GREMLIN Database
Q9HMJ6 - Aldehyde dehydrogenase (Retinol)
UniProt: Q9HMJ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 489 (452)
Sequences: 36376 (21710)
Seq/√Len: 1021.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
301_E397_S5.1541.00
245_A249_E4.0141.00
301_E395_P3.2211.00
273_D310_R3.1651.00
304_Y395_P2.9821.00
30_E42_E2.8211.00
268_E300_H2.8081.00
59_A227_H2.7771.00
376_T379_M2.7681.00
336_E340_D2.6741.00
277_D314_R2.6081.00
193_L196_K2.5971.00
348_R380_A2.5811.00
347_E351_D2.5791.00
308_V393_V2.5461.00
85_A118_D2.4781.00
268_E302_D2.4681.00
87_H90_E2.4351.00
361_D368_E2.3811.00
419_A425_A2.3521.00
346_I367_V2.3191.00
30_E39_L2.3031.00
59_A229_D2.2741.00
199_E205_E2.2611.00
47_T50_D2.2181.00
89_D107_A2.1701.00
88_R111_E2.1671.00
343_L347_E2.1371.00
83_I200_A2.1091.00
355_T374_D2.0551.00
399_D424_R2.0441.00
146_E476_K2.0421.00
410_E457_N2.0261.00
80_A198_F2.0181.00
185_N335_D2.0061.00
220_D224_G1.9961.00
333_I342_I1.9721.00
224_G246_T1.9711.00
348_R352_A1.9511.00
343_L367_V1.9361.00
264_H279_G1.9291.00
427_D431_R1.9161.00
357_E373_S1.9111.00
350_V356_L1.9101.00
145_R470_N1.9011.00
76_I203_L1.8901.00
312_T316_A1.8881.00
306_E310_R1.8861.00
269_D424_R1.8461.00
343_L362_H1.8121.00
56_E227_H1.8031.00
90_E193_L1.7971.00
298_V405_I1.7961.00
242_Q245_A1.7931.00
241_R457_N1.7781.00
83_I86_S1.7731.00
145_R473_T1.7701.00
433_D456_K1.7671.00
52_D221_R1.7491.00
372_L381_A1.7221.00
87_H200_A1.7191.00
382_A394_I1.7181.00
300_H396_F1.6991.00
298_V402_A1.6921.00
52_D56_E1.6841.00
315_A371_V1.6711.00
399_D427_D1.6641.00
377_N405_I1.6641.00
401_E404_E1.6501.00
39_L42_E1.6351.00
355_T373_S1.6271.00
312_T357_E1.6261.00
78_A118_D1.6151.00
83_I201_A1.5981.00
397_S401_E1.5951.00
304_Y308_V1.5851.00
279_G307_Y1.5851.00
380_A384_N1.5801.00
196_K200_A1.5801.00
284_F315_A1.5761.00
85_A114_V1.5711.00
117_T169_A1.5661.00
195_A210_V1.5611.00
103_Y107_A1.5581.00
309_E313_E1.5571.00
214_K217_E1.5571.00
62_Q66_A1.5541.00
69_P72_E1.5481.00
82_E86_S1.5461.00
83_I197_V1.5371.00
272_L310_R1.5351.00
177_S207_V1.5351.00
344_D380_A1.5241.00
336_E365_L1.5211.00
310_R313_E1.5171.00
297_H391_A1.5061.00
52_D225_H1.4991.00
305_D395_P1.4981.00
276_V310_R1.4781.00
356_L372_L1.4721.00
72_E75_R1.4661.00
78_A125_T1.4621.00
79_A82_E1.4591.00
298_V396_F1.4451.00
267_T424_R1.4451.00
28_T42_E1.4391.00
94_L193_L1.4351.00
37_R363_D1.4291.00
268_E424_R1.4271.00
278_S418_H1.4241.00
304_Y373_S1.4241.00
279_G297_H1.4201.00
93_D97_T1.4201.00
415_G434_T1.4181.00
89_D93_D1.4111.00
400_D431_R1.4101.00
314_R317_A1.4061.00
306_E309_E1.4051.00
299_V307_Y1.4051.00
67_D431_R1.4021.00
88_R107_A1.4011.00
81_S118_D1.3991.00
123_F126_R1.3971.00
82_E118_D1.3901.00
144_V430_D1.3891.00
117_T165_I1.3851.00
68_T72_E1.3721.00
401_E405_I1.3691.00
347_E350_V1.3621.00
153_I178_V1.3571.00
32_D39_L1.3511.00
50_D53_A1.3461.00
