Q9HMH3 - HALSA - GREMLIN Contacts

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Q9HMH3 - Uncharacterized protein

UniProt:	Q9HMH3	Sequences: MRITGPYQSFARYETALLGFLSHASGMATAALAARRAAPDSHLLSFGARHVHPSIAAVVERAALIGGFDGFSHVAAGDVLDREPGGTMPHALVICFGRGNQEAAWRAFTDGVGDDVPRIALCDTYSDEKDEVLRAVDELGDDLDAVRLDTTSSRRGDFRHIAREVQWALDAGGNSDVSVFVSGGLTPTDLRGLRDVVDGFGVGGFVSNATPVDFGLDIVEVAGEPAAKRGKLSGTKAVYRTPDGGHHVALASQPAPADATALLEPLLVDGTVSMAFDIDDAAARARQDARAVSFRQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	296 (238)
Sequences:	3193 (1364)
Seq/√Len:	88.4

ECOLI - PNCB
BACSU - PNCB
HALSA - Q9HMH3
SULSO - Q980F6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
77_G	84_P	4.617	1.00
146_V	165_V	4.492	1.00
100_N	103_A	3.753	1.00
5_G	10_F	2.957	1.00
119_I	145_A	2.823	1.00
48_A	56_A	2.822	1.00
106_R	141_D	2.791	1.00
70_G	85_G	2.586	1.00
122_C	165_V	2.500	1.00
167_W	171_A	2.494	1.00
194_R	200_F	2.473	1.00
75_A	78_D	2.423	1.00
178_S	198_D	2.348	1.00
164_E	167_W	2.343	1.00
180_F	199_G	2.317	1.00
166_Q	170_D	2.307	1.00
140_G	174_N	2.296	1.00
96_F	107_A	2.259	1.00
44_L	85_G	2.251	1.00
35_R	69_D	2.239	1.00
35_R	40_D	2.217	1.00
189_D	192_G	2.192	1.00
102_E	137_D	2.179	1.00
122_C	132_V	2.105	1.00
102_E	106_R	2.078	1.00
6_P	9_S	2.073	1.00
43_L	68_F	2.052	1.00
191_R	195_D	2.031	1.00
4_T	235_T	1.995	1.00
131_E	134_R	1.992	1.00
41_S	194_R	1.973	1.00
162_A	181_V	1.957	1.00
59_V	207_S	1.953	1.00
48_A	73_H	1.930	1.00
106_R	110_D	1.917	1.00
122_C	146_V	1.916	1.00
60_E	76_A	1.904	1.00
122_C	168_A	1.876	1.00
64_L	82_R	1.868	1.00
41_S	200_F	1.856	1.00
190_L	202_V	1.819	1.00
75_A	79_V	1.789	1.00
142_D	176_D	1.755	1.00
34_A	43_L	1.679	1.00
243_D	246_H	1.636	1.00
64_L	83_E	1.635	1.00
42_H	69_D	1.622	1.00
220_E	223_G	1.613	1.00
57_A	79_V	1.609	1.00
35_R	43_L	1.588	1.00
131_E	135_A	1.535	1.00
184_G	213_D	1.521	1.00
88_M	93_V	1.515	1.00
109_T	118_R	1.513	1.00
181_V	197_V	1.507	1.00
31_A	68_F	1.504	1.00
3_I	216_L	1.482	1.00
129_K	164_E	1.472	0.99
139_L	143_L	1.469	0.99
130_D	133_L	1.459	0.99
186_T	205_F	1.439	0.99
30_A	33_A	1.438	0.99
138_E	141_D	1.436	0.99
103_A	107_A	1.420	0.99
168_A	172_G	1.400	0.99
44_L	70_G	1.400	0.99
15_T	48_A	1.358	0.99
126_S	129_K	1.355	0.99
136_V	168_A	1.320	0.99
53_P	75_A	1.314	0.99
131_E	136_V	1.302	0.99
244_G	247_H	1.297	0.99
7_Y	95_C	1.296	0.99
