GREMLIN Database
Q9HMJ0 - Uncharacterized protein
UniProt: Q9HMJ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (137)
Sequences: 21316 (17104)
Seq/√Len: 1461.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_H89_A3.0011.00
12_T42_H2.7491.00
14_V108_A2.7181.00
96_P132_R2.5541.00
40_A87_T2.5251.00
12_T40_A2.5021.00
89_A102_Y2.3521.00
29_V142_L2.3491.00
102_Y106_V2.2531.00
110_A142_L2.2241.00
93_G98_E1.9431.00
113_T133_V1.9181.00
111_V139_V1.8981.00
103_A111_V1.8491.00
42_H106_V1.8131.00
42_H87_T1.7951.00
115_T145_R1.7531.00
91_R98_E1.7491.00
42_H108_A1.7481.00
40_A85_S1.7441.00
131_E135_R1.7251.00
44_L102_Y1.6731.00
42_H102_Y1.6711.00
15_I30_A1.6581.00
16_A113_T1.6311.00
12_T109_D1.5671.00
46_V98_E1.5391.00
16_A99_I1.5381.00
98_E101_Q1.5181.00
79_A88_T1.5131.00
28_D81_R1.4951.00
33_V37_F1.4751.00
71_G75_V1.4061.00
104_R138_P1.3841.00
100_S136_T1.3601.00
68_E72_K1.3601.00
111_V137_C1.3581.00
72_K76_S1.3371.00
89_A106_V1.3311.00
132_R136_T1.3201.00
30_A34_A1.3121.00
39_A109_D1.2981.00
15_I27_V1.2951.00
67_L70_R1.2801.00
103_A138_P1.2551.00
64_R68_E1.2491.00
91_R102_Y1.2381.00
78_V82_A1.2171.00
45_Y71_G1.1971.00
95_P129_V1.1881.00
111_V133_V1.1871.00
74_A78_V1.1811.00
44_L91_R1.1541.00
102_Y105_D1.1441.00
24_G81_R1.1441.00
10_I140_P1.1291.00
70_R74_A1.1251.00
103_A139_V1.0871.00
137_C141_V1.0841.00
29_V144_V1.0741.00
76_S80_D1.0721.00
69_E73_D1.0541.00
46_V95_P1.0421.00
67_L71_G1.0371.00
121_E125_L1.0351.00
27_V43_A1.0051.00
74_A77_A0.9971.00
19_G45_Y0.9891.00
76_S79_A0.9891.00
44_L99_I0.9871.00
71_G82_A0.9871.00
113_T130_A0.9851.00
12_T108_A0.9711.00
115_T143_T0.9621.00
10_I29_V0.9551.00
103_A108_A0.9491.00
101_Q105_D0.9471.00
100_S103_A0.9341.00
134_V143_T0.9301.00
71_G74_A0.9271.00
47_L92_A0.9251.00
78_V81_R0.9231.00
65_D69_E0.9221.00
77_A81_R0.9191.00
13_V110_A0.9171.00
12_T106_V0.9161.00
43_A86_V0.9061.00
123_R131_E0.9021.00
91_R105_D0.8971.00
30_A112_A0.8961.00
23_V26_A0.8951.00
120_G123_R0.8911.00
31_L84_V0.8911.00
34_A41_V0.8871.00
70_R73_D0.8751.00
59_V62_D0.8631.00
130_A143_T0.8591.00
47_L90_V0.8521.00
17_T43_A0.8491.00
29_V33_V0.8481.00
14_V102_Y0.8381.00
25_R28_D0.8271.00
14_V111_V0.8271.00
34_A37_F0.8261.00
37_F109_D0.8261.00
118_R122_N0.8251.00
32_D36_R0.8181.00
115_T130_A0.8171.00
57_D60_R0.8141.00
24_G77_A0.8131.00
30_A41_V0.8131.00
20_S23_V0.8021.00
29_V32_D0.7991.00
77_A80_D0.7981.00
24_G28_D0.7981.00
16_A114_G0.7981.00
14_V44_L0.7881.00
102_Y108_A0.7861.00
94_R97_A0.7841.00
15_I41_V0.7811.00
27_V78_V0.7781.00
17_T27_V0.7761.00
100_S133_V0.7701.00
79_A82_A0.7661.00
10_I110_A0.7611.00
29_V140_P0.7611.00
17_T26_A0.7541.00
100_S137_C0.7511.00
31_L82_A0.7481.00
27_V31_L0.7441.00
35_A83_D0.7431.00
34_A39_A0.7421.00
112_A142_L0.7401.00
13_V34_A0.7401.00
72_K88_T0.7391.00
10_I109_D0.7371.00
61_T65_D0.7371.00
120_G124_F0.7371.00
73_D77_A0.7351.00
17_T24_G0.7321.00
75_V88_T0.7281.00
87_T106_V0.7241.00
62_D65_D0.7241.00
31_L35_A0.7221.00
60_R64_R0.7151.00
76_S88_T0.7071.00
99_I133_V0.7061.00
96_P129_V0.7041.00
66_A70_R0.6861.00
117_G126_I0.6811.00
20_S117_G0.6791.00
17_T23_V0.6701.00
73_D76_S0.6661.00
66_A69_E0.6661.00
32_D35_A0.6611.00
15_I26_A0.6611.00
113_T143_T0.6611.00
71_G90_V0.6581.00
30_A39_A0.6411.00
121_E124_F0.6401.00
11_D39_A0.6381.00
33_V36_R0.6371.00
60_R63_M0.6361.00
11_D109_D0.6341.00
22_S146_Q0.6331.00
112_A144_V0.6321.00
107_D139_V0.6301.00
114_G144_V0.6271.00
12_T39_A0.6261.00
69_E72_K0.6221.00
98_E102_Y0.6181.00
96_P100_S0.6161.00
104_R139_V0.5971.00
62_D66_A0.5951.00
18_D23_V0.5941.00
44_L98_E0.5941.00
68_E71_G0.5911.00
96_P136_T0.5881.00
10_I39_A0.5761.00
133_V141_V0.5731.00
58_E62_D0.5731.00
63_M66_A0.5731.00
83_D86_V0.5721.00
97_A101_Q0.5711.00
126_I130_A0.5711.00
25_R146_Q0.5711.00
96_P133_V0.5651.00
58_E61_T0.5631.00
100_S132_R0.5611.00
99_I129_V0.5581.00
22_S25_R0.5551.00
17_T78_V0.5521.00
33_V112_A0.5501.00
47_L64_R0.5501.00
24_G74_A0.5461.00
26_A112_A0.5431.00
43_A88_T0.5371.00
63_M67_L0.5321.00
134_V141_V0.5311.00
61_T64_R0.5281.00
116_R130_A0.5171.00
82_A86_V0.5141.00
45_Y74_A0.5101.00
43_A82_A0.5061.00
93_G101_Q0.5001.00
91_R101_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s3tA 4 0.8854 99.9 0.247 Contact Map
3mt0A 1 0.9236 99.9 0.249 Contact Map
3tnjA 2 0.8089 99.9 0.25 Contact Map
2gm3A 2 0.8408 99.9 0.251 Contact Map
4wnyA 2 0.8025 99.9 0.252 Contact Map
2dumA 2 0.8981 99.9 0.256 Contact Map
2z08A 4 0.7771 99.9 0.261 Contact Map
3hgmA 2 0.8662 99.9 0.262 Contact Map
1mjhA 2 0.8726 99.9 0.264 Contact Map
5ahwA 4 0.8917 99.9 0.265 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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