319_P327_D1.3391.00
345_Y386_H1.3351.00
342_I388_G1.3281.00
96_A106_G1.3281.00
267_T396_F1.3251.00
244_A460_L1.3221.00
93_D324_H1.3211.00
38_E363_D1.3201.00
230_V255_A1.3131.00
87_H193_L1.3091.00
313_E316_A1.3031.00
27_G45_A1.3031.00
396_F405_I1.3011.00
33_D36_T1.3011.00
339_R343_L1.2991.00
339_R367_V1.2951.00
340_D344_D1.2791.00
62_Q177_S1.2761.00
305_D309_E1.2651.00
164_S180_L1.2621.00
352_A380_A1.2561.00
354_A372_L1.2481.00
308_V312_T1.2481.00
55_Y225_H1.2471.00
224_G249_E1.2451.00
398_D401_E1.2441.00
267_T428_I1.2391.00
195_A208_F1.2381.00
336_E339_R1.2261.00
300_H398_D1.2171.00
403_V428_I1.2121.00
265_I402_A1.2091.00
81_S85_A1.2011.00
378_D383_C1.1901.00
467_Y470_N1.1871.00
300_H303_V1.1821.00
303_V306_E1.1741.00
56_E60_D1.1741.00
45_A214_K1.1691.00
220_D246_T1.1611.00
319_P329_V1.1601.00
339_R362_H1.1601.00
96_A323_A1.1571.00
145_R475_E1.1561.00
310_R314_R1.1551.00
344_D348_R1.1531.00
206_G209_N1.1511.00
311_L391_A1.1511.00
142_I426_R1.1511.00
316_A358_T1.1501.00
68_T76_I1.1501.00
466_E470_N1.1411.00
377_N408_S1.1401.00
308_V373_S1.1381.00
429_A478_V1.1371.00
415_G437_I1.1361.00
308_V357_E1.1341.00
93_D103_Y1.1321.00
55_Y227_H1.1281.00
349_T372_L1.1261.00
321_G328_T1.1261.00
55_Y228_A1.1201.00
198_F208_F1.1201.00
307_Y311_L1.1181.00
220_D242_Q1.1161.00
51_V218_I1.1131.00
313_E317_A1.1121.00
184_S214_K1.1121.00
79_A83_I1.1081.00
221_R225_H1.1071.00
80_A197_V1.1071.00
80_A203_L1.0991.00
383_C408_S1.0991.00
242_Q246_T1.0961.00
184_S216_S1.0921.00
168_V208_F1.0921.00
383_C410_E1.0921.00
425_A439_I1.0921.00
239_I242_Q1.0871.00
33_D322_T1.0851.00
57_A209_N1.0851.00
453_G462_R1.0811.00
153_I232_S1.0741.00
400_D427_D1.0721.00
35_S323_A1.0721.00
238_A242_Q1.0711.00
339_R365_L1.0711.00
264_H294_I1.0701.00
148_Q230_V1.0671.00
400_D404_E1.0661.00
41_T188_V1.0661.00
48_T221_R1.0651.00
462_R474_Q1.0641.00
78_A122_S1.0641.00
244_A254_P1.0631.00
91_V193_L1.0601.00
80_A117_T1.0601.00
318_L330_V1.0531.00
265_I428_I1.0501.00
271_D420_G1.0491.00
316_A368_E1.0461.00
403_V431_R1.0461.00
29_L45_A1.0451.00
312_T358_T1.0421.00
467_Y475_E1.0401.00
130_D466_E1.0391.00
159_F290_I1.0361.00
45_A217_E1.0321.00
265_I406_A1.0321.00
261_N295_N1.0321.00
168_V178_V1.0301.00
152_G228_A1.0271.00
130_D467_Y1.0161.00
396_F402_A1.0111.00
37_R365_L1.0041.00
196_K199_E1.0021.00
271_D274_D0.9951.00
61_A177_S0.9931.00
399_D428_I0.9921.00
322_T325_D0.9911.00
421_D424_R0.9871.00
184_S215_G0.9861.00
342_I390_V0.9851.00
352_A379_M0.9841.00
63_T404_E0.9821.00
359_G368_E0.9811.00
144_V478_V0.9781.00
86_S200_A0.9781.00
74_A125_T0.9741.00
195_A199_E0.9731.00
241_R251_L0.9721.00
87_H196_K0.9721.00
113_S165_I0.9691.00
263_V415_G0.9681.00
63_T433_D0.9651.00
124_P173_A0.9541.00
359_G370_T0.9541.00
91_V197_V0.9511.00
150_V177_S0.9481.00
455_Y474_Q0.9411.00
59_A63_T0.9411.00
416_S442_Q0.9401.00
