Q9HMJ6 - HALSA - GREMLIN Contacts

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Q9HMJ6 - Aldehyde dehydrogenase (Retinol)

UniProt:	Q9HMJ6	Sequences: MSDLDFGDVDWNVQYIDGEYVPPGDRGTLEVDDPSTRELFTEIPAGTTDDVDAAYEAAADAQTEWADTPPQERARIVAAASEILASHRDEVVDLLATESGTTYTKGAAEFEASVGITDEAASFPTRMNGDHKQSVVEGKENIVVREPQGVVGIISPWNFPLNLSIRAVAPAVAAGNSVVLKPASNTPVTGGLLIAKVFEAAGLPEGVFNVVTGKGSEIGDRIAGHPHADVISFTGSTAIGRQVAATAGENLALPAMELGGNNVHIVTEDADLDDAVDSGVFGSFLHSGQICISINRHVVHEDVYDEYVERLTERAAALPTGTAHDADTVVGPIIDESQRDQILDYIERTVDAGATLETGGDHDGLVVEPTVLSDATNDMAAACNEHFGPVAPVIPFSDDDEAVEIANSTEYGLSGSVHAGDTGRARDIADRIDTGMIHINDQPVNQEPHLPFGGYKNSGLGRYNGEYVLNEFTQEKWVSIQRETRDYPF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	489 (452)
Sequences:	36376 (21710)
Seq/√Len:	1021.1

ECOLI - PUUC GABD BETB FEAB ALDB ABDH ALDA ASTD EUTE SAD PUTA PAAZ PROA ADHE
BACSU - ALDH4 ROCA ROCA2 ALDH5 ALDH1 ALDY IOLA BETB GABD ALDH3 ALDH2 PROA
HALSA - Q9HMJ6 Q9HQZ2 Q9HRB5 Q9HR91
SULSO - Q97YT9 GAPN KGSDH Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
301_E	397_S	5.154	1.00
245_A	249_E	4.014	1.00
301_E	395_P	3.221	1.00
273_D	310_R	3.165	1.00
304_Y	395_P	2.982	1.00
30_E	42_E	2.821	1.00
268_E	300_H	2.808	1.00
59_A	227_H	2.777	1.00
376_T	379_M	2.768	1.00
336_E	340_D	2.674	1.00
277_D	314_R	2.608	1.00
193_L	196_K	2.597	1.00
348_R	380_A	2.581	1.00
347_E	351_D	2.579	1.00
308_V	393_V	2.546	1.00
85_A	118_D	2.478	1.00
268_E	302_D	2.468	1.00
87_H	90_E	2.435	1.00
361_D	368_E	2.381	1.00
419_A	425_A	2.352	1.00
346_I	367_V	2.319	1.00
30_E	39_L	2.303	1.00
59_A	229_D	2.274	1.00
199_E	205_E	2.261	1.00
47_T	50_D	2.218	1.00
89_D	107_A	2.170	1.00
88_R	111_E	2.167	1.00
343_L	347_E	2.137	1.00
83_I	200_A	2.109	1.00
355_T	374_D	2.055	1.00
399_D	424_R	2.044	1.00
146_E	476_K	2.042	1.00
410_E	457_N	2.026	1.00
80_A	198_F	2.018	1.00
185_N	335_D	2.006	1.00
220_D	224_G	1.996	1.00
333_I	342_I	1.972	1.00
224_G	246_T	1.971	1.00
348_R	352_A	1.951	1.00
343_L	367_V	1.936	1.00
264_H	279_G	1.929	1.00
427_D	431_R	1.916	1.00
357_E	373_S	1.911	1.00
350_V	356_L	1.910	1.00
145_R	470_N	1.901	1.00
76_I	203_L	1.890	1.00
312_T	316_A	1.888	1.00
306_E	310_R	1.886	1.00
269_D	424_R	1.846	1.00
343_L	362_H	1.812	1.00
56_E	227_H	1.803	1.00
90_E	193_L	1.797	1.00
298_V	405_I	1.796	1.00
242_Q	245_A	1.793	1.00
241_R	457_N	1.778	1.00
83_I	86_S	1.773	1.00
145_R	473_T	1.770	1.00
433_D	456_K	1.767	1.00
52_D	221_R	1.749	1.00
372_L	381_A	1.722	1.00
87_H	200_A	1.719	1.00
