Q9HMJ1 - HALSA - GREMLIN Contacts

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Q9HMJ1 - Uncharacterized protein

UniProt:	Q9HMJ1	Sequences: MEDWVIDDEDLSLERKSLLPGRGFFVPDDIHEARKDDAVRERVEGADVIVVADPDADGLACAAILREVYGDAALIPAGPHEIEDGLRRAVEYGNEDCRLFVCDVCPDRFEYVETELADATEHASELRWFDHHQWTAETAAAVRDAGVDLVVGDSEEECTADVTVRSLDADIPERFRELAEVTRDHDLWLKDDDRSDDLADYSYWADTDEYMDTIQEYGADFPDDVLAYIEQRRVEKHELIERAVDRASMKQIDEWTVGVTYGRCSQNEVAEALREQGADAAVVVKPSGSASIRGTETFERAHEVAGQVNGGGHPKAAGCKPDIYDDMLDYAAHWTSQGTTAKQVILDAFRALPDEPADAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (274)
Sequences:	319 (251)
Seq/√Len:	15.2

BACSU - NRNB
HALSA - Q9HMJ1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
60_A	160_A	7.728	1.00
129_F	162_V	4.065	1.00
60_A	178_L	3.386	0.99
273_L	281_A	2.746	0.96
255_W	299_E	2.599	0.95
292_I	319_C	2.588	0.95
60_A	182_T	2.559	0.95
313_H	316_A	2.450	0.93
57_D	132_H	2.348	0.92
134_W	294_G	2.331	0.91
128_W	134_W	2.320	0.91
64_I	163_T	2.312	0.91
251_Q	256_T	2.296	0.91
132_H	313_H	2.171	0.88
184_D	195_S	2.139	0.87
136_A	140_A	2.068	0.85
57_D	313_H	2.004	0.83
128_W	144_D	1.893	0.80
55_D	104_V	1.865	0.79
196_D	200_D	1.860	0.78
205_A	211_M	1.833	0.77
184_D	193_D	1.825	0.77
211_M	214_I	1.814	0.77
173_E	254_E	1.805	0.76
103_D	310_G	1.803	0.76
103_D	311_G	1.803	0.76
103_D	312_G	1.803	0.76
186_D	312_G	1.803	0.76
130_D	312_G	1.803	0.76
130_D	186_D	1.803	0.76
103_D	186_D	1.803	0.76
103_D	131_H	1.803	0.76
130_D	311_G	1.803	0.76
131_H	186_D	1.803	0.76
186_D	311_G	1.803	0.76
131_H	310_G	1.803	0.76
130_D	310_G	1.803	0.76
131_H	311_G	1.803	0.76
131_H	312_G	1.803	0.76
103_D	130_D	1.803	0.76
186_D	310_G	1.803	0.76
178_L	182_T	1.800	0.76
83_E	86_L	1.781	0.75
262_G	269_V	1.779	0.75
250_K	307_Q	1.729	0.73
207_T	210_Y	1.710	0.72
184_D	268_E	1.705	0.72
292_I	321_P	1.680	0.71
206_D	210_Y	1.666	0.70
162_V	187_L	1.666	0.70
102_C	163_T	1.610	0.67
293_R	310_G	1.553	0.64
130_D	293_R	1.553	0.64
293_R	311_G	1.553	0.64
131_H	293_R	1.553	0.64
293_R	312_G	1.553	0.64
103_D	293_R	1.553	0.64
186_D	293_R	1.553	0.64
52_A	55_D	1.541	0.64
105_C	257_V	1.532	0.63
178_L	270_A	1.437	0.58
68_V	115_E	1.433	0.58
132_H	291_S	1.418	0.57
115_E	317_A	1.415	0.57
68_V	317_A	1.404	0.56
182_T	188_W	1.401	0.56
289_S	309_N	1.397	0.56
160_A	226_L	1.397	0.56
69_Y	285_K	1.366	0.54
132_H	186_D	1.365	0.54
132_H	312_G	1.365	0.54
103_D	132_H	1.365	0.54
132_H	310_G	1.365	0.54
132_H	311_G	1.365	0.54
99_L	209_E	1.359	0.54
158_C	255_W	1.353	0.53
134_W	196_D	1.351	0.53
251_Q	254_E	1.328	0.52
159_T	163_T	1.327	0.52
190_K	270_A	1.317	0.51
218_G	221_F	1.315	0.51
261_Y	270_A	1.307	0.51
182_T	270_A	1.293	0.50
267_N	270_A	1.291	0.50
55_D	318_G	1.282	0.49
