Y2543 - HALSA - GREMLIN Contacts

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Y2543 - Protein VNG_2543C

UniProt:	Q9HMH2	Sequences: MGQGQSVILSFEDGARTVELARESVEAFVQNGQREQPGSMRDAFYNRTSAFVRLESTRGRGRLRGCAGAHGSIHELGNHDQQLGHAIVEAAIEAASEASCGSEVEDAELPNIRVSVCTVSNLVLTDDPIEDIELGVHGVAIDGDGQHGWMYPTLPVENDWSVFEYLDRTCRKANLPDGAWQDEDVMVTLFEGQVFRETGDEDDPVEELTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	210 (173)
Sequences:	1178 (965)
Seq/√Len:	73.4

HALSA - Y2543
SULSO - Y193

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_W	190_F	5.432	1.00
122_L	140_A	4.092	1.00
104_V	112_I	3.839	1.00
25_V	95_A	3.541	1.00
142_D	147_H	3.426	1.00
117_C	192_G	3.295	1.00
150_M	168_R	3.295	1.00
92_I	96_S	3.096	1.00
54_L	104_V	3.093	1.00
142_D	186_M	2.996	1.00
161_S	164_E	2.851	1.00
120_S	191_E	2.760	1.00
123_V	189_L	2.736	1.00
136_V	191_E	2.568	1.00
17_T	87_I	2.560	1.00
124_L	186_M	2.550	1.00
70_H	149_W	2.306	1.00
142_D	188_T	2.269	1.00
25_V	114_V	2.242	1.00
93_E	97_E	2.048	1.00
28_F	96_S	1.963	1.00
21_A	87_I	1.860	1.00
137_H	191_E	1.845	1.00
50_A	83_L	1.802	1.00
20_L	88_V	1.791	1.00
50_A	149_W	1.780	1.00
150_M	169_T	1.778	1.00
27_A	31_N	1.729	1.00
29_V	106_D	1.665	1.00
115_S	153_T	1.663	1.00
137_H	189_L	1.653	1.00
153_T	192_G	1.647	1.00
133_E	136_V	1.607	0.99
155_P	165_Y	1.605	0.99
141_I	169_T	1.591	0.99
24_S	88_V	1.561	0.99
127_D	130_E	1.543	0.99
50_A	86_A	1.530	0.99
28_F	92_I	1.528	0.99
20_L	24_S	1.506	0.99
133_E	137_H	1.475	0.99
25_V	91_A	1.470	0.99
96_S	104_V	1.458	0.99
155_P	160_W	1.453	0.99
29_V	96_S	1.405	0.99
89_E	97_E	1.376	0.98
55_E	115_S	1.369	0.98
26_E	30_Q	1.332	0.98
54_L	112_I	1.292	0.97
120_S	193_Q	1.285	0.97
60_R	111_N	1.269	0.97
70_H	140_A	1.251	0.97
64_R	108_E	1.228	0.96
30_Q	106_D	1.220	0.96
126_D	131_D	1.214	0.96
124_L	188_T	1.205	0.96
170_C	185_V	1.194	0.96
71_G	147_H	1.192	0.96
170_C	179_A	1.175	0.95
25_V	96_S	1.152	0.95
54_L	114_V	1.152	0.95
123_V	191_E	1.124	0.94
167_D	187_V	1.121	0.94
29_V	114_V	1.089	0.93
59_G	111_N	1.087	0.93
87_I	118_T	1.075	0.93
24_S	27_A	1.072	0.93
18_V	22_R	1.068	0.93
143_G	184_D	1.068	0.93
27_A	35_E	1.060	0.92
18_V	116_V	1.057	0.92
14_G	193_Q	1.052	0.92
70_H	190_F	1.047	0.92
166_L	187_V	1.025	0.91
26_E	109_L	1.008	0.90
81_Q	89_E	1.004	0.90
24_S	92_I	0.976	0.89
143_G	185_V	0.954	0.88
29_V	109_L	0.952	0.87
