GREMLIN Database
Q9HMJ1 - Uncharacterized protein
UniProt: Q9HMJ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (274)
Sequences: 319 (251)
Seq/√Len: 15.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_A160_A7.7281.00
129_F162_V4.0651.00
60_A178_L3.3860.99
273_L281_A2.7460.96
255_W299_E2.5990.95
292_I319_C2.5880.95
60_A182_T2.5590.95
313_H316_A2.4500.93
57_D132_H2.3480.92
134_W294_G2.3310.91
128_W134_W2.3200.91
64_I163_T2.3120.91
251_Q256_T2.2960.91
132_H313_H2.1710.88
184_D195_S2.1390.87
136_A140_A2.0680.85
57_D313_H2.0040.83
128_W144_D1.8930.80
55_D104_V1.8650.79
196_D200_D1.8600.78
205_A211_M1.8330.77
184_D193_D1.8250.77
211_M214_I1.8140.77
173_E254_E1.8050.76
103_D310_G1.8030.76
103_D311_G1.8030.76
103_D312_G1.8030.76
186_D312_G1.8030.76
130_D312_G1.8030.76
130_D186_D1.8030.76
103_D186_D1.8030.76
103_D131_H1.8030.76
130_D311_G1.8030.76
131_H186_D1.8030.76
186_D311_G1.8030.76
131_H310_G1.8030.76
130_D310_G1.8030.76
131_H311_G1.8030.76
131_H312_G1.8030.76
103_D130_D1.8030.76
186_D310_G1.8030.76
178_L182_T1.8000.76
83_E86_L1.7810.75
262_G269_V1.7790.75
250_K307_Q1.7290.73
207_T210_Y1.7100.72
184_D268_E1.7050.72
292_I321_P1.6800.71
206_D210_Y1.6660.70
162_V187_L1.6660.70
102_C163_T1.6100.67
293_R310_G1.5530.64
130_D293_R1.5530.64
293_R311_G1.5530.64
131_H293_R1.5530.64
293_R312_G1.5530.64
103_D293_R1.5530.64
186_D293_R1.5530.64
52_A55_D1.5410.64
105_C257_V1.5320.63
178_L270_A1.4370.58
68_V115_E1.4330.58
132_H291_S1.4180.57
115_E317_A1.4150.57
68_V317_A1.4040.56
182_T188_W1.4010.56
289_S309_N1.3970.56
160_A226_L1.3970.56
69_Y285_K1.3660.54
132_H186_D1.3650.54
132_H312_G1.3650.54
103_D132_H1.3650.54
132_H310_G1.3650.54
132_H311_G1.3650.54
99_L209_E1.3590.54
158_C255_W1.3530.53
134_W196_D1.3510.53
251_Q254_E1.3280.52
159_T163_T1.3270.52
190_K270_A1.3170.51
218_G221_F1.3150.51
261_Y270_A1.3070.51
182_T270_A1.2930.50
267_N270_A1.2910.50
55_D318_G1.2820.49
53_D56_A1.2750.49
85_G200_D1.2650.49
292_I309_N1.2630.48
148_D175_F1.2620.48
116_L259_V1.2380.47
157_E165_R1.2380.47
57_D291_S1.2370.47
55_D159_T1.2310.47
175_F317_A1.2300.47
132_H318_G1.2300.47
193_D294_G1.2250.46
55_D132_H1.1980.45
118_D122_H1.1970.45
57_D103_D1.1940.45
57_D310_G1.1940.45
57_D186_D1.1940.45
57_D312_G1.1940.45
57_D131_H1.1940.45
57_D130_D1.1940.45
57_D311_G1.1940.45
185_H268_E1.1930.44
141_A215_Q1.1870.44
72_A251_Q1.1840.44
188_W267_N1.1710.43
252_I257_V1.1670.43
302_H317_A1.1590.43
93_G216_E1.1500.42
175_F229_I1.1460.42
254_E288_G1.1430.42
73_A96_D1.1400.42
159_T292_I1.1390.41
117_A237_H1.1360.41
196_D271_E1.1140.40
71_D122_H1.1090.40
290_A314_P1.1070.40
212_D216_E1.1050.40
132_H293_R1.1030.40
211_M224_D1.0970.39
164_V218_G1.0960.39
288_G320_K1.0940.39
266_Q269_V1.0880.39
60_A188_W1.0810.38
64_I179_A1.0790.38
100_F128_W1.0660.38
310_G313_H1.0630.37
131_H313_H1.0630.37
103_D313_H1.0630.37
130_D313_H1.0630.37
186_D313_H1.0630.37
281_A294_G1.0560.37
86_L90_V1.0550.37
57_D318_G1.0400.36
294_G315_K1.0380.36
