GREMLIN Database
Q9HMJ3 - Uncharacterized protein
UniProt: Q9HMJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (272)
Sequences: 22407 (16652)
Seq/√Len: 1009.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_H262_H3.1591.00
71_R86_R2.6961.00
133_F159_A2.6721.00
223_D229_F2.5071.00
56_A80_D2.5021.00
230_L275_G2.4421.00
5_V129_A2.4021.00
263_A269_A2.3911.00
63_R88_D2.3111.00
270_G273_D2.3051.00
228_A256_F2.2711.00
68_D86_R2.1241.00
147_V185_T2.0531.00
60_R87_G2.0371.00
193_A223_D2.0121.00
212_A231_A2.0021.00
48_L53_H1.9741.00
159_A261_V1.9651.00
50_A77_W1.9611.00
263_A277_I1.9561.00
131_C157_A1.9271.00
6_A45_A1.9241.00
237_V272_R1.8871.00
157_A187_D1.8691.00
255_A281_A1.8621.00
46_C77_W1.8481.00
190_V257_T1.7861.00
269_A273_D1.7821.00
75_A81_A1.7761.00
205_E236_T1.7611.00
230_L237_V1.7541.00
60_R120_S1.7421.00
47_A258_A1.7371.00
187_D217_S1.7091.00
146_L158_L1.6981.00
228_A279_A1.6901.00
131_C159_A1.6691.00
73_S76_E1.6681.00
229_F238_H1.6631.00
252_A286_C1.6591.00
208_A231_A1.6551.00
72_A76_E1.6501.00
188_L218_R1.6271.00
272_R276_R1.6241.00
242_R280_A1.6201.00
282_A286_C1.6121.00
260_L274_A1.6091.00
71_R75_A1.6071.00
259_A281_A1.6071.00
210_E214_M1.5891.00
148_A152_S1.5711.00
144_R147_V1.5601.00
223_D238_H1.5461.00
48_L262_H1.5371.00
220_A260_L1.5311.00
143_V181_A1.5011.00
10_A59_S1.4961.00
161_D222_T1.4941.00
4_V48_L1.4921.00
68_D72_A1.4851.00
230_L271_V1.4851.00
239_A275_G1.4681.00
35_E69_R1.4651.00
63_R68_D1.4651.00
223_D226_D1.4641.00
131_C261_V1.4601.00
259_A277_I1.4561.00
157_A188_L1.4441.00
248_D290_G1.4431.00
203_G206_R1.4051.00
210_E213_A1.3831.00
17_G32_D1.3791.00
126_L129_A1.3651.00
150_R187_D1.3561.00
209_S213_A1.3481.00
144_R148_A1.3471.00
242_R276_R1.3451.00
37_A70_V1.3391.00
12_L69_R1.3371.00
148_A151_R1.3271.00
186_A189_F1.3251.00
127_R152_S1.3201.00
42_A74_L1.3191.00
63_R86_R1.3111.00
54_D80_D1.3071.00
150_R185_T1.3061.00
239_A279_A1.3031.00
262_H266_L1.3011.00
162_L191_A1.2971.00
71_R84_V1.2861.00
205_E209_S1.2851.00
67_G91_T1.2811.00
117_A120_S1.2731.00
143_V147_V1.2581.00
244_V287_T1.2581.00
231_A236_T1.2581.00
14_R33_Y1.2491.00
228_A275_G1.2461.00
73_S77_W1.2361.00
37_A73_S1.2241.00
157_A217_S1.2051.00
209_S231_A1.1971.00
209_S236_T1.1941.00
218_R264_W1.1871.00
284_Q288_R1.1821.00
266_L269_A1.1781.00
259_A278_A1.1781.00
218_R271_V1.1751.00
14_R35_E1.1701.00
263_A274_A1.1701.00
222_T256_F1.1651.00
218_R260_L1.1581.00
223_D227_G1.1581.00
246_V286_C1.1561.00
260_L264_W1.1551.00
69_R72_A1.1551.00
65_D68_D1.1441.00
273_D276_R1.1421.00
190_V222_T1.1401.00
260_L278_A1.1321.00
68_D71_R1.1311.00
244_V286_C1.1301.00
49_A79_V1.1291.00
53_H265_V1.1271.00
51_L259_A1.1231.00
134_T158_L1.1211.00
232_T235_T1.1091.00
242_R279_A1.1061.00
44_V133_F1.1041.00
113_V116_V1.1041.00
242_R283_A1.1031.00
284_Q287_T1.0981.00
118_L144_R1.0911.00
196_A221_V1.0881.00
218_R232_T1.0881.00
180_D214_M1.0851.00
45_A55_A1.0841.00
