GREMLIN Database
Q9HMI2 - Dipeptide ABC transporter permease
UniProt: Q9HMI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (303)
Sequences: 19713 (12561)
Seq/√Len: 721.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_D65_V3.3821.00
61_D69_R3.2981.00
30_H66_Q3.1851.00
68_A72_V2.8261.00
72_V76_Q2.7491.00
22_A67_Y2.7241.00
55_Q60_N2.6701.00
238_M265_G2.6281.00
47_Q51_I2.6071.00
302_T306_S2.4061.00
108_Y219_A2.4051.00
251_R257_S2.3711.00
101_V297_I2.3531.00
259_I263_K2.3501.00
35_D54_R2.3201.00
247_M265_G2.2411.00
23_T67_Y2.2091.00
241_V246_Y2.1561.00
64_Y68_A2.1511.00
120_L136_G2.0791.00
94_V303_I2.0651.00
241_V244_Q2.0571.00
90_A93_S2.0351.00
278_G334_V2.0251.00
50_V54_R1.9801.00
256_G259_I1.9721.00
21_V324_A1.9451.00
49_Q52_Q1.9431.00
5_R9_K1.9361.00
242_V265_G1.9201.00
258_K262_M1.9141.00
112_I223_G1.8721.00
115_L119_P1.8501.00
166_F213_M1.8371.00
166_F216_I1.8321.00
87_Q94_V1.8311.00
65_V69_R1.7771.00
46_P49_Q1.7771.00
51_I55_Q1.7701.00
274_I341_L1.7691.00
69_R72_V1.7581.00
255_Q259_I1.7521.00
89_T93_S1.7481.00
52_Q56_E1.7441.00
127_E130_T1.7421.00
133_D235_R1.7261.00
131_L135_F1.7101.00
247_M260_T1.7001.00
51_I54_R1.6831.00
160_S168_A1.6411.00
123_I127_E1.6311.00
73_D78_D1.6231.00
91_V318_G1.6201.00
18_L325_L1.6171.00
92_R96_A1.5811.00
123_I132_T1.5801.00
127_E132_T1.5771.00
337_T340_Y1.5761.00
126_V261_I1.5691.00
249_T253_K1.5661.00
125_A238_M1.5601.00
132_T136_G1.5581.00
116_L119_P1.5091.00
304_L319_T1.5011.00
122_V238_M1.4911.00
275_T338_Y1.4881.00
171_R297_I1.4811.00
245_D248_R1.4761.00
157_L162_F1.4491.00
89_T97_D1.4481.00
150_W154_L1.4441.00
241_V269_A1.4361.00
246_Y268_N1.4311.00
19_F67_Y1.4261.00
14_L328_T1.4251.00
241_V247_M1.4211.00
113_G226_S1.4191.00
116_L227_M1.4071.00
12_L16_P1.4071.00
74_A79_F1.3951.00
101_V171_R1.3911.00
69_R73_D1.3821.00
19_F23_T1.3751.00
104_E171_R1.3711.00
219_A223_G1.3691.00
53_L56_E1.3681.00
79_F318_G1.3441.00
35_D38_R1.3291.00
155_L221_T1.3241.00
241_V265_G1.3231.00
62_P65_V1.3161.00
307_A315_L1.2941.00
65_V68_A1.2931.00
158_A162_F1.2781.00
37_A50_V1.2781.00
253_K264_H1.2771.00
79_F92_R1.2721.00
303_I315_L1.2711.00
117_G234_M1.2691.00
53_L57_L1.2661.00
8_L12_L1.2621.00
223_G227_M1.2521.00
94_V315_L1.2511.00
129_D133_D1.2491.00
114_I277_I1.2471.00
22_A70_F1.2391.00
97_D100_P1.2341.00
81_Q90_A1.2331.00
235_R239_L1.2311.00
104_E108_Y1.2241.00
121_G125_A1.2211.00
117_G230_I1.2191.00
89_T94_V1.2051.00
