GREMLIN Database
Q9HMJ2 - Uncharacterized protein
UniProt: Q9HMJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (250)
Sequences: 555 (363)
Seq/√Len: 23.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_G259_V4.6811.00
205_V236_D3.4451.00
154_A182_A3.2351.00
80_V93_V3.2221.00
11_V50_V3.2161.00
205_V217_V3.0671.00
170_S203_A2.9651.00
105_S141_L2.8360.99
31_R75_S2.7930.99
82_D85_R2.6170.99
247_N252_A2.5320.98
78_A82_D2.4420.98
50_V259_V2.4280.98
11_V238_A2.4120.98
50_V244_L2.3970.98
18_S38_A2.3820.98
186_I220_G2.3570.98
219_V223_V2.3130.97
41_D254_V2.2990.97
17_L38_A2.2680.97
153_L184_G2.2680.97
11_V263_V2.2270.96
56_E159_K2.2270.96
99_D102_A2.1630.96
29_G33_A2.1500.96
159_K221_S2.0970.95
56_E221_S2.0830.95
44_R48_G2.0740.95
225_Q243_A2.0720.95
36_D40_R1.8540.91
97_R126_T1.8510.91
97_R118_N1.8460.90
32_P36_D1.8210.90
229_G265_A1.7760.89
55_V91_V1.7760.89
120_H138_T1.7330.87
26_Y30_N1.7170.87
145_L150_V1.6850.86
248_G258_R1.6580.85
55_V80_V1.6140.83
118_N158_V1.5960.83
134_Q137_E1.5840.82
27_D33_A1.5660.81
27_D30_N1.5650.81
96_L118_N1.5520.81
26_Y29_G1.5520.81
56_E192_T1.5370.80
74_A109_A1.5320.80
249_E252_A1.5290.80
37_A40_R1.5270.80
95_V106_I1.5150.79
54_L114_F1.4910.78
124_R161_S1.4890.78
42_A53_L1.4890.78
78_A81_R1.4850.78
128_Q179_R1.4770.77
41_D59_G1.4730.77
18_S37_A1.4660.77
25_G181_H1.4350.75
14_M45_L1.4320.75
41_D44_R1.4300.75
202_Q206_D1.4080.74
244_L263_V1.4060.74
84_T91_V1.3990.73
56_E158_V1.3980.73
14_M54_L1.3850.72
40_R253_P1.3780.72
39_L87_A1.3750.72
56_E160_H1.3690.72
52_A114_F1.3670.71
47_A256_G1.3610.71
42_A83_I1.3580.71
97_R128_Q1.3540.71
97_R179_R1.3420.70
99_D119_V1.3400.70
158_V192_T1.3290.69
30_N33_A1.3260.69
39_L83_I1.3110.68
40_R43_S1.2990.67
143_D148_A1.2900.67
254_V259_V1.2890.67
108_A146_D1.2870.67
195_A230_A1.2560.65
159_K192_T1.2480.64
23_A60_D1.2440.64
246_Q252_A1.2140.62
24_P140_R1.2060.62
80_V110_A1.2020.61
158_V221_S1.1830.60
50_V263_V1.1830.60
118_N179_R1.1700.59
16_H21_P1.1610.59
12_V52_A1.1570.58
193_G221_S1.1450.57
223_V228_V1.1410.57
160_H179_R1.1380.57
246_Q253_P1.1370.57
260_R264_D1.1350.57
85_R218_F1.1340.57
63_F221_S1.1310.56
13_G16_H1.1240.56
160_H221_S1.1050.55
217_V235_A1.0990.54
57_N62_P1.0980.54
43_S47_A1.0920.54
73_V77_A1.0870.53
155_D221_S1.0810.53
41_D247_N1.0780.53
136_A140_R1.0740.53
173_V207_A1.0600.52
218_F242_T1.0580.51
225_Q265_A1.0550.51
94_N118_N1.0470.51
63_F118_N1.0460.51
116_R129_G1.0450.51
195_A227_T1.0420.50
153_L239_I1.0240.49
123_A133_G1.0230.49
155_D220_G1.0140.48
244_L259_V1.0090.48
56_E193_G1.0090.48
240_V262_L1.0060.48
96_L127_D0.9980.47
229_G260_R0.9940.47
124_R157_D0.9940.47
119_V128_Q0.9830.46
207_A218_F0.9730.46