48_T217_E0.9391.00
148_Q253_L0.9391.00
152_G222_I0.9361.00
273_D306_E0.9341.00
274_D278_S0.9321.00
90_E93_D0.9281.00
87_H197_V0.9271.00
92_V107_A0.9271.00
97_T324_H0.9261.00
404_E408_S0.9251.00
33_D97_T0.9221.00
282_G294_I0.9191.00
280_V314_R0.9181.00
244_A248_G0.9171.00
345_Y348_R0.9161.00
192_L212_T0.9161.00
141_N450_L0.9151.00
78_A121_A0.9121.00
192_L210_V0.9111.00
375_A379_M0.9101.00
229_D433_D0.9071.00
283_S295_N0.9071.00
146_E430_D0.9061.00
150_V228_A0.9051.00
305_D308_V0.9001.00
63_T67_D0.9001.00
48_T52_D0.9001.00
348_R351_D0.8931.00
66_A433_D0.8931.00
344_D347_E0.8871.00
267_T399_D0.8861.00
83_I87_H0.8851.00
99_S186_T0.8851.00
75_R79_A0.8841.00
426_R430_D0.8841.00
264_H418_H0.8821.00
340_D343_L0.8821.00
51_V152_G0.8811.00
151_V230_V0.8801.00
360_G370_T0.8771.00
236_S239_I0.8771.00
70_P74_A0.8761.00
304_Y393_V0.8761.00
276_V311_L0.8751.00
146_E455_Y0.8751.00
350_V372_L0.8741.00
33_D38_E0.8691.00
241_R245_A0.8671.00
74_A78_A0.8661.00
345_Y380_A0.8661.00
113_S161_L0.8661.00
253_L474_Q0.8651.00
101_T109_E0.8631.00
272_L276_V0.8621.00
394_I405_I0.8581.00
276_V314_R0.8561.00
35_S366_V0.8561.00
53_A57_A0.8561.00
267_T419_A0.8541.00
32_D365_L0.8531.00
185_N337_S0.8481.00
450_L477_W0.8471.00
415_G432_I0.8441.00
353_G379_M0.8391.00
81_S121_A0.8381.00
342_I386_H0.8371.00
142_I480_I0.8361.00
377_N394_I0.8321.00
244_A247_A0.8291.00
354_A379_M0.8271.00
417_V428_I0.8201.00
396_F401_E0.8201.00
266_V307_Y0.8201.00
180_L190_G0.8191.00
74_A121_A0.8171.00
231_I247_A0.8161.00
275_A279_G0.8151.00
402_A405_I0.8141.00
167_A463_Y0.8121.00
61_A207_V0.8121.00
148_Q474_Q0.8101.00
403_V407_N0.8091.00
244_A251_L0.8091.00
84_L113_S0.8071.00
373_S395_P0.8051.00
170_P468_V0.8031.00
58_A209_N0.8021.00
276_V307_Y0.8011.00
29_L214_K0.7991.00
49_D52_D0.7991.00
346_I390_V0.7951.00
49_D53_A0.7951.00
174_A473_T0.7931.00
240_G258_L0.7911.00
422_T425_A0.7901.00
46_G50_D0.7901.00
57_A206_G0.7891.00
231_I243_V0.7881.00
262_N295_N0.7871.00
67_D430_D0.7861.00
148_Q176_N0.7851.00
65_W207_V0.7831.00
182_P212_T0.7831.00
171_A178_V0.7821.00
53_A56_E0.7821.00
216_S220_D0.7811.00
309_E312_T0.7801.00
304_Y374_D0.7801.00
164_S168_V0.7791.00
203_L208_F0.7741.00
434_T437_I0.7721.00
78_A82_E0.7711.00
104_T329_V0.7661.00
60_D63_T0.7661.00
77_V173_A0.7661.00
240_G256_M0.7621.00
40_F97_T0.7581.00
99_S334_I0.7571.00
96_A103_Y0.7561.00
311_L371_V0.7521.00
337_S340_D0.7511.00
46_G54_A0.7481.00
152_G231_I0.7471.00
342_I367_V0.7451.00
276_V280_V0.7441.00
60_D64_E0.7431.00
165_I194_I0.7431.00
263_V406_A0.7421.00
233_F239_I0.7421.00
219_G223_A0.7411.00
71_Q125_T0.7401.00
161_L189_T0.7371.00
203_L207_V0.7361.00
213_G218_I0.7361.00
223_A243_V0.7361.00
153_I167_A0.7351.00
194_I198_F0.7341.00
275_A307_Y0.7331.00
97_T188_V0.7321.00
107_A326_A0.7321.00
193_L197_V0.7311.00
85_A88_R0.7291.00
300_H399_D0.7291.00
237_T457_N0.7261.00
