GREMLIN Database
Q9HMI5 - Uncharacterized protein
UniProt: Q9HMI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (151)
Sequences: 125 (99)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_V166_L5.1231.00
38_R44_A4.5230.99
37_Y108_A3.0480.89
95_F108_A3.0410.88
132_F166_L2.6490.80
49_P122_A2.5640.78
146_H157_T2.3390.71
49_P121_P2.2560.68
132_F167_L2.1220.63
51_D97_A2.1100.62
93_R110_E2.0930.62
30_M95_F2.0870.61
40_R107_A2.0870.61
91_T110_E2.0740.61
63_G79_V1.9480.56
101_G132_F1.9320.55
76_F121_P1.8580.52
62_A161_D1.7990.50
30_M46_E1.7770.49
160_H166_L1.7730.49
48_H75_E1.7610.48
108_A117_A1.7570.48
26_L33_I1.7410.47
73_D149_P1.7180.46
50_G72_P1.6270.43
52_V149_P1.6130.42
45_H79_V1.5730.41
134_T142_S1.5530.40
95_F168_P1.5450.39
29_D32_A1.5400.39
96_R150_L1.5370.39
32_A97_A1.5150.38
14_S166_L1.4920.37
69_L107_A1.4810.37
34_A44_A1.4340.35
74_N105_F1.4180.35
91_T129_H1.4110.34
122_A153_R1.4030.34
67_I82_A1.4020.34
84_D118_V1.3960.34
89_F118_V1.3860.33
22_S119_L1.3860.33
36_D42_W1.3830.33
162_A166_L1.3800.33
63_G151_D1.3690.33
121_P153_R1.3380.32
49_P153_R1.2950.30
68_E121_P1.2830.30
142_S147_V1.2780.30
15_A44_A1.2710.29
49_P69_L1.2640.29
49_P76_F1.2640.29
73_D147_V1.2460.28
95_F103_V1.2340.28
161_D166_L1.2280.28
121_P156_L1.2180.28
76_F156_L1.1780.26
135_H166_L1.1710.26
118_V140_A1.1510.25
38_R55_S1.1380.25
104_F165_L1.1380.25
85_A120_V1.1180.24
49_P156_L1.1140.24
27_M135_H1.1140.24
150_L168_P1.1110.24
77_E162_A1.0820.23
93_R131_S1.0680.23
52_V90_D1.0630.23
85_A111_A1.0560.23
145_L160_H1.0320.22
104_F124_Y1.0290.22
72_P120_V1.0130.21
27_M157_T1.0020.21
81_A114_T0.9940.21
37_Y117_A0.9880.21
15_A161_D0.9840.21
53_N104_F0.9510.20
43_S111_A0.9470.20
65_G122_A0.9420.19
49_P75_E0.9390.19
38_R158_F0.9380.19
63_G100_S0.9380.19
134_T169_D0.9350.19
93_R129_H0.9330.19
28_D84_D0.9330.19
38_R161_D0.9230.19
37_Y95_F0.9180.19
69_L121_P0.9170.19
36_D164_E0.9120.19
106_V166_L0.9090.19
64_R167_L0.9050.18
118_V156_L0.9020.18
55_S104_F0.8910.18
74_N98_D0.8900.18
107_A146_H0.8780.18
38_R167_L0.8690.18
21_S92_T0.8660.18
105_F168_P0.8640.17
39_D51_D0.8590.17
48_H121_P0.8550.17
47_L147_V0.8520.17
95_F111_A0.8470.17
45_H51_D0.8370.17
52_V121_P0.8290.17
95_F146_H0.8280.17
69_L120_V0.8190.16
142_S167_L0.8150.16
139_A142_S0.8130.16
100_S118_V0.8080.16
72_P141_G0.8050.16
50_G150_L0.8040.16
52_V112_A0.8030.16
49_P52_V0.8000.16
54_V164_E0.7990.16
81_A137_R0.7960.16
51_D141_G0.7940.16
43_S104_F0.7930.16
21_S147_V0.7770.16
44_A161_D0.7750.15
140_A143_V0.7740.15
45_H141_G0.7670.15