72_A75_A1.0821.00
87_G90_A1.0811.00
188_L260_L1.0711.00
105_M108_A1.0671.00
46_C50_A1.0661.00
263_A266_L1.0661.00
48_L55_A1.0641.00
107_V111_D1.0631.00
10_A70_V1.0591.00
133_F261_V1.0401.00
218_R230_L1.0401.00
53_H266_L1.0381.00
193_A226_D1.0301.00
140_D144_R1.0301.00
188_L264_W1.0281.00
47_A255_A1.0201.00
246_V249_T1.0191.00
49_A78_G1.0171.00
267_G270_G1.0131.00
190_V260_L1.0021.00
241_A279_A1.0011.00
279_A282_A0.9961.00
160_F186_A0.9891.00
147_V151_R0.9891.00
132_V149_L0.9861.00
56_A125_A0.9841.00
14_R93_Y0.9841.00
206_R209_S0.9831.00
255_A285_N0.9781.00
61_V67_G0.9691.00
276_R280_A0.9641.00
56_A83_R0.9621.00
56_A129_A0.9581.00
37_A69_R0.9571.00
260_L271_V0.9551.00
274_A278_A0.9451.00
262_H277_I0.9441.00
17_G34_T0.9431.00
133_F257_T0.9421.00
208_A221_V0.9421.00
10_A42_A0.9411.00
196_A207_A0.9371.00
69_R73_S0.9371.00
16_Y95_L0.9351.00
15_V36_R0.9321.00
108_A111_D0.9311.00
64_D91_T0.9301.00
51_L281_A0.9301.00
48_L258_A0.9281.00
10_A57_V0.9241.00
235_T272_R0.9241.00
90_A115_G0.9231.00
61_V71_R0.9201.00
61_V86_R0.9191.00
6_A41_A0.9181.00
14_R66_A0.9171.00
61_V84_V0.9161.00
49_A54_D0.9151.00
7_V132_V0.9151.00
62_G91_T0.9101.00
5_V58_V0.9061.00
87_G115_G0.8971.00
81_A84_V0.8951.00
134_T146_L0.8911.00
264_W274_A0.8901.00
193_A197_D0.8891.00
246_V287_T0.8871.00
71_R81_A0.8861.00
200_V207_A0.8821.00
107_V110_G0.8731.00
181_A184_A0.8661.00
141_G145_D0.8641.00
122_D144_R0.8631.00
191_A196_A0.8631.00
105_M111_D0.8621.00
85_R120_S0.8611.00
192_N195_A0.8601.00
184_A215_G0.8511.00
270_G274_A0.8491.00
269_A277_I0.8491.00
183_A186_A0.8391.00
161_D190_V0.8371.00
227_G241_A0.8361.00
239_A276_R0.8351.00
70_V91_T0.8301.00
149_L153_G0.8281.00
30_V107_V0.8251.00
5_V56_A0.8251.00
11_V92_S0.8241.00
226_D238_H0.8221.00
147_V181_A0.8181.00
42_A292_R0.8181.00
60_R85_R0.8171.00
256_F279_A0.8161.00
4_V265_V0.8141.00
56_A82_T0.8081.00
104_R108_A0.8071.00
224_G227_G0.7971.00
45_A57_V0.7921.00
247_T289_E0.7881.00
280_A284_Q0.7881.00
99_G103_N0.7801.00
44_V257_T0.7801.00
145_D149_L0.7771.00
208_A212_A0.7751.00
255_A259_A0.7751.00
49_A55_A0.7741.00
12_L66_A0.7741.00
259_A263_A0.7721.00
255_A282_A0.7701.00
237_V275_G0.7671.00
239_A272_R0.7641.00
229_F236_T0.7631.00
244_V283_A0.7631.00
136_A160_F0.7611.00
212_A232_T0.7601.00
131_C265_V0.7561.00
176_A180_D0.7521.00
123_R148_A0.7461.00
279_A283_A0.7401.00
64_D67_G0.7391.00
46_C292_R0.7371.00
161_D191_A0.7371.00
217_S232_T0.7361.00
106_I110_G0.7331.00
245_D287_T0.7311.00
13_D38_G0.7281.00
96_V106_I0.7271.00
159_A190_V0.7271.00
125_A129_A0.7261.00
12_L35_E0.7221.00
71_R85_R0.7211.00
227_G238_H0.7181.00
35_E66_A0.7141.00
212_A233_P0.7101.00
140_D143_V0.7061.00
134_T142_V0.7041.00
143_V146_L0.7031.00
24_P103_N0.7031.00
5_V125_A0.7021.00
106_I109_G0.7021.00
205_E208_A0.6991.00
96_V250_T0.6981.00
51_L277_I0.6971.00
208_A219_V0.6961.00
73_S292_R0.6951.00
105_M109_G0.6911.00
269_A274_A0.6901.00
142_V145_D0.6871.00
