GREMLIN Database
Q9HMI8 - Uncharacterized protein
UniProt: Q9HMI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (143)
Sequences: 6345 (5066)
Seq/√Len: 423.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_D88_W3.3711.00
131_L162_F3.2951.00
36_T41_A3.0051.00
124_T159_K2.9601.00
97_A130_L2.9411.00
52_D114_H2.8051.00
131_L142_V2.7271.00
124_T160_V2.6721.00
33_D42_E2.5121.00
94_A117_Y2.4401.00
158_E164_T2.3951.00
164_T167_A2.2511.00
144_L157_Y2.1781.00
133_H136_A1.9091.00
89_H94_A1.8711.00
92_E116_T1.8661.00
129_A132_G1.8591.00
85_V129_A1.8531.00
128_N160_V1.8471.00
133_H137_S1.7751.00
153_A157_Y1.7371.00
86_V93_I1.7131.00
127_I160_V1.7061.00
74_V77_L1.6311.00
45_A48_A1.6231.00
87_A122_I1.5911.00
35_F46_L1.5541.00
154_V158_E1.5481.00
89_H117_Y1.5261.00
95_G113_V1.5221.00
70_I73_W1.4481.00
88_W91_E1.4291.00
45_A93_I1.4271.00
49_M93_I1.4141.00
92_E114_H1.4101.00
84_D98_T1.3981.00
99_L134_A1.3711.00
155_A158_E1.3621.00
129_A133_H1.3421.00
146_V150_N1.3381.00
35_F86_V1.3251.00
99_L130_L1.3231.00
118_Q152_P1.3191.00
113_V122_I1.2961.00
83_F133_H1.2681.00
89_H120_A1.2681.00
144_L153_A1.2551.00
124_T128_N1.2551.00
134_A142_V1.2201.00
85_V133_H1.2171.00
31_T88_W1.1811.00
47_V51_D1.1791.00
154_V164_T1.1791.00
45_A92_E1.1751.00
132_G136_A1.1691.00
101_P139_A1.1661.00
140_A170_F1.1631.00
95_G126_L1.1581.00
40_D43_I1.1491.00
87_A126_L1.1391.00
66_G69_R1.1191.00
74_V78_L1.1181.00
49_M114_H1.0981.00
88_W93_I1.0951.00
71_R75_A1.0851.00
156_L160_V1.0811.00
151_R155_A1.0811.00
97_A111_I1.0701.00
36_T40_D1.0671.00
141_L165_A1.0641.00
107_Y139_A1.0431.00
131_L135_Q1.0401.00
48_A114_H1.0291.00
114_H117_Y1.0221.00
49_M53_F0.9951.00
44_D48_A0.9941.00
150_N153_A0.9861.00
52_D115_Q0.9821.00
48_A52_D0.9771.00
105_A143_W0.9731.00
146_V157_Y0.9701.00
73_W77_L0.9671.00
117_Y120_A0.9551.00
32_V129_A0.9481.00
67_E71_R0.9421.00
32_V85_V0.9391.00
127_I156_L0.9371.00
148_R167_A0.9301.00
30_I122_I0.9171.00
111_I157_Y0.9161.00
35_F84_D0.9071.00
29_E125_E0.9041.00
53_F112_F0.8851.00
30_I87_A0.8701.00
61_G65_V0.8671.00
128_N132_G0.8641.00
56_E115_Q0.8641.00
146_V153_A0.8511.00
30_I89_H0.8431.00
34_A133_H0.8381.00
30_I117_Y0.8291.00
52_D56_E0.8151.00
52_D116_T0.8131.00
50_Y54_D0.8041.00
68_S72_E0.8031.00
62_V65_V0.8011.00
98_T110_A0.7861.00
125_E129_A0.7821.00
96_H112_F0.7691.00
32_V125_E0.7551.00
127_I157_Y0.7471.00
61_G64_P0.7401.00
115_Q118_Q0.7381.00
94_A116_T0.7361.00
48_A92_E0.7341.00
