GREMLIN Database
Q9HMH8 - Uncharacterized protein
UniProt: Q9HMH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (196)
Sequences: 2672 (1826)
Seq/√Len: 130.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_G198_A3.6611.00
167_D196_R3.6381.00
109_G113_D3.0551.00
60_A64_R2.9131.00
64_R175_V2.8251.00
19_R23_E2.7671.00
61_A68_T2.7321.00
205_A208_A2.6691.00
116_H121_T2.6161.00
59_A63_D2.6101.00
87_F162_G2.4121.00
121_T124_R2.2411.00
36_W88_A2.1701.00
120_A123_A2.1681.00
60_A63_D2.0651.00
117_A216_D1.8831.00
64_R174_N1.8641.00
168_D171_V1.8121.00
121_T142_D1.8011.00
44_F50_N1.7571.00
80_Y86_A1.7471.00
39_G82_E1.7451.00
211_R215_G1.7381.00
18_T161_S1.7341.00
33_V217_H1.7031.00
31_P92_P1.6941.00
85_L206_R1.6801.00
10_G13_A1.6801.00
118_V212_A1.6581.00
21_L32_A1.6391.00
38_P80_Y1.6351.00
73_V152_R1.6261.00
113_D216_D1.6161.00
193_G197_A1.6151.00
139_V146_L1.6051.00
43_A80_Y1.5921.00
23_E154_T1.5801.00
77_A176_L1.5731.00
141_A146_L1.5591.00
13_A17_V1.5391.00
42_V61_A1.5241.00
146_L195_V1.5221.00
113_D116_H1.5191.00
150_A161_S1.4951.00
73_V161_S1.4771.00
60_A175_V1.4501.00
144_G197_A1.4501.00
112_I123_A1.4331.00
147_A163_V1.4281.00
80_Y84_T1.4041.00
64_R171_V1.4041.00
126_G140_Q1.4021.00
166_V209_V1.3931.00
15_T43_A1.3791.00
85_L210_E1.3681.00
15_T18_T1.3671.00
14_D38_P1.3571.00
182_A186_P1.3211.00
42_V176_L1.3201.00
114_A216_D1.2971.00
59_A62_R1.2891.00
105_D109_G1.2791.00
149_V160_T1.2691.00
60_A66_F1.2671.00
180_Y184_G1.2561.00
38_P86_A1.2521.00
171_V174_N1.2381.00
174_N177_D1.2371.00
202_P208_A1.2311.00
144_G193_G1.2191.00
93_A156_G1.2161.00
36_W160_T1.2060.99
141_A198_A1.2000.99
43_A78_V1.1810.99
137_H182_A1.1800.99
178_A182_A1.1790.99
117_A212_A1.1720.99
20_D24_W1.1690.99
207_D210_E1.1580.99
84_T163_V1.1540.99
123_A141_A1.1420.99
124_R143_C1.1330.99
207_D211_R1.1330.99
123_A139_V1.1210.99
36_W43_A1.1190.99
18_T34_R1.1170.99
61_A66_F1.1150.99
209_V213_L1.1100.99
149_V162_G1.0940.99
79_A175_V1.0920.99
14_D80_Y1.0890.99
66_F175_V1.0880.99
206_R210_E1.0820.99
108_V149_V1.0810.99
45_G138_S1.0790.99
56_D62_R1.0660.99
11_R69_V1.0630.99
147_A162_G1.0540.99
112_I139_V1.0450.99
117_A215_G1.0280.98
72_S152_R1.0180.98
196_R203_A1.0090.98
107_M110_D1.0030.98
39_G67_P1.0030.98
104_Y151_Q1.0020.98
105_D125_P0.9980.98
29_N32_A0.9980.98
80_Y161_S0.9960.98
48_D53_G0.9880.98
37_P206_R0.9850.98
142_D198_A0.9780.98
54_Y61_A0.9720.98
214_V218_D0.9700.98
85_L209_V0.9660.97
212_A215_G0.9610.97
37_P210_E0.9600.97
10_G67_P0.9580.97
140_Q143_C0.9580.97
108_V125_P0.9510.97
56_D68_T0.9460.97
15_T80_Y0.9360.97
76_R147_A0.9290.97
38_P69_V0.9280.97
78_V86_A0.9270.97
44_F77_A0.9210.97
93_A153_V0.9210.97
43_A86_A0.9060.96
151_Q160_T0.9000.96
104_Y107_M0.8910.96
114_A212_A0.8910.96
60_A174_N0.8880.96
55_A177_D0.8870.96
35_V210_E0.8850.96
170_R173_A0.8840.96
91_T158_A0.8770.96
55_A63_D0.8700.95
215_G218_D0.8650.95
187_F194_S0.8610.95
15_T86_A0.8600.95
16_A20_D0.8410.94
210_E214_V0.8370.94
114_A213_L0.8360.94
93_A158_A0.8340.94
200_G203_A0.8330.94
135_G138_S0.8290.94
169_R172_I0.8280.94
115_L123_A0.8220.94
76_R163_V0.8210.94
55_A59_A0.8190.94
88_A160_T0.8190.94
204_D212_A0.8090.93
74_G148_G0.8080.93
169_R173_A0.8040.93
55_A60_A0.7990.93
