GREMLIN Database
PYRD - Dihydroorotate dehydrogenase (quinone)
UniProt: Q9HMK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (292)
Sequences: 5201 (3040)
Seq/√Len: 177.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_A328_G3.7541.00
51_D56_T3.6481.00
124_D165_R3.5811.00
49_S56_T3.0391.00
318_G324_R2.9371.00
164_S204_A2.9071.00
53_F210_L2.9011.00
195_A231_D2.8811.00
57_F307_V2.6721.00
223_A280_R2.5651.00
338_F344_A2.5521.00
195_A232_L2.5441.00
202_Q235_D2.4011.00
292_A296_D2.3921.00
90_V126_V2.3741.00
239_A277_V2.3241.00
270_A300_K2.3121.00
278_A306_S2.2971.00
267_R299_E2.2371.00
210_L236_G2.1831.00
271_T300_K2.1451.00
194_L229_A2.1161.00
202_Q209_L2.1001.00
293_T296_D2.0781.00
59_N83_G2.0251.00
274_V285_V2.0241.00
317_E324_R1.9361.00
340_S343_D1.9141.00
267_R296_D1.9001.00
47_R334_E1.8881.00
278_A285_V1.8821.00
59_N326_N1.8561.00
230_N283_Q1.8331.00
339_D343_D1.8031.00
342_E345_V1.7871.00
163_F173_V1.7861.00
291_V308_V1.7621.00
331_S335_R1.7331.00
141_G172_Y1.7201.00
238_V288_V1.7081.00
267_R300_K1.6891.00
332_L336_D1.6851.00
226_V277_V1.6791.00
310_L325_I1.6711.00
110_N264_A1.6651.00
55_Q172_Y1.6371.00
298_Y336_D1.6321.00
62_G86_E1.6161.00
306_S345_V1.6111.00
301_I345_V1.5951.00
295_E299_E1.5941.00
291_V300_K1.5941.00
177_V194_L1.5871.00
297_A325_I1.5851.00
301_I344_A1.5681.00
333_L344_A1.5591.00
185_L188_L1.5481.00
218_H221_A1.5311.00
160_T204_A1.5301.00
121_E125_T1.5101.00
227_E231_D1.5081.00
191_R224_D1.5051.00
295_E332_L1.5021.00
230_N282_D1.5011.00
123_A165_R1.4991.00
70_N121_E1.4801.00
223_A276_F1.4661.00
93_E149_T1.4581.00
301_I341_V1.4431.00
62_G84_H1.4301.00
144_I162_T1.4291.00
144_I163_F1.4191.00
284_P306_S1.4091.00
91_T145_G1.4051.00
61_V326_N1.4021.00
210_L286_V1.3981.00
124_D128_A1.3931.00
251_S336_D1.3901.00
240_T243_T1.3891.00
48_L60_P1.3851.00
221_A224_D1.3821.00
123_A166_V1.3801.00
163_F201_L1.3741.00
195_A199_E1.3701.00
142_V170_V1.3691.00
274_V287_G1.3541.00
243_T269_R1.3361.00
297_A329_L1.3301.00
51_D54_G1.3291.00
245_E269_R1.3241.00
167_G205_G1.3181.00
237_I281_T1.3081.00
202_Q205_G1.2971.00
175_V201_L1.2951.00
297_A308_V1.2911.00
161_Y164_S1.2821.00
248_E303_A1.2811.00
287_G300_K1.2761.00
89_A143_N1.2691.00
47_R330_V1.2681.00
167_G206_A1.2631.00
313_A321_V1.2501.00
92_A147_S1.2361.00
52_A307_V1.2271.00
201_L209_L1.2191.00
333_L338_F1.2071.00
298_Y332_L1.2021.00
61_V325_I1.2021.00
109_D252_H1.2011.00
89_A145_G1.2001.00
323_K327_E1.1981.00
64_A311_Y1.1961.00
160_T200_A1.1931.00
184_G187_E1.1911.00
103_L116_M1.1851.00
192_D196_A1.1831.00
111_A265_P1.1801.00
61_V291_V1.1801.00
78_A138_V1.1661.00
87_V142_V1.1661.00
298_Y329_L1.1531.00
86_E309_Q1.1501.00
92_A162_T1.1501.00
161_Y165_R1.1361.00
293_T321_V1.1341.00
166_V173_V1.1331.00
267_R271_T1.1261.00
324_R328_G1.1251.00
272_E276_F1.1201.00
198_L211_V1.1141.00
330_V334_E1.1031.00
123_A162_T1.0941.00
58_P137_D1.0901.00
228_L232_L1.0901.00
298_Y302_R1.0881.00
227_E280_R1.0861.00
217_L225_A1.0841.00
87_V126_V1.0821.00
110_N317_E1.0781.00
288_V309_Q1.0771.00
243_T266_I1.0751.00
326_N330_V1.0751.00
204_A207_S1.0731.00
251_S335_R1.0721.00
294_A298_Y1.0661.00
179_S182_T1.0651.00
