GREMLIN Database
Q9HMI1 - Dipeptide ABC transporter permease
UniProt: Q9HMI1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (265)
Sequences: 28831 (18704)
Seq/√Len: 1149.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_A221_V2.8191.00
84_G88_Q2.7531.00
141_D191_R2.6851.00
207_E213_D2.4781.00
197_V202_Y2.4611.00
215_R219_R2.4191.00
211_A215_R2.4111.00
129_L144_I2.4081.00
110_I249_F2.4041.00
117_V175_V2.3271.00
121_A179_T2.3211.00
197_V200_D2.3061.00
212_T215_R2.2601.00
214_A218_A2.2301.00
263_L267_N2.1481.00
201_E204_E2.1191.00
203_I221_V2.0981.00
29_L33_L2.0741.00
203_I216_V2.0671.00
103_R264_M1.9981.00
131_I194_A1.9791.00
67_S70_G1.9601.00
136_Y213_D1.9571.00
132_I136_Y1.9451.00
234_T299_G1.9411.00
136_Y140_T1.8891.00
99_D102_K1.8861.00
124_F128_A1.8651.00
87_T90_L1.8331.00
186_F236_N1.7991.00
94_D98_R1.7921.00
135_Y213_D1.7801.00
52_A108_A1.7771.00
139_L143_V1.7601.00
202_Y224_N1.7601.00
134_A194_A1.7341.00
197_V225_T1.7091.00
40_I44_I1.7021.00
96_A103_R1.6821.00
91_F283_F1.6721.00
101_F105_L1.6721.00
125_L183_T1.6461.00
125_L128_A1.6451.00
198_L221_V1.6411.00
122_S182_Y1.6131.00
85_G90_L1.6061.00
140_T144_I1.6041.00
132_I140_T1.6011.00
113_K117_V1.5931.00
26_S30_S1.5851.00
100_I283_F1.5851.00
66_A70_G1.5781.00
193_A196_K1.5751.00
175_V179_T1.5651.00
135_Y217_L1.5461.00
144_I187_A1.5371.00
89_Q99_D1.5321.00
148_M187_A1.5281.00
106_Y109_W1.5181.00
95_A267_N1.5141.00
123_T233_S1.5071.00
268_G280_M1.5001.00
119_V233_S1.4511.00
126_G186_F1.4411.00
54_I57_V1.4311.00
62_S65_R1.4221.00
205_A209_L1.4171.00
196_K200_D1.4141.00
98_R102_K1.4121.00
265_L284_P1.4041.00
130_G134_A1.3981.00
80_W83_S1.3791.00
146_R149_D1.3661.00
126_G190_V1.3651.00
231_V303_R1.3561.00
158_L162_A1.3411.00
38_A301_G1.3361.00
129_L187_A1.3311.00
110_I113_K1.3291.00
191_R195_L1.3241.00
139_L142_N1.3181.00
130_G190_V1.3121.00
238_G292_V1.3071.00
197_V203_I1.2891.00
35_N293_L1.2881.00
197_V221_V1.2831.00
134_A198_L1.2801.00
172_W176_I1.2801.00
65_R68_N1.2711.00
131_I217_L1.2651.00
133_A144_I1.2591.00
179_T183_T1.2521.00
302_M305_A1.2501.00
91_F101_F1.2481.00
278_W282_L1.2431.00
189_V232_Q1.2421.00
163_L177_A1.2371.00
303_R307_D1.2321.00
86_A91_F1.2311.00
104_T287_F1.2261.00
230_T306_L1.2181.00
85_G88_Q1.2131.00
41_G294_G1.2121.00
42_L289_A1.2001.00
206_T220_H1.1851.00
206_T216_V1.1761.00
98_R103_R1.1621.00
41_G301_G1.1611.00
114_Y244_F1.1591.00
98_R106_Y1.1481.00
206_T211_A1.1461.00
194_A225_T1.1441.00
137_S198_L1.1401.00
50_A54_I1.1391.00
36_R39_I1.1291.00
190_V194_A1.1171.00
42_L46_L1.1141.00
151_L184_P1.1131.00
177_A181_V1.1111.00
142_N146_R1.1001.00
131_I222_F1.0951.00
33_L39_I1.0901.00
147_T151_L1.0861.00
190_V229_V1.0811.00
127_V190_V1.0801.00
55_A106_Y1.0771.00
193_A197_V1.0761.00
215_R218_A1.0711.00
204_E207_E1.0651.00
33_L37_L1.0651.00
209_L220_H1.0511.00
154_F159_L1.0511.00
284_P288_L1.0491.00
