Q9HMJ2 - HALSA - GREMLIN Contacts

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Q9HMJ2 - Uncharacterized protein

UniProt:	Q9HMJ2	Sequences: MSLDFDADTPVVGMVHLSPLPGAPGYDDGNRPAIRDAALRDASRLEAGGVDALLVENFGDAPFYADDVPKHVVASMAALVRDITREAEVPVGVNVLRNDAEAAVSIAAAADADFVRVNVHTGARLTDQGVVGGQAAETVRLRDRLDAAEVSMLADIDVKHSAALAERPLSEGVAELLERGHADGVIASGAGTGHATDHDHLQAVVDARDRLDADAPVFVGSGVTQETVGATLDLADGAIVGTALKQNGETTAPVDGDRVRALVDAAR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	267 (250)
Sequences:	555 (363)
Seq/√Len:	23.0

ECOLI - SGCQ
HALSA - Q9HMJ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
48_G	259_V	4.681	1.00
205_V	236_D	3.445	1.00
154_A	182_A	3.235	1.00
80_V	93_V	3.222	1.00
11_V	50_V	3.216	1.00
205_V	217_V	3.067	1.00
170_S	203_A	2.965	1.00
105_S	141_L	2.836	0.99
31_R	75_S	2.793	0.99
82_D	85_R	2.617	0.99
247_N	252_A	2.532	0.98
78_A	82_D	2.442	0.98
50_V	259_V	2.428	0.98
11_V	238_A	2.412	0.98
50_V	244_L	2.397	0.98
18_S	38_A	2.382	0.98
186_I	220_G	2.357	0.98
219_V	223_V	2.313	0.97
41_D	254_V	2.299	0.97
17_L	38_A	2.268	0.97
153_L	184_G	2.268	0.97
11_V	263_V	2.227	0.96
56_E	159_K	2.227	0.96
99_D	102_A	2.163	0.96
29_G	33_A	2.150	0.96
159_K	221_S	2.097	0.95
56_E	221_S	2.083	0.95
44_R	48_G	2.074	0.95
225_Q	243_A	2.072	0.95
36_D	40_R	1.854	0.91
97_R	126_T	1.851	0.91
97_R	118_N	1.846	0.90
32_P	36_D	1.821	0.90
229_G	265_A	1.776	0.89
55_V	91_V	1.776	0.89
120_H	138_T	1.733	0.87
26_Y	30_N	1.717	0.87
145_L	150_V	1.685	0.86
248_G	258_R	1.658	0.85
55_V	80_V	1.614	0.83
118_N	158_V	1.596	0.83
134_Q	137_E	1.584	0.82
27_D	33_A	1.566	0.81
27_D	30_N	1.565	0.81
96_L	118_N	1.552	0.81
26_Y	29_G	1.552	0.81
56_E	192_T	1.537	0.80
74_A	109_A	1.532	0.80
249_E	252_A	1.529	0.80
37_A	40_R	1.527	0.80
95_V	106_I	1.515	0.79
54_L	114_F	1.491	0.78
124_R	161_S	1.489	0.78
42_A	53_L	1.489	0.78
78_A	81_R	1.485	0.78
128_Q	179_R	1.477	0.77
41_D	59_G	1.473	0.77
18_S	37_A	1.466	0.77
25_G	181_H	1.435	0.75
14_M	45_L	1.432	0.75
41_D	44_R	1.430	0.75
202_Q	206_D	1.408	0.74
244_L	263_V	1.406	0.74
84_T	91_V	1.399	0.73
56_E	158_V	1.398	0.73
14_M	54_L	1.385	0.72
40_R	253_P	1.378	0.72
39_L	87_A	1.375	0.72
56_E	160_H	1.369	0.72
52_A	114_F	1.367	0.71
47_A	256_G	1.361	0.71
42_A	83_I	1.358	0.71
97_R	128_Q	1.354	0.71
97_R	179_R	1.342	0.70
99_D	119_V	1.340	0.70
158_V	192_T	1.329	0.69
30_N	33_A	1.326	0.69
39_L	83_I	1.311	0.68
40_R	43_S	1.299	0.67
143_D	148_A	1.290	0.67