382_A	394_I	1.718	1.00
300_H	396_F	1.699	1.00
298_V	402_A	1.692	1.00
52_D	56_E	1.684	1.00
315_A	371_V	1.671	1.00
399_D	427_D	1.664	1.00
377_N	405_I	1.664	1.00
401_E	404_E	1.650	1.00
39_L	42_E	1.635	1.00
355_T	373_S	1.627	1.00
312_T	357_E	1.626	1.00
78_A	118_D	1.615	1.00
83_I	201_A	1.598	1.00
397_S	401_E	1.595	1.00
304_Y	308_V	1.585	1.00
279_G	307_Y	1.585	1.00
380_A	384_N	1.580	1.00
196_K	200_A	1.580	1.00
284_F	315_A	1.576	1.00
85_A	114_V	1.571	1.00
117_T	169_A	1.566	1.00
195_A	210_V	1.561	1.00
103_Y	107_A	1.558	1.00
309_E	313_E	1.557	1.00
214_K	217_E	1.557	1.00
62_Q	66_A	1.554	1.00
69_P	72_E	1.548	1.00
82_E	86_S	1.546	1.00
83_I	197_V	1.537	1.00
272_L	310_R	1.535	1.00
177_S	207_V	1.535	1.00
344_D	380_A	1.524	1.00
336_E	365_L	1.521	1.00
310_R	313_E	1.517	1.00
297_H	391_A	1.506	1.00
52_D	225_H	1.499	1.00
305_D	395_P	1.498	1.00
276_V	310_R	1.478	1.00
356_L	372_L	1.472	1.00
72_E	75_R	1.466	1.00
78_A	125_T	1.462	1.00
79_A	82_E	1.459	1.00
298_V	396_F	1.445	1.00
267_T	424_R	1.445	1.00
28_T	42_E	1.439	1.00
94_L	193_L	1.435	1.00
37_R	363_D	1.429	1.00
268_E	424_R	1.427	1.00
278_S	418_H	1.424	1.00
304_Y	373_S	1.424	1.00
279_G	297_H	1.420	1.00
93_D	97_T	1.420	1.00
415_G	434_T	1.418	1.00
89_D	93_D	1.411	1.00
400_D	431_R	1.410	1.00
314_R	317_A	1.406	1.00
306_E	309_E	1.405	1.00
299_V	307_Y	1.405	1.00
67_D	431_R	1.402	1.00
88_R	107_A	1.401	1.00
81_S	118_D	1.399	1.00
123_F	126_R	1.397	1.00
82_E	118_D	1.390	1.00
144_V	430_D	1.389	1.00
117_T	165_I	1.385	1.00
68_T	72_E	1.372	1.00
401_E	405_I	1.369	1.00
347_E	350_V	1.362	1.00
153_I	178_V	1.357	1.00
32_D	39_L	1.351	1.00
50_D	53_A	1.346	1.00
319_P	327_D	1.339	1.00
345_Y	386_H	1.335	1.00
342_I	388_G	1.328	1.00
96_A	106_G	1.328	1.00
267_T	396_F	1.325	1.00
244_A	460_L	1.322	1.00
93_D	324_H	1.321	1.00
38_E	363_D	1.320	1.00
230_V	255_A	1.313	1.00
87_H	193_L	1.309	1.00
313_E	316_A	1.303	1.00
27_G	45_A	1.303	1.00
396_F	405_I	1.301	1.00
33_D	36_T	1.301	1.00
339_R	343_L	1.299	1.00
339_R	367_V	1.295	1.00
340_D	344_D	1.279	1.00
62_Q	177_S	1.276	1.00
305_D	309_E	1.265	1.00
164_S	180_L	1.262	1.00
352_A	380_A	1.256	1.00
354_A	372_L	1.248	1.00
308_V	312_T	1.248	1.00
55_Y	225_H	1.247	1.00
224_G	249_E	1.245	1.00
398_D	401_E	1.244	1.00
267_T	428_I	1.239	1.00
195_A	208_F	1.238	1.00
336_E	339_R	1.226	1.00
300_H	398_D	1.217	1.00
403_V	428_I	1.212	1.00
265_I	402_A	1.209	1.00
81_S	85_A	1.201	1.00
378_D	383_C	1.190	1.00
467_Y	470_N	1.187	1.00
300_H	303_V	1.182	1.00
