GREMLIN Database
Q9HMH4 - Uncharacterized protein
UniProt: Q9HMH4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 509 (427)
Sequences: 115 (97)
Seq/√Len: 4.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_E480_D4.0090.88
404_Y447_A3.9870.88
311_E436_D3.9300.87
185_I195_M3.6650.83
227_N356_G3.6500.83
278_Q282_D3.5930.82
181_D493_I3.5000.80
294_G298_A3.3330.76
223_Q350_A3.0880.70
315_H354_E3.0840.70
496_A505_V3.0590.69
312_Q436_D2.9550.66
277_L359_T2.9460.66
62_P74_W2.8820.64
202_Q237_G2.8580.64
106_V240_V2.7810.61
70_E110_E2.7390.60
480_D495_N2.6860.59
110_E480_D2.6530.58
143_H415_P2.5410.54
335_D501_Q2.5340.54
311_E322_D2.5260.54
74_W149_E2.5040.53
99_S201_S2.4760.52
212_R505_V2.3850.49
482_F495_N2.3020.47
290_L302_V2.3010.47
452_L493_I2.2330.44
145_N504_A2.2170.44
70_E495_N2.2120.44
69_W480_D2.1960.43
327_V456_G2.1960.43
275_T354_E2.1950.43
311_E480_D2.1900.43
70_E482_F2.1470.42
143_H147_K2.1370.42
156_E480_D2.1370.42
224_E431_W2.1330.41
144_Q356_G2.1110.41
69_W77_E2.0970.40
65_D480_D2.0830.40
69_W74_W2.0660.39
109_L236_D2.0520.39
246_Q313_T2.0410.39
113_Q433_S2.0190.38
236_D333_S2.0070.38
306_P413_L1.9760.37
61_D69_W1.9260.35
250_R507_D1.9170.35
215_T237_G1.9130.35
357_L405_T1.9090.35
290_L398_Y1.9030.35
358_F362_W1.8690.34
148_W354_E1.8690.34
65_D495_N1.8680.34
286_F357_L1.8640.34
62_P149_E1.8550.33
329_V414_V1.8340.33
167_N272_I1.8320.33
70_E76_N1.8310.33
151_M429_Y1.7860.31
99_S152_F1.7850.31
175_Y336_A1.7700.31
144_Q148_W1.7610.31
202_Q205_F1.7380.30
118_D182_R1.7340.30
437_S500_D1.6960.29
156_E495_N1.6830.29
148_W273_A1.6820.29
73_Y494_V1.6670.28
286_F312_Q1.6630.28
146_V227_N1.6600.28
126_A472_D1.6320.27
251_D493_I1.6110.27
50_Q288_E1.5960.26
65_D70_E1.5920.26
54_N163_V1.5750.26
214_N313_T1.5430.25
309_S428_A1.5380.25
154_V496_A1.5180.25
412_K466_N1.5180.25
123_E420_D1.5080.24
76_N480_D1.5060.24
70_E156_E1.5000.24
177_S399_N1.4950.24
147_K350_A1.4890.24
248_C254_C1.4870.24
322_D409_D1.4790.24
268_R490_R1.4710.24
187_S402_H1.4710.24
110_E156_E1.4690.23
116_P300_N1.4590.23
183_I271_G1.4520.23
202_Q224_E1.4450.23
167_N350_A1.4440.23
302_V305_N1.4090.22
457_A460_V1.3960.22
143_H227_N1.3910.22
97_N152_F1.3800.22
213_F496_A1.3760.21
197_E496_A1.3740.21
153_M347_V1.3700.21
185_I456_G1.3450.21
439_S443_E1.3390.21
148_W358_F1.3320.21
496_A502_L1.3280.20
233_I492_T1.3240.20
409_D428_A1.3210.20
478_Y498_T1.3170.20
227_N350_A1.3120.20
329_V507_D1.3120.20
303_Y342_T1.3040.20
77_E480_D1.3040.20
321_V472_D1.3010.20
220_Q272_I1.2970.20
152_F267_D1.2890.20
432_A490_R1.2840.20
89_D282_D1.2810.20
228_A472_D1.2710.19
157_D308_A1.2710.19
177_S180_E1.2590.19
182_R469_R1.2510.19
214_N277_L1.2470.19
148_W227_N1.2440.19