53_D	56_A	1.275	0.49
85_G	200_D	1.265	0.49
292_I	309_N	1.263	0.48
148_D	175_F	1.262	0.48
116_L	259_V	1.238	0.47
157_E	165_R	1.238	0.47
57_D	291_S	1.237	0.47
55_D	159_T	1.231	0.47
175_F	317_A	1.230	0.47
132_H	318_G	1.230	0.47
193_D	294_G	1.225	0.46
55_D	132_H	1.198	0.45
118_D	122_H	1.197	0.45
57_D	103_D	1.194	0.45
57_D	310_G	1.194	0.45
57_D	186_D	1.194	0.45
57_D	312_G	1.194	0.45
57_D	131_H	1.194	0.45
57_D	130_D	1.194	0.45
57_D	311_G	1.194	0.45
185_H	268_E	1.193	0.44
141_A	215_Q	1.187	0.44
72_A	251_Q	1.184	0.44
188_W	267_N	1.171	0.43
252_I	257_V	1.167	0.43
302_H	317_A	1.159	0.43
93_G	216_E	1.150	0.42
175_F	229_I	1.146	0.42
254_E	288_G	1.143	0.42
73_A	96_D	1.140	0.42
159_T	292_I	1.139	0.41
117_A	237_H	1.136	0.41
196_D	271_E	1.114	0.40
71_D	122_H	1.109	0.40
290_A	314_P	1.107	0.40
212_D	216_E	1.105	0.40
132_H	293_R	1.103	0.40
211_M	224_D	1.097	0.39
164_V	218_G	1.096	0.39
288_G	320_K	1.094	0.39
266_Q	269_V	1.088	0.39
60_A	188_W	1.081	0.38
64_I	179_A	1.079	0.38
100_F	128_W	1.066	0.38
310_G	313_H	1.063	0.37
131_H	313_H	1.063	0.37
103_D	313_H	1.063	0.37
130_D	313_H	1.063	0.37
186_D	313_H	1.063	0.37
281_A	294_G	1.056	0.37
86_L	90_V	1.055	0.37
57_D	318_G	1.040	0.36
294_G	315_K	1.038	0.36
211_M	215_Q	1.032	0.36
173_E	251_Q	1.028	0.36
224_D	303_E	1.012	0.35
132_H	316_A	0.999	0.34
52_A	76_P	0.995	0.34
238_E	245_D	0.986	0.33
160_A	202_S	0.981	0.33
164_V	223_D	0.969	0.33
110_E	173_E	0.968	0.32
105_C	222_P	0.967	0.32
52_A	292_I	0.963	0.32
166_S	179_A	0.963	0.32
292_I	302_H	0.957	0.32
90_V	126_L	0.954	0.32
279_D	318_G	0.954	0.32
143_R	247_A	0.952	0.32
54_P	79_P	0.950	0.32
122_H	143_R	0.945	0.31
221_F	227_A	0.942	0.31
57_D	293_R	0.931	0.31
143_R	216_E	0.929	0.31
277_G	317_A	0.928	0.31
88_R	146_G	0.928	0.31
185_H	265_S	0.927	0.30
232_R	236_K	0.920	0.30
164_V	176_R	0.917	0.30
245_D	296_E	0.915	0.30
78_G	129_F	0.907	0.30
177_E	194_R	0.907	0.30
158_C	223_D	0.901	0.29
95_E	189_L	0.897	0.29
51_V	55_D	0.895	0.29
181_V	184_D	0.894	0.29
229_I	265_S	0.893	0.29
104_V	159_T	0.892	0.29
100_F	135_T	0.888	0.29
96_D	292_I	0.887	0.29
52_A	200_D	0.885	0.29
284_V	320_K	0.881	0.28
164_V	172_P	0.881	0.28
74_L	82_I	0.867	0.28
313_H	318_G	0.866	0.28
239_L	258_G	0.863	0.28
280_A	301_A	0.858	0.27
212_D	215_Q	0.855	0.27
154_S	163_T	0.855	0.27
88_R	143_R	0.854	0.27
267_N	271_E	0.853	0.27
249_M	278_A	0.851	0.27
93_G	254_E	0.846	0.27
209_E	292_I	0.845	0.27
152_G	159_T	0.842	0.27
71_D	173_E	0.842	0.27
141_A	284_V	0.841	0.27
105_C	135_T	0.840	0.26
64_I	194_R	0.837	0.26
291_S	313_H	0.837	0.26
174_R	317_A	0.836	0.26
55_D	183_R	0.833	0.26
225_V	228_Y	0.831	0.26
110_E	287_S	0.831	0.26
244_V	276_Q	0.829	0.26
62_A	78_G	0.828	0.26