303_V	306_E	1.174	1.00
56_E	60_D	1.174	1.00
45_A	214_K	1.169	1.00
220_D	246_T	1.161	1.00
319_P	329_V	1.160	1.00
339_R	362_H	1.160	1.00
96_A	323_A	1.157	1.00
145_R	475_E	1.156	1.00
310_R	314_R	1.155	1.00
344_D	348_R	1.153	1.00
206_G	209_N	1.151	1.00
311_L	391_A	1.151	1.00
142_I	426_R	1.151	1.00
316_A	358_T	1.150	1.00
68_T	76_I	1.150	1.00
466_E	470_N	1.141	1.00
377_N	408_S	1.140	1.00
308_V	373_S	1.138	1.00
429_A	478_V	1.137	1.00
415_G	437_I	1.136	1.00
308_V	357_E	1.134	1.00
93_D	103_Y	1.132	1.00
55_Y	227_H	1.128	1.00
349_T	372_L	1.126	1.00
321_G	328_T	1.126	1.00
55_Y	228_A	1.120	1.00
198_F	208_F	1.120	1.00
307_Y	311_L	1.118	1.00
220_D	242_Q	1.116	1.00
51_V	218_I	1.113	1.00
313_E	317_A	1.112	1.00
184_S	214_K	1.112	1.00
79_A	83_I	1.108	1.00
221_R	225_H	1.107	1.00
80_A	197_V	1.107	1.00
80_A	203_L	1.099	1.00
383_C	408_S	1.099	1.00
242_Q	246_T	1.096	1.00
184_S	216_S	1.092	1.00
168_V	208_F	1.092	1.00
383_C	410_E	1.092	1.00
425_A	439_I	1.092	1.00
239_I	242_Q	1.087	1.00
33_D	322_T	1.085	1.00
57_A	209_N	1.085	1.00
453_G	462_R	1.081	1.00
153_I	232_S	1.074	1.00
400_D	427_D	1.072	1.00
35_S	323_A	1.072	1.00
238_A	242_Q	1.071	1.00
339_R	365_L	1.071	1.00
264_H	294_I	1.070	1.00
148_Q	230_V	1.067	1.00
400_D	404_E	1.066	1.00
41_T	188_V	1.066	1.00
48_T	221_R	1.065	1.00
462_R	474_Q	1.064	1.00
78_A	122_S	1.064	1.00
244_A	254_P	1.063	1.00
91_V	193_L	1.060	1.00
80_A	117_T	1.060	1.00
318_L	330_V	1.053	1.00
265_I	428_I	1.050	1.00
271_D	420_G	1.049	1.00
316_A	368_E	1.046	1.00
403_V	431_R	1.046	1.00
29_L	45_A	1.045	1.00
312_T	358_T	1.042	1.00
467_Y	475_E	1.040	1.00
130_D	466_E	1.039	1.00
159_F	290_I	1.036	1.00
45_A	217_E	1.032	1.00
265_I	406_A	1.032	1.00
261_N	295_N	1.032	1.00
168_V	178_V	1.030	1.00
152_G	228_A	1.027	1.00
130_D	467_Y	1.016	1.00
396_F	402_A	1.011	1.00
37_R	365_L	1.004	1.00
196_K	199_E	1.002	1.00
271_D	274_D	0.995	1.00
61_A	177_S	0.993	1.00
399_D	428_I	0.992	1.00
322_T	325_D	0.991	1.00
421_D	424_R	0.987	1.00
184_S	215_G	0.986	1.00
342_I	390_V	0.985	1.00
352_A	379_M	0.984	1.00
63_T	404_E	0.982	1.00
359_G	368_E	0.981	1.00
144_V	478_V	0.978	1.00
86_S	200_A	0.978	1.00
74_A	125_T	0.974	1.00
195_A	199_E	0.973	1.00
241_R	251_L	0.972	1.00
87_H	196_K	0.972	1.00
113_S	165_I	0.969	1.00
263_V	415_G	0.968	1.00
63_T	433_D	0.965	1.00
124_P	173_A	0.954	1.00
359_G	370_T	0.954	1.00
91_V	197_V	0.951	1.00
150_V	177_S	0.948	1.00
455_Y	474_Q	0.941	1.00
59_A	63_T	0.941	1.00
416_S	442_Q	0.940	1.00
