GREMLIN Database
Y2543 - Protein VNG_2543C
UniProt: Q9HMH2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (173)
Sequences: 1178 (965)
Seq/√Len: 73.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_W190_F5.4321.00
122_L140_A4.0921.00
104_V112_I3.8391.00
25_V95_A3.5411.00
142_D147_H3.4261.00
117_C192_G3.2951.00
150_M168_R3.2951.00
92_I96_S3.0961.00
54_L104_V3.0931.00
142_D186_M2.9961.00
161_S164_E2.8511.00
120_S191_E2.7601.00
123_V189_L2.7361.00
136_V191_E2.5681.00
17_T87_I2.5601.00
124_L186_M2.5501.00
70_H149_W2.3061.00
142_D188_T2.2691.00
25_V114_V2.2421.00
93_E97_E2.0481.00
28_F96_S1.9631.00
21_A87_I1.8601.00
137_H191_E1.8451.00
50_A83_L1.8021.00
20_L88_V1.7911.00
50_A149_W1.7801.00
150_M169_T1.7781.00
27_A31_N1.7291.00
29_V106_D1.6651.00
115_S153_T1.6631.00
137_H189_L1.6531.00
153_T192_G1.6471.00
133_E136_V1.6070.99
155_P165_Y1.6050.99
141_I169_T1.5910.99
24_S88_V1.5610.99
127_D130_E1.5430.99
50_A86_A1.5300.99
28_F92_I1.5280.99
20_L24_S1.5060.99
133_E137_H1.4750.99
25_V91_A1.4700.99
96_S104_V1.4580.99
155_P160_W1.4530.99
29_V96_S1.4050.99
89_E97_E1.3760.98
55_E115_S1.3690.98
26_E30_Q1.3320.98
54_L112_I1.2920.97
120_S193_Q1.2850.97
60_R111_N1.2690.97
70_H140_A1.2510.97
64_R108_E1.2280.96
30_Q106_D1.2200.96
126_D131_D1.2140.96
124_L188_T1.2050.96
170_C185_V1.1940.96
71_G147_H1.1920.96
170_C179_A1.1750.95
25_V96_S1.1520.95
54_L114_V1.1520.95
123_V191_E1.1240.94
167_D187_V1.1210.94
29_V114_V1.0890.93
59_G111_N1.0870.93
87_I118_T1.0750.93
24_S27_A1.0720.93
18_V22_R1.0680.93
143_G184_D1.0680.93
27_A35_E1.0600.92
18_V116_V1.0570.92
14_G193_Q1.0520.92
70_H190_F1.0470.92
166_L187_V1.0250.91
26_E109_L1.0080.90
81_Q89_E1.0040.90
24_S92_I0.9760.89
143_G185_V0.9540.88
29_V109_L0.9520.87
141_I187_V0.9480.87
139_V169_T0.9470.87
131_D189_L0.9460.87
158_N168_R0.9420.87
34_R92_I0.9170.85
29_V104_V0.9130.85
139_V148_G0.9020.85
170_C173_A0.9010.84
82_Q85_H0.8980.84
15_A195_F0.8950.84
115_S194_V0.8930.84
40_M43_A0.8890.84
135_G153_T0.8770.83
22_R114_V0.8630.82
53_R157_E0.8580.81
134_L162_V0.8540.81
53_R154_L0.8500.81
105_E173_A0.8490.81
143_G179_A0.8390.80
167_D177_D0.8360.80
81_Q86_A0.8350.80
59_G112_I0.8300.79
125_T131_D0.8250.79
150_M158_N0.8110.78
53_R117_C0.8100.78
86_A90_A0.8080.77
125_T128_P0.8010.77
117_C154_L0.8000.77
132_I137_H0.7940.76
167_D178_G0.7920.76
116_V141_I0.7860.75
49_S72_S0.7830.75
35_E88_V0.7820.75
24_S91_A0.7800.75
69_A81_Q0.7760.74
24_S35_E0.7740.74
20_L84_G0.7670.74
133_E162_V0.7670.74
52_V90_A0.7640.73
15_A19_E0.7610.73
17_T43_A0.7610.73
69_A90_A0.7580.73
146_Q173_A0.7570.73
125_T189_L0.7500.72
45_Y84_G0.7480.72
25_V54_L0.7470.72
59_G104_V0.7460.72
132_I162_V0.7410.71
49_S86_A0.7340.70
46_N83_L0.7340.70
14_G116_V0.7310.70
54_L95_A0.7290.70
154_L165_Y0.7270.70
84_G87_I0.7240.69
154_L157_E0.7230.69
155_P159_D0.7230.69
101_G151_Y0.7180.69
127_D131_D0.7130.68
155_P162_V0.7070.67