110_Q277_I1.1981.00
234_M273_V1.1961.00
58_G61_D1.1941.00
126_V257_S1.1941.00
125_A242_V1.1851.00
143_G228_A1.1851.00
121_G234_M1.1821.00
233_M276_V1.1821.00
23_T27_V1.1721.00
101_V104_E1.1651.00
271_V338_Y1.1611.00
61_D64_Y1.1601.00
4_K7_I1.1501.00
146_V151_S1.1451.00
136_G231_S1.1441.00
14_L332_L1.1391.00
319_T323_F1.1281.00
124_S136_G1.1261.00
58_G69_R1.1161.00
38_R50_V1.1151.00
27_V30_H1.1111.00
230_I280_Q1.1081.00
140_A231_S1.1021.00
75_A78_D1.0971.00
158_A163_L1.0931.00
125_A239_L1.0751.00
221_T225_Y1.0681.00
104_E215_L1.0631.00
336_V340_Y1.0631.00
120_L231_S1.0611.00
93_S97_D1.0561.00
94_V97_D1.0561.00
7_I336_V1.0511.00
330_V334_V1.0441.00
52_Q55_Q1.0401.00
19_F71_L1.0381.00
212_V216_I1.0351.00
282_G327_F1.0321.00
131_L134_H1.0301.00
127_E257_S1.0221.00
148_I291_T1.0211.00
96_A100_P1.0201.00
20_G24_F1.0141.00
154_L158_A1.0111.00
250_A260_T1.0091.00
4_K8_L0.9941.00
257_S260_T0.9931.00
155_L217_L0.9901.00
152_G221_T0.9891.00
306_S310_A0.9871.00
82_S312_D0.9871.00
173_E214_H0.9861.00
18_L328_T0.9841.00
122_V261_I0.9811.00
166_F217_L0.9781.00
216_I220_A0.9771.00
172_I214_H0.9751.00
305_V309_N0.9671.00
303_I307_A0.9651.00
23_T63_V0.9631.00
48_Q52_Q0.9621.00
30_H63_V0.9621.00
55_Q61_D0.9571.00
109_G223_G0.9541.00
27_V63_V0.9521.00
93_S96_A0.9491.00
6_F339_S0.9471.00
234_M238_M0.9471.00
128_Q243_R0.9451.00
251_R260_T0.9451.00
333_L337_T0.9421.00
22_A321_L0.9371.00
81_Q88_G0.9351.00
41_L53_L0.9351.00
112_I219_A0.9351.00
73_D76_Q0.9301.00
238_M269_A0.9261.00
106_A284_L0.9251.00
133_D239_L0.9241.00
82_S89_T0.9211.00
67_Y71_L0.9201.00
16_P19_F0.9191.00
215_L219_A0.9141.00
220_A223_G0.9141.00
167_P170_G0.9131.00
34_G311_N0.9121.00
281_F330_V0.9111.00
255_Q260_T0.9111.00
139_G143_G0.9101.00
11_L332_L0.9061.00
159_F166_F0.8971.00
119_P122_V0.8961.00
72_V75_A0.8921.00
98_K303_I0.8891.00
107_L111_A0.8881.00
159_F163_L0.8861.00
269_A272_P0.8801.00
259_I262_M0.8761.00
129_D134_H0.8751.00
68_A71_L0.8711.00
250_A255_Q0.8711.00
250_A264_H0.8681.00
109_G222_I0.8671.00
282_G330_V0.8581.00
30_H313_Y0.8571.00
104_E107_L0.8561.00
37_A41_L0.8551.00
304_L307_A0.8531.00
137_R231_S0.8521.00
262_M265_G0.8511.00
74_A321_L0.8511.00
274_I334_V0.8511.00
126_V262_M0.8431.00
135_F139_G0.8431.00
48_Q51_I0.8421.00
288_A291_T0.8401.00
293_T302_T0.8391.00
134_H137_R0.8381.00
151_S224_I0.8381.00
119_P123_I0.8351.00
260_T265_G0.8341.00
227_M231_S0.8321.00
118_I234_M0.8301.00
