GREMLIN Database
Q9HMH5 - Isochorismatase
UniProt: Q9HMH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (171)
Sequences: 10025 (6963)
Seq/√Len: 532.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_D120_T3.2751.00
108_D144_S2.7961.00
126_E151_R2.7851.00
116_D150_Y2.7711.00
56_R103_E2.7591.00
45_A50_A2.5571.00
8_T126_E2.5101.00
38_V130_C2.3501.00
129_F142_A2.3301.00
116_D148_R2.3191.00
126_E153_I2.3131.00
15_M38_V2.2721.00
41_L155_A2.2351.00
164_A168_E2.1501.00
7_H125_T2.1111.00
174_A179_G2.0461.00
114_E118_Y2.0151.00
18_G86_D2.0051.00
9_A124_I1.9301.00
139_L143_G1.9081.00
37_A158_A1.9071.00
17_N85_W1.9011.00
44_R48_A1.8991.00
37_A40_A1.8141.00
145_A152_P1.8071.00
109_A141_T1.7761.00
102_V118_Y1.7651.00
8_T128_V1.7471.00
53_V118_Y1.6861.00
156_A183_D1.6661.00
17_N91_D1.6621.00
134_A167_K1.6461.00
12_V42_V1.6391.00
156_A181_V1.6361.00
20_C90_H1.5841.00
128_V155_A1.5631.00
55_T109_A1.5481.00
100_H118_Y1.5191.00
45_A128_V1.5161.00
39_T43_S1.4961.00
46_R99_D1.4871.00
12_V130_C1.4701.00
51_R122_H1.4581.00
134_A159_V1.4561.00
127_L145_A1.4381.00
139_L173_H1.4311.00
85_W88_Q1.3961.00
161_Y167_K1.3851.00
165_S168_E1.3711.00
39_T92_K1.3631.00
129_F141_T1.3511.00
58_V87_A1.3411.00
135_N161_Y1.3341.00
134_A171_L1.3311.00
30_A33_D1.2961.00
138_V154_L1.2911.00
118_Y122_H1.2901.00
12_V38_V1.2741.00
12_V15_M1.2711.00
11_V129_F1.2671.00
156_A171_L1.2661.00
120_T150_Y1.2531.00
36_A92_K1.2511.00
168_E172_D1.2501.00
37_A157_D1.2221.00
82_A103_E1.2151.00
34_A38_V1.2141.00
154_L159_V1.2121.00
139_L170_T1.2041.00
117_G121_A1.2011.00
56_R89_L1.1981.00
10_V45_A1.1841.00
144_S148_R1.1801.00
43_S47_D1.1591.00
13_V137_C1.1521.00
58_V103_E1.1351.00
128_V153_I1.1321.00
41_L158_A1.1241.00
56_R101_V1.1201.00
17_N88_Q1.0651.00
142_A154_L1.0641.00
96_A99_D1.0441.00
159_V167_K1.0281.00
58_V82_A1.0081.00
165_S169_Y1.0071.00
114_E117_G1.0031.00
89_L101_V1.0031.00
8_T50_A0.9911.00
42_V46_R0.9861.00
142_A174_A0.9791.00
134_A161_Y0.9741.00
9_A53_V0.9681.00
127_L152_P0.9641.00
153_I180_E0.9551.00
140_H143_G0.9541.00
44_R47_D0.9481.00
42_V54_Y0.9471.00
60_P82_A0.9341.00
167_K171_L0.9261.00
171_L181_V0.9211.00
34_A160_G0.9121.00
40_A44_R0.9091.00
153_I182_A0.9021.00
163_E166_H0.9001.00
118_Y121_A0.8981.00
125_T151_R0.8931.00
106_T149_D0.8881.00
165_S172_D0.8791.00
88_Q94_T0.8781.00
14_D104_K0.8741.00
155_A158_A0.8721.00
43_S96_A0.8681.00
78_E81_T0.8581.00
54_Y95_V0.8521.00
111_Y148_R0.8511.00
54_Y89_L0.8501.00
15_M132_T0.8461.00
13_V129_F0.8461.00
39_T95_V0.8391.00
11_V115_L0.8321.00
130_C158_A0.8311.00
109_A115_L0.8281.00
41_L130_C0.8241.00
81_T84_S0.8171.00
119_L150_Y0.8151.00
17_N21_H0.8131.00
151_R180_E0.8121.00
35_L39_T0.8081.00
9_A119_L0.8021.00
155_A182_A0.8011.00
166_H169_Y0.7911.00
144_S147_V0.7871.00
40_A43_S0.7831.00
42_V52_I0.7801.00
17_N90_H0.7771.00