254_V	259_V	1.289	0.67
108_A	146_D	1.287	0.67
195_A	230_A	1.256	0.65
159_K	192_T	1.248	0.64
23_A	60_D	1.244	0.64
246_Q	252_A	1.214	0.62
24_P	140_R	1.206	0.62
80_V	110_A	1.202	0.61
158_V	221_S	1.183	0.60
50_V	263_V	1.183	0.60
118_N	179_R	1.170	0.59
16_H	21_P	1.161	0.59
12_V	52_A	1.157	0.58
193_G	221_S	1.145	0.57
223_V	228_V	1.141	0.57
160_H	179_R	1.138	0.57
246_Q	253_P	1.137	0.57
260_R	264_D	1.135	0.57
85_R	218_F	1.134	0.57
63_F	221_S	1.131	0.56
13_G	16_H	1.124	0.56
160_H	221_S	1.105	0.55
217_V	235_A	1.099	0.54
57_N	62_P	1.098	0.54
43_S	47_A	1.092	0.54
73_V	77_A	1.087	0.53
155_D	221_S	1.081	0.53
41_D	247_N	1.078	0.53
136_A	140_R	1.074	0.53
173_V	207_A	1.060	0.52
218_F	242_T	1.058	0.51
225_Q	265_A	1.055	0.51
94_N	118_N	1.047	0.51
63_F	118_N	1.046	0.51
116_R	129_G	1.045	0.51
195_A	227_T	1.042	0.50
153_L	239_I	1.024	0.49
123_A	133_G	1.023	0.49
155_D	220_G	1.014	0.48
244_L	259_V	1.009	0.48
56_E	193_G	1.009	0.48
240_V	262_L	1.006	0.48
96_L	127_D	0.998	0.47
229_G	260_R	0.994	0.47
124_R	157_D	0.994	0.47
119_V	128_Q	0.983	0.46
207_A	218_F	0.973	0.46
118_N	128_Q	0.971	0.45
252_A	258_R	0.969	0.45
155_D	160_H	0.958	0.45
56_E	155_D	0.956	0.44
204_V	241_G	0.953	0.44
77_A	81_R	0.951	0.44
12_V	90_P	0.950	0.44
46_E	89_V	0.941	0.43
93_V	107_A	0.939	0.43
157_D	161_S	0.939	0.43
96_L	192_T	0.938	0.43
70_K	73_V	0.936	0.43
152_M	240_V	0.932	0.43
95_V	99_D	0.931	0.43
143_D	146_D	0.923	0.42
108_A	149_E	0.918	0.42
68_V	99_D	0.915	0.42
261_A	264_D	0.914	0.42
19_P	25_G	0.912	0.41
184_G	231_T	0.912	0.41
190_A	204_V	0.910	0.41
121_T	177_L	0.908	0.41
56_E	186_I	0.894	0.40
119_V	126_T	0.890	0.40
64_Y	69_P	0.889	0.40
196_T	231_T	0.886	0.40
162_A	168_P	0.884	0.40
51_D	236_D	0.879	0.39
82_D	243_A	0.878	0.39
9_T	236_D	0.878	0.39
257_D	261_A	0.872	0.39
14_M	235_A	0.871	0.39
174_A	257_D	0.870	0.39
123_A	130_V	0.865	0.38
36_D	43_S	0.864	0.38
18_S	55_V	0.858	0.38
31_R	79_L	0.856	0.38
223_V	238_A	0.846	0.37
159_K	193_G	0.844	0.37
168_P	171_E	0.841	0.37
65_A	132_G	0.830	0.36
54_L	233_D	0.830	0.36
246_Q	255_D	0.829	0.36
160_H	192_T	0.826	0.36
196_T	223_V	0.813	0.35
74_A	104_V	0.812	0.35
57_N	60_D	0.809	0.35
43_S	87_A	0.807	0.35
19_P	144_R	0.806	0.34
57_N	245_K	0.806	0.34
11_V	184_G	0.803	0.34
14_M	188_S	0.802	0.34
11_V	249_E	0.801	0.34
228_V	232_L	0.799	0.34
131_V	154_A	0.799	0.34
59_G	250_T	0.798	0.34
38_A	55_V	0.797	0.34
26_Y	146_D	0.796	0.34
231_T	238_A	0.795	0.34
