Q9HMI8 - HALSA - GREMLIN Contacts

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Q9HMI8 - Uncharacterized protein

UniProt:	Q9HMI8	Sequences: MPGERVYPEDAAGSFPTPPLRITDSDGREITVDAFTGDADAEIDALVAMYDDFDPEDRAQGVPPVGESRIREWVASLLEQDGFDVVAWHGEEIAGHATLVPDDDATYELAIFVHQTYQGAGIGTELINALLGHAQASGAALVWLSVERWNRPAVALYEKVGFETASAESFEMEMAIRLNDDTG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	183 (143)
Sequences:	6345 (5066)
Seq/√Len:	423.6

ECOLI - MNAT YJGM RIMI PHNO YPEA YEDL YHHY RIML ATDA YIAC YJAB YAFP RIMJ
BACSU - YWNH YTMI YHFO PAIA RIMI YQJY YBFA YYAR YHDJ YSNE YESJ YUAI YDGE YYCN YNAD YOKL YOAA YKKB YJDG YDAF YJCK SPSD
HALSA - Q9HMI8 Q9HMF0 Q9HSL3 Q9HQD2 Q9HRY5 Q9HNJ3 Q9HRY6 Q9HRK6 Q9HMZ2
SULSO - Y209 Q7LXZ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_D	88_W	3.371	1.00
131_L	162_F	3.295	1.00
36_T	41_A	3.005	1.00
124_T	159_K	2.960	1.00
97_A	130_L	2.941	1.00
52_D	114_H	2.805	1.00
131_L	142_V	2.727	1.00
124_T	160_V	2.672	1.00
33_D	42_E	2.512	1.00
94_A	117_Y	2.440	1.00
158_E	164_T	2.395	1.00
164_T	167_A	2.251	1.00
144_L	157_Y	2.178	1.00
133_H	136_A	1.909	1.00
89_H	94_A	1.871	1.00
92_E	116_T	1.866	1.00
129_A	132_G	1.859	1.00
85_V	129_A	1.853	1.00
128_N	160_V	1.847	1.00
133_H	137_S	1.775	1.00
153_A	157_Y	1.737	1.00
86_V	93_I	1.713	1.00
127_I	160_V	1.706	1.00
74_V	77_L	1.631	1.00
45_A	48_A	1.623	1.00
87_A	122_I	1.591	1.00
35_F	46_L	1.554	1.00
154_V	158_E	1.548	1.00
89_H	117_Y	1.526	1.00
95_G	113_V	1.522	1.00
70_I	73_W	1.448	1.00
88_W	91_E	1.429	1.00
45_A	93_I	1.427	1.00
49_M	93_I	1.414	1.00
92_E	114_H	1.410	1.00
84_D	98_T	1.398	1.00
99_L	134_A	1.371	1.00
155_A	158_E	1.362	1.00
129_A	133_H	1.342	1.00
146_V	150_N	1.338	1.00
35_F	86_V	1.325	1.00
99_L	130_L	1.323	1.00
118_Q	152_P	1.319	1.00
113_V	122_I	1.296	1.00
83_F	133_H	1.268	1.00
89_H	120_A	1.268	1.00
144_L	153_A	1.255	1.00
124_T	128_N	1.255	1.00
134_A	142_V	1.220	1.00
85_V	133_H	1.217	1.00
31_T	88_W	1.181	1.00
47_V	51_D	1.179	1.00
154_V	164_T	1.179	1.00
45_A	92_E	1.175	1.00
132_G	136_A	1.169	1.00
101_P	139_A	1.166	1.00
140_A	170_F	1.163	1.00
95_G	126_L	1.158	1.00
40_D	43_I	1.149	1.00
87_A	126_L	1.139	1.00
66_G	69_R	1.119	1.00
74_V	78_L	1.118	1.00
49_M	114_H	1.098	1.00
88_W	93_I	1.095	1.00
71_R	75_A	1.085	1.00
156_L	160_V	1.081	1.00
151_R	155_A	1.081	1.00
97_A	111_I	1.070	1.00
36_T	40_D	1.067	1.00
141_L	165_A	1.064	1.00
107_Y	139_A	1.043	1.00
131_L	135_Q	1.040	1.00
48_A	114_H	1.029	1.00
114_H	117_Y	1.022	1.00
49_M	53_F	0.995	1.00
44_D	48_A	0.994	1.00
150_N	153_A	0.986	1.00
52_D	115_Q	0.982	1.00
48_A	52_D	0.977	1.00
105_A	143_W	0.973	1.00
146_V	157_Y	0.970	1.00
73_W	77_L	0.967	1.00
117_Y	120_A	0.955	1.00
32_V	129_A	0.948	1.00
67_E	71_R	0.942	1.00
32_V	85_V	0.939	1.00
127_I	156_L	0.937	1.00
148_R	167_A	0.930	1.00
30_I	122_I	0.917	1.00
111_I	157_Y	0.916	1.00
35_F	84_D	0.907	1.00
29_E	125_E	0.904	1.00
53_F	112_F	0.885	1.00
30_I	87_A	0.870	1.00
61_G	65_V	0.867	1.00
128_N	132_G	0.864	1.00
56_E	115_Q	0.864	1.00
146_V	153_A	0.851	1.00
30_I	89_H	0.843	1.00
34_A	133_H	0.838	1.00
30_I	117_Y	0.829	1.00