118_N128_Q0.9710.45
252_A258_R0.9690.45
155_D160_H0.9580.45
56_E155_D0.9560.44
204_V241_G0.9530.44
77_A81_R0.9510.44
12_V90_P0.9500.44
46_E89_V0.9410.43
93_V107_A0.9390.43
157_D161_S0.9390.43
96_L192_T0.9380.43
70_K73_V0.9360.43
152_M240_V0.9320.43
95_V99_D0.9310.43
143_D146_D0.9230.42
108_A149_E0.9180.42
68_V99_D0.9150.42
261_A264_D0.9140.42
19_P25_G0.9120.41
184_G231_T0.9120.41
190_A204_V0.9100.41
121_T177_L0.9080.41
56_E186_I0.8940.40
119_V126_T0.8900.40
64_Y69_P0.8890.40
196_T231_T0.8860.40
162_A168_P0.8840.40
51_D236_D0.8790.39
82_D243_A0.8780.39
9_T236_D0.8780.39
257_D261_A0.8720.39
14_M235_A0.8710.39
174_A257_D0.8700.39
123_A130_V0.8650.38
36_D43_S0.8640.38
18_S55_V0.8580.38
31_R79_L0.8560.38
223_V238_A0.8460.37
159_K193_G0.8440.37
168_P171_E0.8410.37
65_A132_G0.8300.36
54_L233_D0.8300.36
246_Q255_D0.8290.36
160_H192_T0.8260.36
196_T223_V0.8130.35
74_A104_V0.8120.35
57_N60_D0.8090.35
43_S87_A0.8070.35
19_P144_R0.8060.34
57_N245_K0.8060.34
11_V184_G0.8030.34
14_M188_S0.8020.34
11_V249_E0.8010.34
228_V232_L0.7990.34
131_V154_A0.7990.34
59_G250_T0.7980.34
38_A55_V0.7970.34
26_Y146_D0.7960.34
231_T238_A0.7950.34
41_D227_T0.7940.34
192_T221_S0.7910.34
43_S53_L0.7900.33
96_L239_I0.7850.33
142_R242_T0.7830.33
15_V38_A0.7830.33
11_V35_R0.7820.33
14_M239_I0.7810.33
106_I240_V0.7810.33
119_V122_G0.7800.33
84_T228_V0.7790.33
169_L204_V0.7780.33
172_G176_L0.7780.33
53_L260_R0.7760.33
46_E87_A0.7740.32
229_G264_D0.7720.32
13_G45_L0.7710.32
38_A79_L0.7690.32
72_V184_G0.7680.32
43_S84_T0.7680.32
58_F124_R0.7680.32
128_Q180_G0.7670.32
47_A151_S0.7610.32
41_D48_G0.7610.32
9_T12_V0.7600.32
223_V231_T0.7590.32
45_L244_L0.7570.31
99_D164_L0.7560.31
45_L235_A0.7550.31
159_K186_I0.7510.31
35_R82_D0.7510.31
14_M118_N0.7500.31
118_N126_T0.7460.31
63_F158_V0.7450.31
110_A187_A0.7430.31
101_E137_E0.7420.31
94_N158_V0.7390.30
22_G241_G0.7330.30
141_L145_L0.7260.30
163_A250_T0.7220.29
232_L238_A0.7180.29
60_D105_S0.7170.29
56_E103_A0.7160.29
10_P249_E0.7130.29
155_D159_K0.7130.29
94_N97_R0.7120.29
40_R84_T0.7070.29
225_Q261_A0.7070.29
139_V152_M0.7040.28
188_S223_V0.7030.28
46_E205_V0.7030.28
53_L89_V0.6990.28
96_L128_Q0.6980.28
122_G127_D0.6970.28
96_L193_G0.6950.28
10_P90_P0.6920.28
115_V239_I0.6910.28
161_S174_A0.6890.28
63_F193_G0.6880.27
74_A173_V0.6880.27
126_T179_R0.6860.27
39_L42_A0.6860.27
226_E261_A0.6840.27
12_V54_L0.6840.27
225_Q262_L0.6820.27
18_S34_I0.6810.27
155_D186_I0.6790.27
78_A109_A0.6780.27
121_T188_S0.6780.27
169_L173_V0.6760.27
100_A117_V0.6750.27
22_G71_H0.6740.27
80_V91_V0.6700.26
113_D149_E0.6630.26
12_V185_V0.6620.26
11_V244_L0.6610.26
69_P141_L0.6610.26
142_R260_R0.6540.26