318_L329_V0.7251.00
92_V96_A0.7251.00
280_V311_L0.7231.00
272_L303_V0.7221.00
103_Y324_H0.7211.00
63_T66_A0.7191.00
273_D314_R0.7171.00
241_R249_E0.7161.00
299_V303_V0.7151.00
33_D324_H0.7141.00
84_L114_V0.7081.00
141_N477_W0.7071.00
92_V103_Y0.7061.00
315_A358_T0.7061.00
76_I201_A0.7031.00
325_D328_T0.7031.00
85_A111_E0.6991.00
64_E68_T0.6981.00
223_A246_T0.6971.00
267_T300_H0.6961.00
345_Y384_N0.6951.00
336_E362_H0.6941.00
420_G423_G0.6921.00
32_D37_R0.6891.00
58_A177_S0.6891.00
180_L208_F0.6881.00
79_A201_A0.6861.00
52_D227_H0.6861.00
185_N334_I0.6841.00
164_S190_G0.6831.00
422_T480_I0.6821.00
148_Q229_D0.6811.00
101_T105_K0.6801.00
90_E196_K0.6791.00
320_T330_V0.6781.00
312_T315_A0.6761.00
335_D338_Q0.6751.00
152_G219_G0.6731.00
66_A431_R0.6731.00
349_T386_H0.6721.00
95_L98_E0.6721.00
439_I480_I0.6711.00
37_R336_E0.6701.00
218_I221_R0.6661.00
65_W76_I0.6661.00
176_N473_T0.6641.00
155_S164_S0.6631.00
94_L188_V0.6631.00
51_V55_Y0.6631.00
338_Q341_Q0.6621.00
59_A62_Q0.6621.00
217_E220_D0.6621.00
315_A318_L0.6611.00
70_P124_P0.6611.00
322_T328_T0.6581.00
298_V382_A0.6581.00
297_H307_Y0.6581.00
398_D404_E0.6571.00
341_Q344_D0.6571.00
247_A254_P0.6561.00
399_D403_V0.6541.00
287_S330_V0.6541.00
82_E85_A0.6541.00
245_A248_G0.6521.00
298_V377_N0.6511.00
253_L471_E0.6501.00
215_G219_G0.6501.00
405_I408_S0.6481.00
269_D419_A0.6471.00
51_V221_R0.6461.00
470_N473_T0.6461.00
27_G217_E0.6461.00
377_N382_A0.6451.00
429_A439_I0.6451.00
246_T249_E0.6431.00
279_G311_L0.6421.00
63_T431_R0.6421.00
179_V209_N0.6381.00
266_V275_A0.6381.00
141_N479_S0.6371.00
350_V361_D0.6351.00
425_A429_A0.6321.00
280_V318_L0.6321.00
28_T44_P0.6311.00
311_L393_V0.6301.00
272_L306_E0.6301.00
110_F114_V0.6301.00
89_D103_Y0.6281.00
44_P212_T0.6281.00
65_W172_V0.6281.00
91_V161_L0.6271.00
360_G368_E0.6271.00
419_A424_R0.6261.00
358_T371_V0.6261.00
433_D455_Y0.6261.00
64_E67_D0.6251.00
274_D277_D0.6241.00
66_A147_P0.6231.00
223_A231_I0.6211.00
367_V370_T0.6211.00
269_D421_D0.6211.00
57_A205_E0.6211.00
422_T426_R0.6191.00
337_S341_Q0.6191.00
255_A471_E0.6171.00
470_N475_E0.6161.00
140_E426_R0.6151.00
333_I338_Q0.6151.00
46_G211_V0.6141.00
144_V476_K0.6131.00
346_I372_L0.6121.00
142_I478_V0.6101.00
164_S194_I0.6091.00
66_A146_E0.6091.00
167_A232_S0.6071.00
56_E59_A0.6071.00
274_D420_G0.6061.00
127_M469_L0.6061.00
184_S341_Q0.6061.00
88_R92_V0.6061.00
101_T159_F0.6051.00
375_A382_A0.6041.00
81_S114_V0.6031.00
43_I187_P0.6031.00
213_G219_G0.6021.00
343_L346_I0.6021.00
198_F203_L0.6011.00
72_E76_I0.5991.00
84_L117_T0.5981.00
244_A256_M0.5981.00
426_R480_I0.5971.00
31_V41_T0.5961.00
95_L109_E0.5951.00
54_A211_V0.5951.00
184_S242_Q0.5951.00
61_A64_E0.5921.00
83_I202_G0.5921.00
168_V180_L0.5911.00
31_V98_E0.5891.00
48_T224_G0.5881.00
343_L350_V0.5881.00
70_P173_A0.5881.00
374_D395_P0.5871.00
