Q9HMH8 - HALSA - GREMLIN Contacts

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Q9HMH8 - Uncharacterized protein

UniProt:	Q9HMH8	Sequences: MRVVRGRAPGRDADTAVTRDLLEWVRANNEPAVRVWPPGRVVAFGRRDANEAGYADAVAAARDREFPTVERSVGGRAVAYTESTLAFARITPAEDMRTGLDARYDAMVGDIIDALHAVGATGARPGEPAASFCPGDHSVQADCGKLAGVAQRVTRGAALTSGVLVVDDRRVIANVLDAVYGALGAPFDPESVGSVRAAGGDPADARDAVERALVGDHDPTVDAVHST	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	227 (196)
Sequences:	2672 (1826)
Seq/√Len:	130.4

ECOLI - LPLA
BACSU - LIPL LPLJ LIPM
HALSA - Q9HMH8 Q9HSK8
SULSO - Q97Z28 Q97U62 Q97Z70 Q97U65

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_G	198_A	3.661	1.00
167_D	196_R	3.638	1.00
109_G	113_D	3.055	1.00
60_A	64_R	2.913	1.00
64_R	175_V	2.825	1.00
19_R	23_E	2.767	1.00
61_A	68_T	2.732	1.00
205_A	208_A	2.669	1.00
116_H	121_T	2.616	1.00
59_A	63_D	2.610	1.00
87_F	162_G	2.412	1.00
121_T	124_R	2.241	1.00
36_W	88_A	2.170	1.00
120_A	123_A	2.168	1.00
60_A	63_D	2.065	1.00
117_A	216_D	1.883	1.00
64_R	174_N	1.864	1.00
168_D	171_V	1.812	1.00
121_T	142_D	1.801	1.00
44_F	50_N	1.757	1.00
80_Y	86_A	1.747	1.00
39_G	82_E	1.745	1.00
211_R	215_G	1.738	1.00
18_T	161_S	1.734	1.00
33_V	217_H	1.703	1.00
31_P	92_P	1.694	1.00
85_L	206_R	1.680	1.00
10_G	13_A	1.680	1.00
118_V	212_A	1.658	1.00
21_L	32_A	1.639	1.00
38_P	80_Y	1.635	1.00
73_V	152_R	1.626	1.00
113_D	216_D	1.616	1.00
193_G	197_A	1.615	1.00
139_V	146_L	1.605	1.00
43_A	80_Y	1.592	1.00
23_E	154_T	1.580	1.00
77_A	176_L	1.573	1.00
141_A	146_L	1.559	1.00
13_A	17_V	1.539	1.00
42_V	61_A	1.524	1.00
146_L	195_V	1.522	1.00
113_D	116_H	1.519	1.00
150_A	161_S	1.495	1.00
73_V	161_S	1.477	1.00
60_A	175_V	1.450	1.00
144_G	197_A	1.450	1.00
112_I	123_A	1.433	1.00
147_A	163_V	1.428	1.00
80_Y	84_T	1.404	1.00
64_R	171_V	1.404	1.00
126_G	140_Q	1.402	1.00
166_V	209_V	1.393	1.00
15_T	43_A	1.379	1.00
85_L	210_E	1.368	1.00
15_T	18_T	1.367	1.00
14_D	38_P	1.357	1.00
182_A	186_P	1.321	1.00
42_V	176_L	1.320	1.00
114_A	216_D	1.297	1.00
59_A	62_R	1.289	1.00
105_D	109_G	1.279	1.00
149_V	160_T	1.269	1.00
60_A	66_F	1.267	1.00
180_Y	184_G	1.256	1.00
38_P	86_A	1.252	1.00
171_V	174_N	1.238	1.00
174_N	177_D	1.237	1.00
202_P	208_A	1.231	1.00
144_G	193_G	1.219	1.00
93_A	156_G	1.216	1.00
36_W	160_T	1.206	0.99
141_A	198_A	1.200	0.99
43_A	78_V	1.181	0.99
137_H	182_A	1.180	0.99
178_A	182_A	1.179	0.99
117_A	212_A	1.172	0.99
20_D	24_W	1.169	0.99
207_D	210_E	1.158	0.99
84_T	163_V	1.154	0.99
123_A	141_A	1.142	0.99
124_R	143_C	1.133	0.99
207_D	211_R	1.133	0.99
123_A	139_V	1.121	0.99
36_W	43_A	1.119	0.99
18_T	34_R	1.117	0.99
61_A	66_F	1.115	0.99