211_M215_Q1.0320.36
173_E251_Q1.0280.36
224_D303_E1.0120.35
132_H316_A0.9990.34
52_A76_P0.9950.34
238_E245_D0.9860.33
160_A202_S0.9810.33
164_V223_D0.9690.33
110_E173_E0.9680.32
105_C222_P0.9670.32
52_A292_I0.9630.32
166_S179_A0.9630.32
292_I302_H0.9570.32
90_V126_L0.9540.32
279_D318_G0.9540.32
143_R247_A0.9520.32
54_P79_P0.9500.32
122_H143_R0.9450.31
221_F227_A0.9420.31
57_D293_R0.9310.31
143_R216_E0.9290.31
277_G317_A0.9280.31
88_R146_G0.9280.31
185_H265_S0.9270.30
232_R236_K0.9200.30
164_V176_R0.9170.30
245_D296_E0.9150.30
78_G129_F0.9070.30
177_E194_R0.9070.30
158_C223_D0.9010.29
95_E189_L0.8970.29
51_V55_D0.8950.29
181_V184_D0.8940.29
229_I265_S0.8930.29
104_V159_T0.8920.29
100_F135_T0.8880.29
96_D292_I0.8870.29
52_A200_D0.8850.29
284_V320_K0.8810.28
164_V172_P0.8810.28
74_L82_I0.8670.28
313_H318_G0.8660.28
239_L258_G0.8630.28
280_A301_A0.8580.27
212_D215_Q0.8550.27
154_S163_T0.8550.27
88_R143_R0.8540.27
267_N271_E0.8530.27
249_M278_A0.8510.27
93_G254_E0.8460.27
209_E292_I0.8450.27
152_G159_T0.8420.27
71_D173_E0.8420.27
141_A284_V0.8410.27
105_C135_T0.8400.26
64_I194_R0.8370.26
291_S313_H0.8370.26
174_R317_A0.8360.26
55_D183_R0.8330.26
225_V228_Y0.8310.26
110_E287_S0.8310.26
244_V276_Q0.8290.26
62_A78_G0.8280.26
57_D316_A0.8230.26
72_A235_E0.8230.26
99_L286_P0.8210.26
180_E308_V0.8180.26
310_G318_G0.8150.25
186_D318_G0.8150.25
311_G318_G0.8150.25
131_H318_G0.8150.25
312_G318_G0.8150.25
103_D318_G0.8150.25
130_D318_G0.8150.25
161_D183_R0.8090.25
151_V187_L0.8090.25
198_L226_L0.8050.25
102_C277_G0.8040.25
133_Q300_R0.8040.25
208_D268_E0.8020.25
141_A165_R0.8000.25
61_C200_D0.7970.25
52_A97_C0.7950.25
293_R313_H0.7910.24
117_A254_E0.7860.24
55_D313_H0.7860.24
222_P230_E0.7830.24
162_V259_V0.7790.24
114_T170_D0.7780.24
227_A256_T0.7770.24
110_E141_A0.7760.24
126_L321_P0.7750.24
190_K301_A0.7720.24
189_L195_S0.7710.24
176_R305_A0.7710.24
191_D209_E0.7700.24
143_R323_I0.7620.23
185_H319_C0.7610.23
116_L291_S0.7600.23
52_A271_E0.7600.23
205_A210_Y0.7580.23
199_A203_Y0.7540.23
134_W158_C0.7540.23
183_R258_G0.7530.23
228_Y259_V0.7490.23
53_D318_G0.7490.23
72_A143_R0.7480.23
189_L301_A0.7460.23
101_V267_N0.7460.23
48_V303_E0.7450.23
134_W198_L0.7430.22
64_I140_A0.7380.22
93_G122_H0.7380.22
204_W210_Y0.7380.22
58_G311_G0.7370.22
58_G186_D0.7370.22
58_G131_H0.7370.22
58_G103_D0.7370.22
58_G312_G0.7370.22
58_G130_D0.7370.22
58_G310_G0.7370.22
222_P304_V0.7360.22
119_A177_E0.7330.22
61_C203_Y0.7320.22
153_D229_I0.7290.22
134_W142_V0.7220.22
129_F187_L0.7210.22
206_D215_Q0.7180.21
236_K268_E0.7180.21
70_G226_L0.7160.21
71_D170_D0.7160.21
226_L229_I0.7140.21
182_T190_K0.7110.21
59_L182_T0.7090.21
121_E170_D0.7070.21
65_L167_L0.7060.21
133_Q192_D0.7020.21
87_R173_E0.7010.21
110_E121_E0.6990.21
116_L128_W0.6970.21
143_R174_R0.6940.21
201_Y258_G0.6880.20
239_L243_A0.6870.20
282_V295_T0.6860.20
80_H319_C0.6850.20
55_D64_I0.6810.20
240_I292_I0.6800.20
88_R317_A0.6780.20
258_G315_K0.6680.20