48_T	217_E	0.939	1.00
148_Q	253_L	0.939	1.00
152_G	222_I	0.936	1.00
273_D	306_E	0.934	1.00
274_D	278_S	0.932	1.00
90_E	93_D	0.928	1.00
87_H	197_V	0.927	1.00
92_V	107_A	0.927	1.00
97_T	324_H	0.926	1.00
404_E	408_S	0.925	1.00
33_D	97_T	0.922	1.00
282_G	294_I	0.919	1.00
280_V	314_R	0.918	1.00
244_A	248_G	0.917	1.00
345_Y	348_R	0.916	1.00
192_L	212_T	0.916	1.00
141_N	450_L	0.915	1.00
78_A	121_A	0.912	1.00
192_L	210_V	0.911	1.00
375_A	379_M	0.910	1.00
229_D	433_D	0.907	1.00
283_S	295_N	0.907	1.00
146_E	430_D	0.906	1.00
150_V	228_A	0.905	1.00
305_D	308_V	0.900	1.00
63_T	67_D	0.900	1.00
48_T	52_D	0.900	1.00
348_R	351_D	0.893	1.00
66_A	433_D	0.893	1.00
344_D	347_E	0.887	1.00
267_T	399_D	0.886	1.00
83_I	87_H	0.885	1.00
99_S	186_T	0.885	1.00
75_R	79_A	0.884	1.00
426_R	430_D	0.884	1.00
264_H	418_H	0.882	1.00
340_D	343_L	0.882	1.00
51_V	152_G	0.881	1.00
151_V	230_V	0.880	1.00
360_G	370_T	0.877	1.00
236_S	239_I	0.877	1.00
70_P	74_A	0.876	1.00
304_Y	393_V	0.876	1.00
276_V	311_L	0.875	1.00
146_E	455_Y	0.875	1.00
350_V	372_L	0.874	1.00
33_D	38_E	0.869	1.00
241_R	245_A	0.867	1.00
74_A	78_A	0.866	1.00
345_Y	380_A	0.866	1.00
113_S	161_L	0.866	1.00
253_L	474_Q	0.865	1.00
101_T	109_E	0.863	1.00
272_L	276_V	0.862	1.00
394_I	405_I	0.858	1.00
276_V	314_R	0.856	1.00
35_S	366_V	0.856	1.00
53_A	57_A	0.856	1.00
267_T	419_A	0.854	1.00
32_D	365_L	0.853	1.00
185_N	337_S	0.848	1.00
450_L	477_W	0.847	1.00
415_G	432_I	0.844	1.00
353_G	379_M	0.839	1.00
81_S	121_A	0.838	1.00
342_I	386_H	0.837	1.00
142_I	480_I	0.836	1.00
377_N	394_I	0.832	1.00
244_A	247_A	0.829	1.00
354_A	379_M	0.827	1.00
417_V	428_I	0.820	1.00
396_F	401_E	0.820	1.00
266_V	307_Y	0.820	1.00
180_L	190_G	0.819	1.00
74_A	121_A	0.817	1.00
231_I	247_A	0.816	1.00
275_A	279_G	0.815	1.00
402_A	405_I	0.814	1.00
167_A	463_Y	0.812	1.00
61_A	207_V	0.812	1.00
148_Q	474_Q	0.810	1.00
403_V	407_N	0.809	1.00
244_A	251_L	0.809	1.00
84_L	113_S	0.807	1.00
373_S	395_P	0.805	1.00
170_P	468_V	0.803	1.00
58_A	209_N	0.802	1.00
276_V	307_Y	0.801	1.00
29_L	214_K	0.799	1.00
49_D	52_D	0.799	1.00
346_I	390_V	0.795	1.00
49_D	53_A	0.795	1.00
174_A	473_T	0.793	1.00
240_G	258_L	0.791	1.00
422_T	425_A	0.790	1.00
46_G	50_D	0.790	1.00
57_A	206_G	0.789	1.00
231_I	243_V	0.788	1.00
262_N	295_N	0.787	1.00
67_D	430_D	0.786	1.00
148_Q	176_N	0.785	1.00
65_W	207_V	0.783	1.00
182_P	212_T	0.783	1.00
171_A	178_V	0.782	1.00
53_A	56_E	0.782	1.00
216_S	220_D	0.781	1.00
309_E	312_T	0.780	1.00