209_V	213_L	1.110	0.99
149_V	162_G	1.094	0.99
79_A	175_V	1.092	0.99
14_D	80_Y	1.089	0.99
66_F	175_V	1.088	0.99
206_R	210_E	1.082	0.99
108_V	149_V	1.081	0.99
45_G	138_S	1.079	0.99
56_D	62_R	1.066	0.99
11_R	69_V	1.063	0.99
147_A	162_G	1.054	0.99
112_I	139_V	1.045	0.99
117_A	215_G	1.028	0.98
72_S	152_R	1.018	0.98
196_R	203_A	1.009	0.98
107_M	110_D	1.003	0.98
39_G	67_P	1.003	0.98
104_Y	151_Q	1.002	0.98
105_D	125_P	0.998	0.98
29_N	32_A	0.998	0.98
80_Y	161_S	0.996	0.98
48_D	53_G	0.988	0.98
37_P	206_R	0.985	0.98
142_D	198_A	0.978	0.98
54_Y	61_A	0.972	0.98
214_V	218_D	0.970	0.98
85_L	209_V	0.966	0.97
212_A	215_G	0.961	0.97
37_P	210_E	0.960	0.97
10_G	67_P	0.958	0.97
140_Q	143_C	0.958	0.97
108_V	125_P	0.951	0.97
56_D	68_T	0.946	0.97
15_T	80_Y	0.936	0.97
76_R	147_A	0.929	0.97
38_P	69_V	0.928	0.97
78_V	86_A	0.927	0.97
44_F	77_A	0.921	0.97
93_A	153_V	0.921	0.97
43_A	86_A	0.906	0.96
151_Q	160_T	0.900	0.96
104_Y	107_M	0.891	0.96
114_A	212_A	0.891	0.96
60_A	174_N	0.888	0.96
55_A	177_D	0.887	0.96
35_V	210_E	0.885	0.96
170_R	173_A	0.884	0.96
91_T	158_A	0.877	0.96
55_A	63_D	0.870	0.95
215_G	218_D	0.865	0.95
187_F	194_S	0.861	0.95
15_T	86_A	0.860	0.95
16_A	20_D	0.841	0.94
210_E	214_V	0.837	0.94
114_A	213_L	0.836	0.94
93_A	158_A	0.834	0.94
200_G	203_A	0.833	0.94
135_G	138_S	0.829	0.94
169_R	172_I	0.828	0.94
115_L	123_A	0.822	0.94
76_R	163_V	0.821	0.94
55_A	59_A	0.819	0.94
88_A	160_T	0.819	0.94
204_D	212_A	0.809	0.93
74_G	148_G	0.808	0.93
169_R	173_A	0.804	0.93
55_A	60_A	0.799	0.93
41_V	67_P	0.799	0.93
112_I	125_P	0.799	0.93
36_W	86_A	0.795	0.93
22_L	154_T	0.795	0.93
208_A	211_R	0.791	0.92
153_V	158_A	0.778	0.92
22_L	26_R	0.777	0.92
43_A	84_T	0.777	0.92
38_P	84_T	0.774	0.92
170_R	174_N	0.768	0.91
15_T	38_P	0.766	0.91
183_L	188_D	0.764	0.91
38_P	88_A	0.761	0.91
44_F	68_T	0.760	0.91
17_V	21_L	0.750	0.90
79_A	171_V	0.747	0.90
137_H	191_S	0.746	0.90
78_V	84_T	0.741	0.90
81_T	171_V	0.738	0.90
151_Q	158_A	0.729	0.89
50_N	56_D	0.725	0.89
40_R	171_V	0.724	0.89
72_S	159_L	0.718	0.88
199_G	202_P	0.718	0.88
110_D	216_D	0.718	0.88
188_D	191_S	0.716	0.88
26_R	30_E	0.715	0.88
42_V	79_A	0.713	0.88
18_T	80_Y	0.712	0.88
171_V	175_V	0.707	0.88
183_L	186_P	0.706	0.87
40_R	66_F	0.703	0.87
21_L	26_R	0.701	0.87
166_V	206_R	0.698	0.87
92_P	157_A	0.698	0.87
199_G	203_A	0.697	0.87
139_V	147_A	0.693	0.86
88_A	161_S	0.684	0.86
137_H	186_P	0.683	0.86
66_F	79_A	0.680	0.85
146_L	193_G	0.678	0.85
9_P	82_E	0.674	0.85
43_A	160_T	0.671	0.85
45_G	48_D	0.670	0.85
107_M	160_T	0.668	0.84
31_P	91_T	0.667	0.84
52_A	185_A	0.666	0.84
115_L	146_L	0.664	0.84