100_M430_V1.2390.19
315_H428_A1.2290.19
117_V149_E1.2270.18
52_G55_A1.2260.18
112_N250_R1.2230.18
286_F397_L1.2110.18
55_A240_V1.2080.18
146_V415_P1.2080.18
316_P505_V1.2070.18
100_M490_R1.2060.18
197_E410_G1.2000.18
326_P347_V1.1960.18
143_H146_V1.1940.18
149_E495_N1.1930.18
71_G114_S1.1920.18
311_E482_F1.1890.18
148_W153_M1.1890.18
95_V255_L1.1850.18
121_S125_F1.1840.18
116_P177_S1.1800.18
309_S425_S1.1800.18
145_N328_S1.1770.18
277_L445_A1.1690.17
145_N159_N1.1630.17
109_L186_V1.1630.17
169_A251_D1.1630.17
309_S324_P1.1620.17
325_T413_L1.1610.17
185_I330_A1.1530.17
65_D156_E1.1510.17
68_G231_G1.1510.17
409_D436_D1.1500.17
236_D294_G1.1450.17
187_S303_Y1.1450.17
109_L212_R1.1370.17
148_W340_P1.1350.17
253_D308_A1.1340.17
76_N110_E1.1260.17
63_D201_S1.1250.17
214_N282_D1.1150.16
74_W81_V1.1150.16
292_E470_I1.1130.16
188_E347_V1.1110.16
110_E495_N1.1090.16
153_M220_Q1.1030.16
167_N302_V1.0970.16
117_V360_M1.0950.16
228_A441_A1.0950.16
73_Y324_P1.0940.16
167_N454_Y1.0930.16
151_M266_S1.0780.16
88_N173_L1.0690.16
287_V309_S1.0680.16
315_H443_E1.0680.16
53_A56_S1.0580.15
499_V502_L1.0560.15
334_T507_D1.0520.15
144_Q227_N1.0510.15
160_A433_S1.0430.15
142_L303_Y1.0420.15
437_S440_D1.0420.15
181_D431_W1.0410.15
74_W117_V1.0370.15
496_A500_D1.0350.15
215_T361_L1.0300.15
62_P81_V1.0250.15
275_T415_P1.0230.15
210_T307_P1.0160.15
144_Q397_L1.0120.15
86_G156_E1.0110.15
282_D396_D1.0070.15
272_I306_P1.0060.15
185_I470_I1.0060.15
243_R310_T1.0050.15
311_E406_D1.0040.15
170_G278_Q1.0000.15
70_E311_E0.9980.15
121_S385_L0.9940.14
123_E439_S0.9930.14
55_A205_F0.9930.14
177_S507_D0.9910.14
71_G506_H0.9880.14
92_L339_V0.9810.14
245_Q429_Y0.9790.14
236_D300_N0.9770.14
64_A305_N0.9750.14
232_I467_V0.9730.14
341_E406_D0.9690.14
106_V300_N0.9670.14
298_A384_H0.9640.14
169_A276_R0.9630.14
261_E305_N0.9630.14
348_D364_P0.9610.14
361_L411_D0.9590.14
446_D484_V0.9580.14
476_S479_A0.9580.14
314_I401_S0.9530.14
69_W482_F0.9520.14
361_L471_P0.9510.14
91_E188_E0.9510.14
78_S480_D0.9510.14
178_P486_T0.9490.14
238_N312_Q0.9440.14
61_D77_E0.9420.14
291_Y329_V0.9420.14
286_F496_A0.9420.14
309_S325_T0.9400.14
118_D272_I0.9360.14
181_D452_L0.9350.14
259_D297_D0.9330.14
69_W76_N0.9320.14
65_D110_E0.9290.13
261_E289_Q0.9270.13
446_D487_T0.9230.13
228_A315_H0.9230.13
91_E96_V0.9220.13
486_T489_G0.9210.13
138_R446_D0.9210.13
173_L229_K0.9200.13
335_D395_L0.9170.13
358_F482_F0.9170.13
185_I317_D0.9150.13
187_S201_S0.9140.13
205_F237_G0.9120.13
292_E437_S0.9110.13
199_T310_T0.9060.13
149_E480_D0.9050.13
69_W311_E0.9050.13
398_Y478_Y0.8990.13
144_Q223_Q0.8980.13
350_A356_G0.8950.13
357_L505_V0.8940.13
186_V504_A0.8880.13
286_F433_S0.8880.13
306_P310_T0.8870.13