110_F145_A0.7711.00
53_V122_H0.7681.00
33_D36_A0.7621.00
106_T112_E0.7581.00
51_R124_I0.7571.00
172_D175_E0.7561.00
7_H126_E0.7551.00
129_F138_V0.7541.00
84_S87_A0.7511.00
132_T160_G0.7501.00
38_V158_A0.7481.00
95_V99_D0.7461.00
135_N173_H0.7441.00
12_V54_Y0.7361.00
36_A39_T0.7311.00
36_A40_A0.7261.00
170_T174_A0.7231.00
72_E75_R0.7191.00
62_G65_E0.7181.00
54_Y98_D0.7101.00
46_R96_A0.7081.00
91_D94_T0.7031.00
34_A132_T0.6961.00
100_H122_H0.6911.00
51_R118_Y0.6901.00
95_V101_V0.6861.00
19_F137_C0.6851.00
135_N166_H0.6821.00
117_G120_T0.6801.00
169_Y173_H0.6761.00
159_V171_L0.6711.00
20_C35_L0.6691.00
35_L90_H0.6681.00
172_D176_W0.6651.00
23_D27_H0.6631.00
135_N162_I0.6611.00
61_P78_E0.6611.00
10_V41_L0.6601.00
146_G179_G0.6591.00
53_V100_H0.6571.00
142_A179_G0.6481.00
18_G24_G0.6471.00
10_V130_C0.6451.00
111_Y147_V0.6421.00
129_F152_P0.6421.00
133_L136_V0.6421.00
39_T94_T0.6411.00
152_P155_A0.6371.00
7_H123_G0.6341.00
29_P32_E0.6301.00
166_H172_D0.6271.00
54_Y101_V0.6261.00
31_S132_T0.6261.00
71_D74_E0.6251.00
169_Y172_D0.6221.00
24_G27_H0.6221.00
133_L161_Y0.6151.00
21_H32_E0.6111.00
54_Y99_D0.6101.00
136_V162_I0.6091.00
60_P63_Q0.6091.00
41_L45_A0.6041.00
13_V138_V0.6021.00
15_M90_H0.6001.00
71_D75_R0.5991.00
83_G88_Q0.5991.00
156_A167_K0.5951.00
85_W91_D0.5910.99
41_L128_V0.5910.99
10_V52_I0.5890.99
35_L93_L0.5880.99
53_V102_V0.5880.99
171_L175_E0.5840.99
42_V45_A0.5830.99
46_R98_D0.5810.99
154_L171_L0.5800.99
156_A175_E0.5800.99
15_M93_L0.5790.99
142_A152_P0.5750.99
43_S94_T0.5740.99
130_C155_A0.5740.99
112_E117_G0.5730.99
27_H32_E0.5710.99
143_G177_L0.5650.99
42_V99_D0.5590.99
90_H93_L0.5590.99
60_P105_H0.5560.99
154_L174_A0.5550.99
102_V114_E0.5540.99
20_C31_S0.5530.99
10_V42_V0.5530.99
46_R52_I0.5410.99
111_Y144_S0.5400.99
18_G80_V0.5400.99
166_H176_W0.5390.99
15_M34_A0.5390.99
180_E183_D0.5350.99
35_L92_K0.5330.99
108_D147_V0.5330.99
166_H170_T0.5320.99
95_V98_D0.5310.99
107_Y141_T0.5310.99
56_R88_Q0.5290.99
54_Y93_L0.5280.99
51_R100_H0.5250.99
56_R87_A0.5230.99
133_L162_I0.5190.99
76_W107_Y0.5170.99
29_P33_D0.5170.99
138_V159_V0.5160.99
45_A51_R0.5140.99
107_Y146_G0.5130.99
146_G177_L0.5130.99
128_V157_D0.5120.99
107_Y147_V0.5060.98
73_F76_W0.5060.98
71_D77_G0.5050.98
100_H103_E0.5040.98
170_T173_H0.5040.98
29_P160_G0.5020.98
60_P65_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irvA 2 1 100 0.139 Contact Map
3kl2A 4 1 100 0.147 Contact Map
3hb7A 3 0.9579 100 0.15 Contact Map
1nbaA 4 1 100 0.159 Contact Map
3hu5A 3 0.9684 100 0.159 Contact Map
3r2jA 2 0.9737 100 0.164 Contact Map
2fq1A 2 0.9789 100 0.164 Contact Map
4l07A 4 0.9789 100 0.181 Contact Map
2wt9A 2 0.9579 100 0.181 Contact Map
1nf9A 2 0.9632 100 0.182 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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