GREMLIN Database
Q9HMJ7 - mRNA 3'-end processing factor homolog
UniProt: Q9HMJ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (373)
Sequences: 5337 (3441)
Seq/√Len: 178.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_V60_I4.2351.00
21_E45_D3.8401.00
48_V143_V3.6891.00
35_P38_P3.4951.00
146_D151_R3.4831.00
389_A393_R3.3161.00
25_L50_S3.3051.00
121_P128_E3.1731.00
49_A82_A3.1221.00
75_T141_A3.0731.00
330_R334_D2.8841.00
74_W79_Y2.8101.00
144_L151_R2.7511.00
128_E146_D2.6091.00
177_V378_L2.4701.00
48_V129_V2.4161.00
123_D128_E2.3981.00
17_L380_N2.2921.00
4_R407_T2.2531.00
129_V145_V2.2461.00
121_P130_T2.2441.00
73_H116_H2.1351.00
180_C379_V2.1241.00
23_L46_A2.0431.00
71_P114_R2.0411.00
19_V25_L2.0341.00
22_S43_T2.0281.00
80_E252_R2.0101.00
80_E253_Y1.9821.00
118_Y141_A1.9781.00
117_G120_V1.9611.00
3_L179_V1.9461.00
79_Y113_S1.9461.00
32_D35_P1.9341.00
40_S43_T1.9161.00
47_V63_L1.9161.00
310_R345_L1.8841.00
82_A113_S1.8551.00
378_L408_C1.8191.00
25_L154_Y1.8121.00
21_E126_G1.7981.00
362_H391_A1.7981.00
206_T316_K1.7491.00
402_P408_C1.7451.00
146_D173_P1.7391.00
207_L213_V1.7281.00
129_V143_V1.7241.00
131_F143_V1.7211.00
47_V70_P1.7191.00
83_L87_R1.6921.00
209_E350_Q1.6891.00
130_T146_D1.6891.00
153_L175_A1.6771.00
370_D395_A1.6691.00
116_H131_F1.6681.00
338_A342_G1.6681.00
132_Y142_H1.6571.00
330_R335_S1.6551.00
19_V145_V1.6411.00
119_G170_T1.6401.00
22_S44_P1.6381.00
24_L44_P1.6351.00
284_A289_A1.6321.00
316_K352_E1.6311.00
176_D375_A1.6281.00
33_T36_Q1.6141.00
77_P256_F1.5611.00
74_W82_A1.5561.00
79_Y115_T1.5521.00
330_R333_I1.5501.00
238_Y281_K1.5461.00
312_N315_N1.5461.00
18_L22_S1.5321.00
376_T400_R1.5321.00
213_V318_A1.5181.00
205_T209_E1.5141.00
23_L127_Y1.5111.00
130_T144_L1.5041.00
239_V247_T1.4941.00
179_V380_N1.4891.00
201_E205_T1.4841.00
215_V226_L1.4681.00
116_H122_F1.4681.00
142_H153_L1.4661.00
376_T398_T1.4481.00
76_P117_G1.4471.00
3_L19_V1.4321.00
339_E344_V1.4301.00
230_C290_I1.4221.00
178_V372_Y1.4141.00
34_P38_P1.4101.00
230_C237_C1.3971.00
46_A73_H1.3921.00
329_G332_L1.3891.00
2_D407_T1.3891.00
57_V82_A1.3811.00
50_S154_Y1.3681.00
178_V369_L1.3621.00
331_S336_G1.3511.00
389_A392_L1.3391.00
369_L397_F1.3381.00
38_P66_G1.3311.00
172_R373_R1.3311.00
205_T350_Q1.3311.00
3_L177_V1.3271.00
284_A288_A1.3261.00
137_V358_A1.3241.00
211_G316_K1.3221.00
204_K208_W1.3121.00
338_A344_V1.3111.00
153_L372_Y1.3031.00
16_A24_L1.3011.00
369_L392_L1.3001.00
329_G335_S1.2991.00
377_V397_F1.2881.00
144_L153_L1.2851.00
49_A74_W1.2841.00
180_C369_L1.2841.00
377_V389_A1.2801.00
403_E406_D1.2791.00
204_K232_A1.2761.00
214_V302_A1.2681.00
400_R408_C1.2631.00
323_Q329_G1.2571.00
18_L24_L1.2541.00
309_I315_N1.2511.00
48_V131_F1.2501.00
203_V230_C1.2481.00
182_S382_G1.2441.00
25_L143_V1.2441.00
198_R201_E1.2421.00
388_F391_A1.2391.00
285_D288_A1.2371.00
379_V399_A1.2371.00
76_P115_T1.2331.00
6_L18_L1.2271.00
153_L178_V1.2211.00
32_D36_Q1.2191.00