57_D	316_A	0.823	0.26
72_A	235_E	0.823	0.26
99_L	286_P	0.821	0.26
180_E	308_V	0.818	0.26
310_G	318_G	0.815	0.25
186_D	318_G	0.815	0.25
311_G	318_G	0.815	0.25
131_H	318_G	0.815	0.25
312_G	318_G	0.815	0.25
103_D	318_G	0.815	0.25
130_D	318_G	0.815	0.25
161_D	183_R	0.809	0.25
151_V	187_L	0.809	0.25
198_L	226_L	0.805	0.25
102_C	277_G	0.804	0.25
133_Q	300_R	0.804	0.25
208_D	268_E	0.802	0.25
141_A	165_R	0.800	0.25
61_C	200_D	0.797	0.25
52_A	97_C	0.795	0.25
293_R	313_H	0.791	0.24
117_A	254_E	0.786	0.24
55_D	313_H	0.786	0.24
222_P	230_E	0.783	0.24
162_V	259_V	0.779	0.24
114_T	170_D	0.778	0.24
227_A	256_T	0.777	0.24
110_E	141_A	0.776	0.24
126_L	321_P	0.775	0.24
190_K	301_A	0.772	0.24
189_L	195_S	0.771	0.24
176_R	305_A	0.771	0.24
191_D	209_E	0.770	0.24
143_R	323_I	0.762	0.23
185_H	319_C	0.761	0.23
116_L	291_S	0.760	0.23
52_A	271_E	0.760	0.23
205_A	210_Y	0.758	0.23
199_A	203_Y	0.754	0.23
134_W	158_C	0.754	0.23
183_R	258_G	0.753	0.23
228_Y	259_V	0.749	0.23
53_D	318_G	0.749	0.23
72_A	143_R	0.748	0.23
189_L	301_A	0.746	0.23
101_V	267_N	0.746	0.23
48_V	303_E	0.745	0.23
134_W	198_L	0.743	0.22
64_I	140_A	0.738	0.22
93_G	122_H	0.738	0.22
204_W	210_Y	0.738	0.22
58_G	311_G	0.737	0.22
58_G	186_D	0.737	0.22
58_G	131_H	0.737	0.22
58_G	103_D	0.737	0.22
58_G	312_G	0.737	0.22
58_G	130_D	0.737	0.22
58_G	310_G	0.737	0.22
222_P	304_V	0.736	0.22
119_A	177_E	0.733	0.22
61_C	203_Y	0.732	0.22
153_D	229_I	0.729	0.22
134_W	142_V	0.722	0.22
129_F	187_L	0.721	0.22
206_D	215_Q	0.718	0.21
236_K	268_E	0.718	0.21
70_G	226_L	0.716	0.21
71_D	170_D	0.716	0.21
226_L	229_I	0.714	0.21
182_T	190_K	0.711	0.21
59_L	182_T	0.709	0.21
121_E	170_D	0.707	0.21
65_L	167_L	0.706	0.21
133_Q	192_D	0.702	0.21
87_R	173_E	0.701	0.21
110_E	121_E	0.699	0.21
116_L	128_W	0.697	0.21
143_R	174_R	0.694	0.21
201_Y	258_G	0.688	0.20
239_L	243_A	0.687	0.20
282_V	295_T	0.686	0.20
80_H	319_C	0.685	0.20
55_D	64_I	0.681	0.20
240_I	292_I	0.680	0.20
88_R	317_A	0.678	0.20
258_G	315_K	0.668	0.20
49_I	52_A	0.666	0.20
187_L	199_A	0.658	0.19
52_A	56_A	0.658	0.19
102_C	159_T	0.654	0.19
94_N	97_C	0.654	0.19
115_E	173_E	0.653	0.19
135_T	159_T	0.652	0.19
113_E	178_L	0.652	0.19
67_E	290_A	0.649	0.19
219_A	222_P	0.648	0.19
100_F	129_F	0.647	0.19
259_V	279_D	0.646	0.19
118_D	254_E	0.646	0.19
102_C	199_A	0.644	0.19
301_A	318_G	0.643	0.19
51_V	151_V	0.641	0.19
114_T	283_V	0.640	0.19
242_R	276_Q	0.639	0.19
100_F	304_V	0.638	0.19
49_I	120_T	0.637	0.19
51_V	85_G	0.636	0.19
74_L	140_A	0.636	0.19
116_L	229_I	0.635	0.18
72_A	79_P	0.632	0.18
161_D	187_L	0.630	0.18
173_E	307_Q	0.629	0.18
58_G	62_A	0.628	0.18
60_A	318_G	0.626	0.18
117_A	121_E	0.624	0.18
119_A	291_S	0.623	0.18