41_D	227_T	0.794	0.34
192_T	221_S	0.791	0.34
43_S	53_L	0.790	0.33
96_L	239_I	0.785	0.33
142_R	242_T	0.783	0.33
15_V	38_A	0.783	0.33
11_V	35_R	0.782	0.33
14_M	239_I	0.781	0.33
106_I	240_V	0.781	0.33
119_V	122_G	0.780	0.33
84_T	228_V	0.779	0.33
169_L	204_V	0.778	0.33
172_G	176_L	0.778	0.33
53_L	260_R	0.776	0.33
46_E	87_A	0.774	0.32
229_G	264_D	0.772	0.32
13_G	45_L	0.771	0.32
38_A	79_L	0.769	0.32
72_V	184_G	0.768	0.32
43_S	84_T	0.768	0.32
58_F	124_R	0.768	0.32
128_Q	180_G	0.767	0.32
47_A	151_S	0.761	0.32
41_D	48_G	0.761	0.32
9_T	12_V	0.760	0.32
223_V	231_T	0.759	0.32
45_L	244_L	0.757	0.31
99_D	164_L	0.756	0.31
45_L	235_A	0.755	0.31
159_K	186_I	0.751	0.31
35_R	82_D	0.751	0.31
14_M	118_N	0.750	0.31
118_N	126_T	0.746	0.31
63_F	158_V	0.745	0.31
110_A	187_A	0.743	0.31
101_E	137_E	0.742	0.31
94_N	158_V	0.739	0.30
22_G	241_G	0.733	0.30
141_L	145_L	0.726	0.30
163_A	250_T	0.722	0.29
232_L	238_A	0.718	0.29
60_D	105_S	0.717	0.29
56_E	103_A	0.716	0.29
10_P	249_E	0.713	0.29
155_D	159_K	0.713	0.29
94_N	97_R	0.712	0.29
40_R	84_T	0.707	0.29
225_Q	261_A	0.707	0.29
139_V	152_M	0.704	0.28
188_S	223_V	0.703	0.28
46_E	205_V	0.703	0.28
53_L	89_V	0.699	0.28
96_L	128_Q	0.698	0.28
122_G	127_D	0.697	0.28
96_L	193_G	0.695	0.28
10_P	90_P	0.692	0.28
115_V	239_I	0.691	0.28
161_S	174_A	0.689	0.28
63_F	193_G	0.688	0.27
74_A	173_V	0.688	0.27
126_T	179_R	0.686	0.27
39_L	42_A	0.686	0.27
226_E	261_A	0.684	0.27
12_V	54_L	0.684	0.27
225_Q	262_L	0.682	0.27
18_S	34_I	0.681	0.27
155_D	186_I	0.679	0.27
78_A	109_A	0.678	0.27
121_T	188_S	0.678	0.27
169_L	173_V	0.676	0.27
100_A	117_V	0.675	0.27
22_G	71_H	0.674	0.27
80_V	91_V	0.670	0.26
113_D	149_E	0.663	0.26
12_V	185_V	0.662	0.26
11_V	244_L	0.661	0.26
69_P	141_L	0.661	0.26
142_R	260_R	0.654	0.26
41_D	109_A	0.654	0.26
118_N	133_G	0.652	0.26
218_F	237_G	0.651	0.25
60_D	221_S	0.648	0.25
173_V	236_D	0.646	0.25
35_R	79_L	0.640	0.25
96_L	201_L	0.637	0.25
70_K	191_G	0.633	0.25
43_S	86_E	0.633	0.25
39_L	86_E	0.631	0.24
100_A	112_A	0.630	0.24
184_G	205_V	0.628	0.24
174_A	177_L	0.626	0.24
56_E	60_D	0.624	0.24
29_G	153_L	0.624	0.24
36_D	197_D	0.623	0.24
204_V	217_V	0.621	0.24
7_A	10_P	0.621	0.24
70_K	102_A	0.616	0.24
56_E	220_G	0.615	0.24
11_V	55_V	0.614	0.24
205_V	213_A	0.612	0.23
122_G	172_G	0.611	0.23
41_D	252_A	0.607	0.23
128_Q	163_A	0.606	0.23
88_E	115_V	0.606	0.23
36_D	206_D	0.604	0.23
118_N	159_K	0.604	0.23