220_I246_V1.2161.00
158_F180_C1.2131.00
123_D126_G1.2101.00
363_A366_R1.2081.00
332_L335_S1.2071.00
56_H381_H1.2031.00
62_A66_G1.1961.00
132_Y144_L1.1921.00
186_D385_C1.1891.00
161_T367_A1.1831.00
118_Y133_N1.1831.00
193_D361_D1.1821.00
390_D393_R1.1801.00
360_A364_G1.1631.00
49_A78_T1.1601.00
207_L235_I1.1591.00
391_A394_D1.1571.00
75_T78_T1.1541.00
338_A343_R1.1531.00
217_A291_V1.1491.00
118_Y140_S1.1421.00
147_D150_T1.1401.00
54_L85_L1.1391.00
344_V348_S1.1331.00
333_I353_Q1.1301.00
84_T249_M1.1301.00
182_S388_F1.1291.00
248_E252_R1.1271.00
331_S335_S1.1251.00
329_G333_I1.1191.00
340_I343_R1.1181.00
10_R384_D1.1131.00
46_A124_A1.1121.00
64_L72_I1.1061.00
273_V278_G1.1041.00
180_C377_V1.0941.00
400_R406_D1.0901.00
339_E342_G1.0891.00
319_M332_L1.0811.00
387_A390_D1.0801.00
23_L45_D1.0761.00
311_S345_L1.0671.00
51_H56_H1.0641.00
48_V145_V1.0511.00
48_V124_A1.0461.00
155_T180_C1.0391.00
46_A71_P1.0361.00
212_T309_I1.0290.99
395_A398_T1.0290.99
19_V154_Y1.0270.99
119_G132_Y1.0250.99
223_T239_V1.0240.99
204_K233_H1.0240.99
332_L347_V1.0230.99
51_H136_H1.0210.99
75_T131_F1.0130.99
49_A60_I1.0130.99
134_A140_S1.0130.99
306_I317_I1.0120.99
369_L377_V1.0110.99
175_A178_V1.0100.99
388_F392_L1.0080.99
33_T38_P1.0060.99
338_A341_D1.0050.99
351_V354_Y1.0020.99
23_L48_V0.9990.99
158_F365_L0.9960.99
231_D259_D0.9950.99
202_S352_E0.9950.99
183_T381_H0.9900.99
3_L17_L0.9870.99
206_T318_A0.9840.99
32_D38_P0.9830.99
307_P343_R0.9790.99
227_L237_C0.9780.99
9_A404_R0.9740.99
56_H157_D0.9710.99
81_L246_V0.9710.99
10_R403_E0.9700.99
21_E125_A0.9670.99
393_R398_T0.9590.99
185_S388_F0.9560.99
217_A223_T0.9560.99
9_A402_P0.9510.99
367_A370_D0.9480.99
329_G334_D0.9450.99
387_A391_A0.9440.99
19_V23_L0.9410.99
50_S179_V0.9390.99
324_V327_T0.9330.99
41_T68_H0.9300.99
25_L179_V0.9280.99
64_L69_R0.9260.99
365_L392_L0.9250.99
229_V356_F0.9230.99
74_W113_S0.9170.99
122_F129_V0.9170.99
392_L395_A0.9130.99
151_R173_P0.9110.99
379_V401_A0.9100.99
180_C365_L0.9090.99
12_V183_T0.9080.99
53_H359_H0.9080.99
25_L145_V0.9030.99
313_P348_S0.9010.99
212_T288_A0.8930.99
228_L257_V0.8900.98
64_L112_V0.8860.98
194_S197_A0.8840.98
52_G137_V0.8820.98
226_L290_I0.8790.98
273_V279_Q0.8780.98
213_V316_K0.8760.98
390_D399_A0.8750.98
340_I344_V0.8750.98
84_T245_R0.8720.98
20_G43_T0.8700.98
140_S156_G0.8680.98
325_A330_R0.8680.98
155_T368_F0.8660.98
377_V393_R0.8640.98
178_V377_V0.8640.98
281_K284_A0.8610.98
209_E316_K0.8610.98
203_V207_L0.8600.98
85_L242_M0.8600.98
215_V320_T0.8600.98
157_D381_H0.8600.98
80_E249_M0.8570.98
317_I349_A0.8550.98
362_H387_A0.8540.98
22_S45_D0.8540.98
17_L25_L0.8520.98
224_Q228_L0.8510.98
197_A201_E0.8490.98
53_H136_H0.8480.98
340_I345_L0.8480.98
51_H359_H0.8480.98
191_D194_S0.8470.98
49_A57_V0.8430.98
281_K289_A0.8400.98
50_S143_V0.8360.98
150_T177_V0.8320.98
304_T307_P0.8300.98
231_D262_A0.8280.98
160_T364_G0.8270.98
51_H55_D0.8270.98
121_P146_D0.8200.97