170_G173_K1.0421.00
128_A131_I1.0401.00
91_F104_T1.0311.00
183_T187_A1.0281.00
93_T99_D1.0231.00
100_I280_M1.0211.00
118_T179_T1.0191.00
301_G305_A1.0181.00
100_I264_M1.0161.00
160_A177_A1.0151.00
109_W113_K1.0131.00
145_M187_A1.0101.00
268_G281_S1.0061.00
44_I48_M0.9941.00
264_M280_M0.9941.00
45_I294_G0.9911.00
283_F286_L0.9901.00
207_E216_V0.9861.00
113_K171_L0.9811.00
190_V225_T0.9761.00
206_T209_L0.9751.00
86_A89_Q0.9751.00
141_D195_L0.9751.00
103_R280_M0.9711.00
137_S199_E0.9651.00
266_S270_T0.9641.00
172_W175_V0.9631.00
237_Y295_F0.9631.00
107_G264_M0.9621.00
141_D145_M0.9571.00
294_G298_L0.9551.00
138_D141_D0.9541.00
102_K106_Y0.9531.00
143_V147_T0.9521.00
37_L40_I0.9501.00
85_G89_Q0.9401.00
227_A303_R0.9351.00
118_T178_L0.9331.00
279_W283_F0.9321.00
47_G51_V0.9311.00
140_T143_V0.9301.00
118_T122_S0.9231.00
127_V229_V0.9171.00
113_K116_T0.9131.00
27_Q31_N0.9101.00
61_L64_L0.9081.00
35_N297_L0.9071.00
142_N145_M0.9051.00
211_A216_V0.9021.00
156_S243_D0.8951.00
295_F299_G0.8881.00
40_I43_T0.8871.00
167_F173_K0.8861.00
104_T283_F0.8781.00
230_T299_G0.8761.00
225_T228_P0.8761.00
138_D142_N0.8711.00
148_M184_P0.8671.00
124_F127_V0.8661.00
130_G194_A0.8661.00
43_T47_G0.8651.00
60_D64_L0.8641.00
213_D216_V0.8631.00
59_Y102_K0.8601.00
84_G87_T0.8531.00
41_G45_I0.8531.00
123_T127_V0.8531.00
44_I294_G0.8501.00
176_I179_T0.8471.00
218_A221_V0.8451.00
83_S86_A0.8441.00
41_G44_I0.8401.00
178_L243_D0.8361.00
168_G173_K0.8321.00
192_G195_L0.8241.00
93_T97_G0.8231.00
169_A173_K0.8221.00
171_L175_V0.8221.00
43_T286_L0.8221.00
102_K105_L0.8211.00
173_K176_I0.8161.00
108_A291_L0.8141.00
30_S33_L0.8121.00
267_N270_T0.8111.00
156_S160_A0.8101.00
33_L36_R0.8071.00
134_A195_L0.8071.00
232_Q236_N0.8071.00
103_R106_Y0.8061.00
105_L109_W0.8051.00
211_A220_H0.7991.00
118_T240_A0.7961.00
133_A141_D0.7951.00
123_T128_A0.7941.00
264_M284_P0.7891.00
129_L183_T0.7861.00
204_E208_A0.7851.00
51_V278_W0.7831.00
123_T186_F0.7801.00
197_V224_N0.7761.00
213_D217_L0.7721.00
116_T120_A0.7611.00
194_A198_L0.7601.00
111_A115_G0.7601.00
200_D204_E0.7591.00
117_V120_A0.7581.00
282_L286_L0.7581.00
128_A132_I0.7571.00
60_D63_A0.7551.00
32_L36_R0.7551.00
163_L173_K0.7531.00
90_L101_F0.7441.00
283_F287_F0.7391.00
39_I290_I0.7391.00
238_G295_F0.7391.00
190_V193_A0.7351.00
51_V105_L0.7341.00
193_A228_P0.7331.00
117_V249_F0.7321.00
105_L108_A0.7291.00
266_S269_V0.7281.00
56_R109_W0.7241.00
86_A90_L0.7241.00
59_Y106_Y0.7231.00
38_A42_L0.7211.00
152_L184_P0.7201.00
61_L88_Q0.7191.00
26_S29_L0.7191.00
94_D277_K0.7191.00
121_A175_V0.7191.00
89_Q93_T0.7181.00
126_G130_G0.7181.00
48_M51_V0.7171.00
288_L292_V0.7151.00
66_A69_L0.7151.00
51_V82_G0.7111.00
304_D310_M0.7091.00
48_M52_A0.7071.00
214_A217_L0.7061.00
193_A225_T0.7031.00
290_I294_G0.7011.00
303_R310_M0.6991.00
42_L298_L0.6981.00
125_L179_T0.6941.00
122_S179_T0.6901.00