199_E232_L1.0611.00
294_A325_I1.0581.00
332_L335_R1.0571.00
163_F205_G1.0471.00
73_I76_A1.0441.00
286_V307_V1.0351.00
121_E129_R1.0240.99
190_G193_Q1.0130.99
332_L338_F1.0110.99
196_A199_E1.0100.99
91_T95_Q1.0070.99
327_E331_S1.0060.99
62_G309_Q1.0010.99
148_K158_D1.0010.99
127_G165_R0.9970.99
264_A292_A0.9970.99
53_F236_G0.9930.99
250_L298_Y0.9910.99
82_F322_A0.9900.99
292_A313_A0.9880.99
213_L277_V0.9820.99
128_A131_D0.9790.99
187_E221_A0.9780.99
200_A203_D0.9760.99
180_P183_P0.9740.99
274_V300_K0.9710.99
74_P78_A0.9680.99
271_T303_A0.9660.99
211_V234_L0.9610.99
310_L321_V0.9570.99
67_F70_N0.9550.99
295_E328_G0.9550.99
196_A200_A0.9410.99
81_G327_E0.9410.99
106_L109_D0.9390.99
294_A332_L0.9340.99
222_V277_V0.9290.99
156_P200_A0.9220.99
55_Q139_P0.9200.99
118_F145_G0.9150.99
160_T164_S0.9100.99
114_N242_T0.9060.99
58_P138_V0.9050.99
320_W324_R0.9040.99
239_A273_Q0.8860.98
52_A210_L0.8800.98
112_L312_T0.8720.98
47_R340_S0.8710.98
264_A267_R0.8670.98
62_G307_V0.8660.98
191_R228_L0.8660.98
52_A286_V0.8640.98
240_T266_I0.8630.98
328_G332_L0.8600.98
46_P334_E0.8580.98
184_G188_L0.8530.98
70_N73_I0.8490.98
210_L238_V0.8460.98
240_T270_A0.8450.98
127_G169_A0.8370.98
116_M120_N0.8360.98
146_K174_V0.8340.98
148_K183_P0.8310.98
175_V211_V0.8300.98
199_E203_D0.8250.98
68_D74_P0.8250.98
50_V306_S0.8240.97
245_E248_E0.8240.97
253_P336_D0.8190.97
81_G323_K0.8170.97
125_T129_R0.8080.97
109_D250_L0.7980.97
327_E330_V0.7980.97
237_I277_V0.7970.97
68_D71_A0.7920.97
268_E272_E0.7910.97
242_T262_S0.7910.97
125_T128_A0.7890.97
92_A161_Y0.7880.97
121_E126_V0.7840.97
63_M82_F0.7830.97
63_M322_A0.7820.97
67_F71_A0.7820.97
187_E190_G0.7810.97
77_L85_I0.7800.97
86_E238_V0.7800.97
302_R336_D0.7800.97
192_D195_A0.7800.97
205_G209_L0.7770.96
249_S252_H0.7770.96
157_D161_Y0.7740.96
160_T203_D0.7730.96
147_S162_T0.7720.96
338_F341_V0.7720.96
95_Q147_S0.7700.96
167_G173_V0.7670.96
331_S334_E0.7660.96
71_A126_V0.7600.96
278_A282_D0.7520.96
193_Q196_A0.7500.96
229_A237_I0.7440.95
127_G166_V0.7430.95
314_L322_A0.7390.95
223_A227_E0.7350.95
61_V308_V0.7320.95
156_P196_A0.7320.95
156_P160_T0.7310.95
292_A317_E0.7280.95
61_V310_L0.7270.95
240_T273_Q0.7270.95
69_K73_I0.7250.95
157_D160_T0.7250.95
131_D134_P0.7250.95
144_I175_V0.7240.95
270_A287_G0.7240.95
179_S186_R0.7180.94
226_V281_T0.7180.94
227_E230_N0.7180.94
223_A277_V0.7160.94
321_V325_I0.7160.94
310_L313_A0.7100.94
302_R332_L0.7080.94
276_F280_R0.7070.94
222_V273_Q0.7030.94
52_A284_P0.7020.94
73_I77_L0.7010.94
230_N281_T0.7010.94
46_P49_S0.7010.94
298_Y344_A0.7010.94
98_N102_R0.6990.94
64_A309_Q0.6980.94
274_V303_A0.6970.94
123_A127_G0.6970.94
269_R272_E0.6960.94
298_Y328_G0.6950.93
244_T276_F0.6940.93
341_V345_V0.6940.93
92_A158_D0.6880.93
76_A79_G0.6850.93
71_A80_L0.6800.93
200_A204_A0.6750.92
86_E143_N0.6750.92
93_E147_S0.6730.92
89_A144_I0.6720.92
67_F73_I0.6700.92
61_V297_A0.6660.92
258_Q275_R0.6640.92
103_L112_L0.6630.92
73_I79_G0.6620.92
253_P302_R0.6610.92
106_L261_L0.6610.92
297_A328_G0.6600.92
57_F172_Y0.6580.92
177_V211_V0.6570.91
139_P171_D0.6510.91
68_D73_I0.6510.91
75_R79_G0.6480.91
229_A285_V0.6470.91
93_E161_Y0.6460.91