134_A142_H0.8200.97
183_T218_F0.8190.97
185_S365_L0.8150.97
196_E232_A0.8130.97
166_V221_G0.8110.97
37_F63_L0.8080.97
332_L336_G0.8010.97
53_H56_H0.8010.97
307_P311_S0.8000.97
333_I336_G0.7970.97
362_H365_L0.7940.97
207_L290_I0.7910.97
280_R283_I0.7910.97
65_S89_T0.7910.97
155_T178_V0.7900.97
384_D401_A0.7890.97
331_S334_D0.7860.97
366_R391_A0.7860.97
210_G287_Q0.7860.97
214_V309_I0.7860.97
33_T37_F0.7850.97
229_V233_H0.7850.97
73_H114_R0.7840.97
80_E83_L0.7810.97
41_T44_P0.7790.97
55_D381_H0.7750.96
87_R90_L0.7750.96
258_R263_L0.7750.96
21_E46_A0.7750.96
142_H158_F0.7710.96
212_T284_A0.7650.96
344_V347_V0.7610.96
57_V85_L0.7570.96
202_S354_Y0.7520.96
200_A229_V0.7500.96
363_A367_A0.7500.96
273_V284_A0.7470.96
341_D344_V0.7470.96
212_T315_N0.7470.96
21_E43_T0.7450.96
55_D359_H0.7440.95
153_L172_R0.7420.95
4_R18_L0.7390.95
32_D37_F0.7390.95
277_D280_R0.7360.95
168_G171_A0.7340.95
25_L380_N0.7320.95
55_D183_T0.7320.95
57_V81_L0.7280.95
116_H129_V0.7270.95
310_R317_I0.7250.95
333_I337_R0.7250.95
5_F17_L0.7240.95
135_G221_G0.7220.95
234_D288_A0.7210.95
79_Y83_L0.7180.95
136_H359_H0.7170.94
229_V232_A0.7140.94
175_A372_Y0.7120.94
3_L378_L0.7080.94
75_T139_G0.7070.94
239_V244_K0.7030.94
231_D237_C0.7030.94
218_F295_G0.7000.94
89_T92_L0.7000.94
202_S206_T0.7000.94
218_F381_H0.6990.94
161_T364_G0.6990.94
359_H381_H0.6940.93
190_D198_R0.6930.93
64_L86_A0.6920.93
203_V213_V0.6910.93
162_D370_D0.6870.93
64_L68_H0.6870.93
23_L124_A0.6850.93
5_F402_P0.6840.93
212_T286_Q0.6820.93
17_L154_Y0.6820.93
150_T176_D0.6820.93
222_R357_S0.6780.93
200_A225_E0.6770.93
204_K229_V0.6770.93
342_G345_L0.6750.93
150_T375_A0.6750.93
222_R358_A0.6730.92
16_A27_F0.6730.92
59_T62_A0.6700.92
195_V356_F0.6680.92
78_T224_Q0.6660.92
214_V315_N0.6620.92
132_Y153_L0.6620.92
158_F360_A0.6620.92
55_D136_H0.6600.92
226_L292_T0.6590.92
342_G403_E0.6580.92
127_Y145_V0.6580.92
88_D91_K0.6580.92
53_H381_H0.6540.91
212_T287_Q0.6520.91
23_L145_V0.6510.91
136_H157_D0.6500.91
218_F321_G0.6480.91
27_F47_V0.6470.91
186_D387_A0.6460.91
369_L389_A0.6450.91
310_R347_V0.6440.91
9_A380_N0.6410.90
60_I72_I0.6410.90
370_D394_D0.6410.90
182_S379_V0.6410.90
85_L220_I0.6410.90
242_M299_G0.6400.90
318_A352_E0.6370.90
193_D356_F0.6370.90
60_I70_P0.6360.90
133_N167_S0.6360.90
84_T87_R0.6350.90
53_H157_D0.6340.90
344_V349_A0.6340.90
133_N139_G0.6340.90
160_T368_F0.6320.90
9_A17_L0.6320.90
186_D386_A0.6300.90
248_E251_L0.6270.90
392_L397_F0.6240.89
152_L177_V0.6240.89
338_A345_L0.6220.89
191_D363_A0.6210.89
202_S205_T0.6200.89
134_A368_F0.6180.89
388_F393_R0.6160.89
5_F9_A0.6150.89
192_R363_A0.6130.88
190_D362_H0.6130.88
245_R248_E0.6120.88
206_T209_E0.6120.88
338_A348_S0.6120.88
22_S40_S0.6120.88
329_G337_R0.6100.88
187_V361_D0.6090.88
133_N140_S0.6070.88
52_G57_V0.6060.88
19_V152_L0.6050.88
87_R110_T0.6050.88
56_H136_H0.6050.88
244_K248_E0.6040.88
23_L129_V0.6040.88
162_D367_A0.6010.87
236_P288_A0.6000.87
