GREMLIN Database
Q9HMI9 - Uncharacterized protein
UniProt: Q9HMI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (131)
Sequences: 19517 (15749)
Seq/√Len: 1376.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_H92_S3.0691.00
7_T37_H2.8971.00
9_L111_A2.8871.00
99_G135_Y2.7951.00
24_Y145_L2.5831.00
7_T35_D2.4451.00
113_F145_L2.3931.00
35_D90_S2.3371.00
92_S105_A2.1991.00
114_V142_Q2.0491.00
116_I136_V2.0431.00
37_H111_A1.9651.00
37_H105_A1.9411.00
134_E138_L1.9251.00
96_Q101_V1.8441.00
39_L105_A1.8241.00
106_A114_V1.8061.00
94_K101_V1.7891.00
10_A25_A1.7801.00
11_P116_I1.7561.00
37_H90_S1.7131.00
41_V101_V1.7111.00
11_P102_I1.6491.00
72_A76_P1.6271.00
7_T112_D1.6151.00
28_V32_Y1.6061.00
101_V104_D1.5951.00
72_A91_T1.4711.00
64_T68_L1.4571.00
34_A112_D1.4381.00
103_L139_Y1.4301.00
68_L72_A1.4211.00
135_Y139_Y1.4141.00
107_A141_S1.3941.00
114_V140_A1.3871.00
19_V74_L1.3641.00
106_A141_S1.3411.00
61_A65_N1.3341.00
10_A22_A1.3281.00
25_A29_A1.3271.00
94_K105_A1.3061.00
65_N69_N1.2881.00
114_V136_V1.2751.00
67_F71_I1.2431.00
98_P132_A1.2041.00
23_E74_L1.1981.00
140_A144_V1.1711.00
69_N72_A1.1591.00
105_A111_A1.1491.00
41_V98_P1.1421.00
40_Y64_T1.1401.00
124_E128_V1.1331.00
106_A142_Q1.1271.00
39_L94_K1.1261.00
7_T111_A1.0891.00
64_T67_F1.0781.00
118_R146_S1.0711.00
69_N73_A1.0671.00
103_L106_A1.0481.00
14_G40_Y1.0451.00
126_G134_E1.0271.00
116_I133_A1.0161.00
71_I75_A1.0081.00
74_L77_D0.9971.00
8_V113_F0.9961.00
24_Y28_V0.9961.00
27_T31_R0.9881.00
57_E61_A0.9851.00
22_A38_A0.9841.00
106_A111_A0.9821.00
39_L102_I0.9631.00
29_A36_A0.9371.00
24_Y27_T0.9321.00
25_A115_V0.9321.00
24_Y143_P0.9301.00
137_L146_S0.9291.00
62_A66_T0.9251.00
73_A77_D0.9131.00
42_L95_R0.9071.00
133_A146_S0.9011.00
12_V22_A0.8971.00
123_E126_G0.8961.00
75_A79_V0.8951.00
9_L105_A0.8901.00
15_T18_S0.8871.00
59_D62_A0.8861.00
9_L39_L0.8711.00
32_Y112_D0.8711.00
58_D62_A0.8711.00
71_I74_L0.8711.00
12_V38_A0.8621.00
18_S21_A0.8521.00
53_G56_A0.8511.00
70_E73_A0.8471.00
25_A36_A0.8461.00
121_M125_T0.8381.00
103_L140_A0.8341.00
12_V21_A0.8321.00
19_V23_E0.8321.00
42_L93_R0.8271.00
9_L114_V0.8241.00
67_F70_E0.8201.00
103_L136_V0.8191.00
118_R133_A0.8141.00
22_A26_V0.8141.00
11_P117_P0.8091.00
73_A76_P0.8021.00
70_E74_L0.7911.00
63_G66_T0.7801.00
69_N91_T0.7751.00
124_E127_D0.7741.00
115_V145_L0.7701.00
20_T23_E0.7681.00
12_V19_V0.7651.00
123_E127_D0.7551.00
12_V18_S0.7421.00
66_T70_E0.7421.00
10_A36_A0.7391.00
55_V59_D0.7311.00
110_D142_Q0.7251.00
102_I136_V0.7241.00
12_V71_I0.7221.00
101_V105_A0.7201.00
29_A32_Y0.7141.00
97_H100_S0.7121.00
15_T120_G0.7091.00
120_G129_L0.7071.00
6_D112_D0.7071.00
28_V31_R0.7051.00
38_A71_I0.7011.00
26_V30_D0.6981.00
39_L101_V0.6921.00
56_A59_D0.6921.00
22_A71_I0.6911.00
8_V29_A0.6881.00
68_L74_L0.6881.00
51_G55_V0.6861.00
63_G67_F0.6791.00
58_D61_A0.6781.00
7_T34_A0.6761.00
29_A34_A0.6711.00
54_D57_E0.6681.00
61_A64_T0.6611.00
23_E78_G0.6601.00
118_R128_V0.6551.00
6_D34_A0.6541.00
68_L71_I0.6541.00
62_A65_N0.6501.00
8_V115_V0.6491.00
28_V115_V0.6481.00
10_A21_A0.6451.00
26_V75_A0.6421.00
99_G136_V0.6371.00
19_V71_I0.6351.00
54_D58_D0.6321.00
59_D63_G0.6311.00
119_E133_A0.6231.00
129_L133_A0.6221.00
60_V64_T0.6151.00
99_G132_A0.6131.00
76_P91_T0.6071.00
99_G103_L0.6061.00
66_T69_N0.6041.00
26_V79_V0.6011.00
75_A78_G0.6011.00
100_S104_D0.5981.00
27_T30_D0.5891.00
107_A142_Q0.5871.00
30_D79_V0.5851.00
137_L144_V0.5831.00
13_D18_S0.5791.00
95_R101_V0.5781.00
116_I146_S0.5751.00
40_Y67_F0.5691.00
99_G139_Y0.5681.00
17_A20_T0.5621.00
51_G56_A0.5621.00
25_A34_A0.5611.00
45_T48_R0.5551.00
67_F74_L0.5541.00
103_L135_Y0.5531.00
72_A75_A0.5491.00
53_G57_E0.5491.00
136_V144_V0.5411.00
38_A89_F0.5391.00
24_Y147_V0.5351.00
28_V145_L0.5341.00
44_E95_R0.5331.00
38_A75_A0.5251.00
64_T93_R0.5201.00
21_A115_V0.5171.00
55_V58_D0.5131.00
96_Q104_D0.5131.00
16_D19_V0.5121.00
46_V49_A0.5101.00
120_G123_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dumA 2 0.9116 99.9 0.167 Contact Map
1mjhA 2 0.9048 99.9 0.167 Contact Map
5ahwA 4 0.9388 99.9 0.187 Contact Map
3s3tA 4 0.9456 99.9 0.19 Contact Map
3hgmA 2 0.932 99.9 0.196 Contact Map
4wnyA 2 0.8503 99.9 0.202 Contact Map
2gm3A 2 0.8095 99.9 0.202 Contact Map
3tnjA 2 0.8299 99.9 0.204 Contact Map
3fdxA 2 0.8435 99.9 0.205 Contact Map
1tq8A 4 0.8367 99.9 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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