477_T0.6450.21
48_L185_G0.6450.21
291_P357_P0.6440.21
49_V299_D0.6440.21
82_A145_L0.6440.21
402_R495_L0.6440.21
176_V398_M0.6430.21
95_G105_G0.6400.21
133_D299_D0.6390.21
10_V98_I0.6380.21
48_L193_V0.6380.21
19_P50_A0.6370.21
61_L205_E0.6370.21
265_F359_R0.6360.21
294_I297_L0.6360.21
369_N427_F0.6360.21
283_W405_Y0.6360.21
307_R314_G0.6360.21
264_D273_M0.6340.21
416_K482_I0.6330.21
114_N199_V0.6320.21
31_Y35_T0.6320.21
84_D308_A0.6320.21
442_I453_L0.6310.21
450_P453_L0.6310.21
398_M439_L0.6290.21
139_D145_L0.6260.21
169_V180_T0.6260.21
74_P486_H0.6250.21
337_H405_Y0.6250.21
369_N394_V0.6250.21
240_A487_G0.6240.21
251_M337_H0.6240.21
184_A187_T0.6230.21
235_H336_G0.6220.21
109_D401_F0.6220.21
259_P341_L0.6220.21
144_A158_A0.6220.21
207_L306_E0.6210.20
248_L486_H0.6170.20
428_E482_I0.6170.20
82_A107_Q0.6160.20
22_I181_L0.6150.20
104_D207_L0.6150.20
413_L473_L0.6140.20
20_Q181_L0.6130.20
10_V14_A0.6120.20
256_M384_E0.6120.20
26_A123_I0.6110.20
288_L295_D0.6100.20
287_A332_L0.6090.20
26_A37_A0.6090.20
65_G171_V0.6060.20
452_M455_P0.6060.20
377_L405_Y0.6050.20
289_S371_T0.6050.20
96_S140_P0.6050.20
69_A210_G0.6040.20
249_V333_A0.6040.20
118_K403_E0.6040.20
441_E446_G0.6030.20
337_H470_E0.6030.20
256_M262_D0.6020.20
258_G345_H0.6010.20
237_L337_H0.6000.20
153_S181_L0.5990.20
266_Y285_R0.5990.20
163_L168_L0.5980.20
316_D499_E0.5980.20
155_D159_V0.5980.20
369_N404_F0.5980.20
306_E327_D0.5970.20
69_A76_V0.5970.20
300_A304_R0.5950.19
172_S242_E0.5950.19
10_V15_S0.5950.19
282_H331_A0.5940.19
67_A155_D0.5930.19
264_D336_G0.5930.19
24_A135_D0.5920.19
366_A379_E0.5910.19
14_A98_I0.5910.19
49_V406_S0.5900.19
117_R169_V0.5900.19
308_A316_D0.5890.19
73_L276_D0.5880.19
217_F256_M0.5870.19
267_I283_W0.5860.19
273_M332_L0.5840.19
451_E466_G0.5840.19
79_Y224_A0.5820.19
430_F433_H0.5790.19
20_Q80_R0.5790.19
245_T370_D0.5780.19
75_E168_L0.5780.19
135_D391_D0.5780.19
282_H337_H0.5780.19
7_Q444_N0.5770.19
378_L420_N0.5770.19
25_L53_E0.5760.19
430_F442_I0.5760.19
93_E185_G0.5750.19
150_D182_T0.5750.19
78_L131_D0.5750.19
390_D468_A0.5740.19
420_N430_F0.5740.19
161_D304_R0.5730.19
420_N452_M0.5730.19
70_T158_A0.5730.19
126_G169_V0.5720.19
82_A106_P0.5710.19
145_L148_L0.5710.19
264_D270_C0.5710.19
362_S383_I0.5710.19
372_L396_D0.5680.18
374_A494_F0.5680.18
97_V325_D0.5670.18
42_A444_N0.5670.18
207_L299_D0.5620.18
213_A438_E0.5610.18
290_N440_I0.5610.18
329_A500_V0.5610.18
286_F337_H0.5610.18
198_E300_A0.5600.18
44_E314_G0.5590.18
64_E110_I0.5580.18
164_A287_A0.5580.18
285_R364_E0.5570.18
384_E443_G0.5570.18
128_L329_A0.5560.18
61_L149_T0.5550.18
262_D283_W0.5550.18
108_V491_D0.5540.18
11_L15_S0.5530.18
202_L210_G0.5510.18
200_G459_D0.5510.18
285_R337_H0.5510.18
113_S161_D0.5500.18
420_N431_G0.5500.18
384_E455_P0.5490.18
244_V381_F0.5480.18
169_V177_R0.5480.18
74_P107_Q0.5480.18
199_V206_L0.5480.18
222_V234_T0.5460.18
202_L346_L0.5440.18
449_R466_G0.5430.17
64_E166_R0.5430.17
119_G437_G0.5420.17
195_A294_I0.5410.17
420_N461_D0.5400.17
377_L487_G0.5390.17
142_A145_L0.5380.17
55_T295_D0.5380.17
455_P475_L0.5380.17
106_P155_D0.5360.17
240_A366_A0.5350.17
285_R404_F0.5350.17
38_G42_A0.5340.17
236_V248_L0.5320.17
26_A113_S0.5320.17
122_T131_D0.5320.17
96_S136_P0.5310.17
78_L137_E0.5300.17
444_N452_M0.5300.17
81_A298_P0.5300.17
266_Y456_L0.5290.17
25_L49_V0.5290.17
27_A205_E0.5280.17
405_Y443_G0.5260.17
259_P344_R0.5240.17
453_L461_D0.5240.17
261_V332_L0.5240.17
21_R194_E0.5230.17
365_K413_L0.5220.17
51_V74_P0.5220.17
366_A477_T0.5220.17
365_K439_L0.5210.17
418_T450_P0.5210.17
237_L381_F0.5210.17
286_F379_E0.5200.17
51_V249_V0.5190.17
96_S311_E0.5190.17
47_G121_G0.5190.17
425_P436_T0.5180.17
142_A197_D0.5170.17
168_L235_H0.5170.17
375_T487_G0.5160.17
119_G124_D0.5160.17
63_D143_D0.5150.17
67_A296_E0.5150.17
169_V175_T0.5120.16
123_I229_H0.5110.16
265_F369_N0.5100.16
362_S477_T0.5100.16
23_E27_A0.5090.16
413_L468_A0.5080.16
369_N490_C0.5080.16
36_I47_G0.5070.16
369_N384_E0.5060.16
233_K496_R0.5050.16
52_T58_T0.5050.16
373_D428_E0.5040.16
256_M444_N0.5040.16
181_L440_I0.5040.16
35_T181_L0.5020.16
68_Y77_R0.5010.16
47_G186_V0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l4gA 2 0.9641 100 0.378 Contact Map
2odrC 4 0.5159 100 0.679 Contact Map
2du7A 7 0.5876 100 0.686 Contact Map
1b7yA 2 0.498 100 0.688 Contact Map
2odrB 3 0.5159 100 0.69 Contact Map
2odrD 4 0.5159 100 0.69 Contact Map
2odrA 4 0.5159 100 0.691 Contact Map
2du3A 4 0.5976 100 0.696 Contact Map
4p72C 2 0.4701 100 0.72 Contact Map
3pcoA 2 0.6235 100 0.728 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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