49_I52_A0.6660.20
187_L199_A0.6580.19
52_A56_A0.6580.19
102_C159_T0.6540.19
94_N97_C0.6540.19
115_E173_E0.6530.19
135_T159_T0.6520.19
113_E178_L0.6520.19
67_E290_A0.6490.19
219_A222_P0.6480.19
100_F129_F0.6470.19
259_V279_D0.6460.19
118_D254_E0.6460.19
102_C199_A0.6440.19
301_A318_G0.6430.19
51_V151_V0.6410.19
114_T283_V0.6400.19
242_R276_Q0.6390.19
100_F304_V0.6380.19
49_I120_T0.6370.19
51_V85_G0.6360.19
74_L140_A0.6360.19
116_L229_I0.6350.18
72_A79_P0.6320.18
161_D187_L0.6300.18
173_E307_Q0.6290.18
58_G62_A0.6280.18
60_A318_G0.6260.18
117_A121_E0.6240.18
119_A291_S0.6230.18
64_I289_S0.6220.18
106_P318_G0.6210.18
120_T309_N0.6190.18
90_V117_A0.6170.18
75_I95_E0.6160.18
270_A304_V0.6150.18
139_A230_E0.6150.18
194_R221_F0.6140.18
237_H305_A0.6130.18
105_C128_W0.6110.18
162_V188_W0.6110.18
116_L126_L0.6100.18
52_A159_T0.6050.17
52_A59_L0.6020.17
147_V173_E0.6020.17
299_E307_Q0.6000.17
118_D148_D0.5930.17
172_P323_I0.5910.17
134_W202_S0.5910.17
74_L100_F0.5890.17
255_W307_Q0.5850.17
62_A207_T0.5850.17
69_Y262_G0.5840.17
71_D292_I0.5790.17
183_R189_L0.5790.17
56_A102_C0.5780.17
195_S260_T0.5770.17
198_L260_T0.5750.17
117_A173_E0.5730.16
154_S294_G0.5720.16
160_A182_T0.5720.16
95_E121_E0.5710.16
240_I269_V0.5710.16
136_A284_V0.5710.16
194_R218_G0.5700.16
291_S316_A0.5690.16
173_E205_A0.5670.16
118_D216_E0.5620.16
154_S287_S0.5620.16
73_A168_D0.5600.16
220_D304_V0.5550.16
79_P264_C0.5520.16
110_E114_T0.5520.16
63_A242_R0.5500.16
101_V243_A0.5500.16
114_T141_A0.5490.16
253_D276_Q0.5490.16
177_E306_G0.5480.16
62_A76_P0.5450.16
77_A85_G0.5450.16
247_A285_K0.5420.16
247_A286_P0.5420.16
143_R150_V0.5420.16
60_A279_D0.5410.15
188_W268_E0.5410.15
164_V271_E0.5400.15
134_W173_E0.5400.15
50_V324_Y0.5400.15
131_H291_S0.5380.15
103_D291_S0.5380.15
130_D291_S0.5380.15
291_S311_G0.5380.15
186_D291_S0.5380.15
291_S310_G0.5380.15
291_S312_G0.5380.15
244_V304_V0.5380.15
173_E216_E0.5370.15
88_R92_Y0.5360.15
216_E309_N0.5350.15
64_I247_A0.5330.15
50_V62_A0.5330.15
176_R251_Q0.5330.15
71_D74_L0.5310.15
127_R297_T0.5270.15
59_L185_H0.5270.15
48_V98_R0.5270.15
95_E118_D0.5260.15
69_Y238_E0.5250.15
258_G281_A0.5240.15
111_Y115_E0.5210.15
207_T214_I0.5200.15
305_A318_G0.5200.15
221_F304_V0.5170.15
133_Q302_H0.5150.15
47_D87_R0.5130.15
300_R317_A0.5120.15
114_T307_Q0.5110.15
121_E227_A0.5100.15
293_R318_G0.5080.15
171_I176_R0.5070.15
93_G120_T0.5030.14
99_L126_L0.5010.14
79_P266_Q0.5010.14
47_D308_V0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3devA 2 0.7778 100 0.725 Contact Map
4ls9A 2 0.7778 100 0.725 Contact Map
4py9A 2 0.8222 100 0.733 Contact Map
2zxrA 1 0.8333 99.9 0.785 Contact Map
2hawA 2 0.7333 99.8 0.804 Contact Map
4rpaA 3 0.7417 99.7 0.829 Contact Map
2eb0A 2 0.7306 99.2 0.871 Contact Map
1k20A 2 0.7278 99.1 0.88 Contact Map
1wpnA 2 0.4417 98.8 0.893 Contact Map
2qb7A 1 0.8472 98 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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