52_D	56_E	0.815	1.00
52_D	116_T	0.813	1.00
50_Y	54_D	0.804	1.00
68_S	72_E	0.803	1.00
62_V	65_V	0.801	1.00
98_T	110_A	0.786	1.00
125_E	129_A	0.782	1.00
96_H	112_F	0.769	1.00
32_V	125_E	0.755	1.00
127_I	157_Y	0.747	1.00
61_G	64_P	0.740	1.00
115_Q	118_Q	0.738	1.00
94_A	116_T	0.736	1.00
48_A	92_E	0.734	1.00
67_E	70_I	0.731	1.00
97_A	126_L	0.730	1.00
51_D	55_P	0.724	1.00
48_A	51_D	0.722	1.00
96_H	110_A	0.718	1.00
92_E	117_Y	0.715	1.00
105_A	108_E	0.715	1.00
107_Y	110_A	0.713	1.00
40_D	71_R	0.707	1.00
66_G	70_I	0.707	1.00
113_V	117_Y	0.706	1.00
106_T	134_A	0.696	1.00
111_I	153_A	0.685	1.00
42_E	88_W	0.684	1.00
46_L	93_I	0.682	1.00
131_L	156_L	0.682	1.00
123_G	126_L	0.681	1.00
94_A	122_I	0.680	1.00
145_S	168_E	0.677	1.00
70_I	74_V	0.677	1.00
69_R	73_W	0.673	1.00
142_V	162_F	0.667	1.00
122_I	125_E	0.665	1.00
123_G	156_L	0.665	1.00
125_E	128_N	0.661	0.99
50_Y	96_H	0.655	0.99
68_S	76_S	0.653	0.99
151_R	154_V	0.651	0.99
101_P	137_S	0.649	0.99
29_E	89_H	0.649	0.99
119_G	155_A	0.647	0.99
35_F	42_E	0.647	0.99
131_L	160_V	0.646	0.99
30_I	125_E	0.646	0.99
119_G	152_P	0.644	0.99
56_E	59_A	0.641	0.99
40_D	75_A	0.636	0.99
109_L	127_I	0.631	0.99
35_F	43_I	0.631	0.99
33_D	36_T	0.628	0.99
121_G	124_T	0.628	0.99
105_A	140_A	0.626	0.99
111_I	127_I	0.625	0.99
151_R	158_E	0.624	0.99
89_H	92_E	0.621	0.99
106_T	141_L	0.619	0.99
72_E	76_S	0.619	0.99
50_Y	112_F	0.618	0.99
158_E	163_E	0.618	0.99
105_A	165_A	0.617	0.99
54_D	112_F	0.615	0.99
66_G	74_V	0.614	0.99
69_R	72_E	0.612	0.99
107_Y	142_V	0.611	0.99
113_V	123_G	0.598	0.99
134_A	139_A	0.596	0.99
146_V	154_V	0.588	0.99
152_P	155_A	0.587	0.99
153_A	156_L	0.587	0.99
49_M	112_F	0.586	0.99
55_P	59_A	0.585	0.99
111_I	130_L	0.585	0.99
117_Y	122_I	0.580	0.99
99_L	133_H	0.578	0.99
141_L	171_E	0.575	0.99
143_W	165_A	0.572	0.99
60_Q	65_V	0.569	0.98
36_T	42_E	0.566	0.98
132_G	135_Q	0.565	0.98
165_A	169_S	0.565	0.98
74_V	79_E	0.563	0.98
47_V	70_I	0.557	0.98
32_V	126_L	0.554	0.98
43_I	47_V	0.550	0.98
68_S	74_V	0.548	0.98
124_T	155_A	0.548	0.98
111_I	123_G	0.546	0.98
105_A	110_A	0.542	0.98
149_W	154_V	0.541	0.98
165_A	168_E	0.534	0.98
148_R	164_T	0.533	0.98
119_G	124_T	0.532	0.98
54_D	118_Q	0.530	0.98
44_D	67_E	0.530	0.98
104_D	165_A	0.528	0.97
108_E	127_I	0.527	0.97
152_P	156_L	0.524	0.97
45_A	88_W	0.523	0.97
83_F	137_S	0.523	0.97
87_A	95_G	0.523	0.97
85_V	97_A	0.516	0.97
75_A	79_E	0.515	0.97
28_R	31_T	0.511	0.97
50_Y	57_D	0.509	0.97
88_W	94_A	0.505	0.97
150_N	154_V	0.503	0.97
122_I	126_L	0.503	0.97
113_V	126_L	0.503	0.97
107_Y	134_A	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dr6A	2	0.8306	99.9	0.397	Contact Map
2j8mA	2	0.8306	99.9	0.403	Contact Map
3zj0A	1	0.8142	99.8	0.409	Contact Map
2q7bA	2	0.8142	99.8	0.409	Contact Map
4j3gA	2	0.8361	99.8	0.416	Contact Map
4bmhA	1	0.8197	99.8	0.422	Contact Map
3fynA	2	0.7814	99.8	0.423	Contact Map
1s3zA	2	0.7596	99.8	0.425	Contact Map
3r9fA	1	0.9016	99.8	0.428	Contact Map
3tcvA	2	0.9344	99.8	0.431	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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