117_G121_G0.8301.00
237_S269_A0.8291.00
110_Q281_F0.8281.00
237_S241_V0.8281.00
41_L45_A0.8221.00
234_M237_S0.8211.00
325_L329_L0.8181.00
329_L333_L0.8181.00
339_S345_I0.8171.00
95_L318_G0.8141.00
159_F165_V0.8121.00
47_Q50_V0.8121.00
114_I119_P0.8111.00
121_G238_M0.8111.00
338_Y345_I0.8051.00
37_A54_R0.8031.00
109_G113_G0.8021.00
240_E244_Q0.8011.00
37_A53_L0.8011.00
152_G294_V0.7971.00
102_T106_A0.7951.00
120_L227_M0.7941.00
83_Y314_P0.7941.00
107_L281_F0.7931.00
23_T64_Y0.7921.00
128_Q239_L0.7881.00
313_Y317_Q0.7851.00
118_I273_V0.7841.00
117_G231_S0.7811.00
122_V266_F0.7801.00
70_F74_A0.7781.00
174_S213_M0.7771.00
116_L120_L0.7721.00
108_Y297_I0.7721.00
338_Y342_D0.7671.00
103_L107_L0.7661.00
95_L319_T0.7631.00
25_V320_V0.7501.00
100_P103_L0.7501.00
171_R215_L0.7461.00
10_R13_L0.7441.00
336_V339_S0.7441.00
16_P20_G0.7401.00
45_A50_V0.7381.00
317_Q320_V0.7351.00
113_G223_G0.7351.00
72_V77_F0.7311.00
132_T135_F0.7301.00
318_G322_T0.7281.00
15_V19_F0.7261.00
105_L219_A0.7251.00
148_I224_I0.7181.00
71_L75_A0.7171.00
216_I219_A0.7171.00
71_L74_A0.7151.00
234_M269_A0.7151.00
303_I319_T0.7131.00
226_S229_L0.7131.00
307_A316_V0.7121.00
12_L336_V0.7091.00
274_I337_T0.7041.00
257_S261_I0.7011.00
100_P104_E0.7001.00
49_Q53_L0.6971.00
298_E302_T0.6961.00
108_Y112_I0.6961.00
144_I228_A0.6931.00
162_F165_V0.6831.00
116_L223_G0.6811.00
143_G224_I0.6791.00
304_L308_I0.6791.00
140_A228_A0.6791.00
221_T291_T0.6761.00
108_Y216_I0.6761.00
159_F217_L0.6741.00
293_T306_S0.6721.00
99_I103_L0.6721.00
306_S309_N0.6681.00
45_A49_Q0.6671.00
213_M216_I0.6651.00
237_S240_E0.6651.00
136_G140_A0.6641.00
171_R174_S0.6611.00
293_T305_V0.6611.00
96_A99_I0.6591.00
37_A57_L0.6571.00
148_I151_S0.6571.00
77_F81_Q0.6551.00
27_V31_L0.6551.00
304_L323_F0.6541.00
40_I53_L0.6531.00
25_V99_I0.6511.00
91_V303_I0.6501.00
94_V98_K0.6491.00
135_F138_I0.6461.00
133_D137_R0.6461.00
124_S133_D0.6441.00
111_A115_L0.6431.00
17_V328_T0.6431.00
148_I152_G0.6401.00
250_A253_K0.6391.00
234_M266_F0.6371.00
323_F327_F0.6371.00
230_I276_V0.6361.00
98_K302_T0.6321.00
170_G214_H0.6301.00
51_I60_N0.6281.00
156_I168_A0.6271.00
65_V72_V0.6261.00
246_Y250_A0.6251.00
29_L316_V0.6231.00
261_I265_G0.6221.00
169_S296_G0.6201.00
102_T288_A0.6191.00
138_I142_S0.6161.00
115_L118_I0.6131.00
157_L161_T0.6121.00
174_S212_V0.6101.00
91_V315_L0.6071.00
87_Q315_L0.6071.00
316_V320_V0.6041.00
6_F332_L0.6021.00