46_L50_A0.6851.00
28_F301_G0.6801.00
267_N275_T0.6771.00
244_F248_S0.6761.00
27_Q304_D0.6761.00
242_I245_A0.6701.00
282_L285_G0.6671.00
48_M291_L0.6671.00
86_A286_L0.6671.00
298_L302_M0.6651.00
234_T295_F0.6641.00
216_V221_V0.6631.00
182_Y185_R0.6611.00
195_L198_L0.6581.00
292_V296_N0.6551.00
36_R40_I0.6551.00
60_D102_K0.6531.00
281_S285_G0.6491.00
104_T284_P0.6461.00
145_M148_M0.6441.00
137_S141_D0.6441.00
143_V146_R0.6421.00
181_V184_P0.6401.00
46_L285_G0.6351.00
39_I293_L0.6351.00
169_A172_W0.6291.00
67_S89_Q0.6291.00
133_A145_M0.6261.00
32_L38_A0.6261.00
156_S159_L0.6261.00
162_A166_I0.6201.00
90_L99_D0.6191.00
60_D101_F0.6191.00
32_L297_L0.6121.00
125_L129_L0.6121.00
243_D246_A0.6111.00
174_V244_F0.6101.00
61_L102_K0.6091.00
144_I148_M0.6081.00
64_L69_L0.6081.00
65_R69_L0.6061.00
148_M183_T0.6051.00
186_F232_Q0.6041.00
173_K177_A0.6021.00
137_S195_L0.5991.00
119_V237_Y0.5981.00
51_V108_A0.5981.00
135_Y198_L0.5981.00
39_I43_T0.5971.00
211_A214_A0.5921.00
37_L41_G0.5911.00
245_A263_L0.5911.00
135_Y218_A0.5891.00
265_L288_L0.5891.00
186_F190_V0.5891.00
108_A112_I0.5891.00
242_I246_A0.5881.00
136_Y217_L0.5871.00
112_I116_T0.5861.00
126_G187_A0.5841.00
159_L181_V0.5801.00
115_G240_A0.5801.00
231_V234_T0.5801.00
70_G83_S0.5791.00
240_A243_D0.5761.00
119_V236_N0.5751.00
185_R236_N0.5741.00
241_I245_A0.5731.00
55_A276_G0.5721.00
81_A85_G0.5721.00
30_S34_S0.5681.00
264_M267_N0.5661.00
120_A124_F0.5641.00
180_L183_T0.5641.00
44_I290_I0.5631.00
184_P187_A0.5591.00
43_T46_L0.5581.00
48_M82_G0.5581.00
117_V172_W0.5571.00
48_M290_I0.5571.00
156_S180_L0.5571.00
35_N301_G0.5551.00
203_I207_E0.5531.00
245_A266_S0.5491.00
264_M268_G0.5471.00
134_A141_D0.5461.00
146_R150_V0.5451.00
218_A223_P0.5431.00
179_T182_Y0.5421.00
182_Y236_N0.5401.00
151_L183_T0.5391.00
119_V123_T0.5391.00
129_L132_I0.5331.00
27_Q30_S0.5331.00
176_I180_L0.5331.00
44_I83_S0.5321.00
123_T229_V0.5311.00
115_G237_Y0.5311.00
109_W112_I0.5311.00
61_L89_Q0.5291.00
279_W282_L0.5251.00
145_M149_D0.5251.00
164_V168_G0.5241.00
103_R107_G0.5231.00
185_R232_Q0.5221.00
300_D303_R0.5181.00
84_G89_Q0.5151.00
45_I295_F0.5151.00
189_V193_A0.5141.00
38_A41_G0.5131.00
245_A267_N0.5121.00
27_Q310_M0.5121.00
149_D152_L0.5121.00
63_A106_Y0.5111.00
45_I298_L0.5081.00
35_N38_A0.5061.00
160_A246_A0.5041.00
66_A96_A0.5031.00
212_T216_V0.5011.00
154_F158_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.8032 99.9 0.657 Contact Map
3d31C 2 0.7333 99.9 0.661 Contact Map
3tuiA 2 0.6444 99.9 0.668 Contact Map
2onkC 2 0.7524 99.9 0.677 Contact Map
3rlfF 1 0.873 99.8 0.689 Contact Map
4ymuD 2 0.6603 99.8 0.7 Contact Map
4tquN 1 0.8381 99.8 0.712 Contact Map
3rlfG 1 0.819 99.8 0.718 Contact Map
3j9pD 4 0.7365 41.4 0.948 Contact Map
2kogA 1 0.1746 15 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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