103_A	106_R	1.258	0.98
131_E	138_E	1.231	0.98
23_H	27_M	1.226	0.98
134_R	138_E	1.226	0.98
243_D	247_H	1.223	0.98
135_A	138_E	1.218	0.98
134_R	137_D	1.198	0.98
85_G	199_G	1.194	0.98
165_V	168_A	1.190	0.98
132_V	165_V	1.179	0.97
239_Y	249_A	1.176	0.97
32_L	36_R	1.173	0.97
145_A	178_S	1.172	0.97
143_L	177_V	1.166	0.97
97_G	100_N	1.144	0.97
7_Y	11_A	1.142	0.97
159_R	163_R	1.141	0.97
92_L	96_F	1.141	0.97
102_E	134_R	1.133	0.97
35_R	39_P	1.130	0.97
133_L	168_A	1.129	0.97
132_V	168_A	1.128	0.97
109_T	142_D	1.115	0.96
38_A	43_L	1.109	0.96
34_A	202_V	1.109	0.96
168_A	171_A	1.105	0.96
145_A	177_V	1.086	0.96
20_F	58_V	1.086	0.96
133_L	136_V	1.081	0.96
33_A	187_P	1.076	0.96
131_E	140_G	1.070	0.96
106_R	138_E	1.069	0.96
107_A	110_D	1.055	0.95
119_I	180_F	1.051	0.95
2_R	235_T	1.048	0.95
51_V	59_V	1.046	0.95
130_D	134_R	1.044	0.95
204_G	211_P	1.029	0.95
44_L	199_G	1.019	0.94
37_A	191_R	1.013	0.94
23_H	59_V	1.009	0.94
3_I	17_L	1.006	0.94
24_A	62_A	1.003	0.94
57_A	80_L	0.996	0.93
22_S	214_F	0.989	0.93
44_L	180_F	0.988	0.93
103_A	110_D	0.979	0.93
148_L	161_I	0.979	0.93
105_W	120_A	0.978	0.93
170_D	196_V	0.976	0.93
52_H	55_I	0.974	0.93
181_V	193_L	0.972	0.93
74_V	84_P	0.971	0.93
41_S	198_D	0.959	0.92
127_D	148_L	0.955	0.92
30_A	34_A	0.954	0.92
109_T	138_E	0.941	0.91
243_D	248_V	0.930	0.91
3_I	10_F	0.929	0.91
166_Q	198_D	0.929	0.91
34_A	37_A	0.920	0.90
244_G	248_V	0.917	0.90
16_A	20_F	0.914	0.90
174_N	177_V	0.914	0.90
148_L	181_V	0.911	0.90
31_A	35_R	0.909	0.90
136_V	140_G	0.908	0.90
15_T	56_A	0.905	0.90
43_L	190_L	0.897	0.89
183_G	189_D	0.892	0.89
187_P	205_F	0.875	0.88
97_G	103_A	0.875	0.88
245_G	248_V	0.874	0.88
95_C	221_V	0.873	0.88
160_H	164_E	0.873	0.88
159_R	193_L	0.872	0.88
55_I	58_V	0.864	0.87
31_A	66_G	0.862	0.87
114_D	142_D	0.861	0.87
188_T	192_G	0.850	0.87
160_H	192_G	0.848	0.86
33_A	37_A	0.847	0.86
13_Y	24_A	0.845	0.86
160_H	163_R	0.842	0.86
180_F	183_G	0.837	0.86
184_G	204_G	0.835	0.86
57_A	75_A	0.834	0.86
127_D	161_I	0.832	0.85
231_K	235_T	0.830	0.85
18_L	22_S	0.827	0.85
47_G	51_V	0.811	0.84
122_C	148_L	0.810	0.84
68_F	206_V	0.810	0.84
35_R	68_F	0.802	0.83
101_Q	105_W	0.794	0.83
30_A	37_A	0.791	0.82
162_A	179_V	0.789	0.82
133_L	137_D	0.786	0.82
47_G	207_S	0.786	0.82
25_S	214_F	0.785	0.82
23_H	51_V	0.784	0.82
71_F	77_G	0.778	0.81