61_G113_R0.7060.67
150_M190_F0.7050.67
51_F67_A0.6990.67
13_D43_A0.6990.67
49_S195_F0.6950.66
94_A108_E0.6930.66
179_A185_V0.6890.65
81_Q85_H0.6870.65
26_E32_G0.6860.65
166_L173_A0.6810.65
141_I158_N0.6810.65
17_T44_F0.6800.64
23_E32_G0.6750.64
89_E93_E0.6740.64
117_C153_T0.6700.63
96_S106_D0.6690.63
21_A24_S0.6670.63
146_Q155_P0.6630.62
22_R26_E0.6620.62
141_I148_G0.6560.62
107_A110_P0.6550.62
115_S173_A0.6510.61
113_R196_R0.6470.61
156_V165_Y0.6460.60
128_P166_L0.6420.60
91_A96_S0.6400.60
164_E168_R0.6380.60
36_Q110_P0.6380.60
55_E113_R0.6380.60
157_E168_R0.6360.59
153_T194_V0.6360.59
27_A32_G0.6350.59
185_V192_G0.6290.58
100_C151_Y0.6270.58
20_L87_I0.6270.58
135_G157_E0.6260.58
142_D178_G0.6240.58
99_S102_S0.6240.58
23_E27_A0.6230.58
179_A183_E0.6220.58
125_T134_L0.6200.57
70_H139_V0.6200.57
132_I139_V0.6140.57
25_V28_F0.6130.56
106_D126_D0.6130.56
97_E147_H0.6090.56
124_L176_P0.6090.56
117_C194_V0.6090.56
132_I165_Y0.6070.56
143_G146_Q0.6040.55
25_V92_I0.6040.55
59_G105_E0.5980.55
158_N169_T0.5970.55
51_F172_K0.5960.54
166_L170_C0.5960.54
12_E23_E0.5900.54
49_S149_W0.5890.54
72_S120_S0.5890.54
190_F194_V0.5870.53
140_A149_W0.5860.53
115_S120_S0.5850.53
41_R185_V0.5820.53
24_S87_I0.5800.52
139_V189_L0.5790.52
100_C119_V0.5780.52
134_L160_W0.5750.52
133_E191_E0.5750.52
16_R41_R0.5740.52
12_E178_G0.5720.51
145_G178_G0.5720.51
170_C176_P0.5660.51
148_G169_T0.5630.50
143_G182_D0.5630.50
90_A160_W0.5620.50
92_I113_R0.5600.50
55_E196_R0.5570.50
103_E123_V0.5560.49
176_P179_A0.5530.49
83_L89_E0.5530.49
24_S97_E0.5510.49
150_M154_L0.5500.49
125_T187_V0.5480.48
99_S150_M0.5450.48
70_H86_A0.5420.48
42_D60_R0.5390.47
70_H122_L0.5380.47
27_A30_Q0.5370.47
16_R19_E0.5370.47
170_C181_Q0.5360.47
139_V166_L0.5350.47
71_G120_S0.5350.47
64_R101_G0.5340.47
176_P184_D0.5340.47
177_D183_E0.5330.47
90_A93_E0.5330.47
71_G122_L0.5330.47
109_L112_I0.5250.46
66_C154_L0.5250.46
55_E61_G0.5230.45
51_F66_C0.5220.45
49_S159_D0.5220.45
173_A188_T0.5190.45
118_T193_Q0.5180.45
19_E178_G0.5180.45
163_F167_D0.5170.45
175_L180_W0.5140.44
29_V95_A0.5140.44
107_A163_F0.5140.44
148_G187_V0.5140.44
63_L100_C0.5130.44
187_V192_G0.5130.44
48_T86_A0.5130.44
143_G169_T0.5120.44
150_M155_P0.5120.44
14_G112_I0.5110.44
179_A189_L0.5080.44
155_P169_T0.5070.43
90_A140_A0.5070.43
171_R177_D0.5050.43
25_V93_E0.5040.43
66_C172_K0.5010.43
69_A86_A0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wscA 1 0.9524 100 0.177 Contact Map
1vajA 1 0.9333 100 0.184 Contact Map
1zq7A 4 0.9143 100 0.187 Contact Map
2d2rA 2 0.2952 61.8 0.944 Contact Map
3sgvB 2 0.3571 14.3 0.96 Contact Map
4myzA 4 0.2524 6.9 0.966 Contact Map
4gmvA 1 0.4048 6.3 0.966 Contact Map
3ewtE 1 0.0667 5.2 0.968 Contact Map
2og0A 1 0.2238 4.9 0.968 Contact Map
3tcaA 1 0.3333 4.9 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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