248_C252_W0.8860.13
312_Q471_P0.8840.13
85_D309_S0.8820.13
75_Y149_E0.8810.13
350_A409_D0.8800.13
327_V410_G0.8760.13
70_E74_W0.8760.13
346_S351_S0.8750.13
329_V502_L0.8740.13
63_D412_K0.8710.13
102_R248_C0.8680.13
104_E252_W0.8670.13
249_E426_E0.8660.13
95_V197_E0.8650.13
69_W110_E0.8640.13
102_R254_C0.8630.13
337_W444_F0.8620.13
282_D412_K0.8590.13
154_V355_A0.8580.12
202_Q408_W0.8580.12
113_Q128_D0.8570.12
171_S177_S0.8490.12
146_V358_F0.8480.12
67_L405_T0.8480.12
290_L298_A0.8420.12
316_P410_G0.8400.12
303_Y316_P0.8400.12
121_S300_N0.8390.12
253_D282_D0.8380.12
345_D434_T0.8380.12
192_S259_D0.8360.12
61_D74_W0.8350.12
164_L342_T0.8340.12
112_N249_E0.8330.12
177_S182_R0.8330.12
182_R295_G0.8320.12
160_A413_L0.8310.12
393_D401_S0.8300.12
143_H397_L0.8290.12
203_E235_G0.8270.12
203_E234_E0.8270.12
235_G280_Y0.8270.12
234_E353_G0.8270.12
203_E206_H0.8270.12
234_E283_G0.8270.12
234_E280_Y0.8270.12
280_Y353_G0.8270.12
280_Y283_G0.8270.12
206_H353_G0.8270.12
206_H234_E0.8270.12
203_E353_G0.8270.12
203_E283_G0.8270.12
235_G353_G0.8270.12
206_H235_G0.8270.12
206_H280_Y0.8270.12
235_G283_G0.8270.12
206_H283_G0.8270.12
283_G353_G0.8270.12
203_E280_Y0.8270.12
93_H433_S0.8250.12
99_S155_G0.8240.12
244_Y408_W0.8230.12
67_L357_L0.8220.12
205_F224_E0.8210.12
122_R331_D0.8200.12
205_F238_N0.8180.12
77_E300_N0.8170.12
86_G348_D0.8160.12
205_F306_P0.8150.12
310_T327_V0.8140.12
58_S71_G0.8130.12
201_S348_D0.8110.12
277_L334_T0.8080.12
243_R286_F0.8060.12
102_R252_W0.8030.12
248_C416_Y0.8020.12
184_A213_F0.8010.12
312_Q482_F0.8000.12
97_N480_D0.7990.12
162_D194_Q0.7980.12
278_Q306_P0.7980.12
104_E111_F0.7970.12
144_Q147_K0.7970.12
196_D501_Q0.7970.12
412_K420_D0.7940.12
147_K227_N0.7880.12
89_D281_S0.7850.12
61_D110_E0.7810.11
70_E77_E0.7810.11
224_E351_S0.7810.11
147_K164_L0.7800.11
402_H405_T0.7780.11
150_A433_S0.7770.11
245_Q505_V0.7730.11
146_V356_G0.7730.11
383_T398_Y0.7730.11
174_G211_H0.7720.11
85_D441_A0.7720.11
216_S393_D0.7710.11
232_I300_N0.7710.11
92_L220_Q0.7700.11
109_L213_F0.7680.11
236_D256_R0.7680.11
69_W73_Y0.7670.11
303_Y333_S0.7670.11
110_E482_F0.7650.11
113_Q488_E0.7650.11
63_D99_S0.7650.11
112_N326_P0.7650.11
294_G484_V0.7640.11
199_T366_Y0.7630.11
113_Q443_E0.7630.11
294_G471_P0.7620.11
273_A364_P0.7620.11
120_I246_Q0.7620.11
92_L413_L0.7600.11
157_D229_K0.7590.11
223_Q356_G0.7580.11
336_A507_D0.7560.11
250_R328_S0.7550.11
201_S269_H0.7550.11
297_D309_S0.7550.11
102_R296_W0.7520.11
140_G341_E0.7510.11
119_V506_H0.7510.11
199_T415_P0.7480.11
202_Q215_T0.7470.11
336_A466_N0.7460.11
231_G269_H0.7460.11
411_D482_F0.7440.11
250_R329_V0.7440.11
322_D480_D0.7430.11
278_Q364_P0.7420.11
74_W187_S0.7410.11
204_L207_G0.7410.11