304_Y	374_D	0.780	1.00
164_S	168_V	0.779	1.00
203_L	208_F	0.774	1.00
434_T	437_I	0.772	1.00
78_A	82_E	0.771	1.00
104_T	329_V	0.766	1.00
60_D	63_T	0.766	1.00
77_V	173_A	0.766	1.00
240_G	256_M	0.762	1.00
40_F	97_T	0.758	1.00
99_S	334_I	0.757	1.00
96_A	103_Y	0.756	1.00
311_L	371_V	0.752	1.00
337_S	340_D	0.751	1.00
46_G	54_A	0.748	1.00
152_G	231_I	0.747	1.00
342_I	367_V	0.745	1.00
276_V	280_V	0.744	1.00
60_D	64_E	0.743	1.00
165_I	194_I	0.743	1.00
263_V	406_A	0.742	1.00
233_F	239_I	0.742	1.00
219_G	223_A	0.741	1.00
71_Q	125_T	0.740	1.00
161_L	189_T	0.737	1.00
203_L	207_V	0.736	1.00
213_G	218_I	0.736	1.00
223_A	243_V	0.736	1.00
153_I	167_A	0.735	1.00
194_I	198_F	0.734	1.00
275_A	307_Y	0.733	1.00
97_T	188_V	0.732	1.00
107_A	326_A	0.732	1.00
193_L	197_V	0.731	1.00
85_A	88_R	0.729	1.00
300_H	399_D	0.729	1.00
237_T	457_N	0.726	1.00
318_L	329_V	0.725	1.00
92_V	96_A	0.725	1.00
280_V	311_L	0.723	1.00
272_L	303_V	0.722	1.00
103_Y	324_H	0.721	1.00
63_T	66_A	0.719	1.00
273_D	314_R	0.717	1.00
241_R	249_E	0.716	1.00
299_V	303_V	0.715	1.00
33_D	324_H	0.714	1.00
84_L	114_V	0.708	1.00
141_N	477_W	0.707	1.00
92_V	103_Y	0.706	1.00
315_A	358_T	0.706	1.00
76_I	201_A	0.703	1.00
325_D	328_T	0.703	1.00
85_A	111_E	0.699	1.00
64_E	68_T	0.698	1.00
223_A	246_T	0.697	1.00
267_T	300_H	0.696	1.00
345_Y	384_N	0.695	1.00
336_E	362_H	0.694	1.00
420_G	423_G	0.692	1.00
32_D	37_R	0.689	1.00
58_A	177_S	0.689	1.00
180_L	208_F	0.688	1.00
79_A	201_A	0.686	1.00
52_D	227_H	0.686	1.00
185_N	334_I	0.684	1.00
164_S	190_G	0.683	1.00
422_T	480_I	0.682	1.00
148_Q	229_D	0.681	1.00
101_T	105_K	0.680	1.00
90_E	196_K	0.679	1.00
320_T	330_V	0.678	1.00
312_T	315_A	0.676	1.00
335_D	338_Q	0.675	1.00
152_G	219_G	0.673	1.00
66_A	431_R	0.673	1.00
349_T	386_H	0.672	1.00
95_L	98_E	0.672	1.00
439_I	480_I	0.671	1.00
37_R	336_E	0.670	1.00
218_I	221_R	0.666	1.00
65_W	76_I	0.666	1.00
176_N	473_T	0.664	1.00
155_S	164_S	0.663	1.00
94_L	188_V	0.663	1.00
51_V	55_Y	0.663	1.00
338_Q	341_Q	0.662	1.00
59_A	62_Q	0.662	1.00
217_E	220_D	0.662	1.00
315_A	318_L	0.661	1.00
70_P	124_P	0.661	1.00
322_T	328_T	0.658	1.00
298_V	382_A	0.658	1.00
297_H	307_Y	0.658	1.00
398_D	404_E	0.657	1.00
341_Q	344_D	0.657	1.00
247_A	254_P	0.656	1.00
399_D	403_V	0.654	1.00
287_S	330_V	0.654	1.00
82_E	85_A	0.654	1.00
245_A	248_G	0.652	1.00
298_V	377_N	0.651	1.00
253_L	471_E	0.650	1.00
215_G	219_G	0.650	1.00
405_I	408_S	0.648	1.00
269_D	419_A	0.647	1.00
51_V	221_R	0.646	1.00