71_H	105_S	0.603	0.23
69_P	163_A	0.603	0.23
111_D	142_R	0.602	0.23
65_A	118_N	0.602	0.23
118_N	154_A	0.599	0.23
89_V	169_L	0.594	0.23
197_D	247_N	0.594	0.23
8_D	86_E	0.593	0.23
159_K	220_G	0.589	0.22
139_V	244_L	0.584	0.22
101_E	247_N	0.583	0.22
130_V	195_A	0.577	0.22
58_F	179_R	0.577	0.22
219_V	231_T	0.577	0.22
228_V	243_A	0.576	0.22
155_D	158_V	0.572	0.22
75_S	256_G	0.570	0.21
255_D	262_L	0.569	0.21
11_V	108_A	0.567	0.21
27_D	73_V	0.567	0.21
50_V	53_L	0.564	0.21
156_I	173_V	0.564	0.21
121_T	232_L	0.564	0.21
45_L	50_V	0.563	0.21
10_P	17_L	0.563	0.21
46_E	88_E	0.561	0.21
21_P	248_G	0.561	0.21
62_P	189_G	0.560	0.21
14_M	241_G	0.559	0.21
97_R	158_V	0.558	0.21
8_D	47_A	0.556	0.21
37_A	227_T	0.551	0.21
198_H	226_E	0.549	0.20
125_L	161_S	0.543	0.20
27_D	54_L	0.543	0.20
125_L	152_M	0.542	0.20
68_V	73_V	0.542	0.20
30_N	77_A	0.541	0.20
34_I	79_L	0.541	0.20
67_D	79_L	0.539	0.20
213_A	216_P	0.539	0.20
156_I	182_A	0.539	0.20
54_L	135_A	0.538	0.20
8_D	198_H	0.538	0.20
93_V	243_A	0.535	0.20
128_Q	160_H	0.535	0.20
118_N	155_D	0.534	0.20
230_A	264_D	0.532	0.20
83_I	176_L	0.531	0.20
137_E	261_A	0.530	0.20
107_A	115_V	0.526	0.19
115_V	138_T	0.526	0.19
39_L	115_V	0.526	0.19
54_L	119_V	0.524	0.19
19_P	38_A	0.523	0.19
197_D	252_A	0.522	0.19
154_A	221_S	0.521	0.19
122_G	163_A	0.519	0.19
165_A	175_E	0.519	0.19
82_D	241_G	0.518	0.19
133_G	163_A	0.517	0.19
118_N	135_A	0.516	0.19
85_R	185_V	0.516	0.19
83_I	86_E	0.514	0.19
188_S	220_G	0.512	0.19
18_S	240_V	0.512	0.19
137_E	214_D	0.511	0.19
54_L	225_Q	0.511	0.19
103_A	224_T	0.511	0.19
67_D	115_V	0.510	0.19
22_G	26_Y	0.509	0.19
255_D	259_V	0.509	0.19
73_V	216_P	0.508	0.19
63_F	159_K	0.507	0.19
107_A	239_I	0.506	0.19
121_T	176_L	0.505	0.19
60_D	160_H	0.503	0.18
38_A	91_V	0.503	0.18
56_E	118_N	0.502	0.18
107_A	150_V	0.502	0.18
58_F	94_N	0.502	0.18
57_N	63_F	0.500	0.18
140_R	166_E	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4r9xA	2	0.7865	99.8	0.799	Contact Map
1ujpA	1	0.7603	99.8	0.801	Contact Map
3vndA	3	0.8202	99.8	0.803	Contact Map
2ekcA	1	0.8352	99.8	0.804	Contact Map
3thaA	2	0.8277	99.8	0.807	Contact Map
3navA	2	0.8277	99.7	0.809	Contact Map
1geqA	1	0.8202	99.7	0.809	Contact Map
4ht3A	1	0.8464	99.7	0.811	Contact Map
1rd5A	6	0.839	99.7	0.815	Contact Map
2yw3A	4	0.7266	99.7	0.822	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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