82_D476_S0.7410.11
118_D192_S0.7390.11
483_R506_H0.7390.11
285_V317_D0.7370.11
69_W495_N0.7370.11
447_A458_E0.7360.11
236_D298_A0.7340.11
236_D413_L0.7320.11
125_F404_Y0.7320.11
288_E395_L0.7320.11
103_V150_A0.7310.11
405_T427_T0.7280.11
240_V328_S0.7280.11
322_D436_D0.7190.11
65_D482_F0.7190.11
466_N507_D0.7180.11
184_A410_G0.7170.11
459_R500_D0.7160.11
336_A501_Q0.7150.11
246_Q263_P0.7140.11
120_I262_S0.7130.11
80_S330_A0.7100.11
220_Q310_T0.7080.11
75_Y187_S0.7070.11
147_K356_G0.7060.11
286_F348_D0.7060.11
338_T466_N0.7050.11
316_P506_H0.7020.11
277_L332_T0.7010.10
100_M115_V0.7000.10
73_Y284_P0.6950.10
254_C416_Y0.6950.10
163_V272_I0.6940.10
385_L507_D0.6940.10
125_F186_V0.6940.10
237_G361_L0.6920.10
394_T486_T0.6910.10
420_D457_A0.6900.10
141_T405_T0.6880.10
303_Y410_G0.6870.10
143_H356_G0.6870.10
295_G359_T0.6860.10
106_V255_L0.6830.10
144_Q340_P0.6830.10
208_L316_P0.6810.10
253_D290_L0.6770.10
145_N357_L0.6770.10
155_G476_S0.6760.10
437_S493_I0.6750.10
365_S404_Y0.6750.10
312_Q406_D0.6700.10
401_S433_S0.6700.10
402_H409_D0.6680.10
339_V506_H0.6670.10
68_G254_C0.6660.10
192_S249_E0.6660.10
191_E274_L0.6640.10
188_E498_T0.6640.10
273_A332_T0.6600.10
148_W356_G0.6580.10
85_D116_P0.6580.10
210_T215_T0.6570.10
340_P427_T0.6570.10
100_M231_G0.6560.10
273_A325_T0.6550.10
310_T313_T0.6550.10
93_H185_I0.6540.10
98_R284_P0.6530.10
301_D447_A0.6510.10
334_T504_A0.6500.10
217_E498_T0.6490.10
101_A200_L0.6440.10
364_P454_Y0.6420.10
227_N310_T0.6420.10
152_F314_I0.6420.10
186_V255_L0.6410.10
310_T472_D0.6400.10
220_Q328_S0.6380.10
352_F506_H0.6370.10
107_R296_W0.6360.10
89_D189_D0.6360.10
112_N427_T0.6350.10
195_M456_G0.6340.10
196_D456_G0.6340.10
201_S410_G0.6330.10
278_Q313_T0.6330.10
101_A296_W0.6330.10
183_I451_L0.6320.10
403_P446_D0.6300.10
201_S286_F0.6300.10
354_E455_H0.6290.10
312_Q480_D0.6290.10
77_E269_H0.6290.10
137_T442_T0.6280.10
341_E415_P0.6260.10
212_R441_A0.6220.10
68_G337_W0.6200.10
255_L487_T0.6200.10
208_L213_F0.6180.10
254_C296_W0.6160.10
138_R504_A0.6160.10
122_R298_A0.6150.10
276_R351_S0.6140.10
232_I313_T0.6140.10
66_T414_V0.6130.09
104_E254_C0.6130.09
300_N385_L0.6130.09
98_R102_R0.6120.09
262_S276_R0.6110.09
111_F254_C0.6110.09
286_F316_P0.6110.09
231_G337_W0.6100.09
167_N276_R0.6100.09
248_C296_W0.6100.09
278_Q413_L0.6050.09
323_E433_S0.6030.09
50_Q298_A0.6010.09
138_R438_A0.6010.09
490_R502_L0.6000.09
93_H313_T0.5970.09
187_S505_V0.5970.09
146_V354_E0.5970.09
301_D343_G0.5960.09
335_D465_P0.5940.09
153_M314_I0.5940.09
106_V493_I0.5940.09
138_R157_D0.5910.09
309_S312_Q0.5900.09
66_T478_Y0.5900.09
72_G75_Y0.5900.09
142_L160_A0.5890.09
148_W223_Q0.5870.09
54_N459_R0.5870.09
82_D95_V0.5850.09