67_E70_I0.7311.00
97_A126_L0.7301.00
51_D55_P0.7241.00
48_A51_D0.7221.00
96_H110_A0.7181.00
92_E117_Y0.7151.00
105_A108_E0.7151.00
107_Y110_A0.7131.00
40_D71_R0.7071.00
66_G70_I0.7071.00
113_V117_Y0.7061.00
106_T134_A0.6961.00
111_I153_A0.6851.00
42_E88_W0.6841.00
46_L93_I0.6821.00
131_L156_L0.6821.00
123_G126_L0.6811.00
94_A122_I0.6801.00
145_S168_E0.6771.00
70_I74_V0.6771.00
69_R73_W0.6731.00
142_V162_F0.6671.00
122_I125_E0.6651.00
123_G156_L0.6651.00
125_E128_N0.6610.99
50_Y96_H0.6550.99
68_S76_S0.6530.99
151_R154_V0.6510.99
101_P137_S0.6490.99
29_E89_H0.6490.99
119_G155_A0.6470.99
35_F42_E0.6470.99
131_L160_V0.6460.99
30_I125_E0.6460.99
119_G152_P0.6440.99
56_E59_A0.6410.99
40_D75_A0.6360.99
109_L127_I0.6310.99
35_F43_I0.6310.99
33_D36_T0.6280.99
121_G124_T0.6280.99
105_A140_A0.6260.99
111_I127_I0.6250.99
151_R158_E0.6240.99
89_H92_E0.6210.99
106_T141_L0.6190.99
72_E76_S0.6190.99
50_Y112_F0.6180.99
158_E163_E0.6180.99
105_A165_A0.6170.99
54_D112_F0.6150.99
66_G74_V0.6140.99
69_R72_E0.6120.99
107_Y142_V0.6110.99
113_V123_G0.5980.99
134_A139_A0.5960.99
146_V154_V0.5880.99
152_P155_A0.5870.99
153_A156_L0.5870.99
49_M112_F0.5860.99
55_P59_A0.5850.99
111_I130_L0.5850.99
117_Y122_I0.5800.99
99_L133_H0.5780.99
141_L171_E0.5750.99
143_W165_A0.5720.99
60_Q65_V0.5690.98
36_T42_E0.5660.98
132_G135_Q0.5650.98
165_A169_S0.5650.98
74_V79_E0.5630.98
47_V70_I0.5570.98
32_V126_L0.5540.98
43_I47_V0.5500.98
68_S74_V0.5480.98
124_T155_A0.5480.98
111_I123_G0.5460.98
105_A110_A0.5420.98
149_W154_V0.5410.98
165_A168_E0.5340.98
148_R164_T0.5330.98
119_G124_T0.5320.98
54_D118_Q0.5300.98
44_D67_E0.5300.98
104_D165_A0.5280.97
108_E127_I0.5270.97
152_P156_L0.5240.97
45_A88_W0.5230.97
83_F137_S0.5230.97
87_A95_G0.5230.97
85_V97_A0.5160.97
75_A79_E0.5150.97
28_R31_T0.5110.97
50_Y57_D0.5090.97
88_W94_A0.5050.97
150_N154_V0.5030.97
122_I126_L0.5030.97
113_V126_L0.5030.97
107_Y134_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dr6A 2 0.8306 99.9 0.397 Contact Map
2j8mA 2 0.8306 99.9 0.403 Contact Map
3zj0A 1 0.8142 99.8 0.409 Contact Map
2q7bA 2 0.8142 99.8 0.409 Contact Map
4j3gA 2 0.8361 99.8 0.416 Contact Map
4bmhA 1 0.8197 99.8 0.422 Contact Map
3fynA 2 0.7814 99.8 0.423 Contact Map
1s3zA 2 0.7596 99.8 0.425 Contact Map
3r9fA 1 0.9016 99.8 0.428 Contact Map
3tcvA 2 0.9344 99.8 0.431 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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