41_D109_A0.6540.26
118_N133_G0.6520.26
218_F237_G0.6510.25
60_D221_S0.6480.25
173_V236_D0.6460.25
35_R79_L0.6400.25
96_L201_L0.6370.25
70_K191_G0.6330.25
43_S86_E0.6330.25
39_L86_E0.6310.24
100_A112_A0.6300.24
184_G205_V0.6280.24
174_A177_L0.6260.24
56_E60_D0.6240.24
29_G153_L0.6240.24
36_D197_D0.6230.24
204_V217_V0.6210.24
7_A10_P0.6210.24
70_K102_A0.6160.24
56_E220_G0.6150.24
11_V55_V0.6140.24
205_V213_A0.6120.23
122_G172_G0.6110.23
41_D252_A0.6070.23
128_Q163_A0.6060.23
88_E115_V0.6060.23
36_D206_D0.6040.23
118_N159_K0.6040.23
71_H105_S0.6030.23
69_P163_A0.6030.23
111_D142_R0.6020.23
65_A118_N0.6020.23
118_N154_A0.5990.23
89_V169_L0.5940.23
197_D247_N0.5940.23
8_D86_E0.5930.23
159_K220_G0.5890.22
139_V244_L0.5840.22
101_E247_N0.5830.22
130_V195_A0.5770.22
58_F179_R0.5770.22
219_V231_T0.5770.22
228_V243_A0.5760.22
155_D158_V0.5720.22
75_S256_G0.5700.21
255_D262_L0.5690.21
11_V108_A0.5670.21
27_D73_V0.5670.21
50_V53_L0.5640.21
156_I173_V0.5640.21
121_T232_L0.5640.21
45_L50_V0.5630.21
10_P17_L0.5630.21
46_E88_E0.5610.21
21_P248_G0.5610.21
62_P189_G0.5600.21
14_M241_G0.5590.21
97_R158_V0.5580.21
8_D47_A0.5560.21
37_A227_T0.5510.21
198_H226_E0.5490.20
125_L161_S0.5430.20
27_D54_L0.5430.20
125_L152_M0.5420.20
68_V73_V0.5420.20
30_N77_A0.5410.20
34_I79_L0.5410.20
67_D79_L0.5390.20
213_A216_P0.5390.20
156_I182_A0.5390.20
54_L135_A0.5380.20
8_D198_H0.5380.20
93_V243_A0.5350.20
128_Q160_H0.5350.20
118_N155_D0.5340.20
230_A264_D0.5320.20
83_I176_L0.5310.20
137_E261_A0.5300.20
107_A115_V0.5260.19
115_V138_T0.5260.19
39_L115_V0.5260.19
54_L119_V0.5240.19
19_P38_A0.5230.19
197_D252_A0.5220.19
154_A221_S0.5210.19
122_G163_A0.5190.19
165_A175_E0.5190.19
82_D241_G0.5180.19
133_G163_A0.5170.19
118_N135_A0.5160.19
85_R185_V0.5160.19
83_I86_E0.5140.19
188_S220_G0.5120.19
18_S240_V0.5120.19
137_E214_D0.5110.19
54_L225_Q0.5110.19
103_A224_T0.5110.19
67_D115_V0.5100.19
22_G26_Y0.5090.19
255_D259_V0.5090.19
73_V216_P0.5080.19
63_F159_K0.5070.19
107_A239_I0.5060.19
121_T176_L0.5050.19
60_D160_H0.5030.18
38_A91_V0.5030.18
56_E118_N0.5020.18
107_A150_V0.5020.18
58_F94_N0.5020.18
57_N63_F0.5000.18
140_R166_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r9xA 2 0.7865 99.8 0.799 Contact Map
1ujpA 1 0.7603 99.8 0.801 Contact Map
3vndA 3 0.8202 99.8 0.803 Contact Map
2ekcA 1 0.8352 99.8 0.804 Contact Map
3thaA 2 0.8277 99.8 0.807 Contact Map
3navA 2 0.8277 99.7 0.809 Contact Map
1geqA 1 0.8202 99.7 0.809 Contact Map
4ht3A 1 0.8464 99.7 0.811 Contact Map
1rd5A 6 0.839 99.7 0.815 Contact Map
2yw3A 4 0.7266 99.7 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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