236_K	239_Y	0.776	0.81
184_G	211_P	0.771	0.81
163_R	196_V	0.770	0.81
22_S	26_G	0.768	0.81
241_T	249_A	0.766	0.80
129_K	133_L	0.764	0.80
133_L	140_G	0.762	0.80
41_S	190_L	0.761	0.80
50_H	204_G	0.761	0.80
20_F	53_P	0.751	0.79
94_I	184_G	0.751	0.79
166_Q	179_V	0.747	0.79
150_T	217_D	0.747	0.79
130_D	135_A	0.746	0.79
71_F	76_A	0.743	0.78
51_V	207_S	0.740	0.78
30_A	187_P	0.736	0.78
31_A	34_A	0.734	0.77
85_G	180_F	0.733	0.77
113_G	142_D	0.733	0.77
159_R	162_A	0.732	0.77
76_A	82_R	0.725	0.77
63_A	68_F	0.724	0.77
185_L	193_L	0.724	0.77
132_V	135_A	0.722	0.76
33_A	38_A	0.719	0.76
97_G	224_E	0.719	0.76
118_R	143_L	0.718	0.76
184_G	205_F	0.711	0.75
29_T	33_A	0.711	0.75
101_Q	134_R	0.708	0.75
166_Q	176_D	0.706	0.75
136_V	172_G	0.704	0.74
242_P	247_H	0.704	0.74
192_G	195_D	0.704	0.74
97_G	226_A	0.702	0.74
241_T	244_G	0.696	0.74
230_G	235_T	0.696	0.74
35_R	42_H	0.696	0.74
159_R	192_G	0.693	0.73
63_A	206_V	0.691	0.73
131_E	139_L	0.690	0.73
140_G	143_L	0.689	0.73
58_V	80_L	0.688	0.73
57_A	61_R	0.684	0.72
131_E	141_D	0.684	0.72
54_S	58_V	0.683	0.72
106_R	139_L	0.682	0.72
53_P	94_I	0.681	0.72
119_I	177_V	0.678	0.72
162_A	196_V	0.676	0.71
24_A	58_V	0.671	0.71
106_R	137_D	0.670	0.71
112_V	115_D	0.669	0.71
136_V	139_L	0.669	0.71
48_A	53_P	0.669	0.71
11_A	91_A	0.667	0.70
20_F	24_A	0.657	0.69
46_F	127_D	0.656	0.69
39_P	194_R	0.656	0.69
184_G	209_A	0.654	0.69
170_D	175_S	0.651	0.69
25_S	212_V	0.651	0.69
7_Y	10_F	0.651	0.69
237_A	249_A	0.650	0.69
146_V	179_V	0.649	0.68
43_L	202_V	0.647	0.68
148_L	162_A	0.647	0.68
46_F	213_D	0.646	0.68
132_V	136_V	0.646	0.68
43_L	69_D	0.645	0.68
178_S	199_G	0.642	0.68
17_L	216_L	0.641	0.67
94_I	227_A	0.641	0.67
239_Y	247_H	0.640	0.67
62_A	66_G	0.637	0.67
28_A	62_A	0.637	0.67
15_T	18_L	0.635	0.67
37_A	40_D	0.629	0.66
133_L	138_E	0.628	0.66
87_T	90_H	0.628	0.66
176_D	244_G	0.625	0.65
227_A	230_G	0.622	0.65
242_P	246_H	0.618	0.65
206_V	215_G	0.616	0.64
37_A	185_L	0.616	0.64
115_D	144_D	0.615	0.64
119_I	144_D	0.614	0.64
55_I	66_G	0.614	0.64
114_D	144_D	0.612	0.64
46_F	70_G	0.608	0.63
163_R	232_L	0.597	0.62
33_A	186_T	0.597	0.62
71_F	150_T	0.597	0.62
25_S	29_T	0.594	0.62
97_G	223_G	0.590	0.61
132_V	146_V	0.589	0.61
64_L	81_D	0.589	0.61
166_Q	196_V	0.589	0.61
108_F	213_D	0.588	0.61
181_V	230_G	0.586	0.61
109_T	113_G	0.586	0.61