64_I	289_S	0.622	0.18
106_P	318_G	0.621	0.18
120_T	309_N	0.619	0.18
90_V	117_A	0.617	0.18
75_I	95_E	0.616	0.18
270_A	304_V	0.615	0.18
139_A	230_E	0.615	0.18
194_R	221_F	0.614	0.18
237_H	305_A	0.613	0.18
105_C	128_W	0.611	0.18
162_V	188_W	0.611	0.18
116_L	126_L	0.610	0.18
52_A	159_T	0.605	0.17
52_A	59_L	0.602	0.17
147_V	173_E	0.602	0.17
299_E	307_Q	0.600	0.17
118_D	148_D	0.593	0.17
172_P	323_I	0.591	0.17
134_W	202_S	0.591	0.17
74_L	100_F	0.589	0.17
255_W	307_Q	0.585	0.17
62_A	207_T	0.585	0.17
69_Y	262_G	0.584	0.17
71_D	292_I	0.579	0.17
183_R	189_L	0.579	0.17
56_A	102_C	0.578	0.17
195_S	260_T	0.577	0.17
198_L	260_T	0.575	0.17
117_A	173_E	0.573	0.16
154_S	294_G	0.572	0.16
160_A	182_T	0.572	0.16
95_E	121_E	0.571	0.16
240_I	269_V	0.571	0.16
136_A	284_V	0.571	0.16
194_R	218_G	0.570	0.16
291_S	316_A	0.569	0.16
173_E	205_A	0.567	0.16
118_D	216_E	0.562	0.16
154_S	287_S	0.562	0.16
73_A	168_D	0.560	0.16
220_D	304_V	0.555	0.16
79_P	264_C	0.552	0.16
110_E	114_T	0.552	0.16
63_A	242_R	0.550	0.16
101_V	243_A	0.550	0.16
114_T	141_A	0.549	0.16
253_D	276_Q	0.549	0.16
177_E	306_G	0.548	0.16
62_A	76_P	0.545	0.16
77_A	85_G	0.545	0.16
247_A	285_K	0.542	0.16
247_A	286_P	0.542	0.16
143_R	150_V	0.542	0.16
60_A	279_D	0.541	0.15
188_W	268_E	0.541	0.15
164_V	271_E	0.540	0.15
134_W	173_E	0.540	0.15
50_V	324_Y	0.540	0.15
131_H	291_S	0.538	0.15
103_D	291_S	0.538	0.15
130_D	291_S	0.538	0.15
291_S	311_G	0.538	0.15
186_D	291_S	0.538	0.15
291_S	310_G	0.538	0.15
291_S	312_G	0.538	0.15
244_V	304_V	0.538	0.15
173_E	216_E	0.537	0.15
88_R	92_Y	0.536	0.15
216_E	309_N	0.535	0.15
64_I	247_A	0.533	0.15
50_V	62_A	0.533	0.15
176_R	251_Q	0.533	0.15
71_D	74_L	0.531	0.15
127_R	297_T	0.527	0.15
59_L	185_H	0.527	0.15
48_V	98_R	0.527	0.15
95_E	118_D	0.526	0.15
69_Y	238_E	0.525	0.15
258_G	281_A	0.524	0.15
111_Y	115_E	0.521	0.15
207_T	214_I	0.520	0.15
305_A	318_G	0.520	0.15
221_F	304_V	0.517	0.15
133_Q	302_H	0.515	0.15
47_D	87_R	0.513	0.15
300_R	317_A	0.512	0.15
114_T	307_Q	0.511	0.15
121_E	227_A	0.510	0.15
293_R	318_G	0.508	0.15
171_I	176_R	0.507	0.15
93_G	120_T	0.503	0.14
99_L	126_L	0.501	0.14
79_P	266_Q	0.501	0.14
47_D	308_V	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3devA	2	0.7778	100	0.725	Contact Map
4ls9A	2	0.7778	100	0.725	Contact Map
4py9A	2	0.8222	100	0.733	Contact Map
2zxrA	1	0.8333	99.9	0.785	Contact Map
2hawA	2	0.7333	99.8	0.804	Contact Map
4rpaA	3	0.7417	99.7	0.829	Contact Map
2eb0A	2	0.7306	99.2	0.871	Contact Map
1k20A	2	0.7278	99.1	0.88	Contact Map
1wpnA	2	0.4417	98.8	0.893	Contact Map
2qb7A	1	0.8472	98	0.916	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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