71_A132_A0.6450.91
332_L344_A0.6450.91
277_V281_T0.6450.91
52_A306_S0.6440.91
264_A296_D0.6430.91
74_P80_L0.6430.91
276_F279_E0.6420.91
57_F84_H0.6400.90
97_G122_G0.6400.90
333_L341_V0.6390.90
170_V173_V0.6390.90
165_R168_D0.6390.90
180_P260_G0.6370.90
130_L140_V0.6360.90
272_E275_R0.6350.90
166_V169_A0.6340.90
163_F197_I0.6330.90
167_G207_S0.6300.90
46_P330_V0.6300.90
190_G221_A0.6290.90
237_I285_V0.6290.90
57_F62_G0.6290.90
109_D249_S0.6270.89
73_I80_L0.6270.89
247_P299_E0.6260.89
238_V309_Q0.6260.89
202_Q232_L0.6260.89
242_T260_G0.6250.89
163_F167_G0.6250.89
74_P136_P0.6250.89
213_L237_I0.6230.89
213_L273_Q0.6230.89
267_R274_V0.6200.89
160_T197_I0.6190.89
191_R195_A0.6180.89
224_D228_L0.6160.89
186_R214_S0.6160.89
163_F204_A0.6160.89
209_L235_D0.6110.88
91_T120_N0.6100.88
142_V166_V0.6090.88
74_P130_L0.6090.88
48_L326_N0.6030.88
172_Y238_V0.6030.88
237_I283_Q0.6020.88
222_V280_R0.6000.87
95_Q145_G0.5990.87
172_Y309_Q0.5970.87
124_D161_Y0.5970.87
84_H309_Q0.5940.87
330_V333_L0.5940.87
82_F326_N0.5920.87
76_A80_L0.5920.87
126_V166_V0.5910.87
53_F172_Y0.5910.87
297_A301_I0.5890.86
160_T201_L0.5890.86
65_A88_G0.5870.86
133_E136_P0.5860.86
275_R279_E0.5830.86
74_P79_G0.5810.86
301_I308_V0.5790.85
49_S58_P0.5790.85
46_P60_P0.5770.85
52_A57_F0.5770.85
50_V60_P0.5720.85
271_T287_G0.5710.85
75_R133_E0.5700.85
70_N74_P0.5670.84
114_N260_G0.5670.84
116_M119_N0.5620.84
253_P338_F0.5600.83
139_P172_Y0.5580.83
73_I78_A0.5560.83
336_D344_A0.5550.83
69_K74_P0.5540.83
84_H139_P0.5540.83
54_G208_P0.5520.83
126_V142_V0.5490.82
182_T186_R0.5490.82
89_A172_Y0.5490.82
71_A74_P0.5480.82
320_W323_K0.5470.82
244_T258_Q0.5460.82
90_V142_V0.5460.82
148_K179_S0.5450.82
93_E124_D0.5430.82
118_F179_S0.5410.81
111_A266_I0.5360.81
47_R50_V0.5360.81
174_V238_V0.5360.81
178_S181_N0.5320.80
329_L333_L0.5310.80
251_S295_E0.5310.80
333_L339_D0.5300.80
113_V245_E0.5300.80
114_N178_S0.5280.80
235_D284_P0.5270.80
78_A85_I0.5260.80
66_G311_Y0.5250.79
63_M77_L0.5240.79
195_A228_L0.5230.79
291_V297_A0.5220.79
267_R270_A0.5220.79
156_P193_Q0.5210.79
72_E121_E0.5190.79
87_V90_V0.5180.79
275_R299_E0.5160.78
301_I333_L0.5140.78
70_N78_A0.5130.78
291_V310_L0.5130.78
271_T275_R0.5130.78
214_S217_L0.5110.78
325_I328_G0.5100.77
198_L234_L0.5100.77
178_S260_G0.5090.77
271_T274_V0.5080.77
175_V198_L0.5080.77
130_L142_V0.5070.77
85_I138_V0.5060.77
86_E288_V0.5050.77
109_D251_S0.5050.77
313_A317_E0.5050.77
62_G141_G0.5050.77
225_A229_A0.5050.77
202_Q234_L0.5040.77
117_G120_N0.5040.77
123_A126_V0.5030.76
248_E251_S0.5030.76
224_D227_E0.5030.76
213_L239_A0.5020.76
108_D252_H0.5010.76
143_N174_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cq8A 1 0.9685 100 0.32 Contact Map
1tv5A 3 0.9685 100 0.335 Contact Map
4oqvA 1 0.9484 100 0.364 Contact Map
1f76A 1 0.9284 100 0.442 Contact Map
4ef8A 2 0.851 100 0.457 Contact Map
1ep3A 2 0.8481 100 0.493 Contact Map
2e6fA 2 0.8453 100 0.515 Contact Map
1jubA 2 0.8424 100 0.519 Contact Map
3oixA 3 0.8195 100 0.536 Contact Map
1gteA 4 0.9771 100 0.536 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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