83_F156_L0.7660.15
70_L73_D0.7620.15
140_A145_L0.7470.15
18_N100_S0.7370.15
127_P136_L0.7350.15
79_V156_L0.7340.15
90_D112_A0.7290.15
39_D114_T0.7230.14
50_G75_E0.7210.14
62_A158_F0.7190.14
159_A165_L0.7190.14
147_V169_D0.7180.14
84_D139_A0.7140.14
76_F153_R0.7090.14
63_G114_T0.7060.14
68_E76_F0.7010.14
94_V167_L0.7000.14
101_G127_P0.6990.14
103_V137_R0.6960.14
29_D166_L0.6960.14
73_D152_E0.6960.14
33_I123_Y0.6930.14
66_G124_Y0.6930.14
63_G77_E0.6900.14
105_F126_P0.6880.14
69_L156_L0.6820.14
71_V169_D0.6780.13
61_A74_N0.6780.13
25_A83_F0.6770.13
33_I48_H0.6760.13
33_I76_F0.6750.13
45_H99_T0.6700.13
101_G146_H0.6690.13
109_V144_R0.6620.13
46_E144_R0.6590.13
122_A156_L0.6520.13
119_L140_A0.6490.13
41_G98_D0.6480.13
85_A131_S0.6460.13
110_E126_P0.6460.13
111_A158_F0.6390.13
62_A125_S0.6380.13
79_V118_V0.6350.13
118_V149_P0.6310.13
37_Y69_L0.6290.13
15_A38_R0.6250.13
136_L147_V0.6230.12
77_E94_V0.6210.12
16_A166_L0.6200.12
52_V122_A0.6200.12
62_A93_R0.6190.12
47_L145_L0.6180.12
13_P16_A0.6150.12
45_H82_A0.6080.12
96_R168_P0.6070.12
117_A163_P0.6070.12
62_A140_A0.6060.12
107_A148_R0.6050.12
37_Y154_R0.5990.12
72_P150_L0.5930.12
103_V168_P0.5870.12
30_M156_L0.5840.12
41_G135_H0.5820.12
28_D157_T0.5800.12
77_E84_D0.5780.12
93_R154_R0.5770.12
31_A65_G0.5760.12
28_D83_F0.5760.12
30_M136_L0.5730.12
153_R156_L0.5710.12
15_A94_V0.5640.11
29_D161_D0.5620.11
88_G137_R0.5620.11
26_L78_P0.5600.11
54_V132_F0.5590.11
18_N22_S0.5580.11
49_P68_E0.5560.11
131_S139_A0.5550.11
86_A90_D0.5550.11
15_A60_D0.5550.11
39_D134_T0.5530.11
68_E148_R0.5500.11
82_A113_A0.5500.11
29_D105_F0.5460.11
39_D43_S0.5460.11
133_T164_E0.5410.11
115_E130_E0.5370.11
13_P77_E0.5350.11
150_L164_E0.5340.11
66_G146_H0.5340.11
74_N149_P0.5310.11
43_S73_D0.5290.11
66_G160_H0.5270.11
95_F105_F0.5260.11
104_F148_R0.5240.11
143_V167_L0.5220.11
107_A151_D0.5180.11
40_R157_T0.5150.11
71_V80_A0.5130.11
23_W27_M0.5120.11
28_D127_P0.5090.11
45_H89_F0.5090.11
45_H161_D0.5040.10
102_T152_E0.5040.10
76_F155_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lmcA 1 0.2456 33.3 0.942 Contact Map
1ps9A 1 0.8947 30.3 0.944 Contact Map
3hgjA 2 0.8947 24.1 0.946 Contact Map
3gr7A 3 0.883 15.4 0.951 Contact Map
1z41A 3 0.883 13.7 0.952 Contact Map
1b25A 3 0.3918 11.9 0.953 Contact Map
3l5lA 2 0.8947 10.2 0.954 Contact Map
4l4wA 1 0.7485 8.1 0.956 Contact Map
3kruA 3 0.8889 6.9 0.958 Contact Map
3gkaA 1 0.9064 5.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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