242_P	248_V	0.586	0.61
92_L	112_V	0.585	0.60
45_S	89_P	0.584	0.60
62_A	65_I	0.584	0.60
46_F	87_T	0.583	0.60
243_D	249_A	0.583	0.60
142_D	175_S	0.583	0.60
77_G	83_E	0.582	0.60
93_V	104_A	0.581	0.60
5_G	13_Y	0.577	0.59
6_P	13_Y	0.575	0.59
55_I	183_G	0.574	0.59
142_D	174_N	0.571	0.59
61_R	65_I	0.566	0.58
119_I	143_L	0.564	0.58
39_P	191_R	0.559	0.57
115_D	119_I	0.556	0.57
230_G	233_S	0.556	0.57
96_F	125_Y	0.553	0.56
220_E	235_T	0.552	0.56
30_A	208_N	0.552	0.56
5_G	16_A	0.551	0.56
34_A	190_L	0.550	0.56
108_F	119_I	0.550	0.56
45_S	205_F	0.549	0.56
164_E	171_A	0.549	0.56
188_T	205_F	0.548	0.55
18_L	216_L	0.547	0.55
133_L	141_D	0.546	0.55
158_F	193_L	0.546	0.55
186_T	189_D	0.546	0.55
12_R	218_I	0.544	0.55
45_S	71_F	0.544	0.55
101_Q	158_F	0.543	0.55
229_R	232_L	0.543	0.55
88_M	104_A	0.541	0.55
241_T	247_H	0.540	0.54
148_L	226_A	0.539	0.54
36_R	39_P	0.539	0.54
220_E	225_P	0.539	0.54
88_M	208_N	0.539	0.54
32_L	204_G	0.538	0.54
23_H	52_H	0.537	0.54
188_T	191_R	0.537	0.54
19_G	23_H	0.535	0.54
45_S	50_H	0.534	0.54
46_F	89_P	0.534	0.54
43_L	148_L	0.534	0.54
130_D	136_V	0.532	0.53
144_D	177_V	0.532	0.53
7_Y	221_V	0.531	0.53
16_A	53_P	0.530	0.53
176_D	243_D	0.529	0.53
166_Q	178_S	0.528	0.53
14_E	201_G	0.528	0.53
89_P	162_A	0.527	0.53
13_Y	58_V	0.524	0.52
239_Y	243_D	0.524	0.52
146_V	168_A	0.523	0.52
49_R	90_H	0.522	0.52
129_K	168_A	0.520	0.52
92_L	107_A	0.520	0.52
57_A	60_E	0.519	0.52
64_L	68_F	0.517	0.51
47_G	50_H	0.515	0.51
208_N	212_V	0.514	0.51
23_H	58_V	0.514	0.51
94_I	97_G	0.513	0.51
19_G	46_F	0.513	0.51
71_F	82_R	0.513	0.51
55_I	60_E	0.509	0.50
63_A	66_G	0.509	0.50
5_G	148_L	0.507	0.50
133_L	171_A	0.507	0.50
102_E	138_E	0.507	0.50
112_V	118_R	0.506	0.50
44_L	218_I	0.505	0.50
135_A	139_L	0.504	0.50
175_S	245_G	0.502	0.49
34_A	186_T	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4yubA	2	0.9459	100	0.198	Contact Map
2i14A	5	0.9932	100	0.246	Contact Map
2i1oA	5	0.9764	100	0.271	Contact Map
4mzyA	2	0.9662	100	0.286	Contact Map
1ybeA	2	0.8108	100	0.321	Contact Map
4lvfA	2	0.9493	100	0.323	Contact Map
3os4A	1	0.8074	100	0.323	Contact Map
2im5A	1	0.8142	100	0.325	Contact Map
1yirA	1	0.8007	100	0.332	Contact Map
1vlpA	1	0.8243	100	0.334	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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