116_H	120_A	0.664	0.84
22_L	159_L	0.664	0.84
89_R	107_M	0.661	0.84
211_R	218_D	0.661	0.84
76_R	138_S	0.657	0.83
172_I	192_V	0.655	0.83
126_G	135_G	0.655	0.83
18_T	38_P	0.653	0.83
28_N	92_P	0.650	0.83
86_A	149_V	0.648	0.83
11_R	67_P	0.645	0.82
43_A	163_V	0.644	0.82
178_A	186_P	0.641	0.82
48_D	70_E	0.640	0.82
208_A	212_A	0.636	0.81
205_A	209_V	0.634	0.81
66_F	171_V	0.631	0.81
78_V	163_V	0.630	0.81
117_A	208_A	0.630	0.81
166_V	204_D	0.629	0.81
202_P	205_A	0.628	0.81
149_V	161_S	0.626	0.80
38_P	43_A	0.622	0.80
200_G	205_A	0.620	0.80
199_G	208_A	0.620	0.80
194_S	197_A	0.618	0.80
101_D	136_D	0.617	0.79
147_A	164_L	0.615	0.79
15_T	44_F	0.614	0.79
90_I	159_L	0.613	0.79
182_A	191_S	0.608	0.78
88_A	159_L	0.607	0.78
181_G	184_G	0.605	0.78
73_V	159_L	0.604	0.78
15_T	84_T	0.603	0.78
111_I	139_V	0.595	0.77
193_G	196_R	0.595	0.77
205_A	213_L	0.594	0.77
105_D	208_A	0.594	0.77
36_W	80_Y	0.586	0.76
87_F	160_T	0.584	0.76
14_D	18_T	0.579	0.75
111_I	213_L	0.575	0.75
54_Y	68_T	0.574	0.74
93_A	96_M	0.574	0.74
138_S	160_T	0.572	0.74
209_V	215_G	0.569	0.74
17_V	20_D	0.568	0.74
165_V	172_I	0.567	0.73
108_V	139_V	0.566	0.73
138_S	147_A	0.563	0.73
116_H	123_A	0.560	0.73
96_M	158_A	0.558	0.72
166_V	196_R	0.558	0.72
19_R	154_T	0.558	0.72
26_R	29_N	0.554	0.72
146_L	194_S	0.552	0.72
18_T	86_A	0.551	0.71
17_V	32_A	0.549	0.71
179_V	183_L	0.549	0.71
19_R	152_R	0.547	0.71
110_D	114_A	0.541	0.70
21_L	90_I	0.541	0.70
39_G	211_R	0.541	0.70
117_A	204_D	0.541	0.70
52_A	183_L	0.537	0.69
23_E	27_A	0.537	0.69
33_V	87_F	0.536	0.69
121_T	198_A	0.534	0.69
85_L	166_V	0.534	0.69
16_A	19_R	0.527	0.68
136_D	185_A	0.527	0.68
155_R	174_N	0.525	0.68
11_R	61_A	0.523	0.67
9_P	13_A	0.523	0.67
165_V	192_V	0.522	0.67
45_G	70_E	0.517	0.67
71_R	75_G	0.515	0.66
107_M	158_A	0.514	0.66
138_S	192_V	0.513	0.66
35_V	213_L	0.513	0.66
212_A	216_D	0.512	0.66
59_A	211_R	0.511	0.66
26_R	31_P	0.509	0.65
72_S	149_V	0.508	0.65
48_D	187_F	0.506	0.65
12_D	67_P	0.505	0.65
89_R	111_I	0.502	0.64
60_A	171_V	0.502	0.64
88_A	150_A	0.501	0.64
153_V	172_I	0.501	0.64
78_V	85_L	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2c8mA	1	0.9251	100	0.267	Contact Map
3a7rA	1	0.9119	100	0.276	Contact Map
2e5aA	1	0.9251	100	0.279	Contact Map
2p0lA	1	0.9736	100	0.279	Contact Map
1vqzA	1	0.9295	100	0.315	Contact Map
2p5iA	1	0.9648	100	0.321	Contact Map
2qhsA	1	0.9075	100	0.406	Contact Map
1w66A	1	0.8855	100	0.431	Contact Map
2dxuA	2	0.7665	97.9	0.862	Contact Map
2eayA	2	0.6696	97.4	0.875	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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