470_N	473_T	0.646	1.00
27_G	217_E	0.646	1.00
377_N	382_A	0.645	1.00
429_A	439_I	0.645	1.00
246_T	249_E	0.643	1.00
279_G	311_L	0.642	1.00
63_T	431_R	0.642	1.00
179_V	209_N	0.638	1.00
266_V	275_A	0.638	1.00
141_N	479_S	0.637	1.00
350_V	361_D	0.635	1.00
425_A	429_A	0.632	1.00
280_V	318_L	0.632	1.00
28_T	44_P	0.631	1.00
311_L	393_V	0.630	1.00
272_L	306_E	0.630	1.00
110_F	114_V	0.630	1.00
89_D	103_Y	0.628	1.00
44_P	212_T	0.628	1.00
65_W	172_V	0.628	1.00
91_V	161_L	0.627	1.00
360_G	368_E	0.627	1.00
419_A	424_R	0.626	1.00
358_T	371_V	0.626	1.00
433_D	455_Y	0.626	1.00
64_E	67_D	0.625	1.00
274_D	277_D	0.624	1.00
66_A	147_P	0.623	1.00
223_A	231_I	0.621	1.00
367_V	370_T	0.621	1.00
269_D	421_D	0.621	1.00
57_A	205_E	0.621	1.00
422_T	426_R	0.619	1.00
337_S	341_Q	0.619	1.00
255_A	471_E	0.617	1.00
470_N	475_E	0.616	1.00
140_E	426_R	0.615	1.00
333_I	338_Q	0.615	1.00
46_G	211_V	0.614	1.00
144_V	476_K	0.613	1.00
346_I	372_L	0.612	1.00
142_I	478_V	0.610	1.00
164_S	194_I	0.609	1.00
66_A	146_E	0.609	1.00
167_A	232_S	0.607	1.00
56_E	59_A	0.607	1.00
274_D	420_G	0.606	1.00
127_M	469_L	0.606	1.00
184_S	341_Q	0.606	1.00
88_R	92_V	0.606	1.00
101_T	159_F	0.605	1.00
375_A	382_A	0.604	1.00
81_S	114_V	0.603	1.00
43_I	187_P	0.603	1.00
213_G	219_G	0.602	1.00
343_L	346_I	0.602	1.00
198_F	203_L	0.601	1.00
72_E	76_I	0.599	1.00
84_L	117_T	0.598	1.00
244_A	256_M	0.598	1.00
426_R	480_I	0.597	1.00
31_V	41_T	0.596	1.00
95_L	109_E	0.595	1.00
54_A	211_V	0.595	1.00
184_S	242_Q	0.595	1.00
61_A	64_E	0.592	1.00
83_I	202_G	0.592	1.00
168_V	180_L	0.591	1.00
31_V	98_E	0.589	1.00
48_T	224_G	0.588	1.00
343_L	350_V	0.588	1.00
70_P	173_A	0.588	1.00
374_D	395_P	0.587	1.00
96_A	324_H	0.587	1.00
95_L	189_T	0.586	1.00
95_L	106_G	0.583	1.00
177_S	209_N	0.582	1.00
345_Y	349_T	0.581	1.00
93_D	96_A	0.580	1.00
386_H	390_V	0.579	1.00
127_M	473_T	0.578	1.00
151_V	176_N	0.578	1.00
292_I	446_Q	0.577	1.00
76_I	202_G	0.577	1.00
220_D	223_A	0.575	1.00
230_V	471_E	0.572	1.00
423_G	426_R	0.572	1.00
129_G	133_Q	0.572	1.00
403_V	427_D	0.572	1.00
128_N	131_H	0.571	1.00
417_V	425_A	0.571	1.00
299_V	393_V	0.570	1.00
48_T	220_D	0.569	1.00
375_A	381_A	0.568	1.00
377_N	404_E	0.568	1.00
352_A	378_D	0.567	1.00
356_L	370_T	0.567	1.00
84_L	161_L	0.567	1.00
216_S	242_Q	0.565	1.00
40_F	188_V	0.565	1.00
194_I	197_V	0.562	1.00
299_V	304_Y	0.560	1.00
282_G	442_Q	0.560	1.00
92_V	110_F	0.559	1.00
237_T	241_R	0.558	1.00
122_S	125_T	0.558	1.00