66_A93_Y0.6841.00
7_V145_D0.6841.00
150_R153_G0.6831.00
159_A188_L0.6811.00
206_R210_E0.6791.00
205_E238_H0.6791.00
256_F278_A0.6751.00
51_L262_H0.6751.00
103_N106_I0.6751.00
256_F275_G0.6741.00
196_A211_F0.6701.00
220_A230_L0.6691.00
159_A257_T0.6681.00
204_P207_A0.6641.00
205_E231_A0.6581.00
282_A285_N0.6541.00
4_V53_H0.6501.00
207_A211_F0.6501.00
184_A214_M0.6481.00
34_T289_E0.6471.00
27_G40_V0.6421.00
59_S84_V0.6411.00
256_F282_A0.6401.00
38_G43_N0.6401.00
65_D69_R0.6401.00
225_S243_A0.6381.00
106_I111_D0.6371.00
209_S212_A0.6361.00
205_E229_F0.6341.00
89_D115_G0.6341.00
112_A115_G0.6291.00
54_D130_D0.6241.00
23_A26_G0.6241.00
83_R125_A0.6221.00
275_G279_A0.6181.00
149_L158_L0.6161.00
121_S124_D0.6121.00
45_A79_V0.6111.00
16_Y30_V0.6111.00
97_L107_V0.6111.00
40_V163_A0.6071.00
204_P223_D0.6061.00
97_L105_M0.6051.00
16_Y33_Y0.6011.00
208_A236_T0.5971.00
267_G274_A0.5971.00
228_A239_A0.5951.00
220_A256_F0.5931.00
177_D180_D0.5921.00
204_P208_A0.5881.00
258_A262_H0.5861.00
9_S163_A0.5841.00
42_A57_V0.5831.00
51_L258_A0.5811.00
68_D75_A0.5791.00
180_D184_A0.5781.00
65_D72_A0.5761.00
83_R86_R0.5761.00
196_A204_P0.5751.00
232_T237_V0.5751.00
146_L185_T0.5721.00
141_G144_R0.5711.00
48_L261_V0.5711.00
161_D254_D0.5691.00
17_G289_E0.5681.00
114_P117_A0.5661.00
113_V117_A0.5611.00
131_C188_L0.5601.00
9_S137_Y0.5601.00
4_V131_C0.5591.00
158_L186_A0.5571.00
37_A292_R0.5571.00
215_G219_V0.5571.00
24_P99_G0.5561.00
103_N109_G0.5551.00
273_D277_I0.5551.00
146_L182_A0.5521.00
40_V137_Y0.5521.00
189_F219_V0.5511.00
250_T291_A0.5501.00
54_D265_V0.5491.00
232_T271_V0.5481.00
118_L140_D0.5461.00
193_A224_G0.5441.00
116_V120_S0.5421.00
130_D157_A0.5421.00
177_D181_A0.5391.00
49_A77_W0.5371.00
194_G198_S0.5361.00
14_R95_L0.5361.00
145_D148_A0.5341.00
208_A211_F0.5321.00
271_V274_A0.5311.00
212_A216_A0.5291.00
6_A48_L0.5291.00
10_A74_L0.5281.00
197_D202_V0.5281.00
143_V185_T0.5281.00
216_A219_V0.5281.00
104_R110_G0.5261.00
44_V261_V0.5251.00
105_M110_G0.5251.00
271_V275_G0.5251.00
160_F182_A0.5221.00
74_L79_V0.5211.00
187_D218_R0.5211.00
190_V220_A0.5201.00
63_R89_D0.5171.00
17_G98_R0.5161.00
202_V206_R0.5161.00
125_A128_A0.5161.00
42_A46_C0.5151.00
63_R87_G0.5131.00
104_R111_D0.5131.00
196_A231_A0.5061.00
132_V145_D0.5061.00
159_A264_W0.5051.00
200_V210_E0.5051.00
131_C264_W0.5041.00
220_A275_G0.5011.00
160_F179_V0.5001.00
82_T125_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbcA 2 0.9604 100 0.157 Contact Map
2fv7A 2 0.9604 100 0.185 Contact Map
4xdaA 2 0.9571 100 0.19 Contact Map
3ry7A 2 0.9604 100 0.195 Contact Map
4du5A 2 0.9241 100 0.195 Contact Map
1rkdA 2 0.9571 100 0.196 Contact Map
3ljsA 2 0.967 100 0.197 Contact Map
3hj6A 2 0.8911 100 0.203 Contact Map
1vm7A 2 0.9406 100 0.203 Contact Map
3ikhA 2 0.9175 100 0.205 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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