502_L507_D0.5830.09
110_E436_D0.5820.09
437_S489_G0.5820.09
122_R209_Q0.5820.09
62_P75_Y0.5820.09
277_L490_R0.5810.09
68_G248_C0.5800.09
219_N467_V0.5790.09
343_G499_V0.5790.09
214_N218_L0.5770.09
185_I361_L0.5770.09
148_W362_W0.5760.09
367_V395_L0.5750.09
350_A357_L0.5750.09
269_H360_M0.5750.09
221_S253_D0.5740.09
139_N233_I0.5740.09
109_L300_N0.5730.09
176_Y209_Q0.5730.09
494_V497_P0.5720.09
69_W75_Y0.5690.09
62_P69_W0.5680.09
185_I352_F0.5670.09
93_H97_N0.5660.09
173_L456_G0.5660.09
244_Y444_F0.5660.09
202_Q232_I0.5660.09
330_A426_E0.5630.09
103_V413_L0.5620.09
203_E307_P0.5620.09
307_P353_G0.5620.09
235_G307_P0.5620.09
234_E307_P0.5620.09
283_G307_P0.5620.09
206_H307_P0.5620.09
280_Y307_P0.5620.09
90_S309_S0.5620.09
52_G130_A0.5610.09
80_S412_K0.5610.09
115_V228_A0.5610.09
342_T498_T0.5610.09
200_L248_C0.5590.09
238_N297_D0.5570.09
81_V149_E0.5560.09
157_D225_L0.5560.09
312_Q409_D0.5550.09
175_Y459_R0.5540.09
307_P411_D0.5540.09
92_L306_P0.5520.09
262_S412_K0.5500.09
72_G111_F0.5500.09
249_E293_S0.5500.09
62_P96_V0.5490.09
108_G394_T0.5480.09
87_L180_E0.5480.09
167_N354_E0.5460.09
263_P298_A0.5450.09
257_P335_D0.5440.09
77_E97_N0.5430.09
397_L450_E0.5430.09
69_W149_E0.5430.09
152_F269_H0.5430.09
227_N275_T0.5420.09
51_P106_V0.5410.09
329_V334_T0.5390.09
123_E424_T0.5390.09
100_M416_Y0.5380.09
252_W416_Y0.5360.09
330_A504_A0.5360.09
438_A493_I0.5350.09
232_I477_G0.5350.09
160_A396_D0.5350.09
354_E411_D0.5340.09
61_D480_D0.5340.09
345_D507_D0.5330.09
102_R416_Y0.5320.09
501_Q505_V0.5310.09
286_F434_T0.5300.09
82_D467_V0.5290.09
147_K223_Q0.5290.09
97_N168_R0.5280.09
196_D278_Q0.5280.09
354_E428_A0.5260.09
200_L448_Y0.5230.09
110_E149_E0.5230.09
63_D76_N0.5230.09
243_R458_E0.5220.09
111_F429_Y0.5220.09
65_D115_V0.5220.09
161_I437_S0.5210.09
340_P457_A0.5200.09
356_G427_T0.5200.09
199_T436_D0.5190.09
121_S128_D0.5180.09
294_G352_F0.5170.09
241_D413_L0.5160.09
70_E223_Q0.5150.08
271_G427_T0.5140.08
65_D436_D0.5120.08
128_D300_N0.5110.08
180_E340_P0.5100.08
143_H148_W0.5090.08
115_V152_F0.5090.08
311_E409_D0.5070.08
109_L507_D0.5050.08
143_H195_M0.5050.08
224_E350_A0.5040.08
115_V237_G0.5040.08
158_E201_S0.5030.08
110_E311_E0.5020.08
398_Y438_A0.5010.08
164_L325_T0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cmnA 1 0.5049 86.8 0.973 Contact Map
4arfA 2 0.6601 67.4 0.978 Contact Map
3vtgA 1 0.2692 63.2 0.978 Contact Map
1c7kA 1 0.2554 60.6 0.978 Contact Map
3edhA 1 0.2731 56 0.979 Contact Map
4in9A 1 0.2888 49.7 0.98 Contact Map
1hv5A 2 0.2927 48.6 0.98 Contact Map
1cgeA 1 0.2986 44.3 0.98 Contact Map
1i76A 1 0.2967 42.1 0.981 Contact Map
2ejqA 1 0.22 36.9 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0129 seconds.