119_G130_T0.5990.87
239_V263_L0.5980.87
379_V389_A0.5970.87
177_V375_A0.5950.87
164_R196_E0.5930.87
157_D359_H0.5900.86
60_I86_A0.5900.86
62_A65_S0.5900.86
21_E127_Y0.5890.86
366_R395_A0.5880.86
6_L39_V0.5860.86
77_P138_P0.5860.86
199_F356_F0.5860.86
337_R348_S0.5850.86
47_V68_H0.5850.86
281_K291_V0.5850.86
330_R336_G0.5840.86
319_M333_I0.5840.86
48_V125_A0.5840.86
34_P37_F0.5830.86
252_R255_G0.5830.86
19_V179_V0.5830.86
44_P47_V0.5820.86
41_T69_R0.5810.86
76_P80_E0.5800.86
251_L260_G0.5790.85
174_E372_Y0.5750.85
402_P406_D0.5750.85
19_V127_Y0.5740.85
110_T113_S0.5740.85
24_L47_V0.5740.85
213_V289_A0.5720.85
116_H141_A0.5690.84
390_D401_A0.5690.84
160_T170_T0.5690.84
341_D345_L0.5680.84
299_G303_M0.5660.84
156_G183_T0.5660.84
11_E30_K0.5640.84
228_L231_D0.5630.84
290_I309_I0.5630.84
192_R367_A0.5620.84
151_R174_E0.5620.84
214_V306_I0.5620.84
338_A347_V0.5610.84
56_H359_H0.5610.84
82_A110_T0.5610.84
340_I347_V0.5590.83
221_G250_L0.5570.83
25_L152_L0.5560.83
202_S318_A0.5560.83
247_T292_T0.5560.83
200_A232_A0.5550.83
124_A208_W0.5540.83
146_D149_D0.5540.83
53_H181_E0.5530.83
183_T359_H0.5510.83
366_R392_L0.5490.82
206_T213_V0.5480.82
14_R323_Q0.5480.82
364_G367_A0.5450.82
342_G346_P0.5450.82
185_S392_L0.5450.82
142_H178_V0.5430.82
180_C389_A0.5410.81
181_E359_H0.5410.81
368_F372_Y0.5400.81
366_R394_D0.5400.81
83_L113_S0.5390.81
223_T247_T0.5390.81
362_H366_R0.5380.81
306_I310_R0.5380.81
76_P253_Y0.5380.81
201_E204_K0.5380.81
136_H381_H0.5380.81
299_G327_T0.5380.81
294_S298_S0.5370.81
377_V392_L0.5370.81
301_P305_Y0.5360.81
258_R262_A0.5360.81
124_A129_V0.5360.81
86_A92_L0.5350.81
152_L179_V0.5320.80
7_G11_E0.5310.80
134_A141_A0.5310.80
27_F63_L0.5290.80
273_V280_R0.5290.80
338_A346_P0.5280.80
77_P253_Y0.5280.80
342_G349_A0.5250.79
52_G81_L0.5250.79
63_L70_P0.5240.79
154_Y179_V0.5240.79
116_H143_V0.5240.79
130_T173_P0.5230.79
367_A371_D0.5200.79
226_L230_C0.5200.79
339_E343_R0.5190.79
92_L299_G0.5170.78
155_T183_T0.5170.78
56_H218_F0.5160.78
341_D347_V0.5160.78
205_T208_W0.5160.78
56_H183_T0.5160.78
309_I314_V0.5150.78
342_G348_S0.5150.78
200_A204_K0.5140.78
54_L242_M0.5140.78
217_A292_T0.5130.78
52_G78_T0.5100.78
16_A59_T0.5100.78
144_L173_P0.5100.78
321_G327_T0.5100.78
332_L337_R0.5100.78
13_G31_A0.5100.78
310_R339_E0.5060.77
361_D364_G0.5060.77
307_P341_D0.5050.77
286_Q289_A0.5040.77
334_D337_R0.5040.77
362_H388_F0.5040.77
214_V317_I0.5020.76
237_C289_A0.5020.76
331_S337_R0.5020.76
57_V220_I0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iekA 3 0.9878 100 0.284 Contact Map
2i7tA 1 0.8927 100 0.284 Contact Map
2ycbA 2 1 100 0.289 Contact Map
2xr1A 2 0.9829 100 0.304 Contact Map
3af5A 1 1 100 0.305 Contact Map
2i7xA 1 0.9805 100 0.368 Contact Map
3bk2A 2 0.9195 100 0.387 Contact Map
3zq4A 3 0.9049 100 0.395 Contact Map
2az4A 1 0.9073 100 0.477 Contact Map
4b87A 1 0.7659 100 0.532 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0119 seconds.