96_A324_H0.5871.00
95_L189_T0.5861.00
95_L106_G0.5831.00
177_S209_N0.5821.00
345_Y349_T0.5811.00
93_D96_A0.5801.00
386_H390_V0.5791.00
127_M473_T0.5781.00
151_V176_N0.5781.00
292_I446_Q0.5771.00
76_I202_G0.5771.00
220_D223_A0.5751.00
230_V471_E0.5721.00
423_G426_R0.5721.00
129_G133_Q0.5721.00
403_V427_D0.5721.00
128_N131_H0.5711.00
417_V425_A0.5711.00
299_V393_V0.5701.00
48_T220_D0.5691.00
375_A381_A0.5681.00
377_N404_E0.5681.00
352_A378_D0.5671.00
356_L370_T0.5671.00
84_L161_L0.5671.00
216_S242_Q0.5651.00
40_F188_V0.5651.00
194_I197_V0.5621.00
299_V304_Y0.5601.00
282_G442_Q0.5601.00
92_V110_F0.5591.00
237_T241_R0.5581.00
122_S125_T0.5581.00
350_V353_G0.5571.00
110_F161_L0.5571.00
264_H297_H0.5561.00
346_I370_T0.5561.00
119_E123_F0.5561.00
333_I367_V0.5541.00
423_G427_D0.5541.00
264_H416_S0.5541.00
84_L194_I0.5521.00
312_T371_V0.5521.00
58_A179_V0.5481.00
81_S117_T0.5471.00
372_L375_A0.5461.00
290_I293_S0.5461.00
283_S391_A0.5461.00
268_E396_F0.5451.00
406_A432_I0.5431.00
437_I476_K0.5431.00
319_P325_D0.5431.00
402_A406_A0.5421.00
57_A61_A0.5421.00
262_N414_S0.5421.00
174_A469_L0.5411.00
340_D362_H0.5401.00
357_E374_D0.5391.00
59_A150_V0.5391.00
223_A250_N0.5381.00
403_V432_I0.5381.00
161_L194_I0.5381.00
417_V439_I0.5351.00
91_V110_F0.5351.00
272_L275_A0.5341.00
150_V229_D0.5341.00
58_A150_V0.5311.00
356_L360_G0.5301.00
54_A209_N0.5301.00
297_H393_V0.5301.00
272_L307_Y0.5301.00
31_V187_P0.5291.00
120_A170_P0.5291.00
343_L361_D0.5291.00
27_G47_T0.5291.00
276_V303_V0.5271.00
172_V208_F0.5271.00
438_H441_D0.5271.00
232_S472_F0.5261.00
381_A386_H0.5261.00
320_T329_V0.5251.00
80_A83_I0.5241.00
151_V178_V0.5241.00
352_A376_T0.5241.00
153_I168_V0.5241.00
270_A275_A0.5241.00
128_N132_K0.5231.00
273_D313_E0.5231.00
162_N166_R0.5221.00
199_E202_G0.5211.00
221_R224_G0.5211.00
76_I80_A0.5211.00
109_E159_F0.5201.00
112_A162_N0.5191.00
43_I188_V0.5191.00
84_L91_V0.5151.00
238_A337_S0.5151.00
166_R464_N0.5141.00
433_D474_Q0.5141.00
428_I432_I0.5141.00
254_P460_L0.5131.00
146_E433_D0.5131.00
301_E304_Y0.5121.00
269_D420_G0.5111.00
294_I416_S0.5111.00
75_R78_A0.5091.00
248_G251_L0.5081.00
88_R114_V0.5071.00
71_Q75_R0.5061.00
99_S286_H0.5051.00
399_D431_R0.5051.00
123_F466_E0.5051.00
432_I437_I0.5021.00
112_A446_Q0.5021.00
151_V232_S0.5011.00
217_E221_R0.5001.00
79_A202_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ek1A 5 0.9857 100 0.022 Contact Map
1a4sA 4 0.9918 100 0.025 Contact Map
4o5hA 4 0.9836 100 0.026 Contact Map
4yweA 5 0.9571 100 0.027 Contact Map
4qf6A 4 0.9816 100 0.029 Contact Map
2d4eA 4 0.9918 100 0.03 Contact Map
4pz2A 4 0.9775 100 0.031 Contact Map
4qtoA 4 0.9898 100 0.032 Contact Map
4pxlA 4 0.9775 100 0.032 Contact Map
4wj9A 4 0.9836 100 0.032 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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