41_V67_P0.7990.93
112_I125_P0.7990.93
36_W86_A0.7950.93
22_L154_T0.7950.93
208_A211_R0.7910.92
153_V158_A0.7780.92
22_L26_R0.7770.92
43_A84_T0.7770.92
38_P84_T0.7740.92
170_R174_N0.7680.91
15_T38_P0.7660.91
183_L188_D0.7640.91
38_P88_A0.7610.91
44_F68_T0.7600.91
17_V21_L0.7500.90
79_A171_V0.7470.90
137_H191_S0.7460.90
78_V84_T0.7410.90
81_T171_V0.7380.90
151_Q158_A0.7290.89
50_N56_D0.7250.89
40_R171_V0.7240.89
72_S159_L0.7180.88
199_G202_P0.7180.88
110_D216_D0.7180.88
188_D191_S0.7160.88
26_R30_E0.7150.88
42_V79_A0.7130.88
18_T80_Y0.7120.88
171_V175_V0.7070.88
183_L186_P0.7060.87
40_R66_F0.7030.87
21_L26_R0.7010.87
166_V206_R0.6980.87
92_P157_A0.6980.87
199_G203_A0.6970.87
139_V147_A0.6930.86
88_A161_S0.6840.86
137_H186_P0.6830.86
66_F79_A0.6800.85
146_L193_G0.6780.85
9_P82_E0.6740.85
43_A160_T0.6710.85
45_G48_D0.6700.85
107_M160_T0.6680.84
31_P91_T0.6670.84
52_A185_A0.6660.84
115_L146_L0.6640.84
116_H120_A0.6640.84
22_L159_L0.6640.84
89_R107_M0.6610.84
211_R218_D0.6610.84
76_R138_S0.6570.83
172_I192_V0.6550.83
126_G135_G0.6550.83
18_T38_P0.6530.83
28_N92_P0.6500.83
86_A149_V0.6480.83
11_R67_P0.6450.82
43_A163_V0.6440.82
178_A186_P0.6410.82
48_D70_E0.6400.82
208_A212_A0.6360.81
205_A209_V0.6340.81
66_F171_V0.6310.81
78_V163_V0.6300.81
117_A208_A0.6300.81
166_V204_D0.6290.81
202_P205_A0.6280.81
149_V161_S0.6260.80
38_P43_A0.6220.80
200_G205_A0.6200.80
199_G208_A0.6200.80
194_S197_A0.6180.80
101_D136_D0.6170.79
147_A164_L0.6150.79
15_T44_F0.6140.79
90_I159_L0.6130.79
182_A191_S0.6080.78
88_A159_L0.6070.78
181_G184_G0.6050.78
73_V159_L0.6040.78
15_T84_T0.6030.78
111_I139_V0.5950.77
193_G196_R0.5950.77
205_A213_L0.5940.77
105_D208_A0.5940.77
36_W80_Y0.5860.76
87_F160_T0.5840.76
14_D18_T0.5790.75
111_I213_L0.5750.75
54_Y68_T0.5740.74
93_A96_M0.5740.74
138_S160_T0.5720.74
209_V215_G0.5690.74
17_V20_D0.5680.74
165_V172_I0.5670.73
108_V139_V0.5660.73
138_S147_A0.5630.73
116_H123_A0.5600.73
96_M158_A0.5580.72
166_V196_R0.5580.72
19_R154_T0.5580.72
26_R29_N0.5540.72
146_L194_S0.5520.72
18_T86_A0.5510.71
17_V32_A0.5490.71
179_V183_L0.5490.71
19_R152_R0.5470.71
110_D114_A0.5410.70
21_L90_I0.5410.70
39_G211_R0.5410.70
117_A204_D0.5410.70
52_A183_L0.5370.69
23_E27_A0.5370.69
33_V87_F0.5360.69
121_T198_A0.5340.69
85_L166_V0.5340.69
16_A19_R0.5270.68
136_D185_A0.5270.68
155_R174_N0.5250.68
11_R61_A0.5230.67
9_P13_A0.5230.67
165_V192_V0.5220.67
45_G70_E0.5170.67
71_R75_G0.5150.66
107_M158_A0.5140.66
138_S192_V0.5130.66
35_V213_L0.5130.66
212_A216_D0.5120.66
59_A211_R0.5110.66
26_R31_P0.5090.65
72_S149_V0.5080.65
48_D187_F0.5060.65
12_D67_P0.5050.65
89_R111_I0.5020.64
60_A171_V0.5020.64
88_A150_A0.5010.64
153_V172_I0.5010.64
78_V85_L0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c8mA 1 0.9251 100 0.267 Contact Map
3a7rA 1 0.9119 100 0.276 Contact Map
2e5aA 1 0.9251 100 0.279 Contact Map
2p0lA 1 0.9736 100 0.279 Contact Map
1vqzA 1 0.9295 100 0.315 Contact Map
2p5iA 1 0.9648 100 0.321 Contact Map
2qhsA 1 0.9075 100 0.406 Contact Map
1w66A 1 0.8855 100 0.431 Contact Map
2dxuA 2 0.7665 97.9 0.862 Contact Map
2eayA 2 0.6696 97.4 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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