GREMLIN Database
RS6E - 30S ribosomal protein S6e
UniProt: Q9HMJ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 131 (123)
Sequences: 452 (259)
Seq/√Len: 23.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_G50_V3.7381.00
64_R81_A2.7360.99
101_V108_L2.4610.98
34_I52_I2.4090.98
55_G63_M2.2980.97
12_E115_H2.2240.97
72_L94_V2.2070.96
63_M105_V2.1560.96
77_L96_V2.1310.96
32_R38_V2.1230.96
79_G85_P2.0580.95
69_G102_S1.9960.94
8_V19_F1.9450.93
20_E58_D1.9140.92
121_A125_G1.9110.92
102_S105_V1.8270.90
120_V124_L1.8260.90
8_V50_V1.8030.90
72_L80_G1.7670.89
29_F42_A1.7050.87
45_L50_V1.7020.87
18_Q107_Q1.6730.86
50_V110_V1.6650.86
67_V96_V1.5990.83
5_Q9_A1.5570.82
97_R104_A1.5380.81
74_E95_T1.5230.80
29_F46_D1.5180.80
53_T109_N1.5160.80
44_G57_D1.4820.78
28_R39_D1.4780.78
73_M95_T1.4750.78
52_I91_R1.4750.78
8_V110_V1.4500.77
29_F38_V1.4320.76
64_R82_G1.4280.75
57_D72_L1.4270.75
51_E111_A1.3620.72
89_G97_R1.3590.72
34_I41_G1.3510.71
26_A110_V1.3460.71
33_E99_K1.3340.70
54_G57_D1.2810.67
21_V63_M1.2790.67
40_G45_L1.2650.66
79_G95_T1.2560.66
87_E91_R1.2550.65
12_E103_E1.2360.64
18_Q109_N1.2210.63
119_P122_E1.2140.63
56_S83_F1.2110.63
47_G55_G1.2080.62
6_V110_V1.1990.62
27_N43_V1.1640.59
79_G88_D1.1350.57
23_G56_S1.1200.56
53_T92_K1.1180.56
66_D75_V1.1130.56
32_R92_K1.1100.56
33_E100_E1.1010.55
115_H119_P1.0760.53
19_F31_G1.0600.52
69_G106_A1.0500.52
63_M101_V1.0470.51
10_D13_S1.0390.51
58_D72_L1.0310.50
16_T84_N1.0270.50
56_S86_D1.0070.49
81_A92_K0.9930.48
26_A109_N0.9860.47
74_E105_V0.9830.47
61_R95_T0.9730.46
52_I111_A0.9710.46
10_D15_R0.9240.43
28_R42_A0.9080.42
22_D95_T0.9080.42
85_P109_N0.9040.41
19_F44_G0.8940.41
38_V42_A0.8860.40
48_Y116_G0.8750.39
54_G60_G0.8660.39
83_F86_D0.8280.36
30_I86_D0.8250.36
59_A72_L0.8240.36
40_G43_V0.8200.36
80_G101_V0.8160.36
45_L104_A0.8080.35
69_G107_Q0.8040.35
35_G53_T0.7990.35
7_A16_T0.7930.34
71_D109_N0.7850.34
33_E56_S0.7840.34
122_E125_G0.7770.33
49_T114_E0.7760.33
76_L93_R0.7720.33
10_D27_N0.7700.33
56_S85_P0.7690.33
62_P86_D0.7670.33
41_G46_D0.7620.32
21_V110_V0.7320.30
84_N101_V0.7320.30
19_F29_F0.7290.30
20_E68_D0.7280.30
34_I56_S0.7280.30
73_M125_G0.7210.30
43_V112_I0.7180.30
42_A50_V0.7160.29
8_V101_V0.7130.29
14_G92_K0.7110.29
93_R116_G0.7090.29
79_G83_F0.7030.29
61_R74_E0.7000.29
50_V78_E0.6960.28
54_G62_P0.6920.28
86_D111_A0.6820.28
9_A91_R0.6820.28
65_E99_K0.6800.27
56_S107_Q0.6760.27
23_G100_E0.6730.27
9_A40_G0.6720.27
37_A51_E0.6700.27
5_Q94_V0.6690.27
32_R37_A0.6680.27
23_G51_E0.6630.26
13_S71_D0.6570.26
117_E121_A0.6550.26
38_V101_V0.6470.26
8_V45_L0.6430.25
64_R96_V0.6420.25
38_V75_V0.6390.25
48_Y112_I0.6360.25
28_R36_A0.6350.25
18_Q28_R0.6330.25
41_G44_G0.6320.25
35_G109_N0.6270.25
79_G84_N0.6270.25
40_G104_A0.6250.24
34_I109_N0.6200.24
10_D39_D0.6160.24
37_A49_T0.6140.24
11_P99_K0.6140.24
61_R72_L0.6090.24
62_P82_G0.6090.24
48_Y114_E0.6040.23
4_F8_V0.5980.23
77_L82_G0.5920.23
12_E29_F0.5890.23
80_G93_R0.5850.22
24_Q51_E0.5810.22
4_F97_R0.5780.22
35_G51_E0.5720.22
48_Y104_A0.5720.22
18_Q79_G0.5700.22
21_V33_E0.5700.22
63_M98_G0.5690.22
27_N38_V0.5660.22
5_Q106_A0.5660.22
6_V20_E0.5650.21
7_A17_Y0.5620.21
9_A109_N0.5610.21
26_A36_A0.5590.21
39_D42_A0.5580.21
85_P88_D0.5530.21
69_G109_N0.5470.21
33_E36_A0.5470.21
9_A18_Q0.5450.21
53_T107_Q0.5430.20
10_D109_N0.5390.20
31_G39_D0.5380.20
74_E94_V0.5370.20
30_I91_R0.5350.20
57_D89_G0.5280.20
81_A112_I0.5270.20
60_G97_R0.5230.20
93_R98_G0.5210.19
82_G105_V0.5140.19
15_R126_A0.5130.19
25_D33_E0.5120.19
28_R105_V0.5100.19
70_S102_S0.5080.19
71_D102_S0.5050.19
6_V114_E0.5020.19
24_Q94_V0.5020.19
36_A39_D0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bpeY 1 0.9771 100 0.066 Contact Map
3j7aH 1 0.9771 100 0.067 Contact Map
4ujpH 1 0.9771 100 0.079 Contact Map
4w23G 1 0.9771 100 0.084 Contact Map
3j60G 1 0.9771 100 0.088 Contact Map
3zey3 1 0.9771 100 0.092 Contact Map
3j20G 1 0.8702 100 0.127 Contact Map
4q28A 1 0.3969 21.3 0.946 Contact Map
1grjA 1 0.3893 10.6 0.953 Contact Map
2bwfA 1 0.5496 6.9 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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