289_V305_V0.6011.00
106_A288_A0.6001.00
155_L220_A0.5951.00
230_I234_M0.5901.00
229_L276_V0.5891.00
305_V308_I0.5891.00
22_A71_L0.5871.00
248_R251_R0.5871.00
326_L330_V0.5861.00
160_S164_G0.5861.00
289_V293_T0.5861.00
223_G226_S0.5851.00
280_Q283_S0.5851.00
82_S87_Q0.5841.00
278_G330_V0.5831.00
315_L319_T0.5831.00
112_I220_A0.5831.00
255_Q264_H0.5821.00
327_F331_N0.5821.00
247_M251_R0.5791.00
334_V338_Y0.5781.00
11_L15_V0.5781.00
30_H317_Q0.5771.00
217_L221_T0.5761.00
262_M267_R0.5761.00
146_V150_W0.5731.00
228_A231_S0.5721.00
270_L273_V0.5721.00
13_L16_P0.5701.00
114_I230_I0.5701.00
167_P214_H0.5691.00
127_E133_D0.5691.00
150_W153_P0.5681.00
324_A328_T0.5671.00
159_F162_F0.5671.00
134_H138_I0.5651.00
125_A133_D0.5641.00
122_V262_M0.5631.00
56_E88_G0.5621.00
148_I225_Y0.5621.00
271_V345_I0.5611.00
255_Q258_K0.5601.00
54_R60_N0.5601.00
110_Q114_I0.5591.00
10_R335_D0.5591.00
26_F30_H0.5581.00
276_V280_Q0.5571.00
229_L233_M0.5561.00
258_K261_I0.5511.00
230_I273_V0.5511.00
130_T133_D0.5501.00
245_D249_T0.5501.00
220_A224_I0.5431.00
63_V66_Q0.5421.00
9_K12_L0.5421.00
106_A110_Q0.5411.00
332_L336_V0.5381.00
238_M242_V0.5361.00
256_G260_T0.5361.00
6_F10_R0.5351.00
104_E297_I0.5351.00
130_T134_H0.5321.00
233_M237_S0.5301.00
126_V242_V0.5301.00
102_T292_E0.5281.00
226_S280_Q0.5281.00
108_Y215_L0.5271.00
138_I141_L0.5271.00
229_L283_S0.5261.00
229_L280_Q0.5261.00
108_Y111_A0.5251.00
124_S137_R0.5241.00
225_Y228_A0.5241.00
130_T135_F0.5241.00
244_Q248_R0.5221.00
6_F9_K0.5181.00
339_S346_Q0.5181.00
114_I118_I0.5181.00
109_G288_A0.5181.00
95_L300_I0.5171.00
36_P313_Y0.5151.00
54_R59_L0.5141.00
45_A48_Q0.5111.00
282_G286_G0.5111.00
6_F336_V0.5111.00
226_S283_S0.5111.00
150_W294_V0.5081.00
222_I288_A0.5060.99
119_P262_M0.5060.99
308_I316_V0.5050.99
282_G334_V0.5040.99
292_E299_G0.5040.99
25_V30_H0.5020.99
26_F67_Y0.5010.99
274_I338_Y0.5000.99
314_P317_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.6023 99.9 0.687 Contact Map
3rlfF 1 0.7752 99.9 0.702 Contact Map
4tquM 1 0.7839 99.9 0.708 Contact Map
4ymuD 2 0.6052 99.8 0.721 Contact Map
2onkC 2 0.7176 99.8 0.722 Contact Map
3d31C 2 0.7118 99.8 0.723 Contact Map
4tquN 1 0.7406 99.8 0.739 Contact Map
3rlfG 1 0.7896 99.7 0.748 Contact Map
4lz6A 1 0.2824 5.7 0.968 Contact Map
2yevC 1 0.0807 5.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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