350_V	353_G	0.557	1.00
110_F	161_L	0.557	1.00
264_H	297_H	0.556	1.00
346_I	370_T	0.556	1.00
119_E	123_F	0.556	1.00
333_I	367_V	0.554	1.00
423_G	427_D	0.554	1.00
264_H	416_S	0.554	1.00
84_L	194_I	0.552	1.00
312_T	371_V	0.552	1.00
58_A	179_V	0.548	1.00
81_S	117_T	0.547	1.00
372_L	375_A	0.546	1.00
290_I	293_S	0.546	1.00
283_S	391_A	0.546	1.00
268_E	396_F	0.545	1.00
406_A	432_I	0.543	1.00
437_I	476_K	0.543	1.00
319_P	325_D	0.543	1.00
402_A	406_A	0.542	1.00
57_A	61_A	0.542	1.00
262_N	414_S	0.542	1.00
174_A	469_L	0.541	1.00
340_D	362_H	0.540	1.00
357_E	374_D	0.539	1.00
59_A	150_V	0.539	1.00
223_A	250_N	0.538	1.00
403_V	432_I	0.538	1.00
161_L	194_I	0.538	1.00
417_V	439_I	0.535	1.00
91_V	110_F	0.535	1.00
272_L	275_A	0.534	1.00
150_V	229_D	0.534	1.00
58_A	150_V	0.531	1.00
356_L	360_G	0.530	1.00
54_A	209_N	0.530	1.00
297_H	393_V	0.530	1.00
272_L	307_Y	0.530	1.00
31_V	187_P	0.529	1.00
120_A	170_P	0.529	1.00
343_L	361_D	0.529	1.00
27_G	47_T	0.529	1.00
276_V	303_V	0.527	1.00
172_V	208_F	0.527	1.00
438_H	441_D	0.527	1.00
232_S	472_F	0.526	1.00
381_A	386_H	0.526	1.00
320_T	329_V	0.525	1.00
80_A	83_I	0.524	1.00
151_V	178_V	0.524	1.00
352_A	376_T	0.524	1.00
153_I	168_V	0.524	1.00
270_A	275_A	0.524	1.00
128_N	132_K	0.523	1.00
273_D	313_E	0.523	1.00
162_N	166_R	0.522	1.00
199_E	202_G	0.521	1.00
221_R	224_G	0.521	1.00
76_I	80_A	0.521	1.00
109_E	159_F	0.520	1.00
112_A	162_N	0.519	1.00
43_I	188_V	0.519	1.00
84_L	91_V	0.515	1.00
238_A	337_S	0.515	1.00
166_R	464_N	0.514	1.00
433_D	474_Q	0.514	1.00
428_I	432_I	0.514	1.00
254_P	460_L	0.513	1.00
146_E	433_D	0.513	1.00
301_E	304_Y	0.512	1.00
269_D	420_G	0.511	1.00
294_I	416_S	0.511	1.00
75_R	78_A	0.509	1.00
248_G	251_L	0.508	1.00
88_R	114_V	0.507	1.00
71_Q	75_R	0.506	1.00
99_S	286_H	0.505	1.00
399_D	431_R	0.505	1.00
123_F	466_E	0.505	1.00
432_I	437_I	0.502	1.00
112_A	446_Q	0.502	1.00
151_V	232_S	0.501	1.00
217_E	221_R	0.500	1.00
79_A	202_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ek1A	5	0.9857	100	0.022	Contact Map
1a4sA	4	0.9918	100	0.025	Contact Map
4o5hA	4	0.9836	100	0.026	Contact Map
4yweA	5	0.9571	100	0.027	Contact Map
4qf6A	4	0.9816	100	0.029	Contact Map
2d4eA	4	0.9918	100	0.03	Contact Map
4pz2A	4	0.9775	100	0.031	Contact Map
4qtoA	4	0.9898	100	0.032	Contact Map
4pxlA	4	0.9775	100	0.032	Contact Map
4wj9A	4	0.9836	100	0.032	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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