141_I	187_V	0.948	0.87
139_V	169_T	0.947	0.87
131_D	189_L	0.946	0.87
158_N	168_R	0.942	0.87
34_R	92_I	0.917	0.85
29_V	104_V	0.913	0.85
139_V	148_G	0.902	0.85
170_C	173_A	0.901	0.84
82_Q	85_H	0.898	0.84
15_A	195_F	0.895	0.84
115_S	194_V	0.893	0.84
40_M	43_A	0.889	0.84
135_G	153_T	0.877	0.83
22_R	114_V	0.863	0.82
53_R	157_E	0.858	0.81
134_L	162_V	0.854	0.81
53_R	154_L	0.850	0.81
105_E	173_A	0.849	0.81
143_G	179_A	0.839	0.80
167_D	177_D	0.836	0.80
81_Q	86_A	0.835	0.80
59_G	112_I	0.830	0.79
125_T	131_D	0.825	0.79
150_M	158_N	0.811	0.78
53_R	117_C	0.810	0.78
86_A	90_A	0.808	0.77
125_T	128_P	0.801	0.77
117_C	154_L	0.800	0.77
132_I	137_H	0.794	0.76
167_D	178_G	0.792	0.76
116_V	141_I	0.786	0.75
49_S	72_S	0.783	0.75
35_E	88_V	0.782	0.75
24_S	91_A	0.780	0.75
69_A	81_Q	0.776	0.74
24_S	35_E	0.774	0.74
20_L	84_G	0.767	0.74
133_E	162_V	0.767	0.74
52_V	90_A	0.764	0.73
15_A	19_E	0.761	0.73
17_T	43_A	0.761	0.73
69_A	90_A	0.758	0.73
146_Q	173_A	0.757	0.73
125_T	189_L	0.750	0.72
45_Y	84_G	0.748	0.72
25_V	54_L	0.747	0.72
59_G	104_V	0.746	0.72
132_I	162_V	0.741	0.71
49_S	86_A	0.734	0.70
46_N	83_L	0.734	0.70
14_G	116_V	0.731	0.70
54_L	95_A	0.729	0.70
154_L	165_Y	0.727	0.70
84_G	87_I	0.724	0.69
154_L	157_E	0.723	0.69
155_P	159_D	0.723	0.69
101_G	151_Y	0.718	0.69
127_D	131_D	0.713	0.68
155_P	162_V	0.707	0.67
61_G	113_R	0.706	0.67
150_M	190_F	0.705	0.67
51_F	67_A	0.699	0.67
13_D	43_A	0.699	0.67
49_S	195_F	0.695	0.66
94_A	108_E	0.693	0.66
179_A	185_V	0.689	0.65
81_Q	85_H	0.687	0.65
26_E	32_G	0.686	0.65
166_L	173_A	0.681	0.65
141_I	158_N	0.681	0.65
17_T	44_F	0.680	0.64
23_E	32_G	0.675	0.64
89_E	93_E	0.674	0.64
117_C	153_T	0.670	0.63
96_S	106_D	0.669	0.63
21_A	24_S	0.667	0.63
146_Q	155_P	0.663	0.62
22_R	26_E	0.662	0.62
141_I	148_G	0.656	0.62
107_A	110_P	0.655	0.62
115_S	173_A	0.651	0.61
113_R	196_R	0.647	0.61
156_V	165_Y	0.646	0.60
128_P	166_L	0.642	0.60
91_A	96_S	0.640	0.60
164_E	168_R	0.638	0.60
36_Q	110_P	0.638	0.60
55_E	113_R	0.638	0.60
157_E	168_R	0.636	0.59
153_T	194_V	0.636	0.59
27_A	32_G	0.635	0.59
185_V	192_G	0.629	0.58
100_C	151_Y	0.627	0.58
20_L	87_I	0.627	0.58
135_G	157_E	0.626	0.58
142_D	178_G	0.624	0.58
99_S	102_S	0.624	0.58
23_E	27_A	0.623	0.58
179_A	183_E	0.622	0.58
125_T	134_L	0.620	0.57
70_H	139_V	0.620	0.57
132_I	139_V	0.614	0.57
25_V	28_F	0.613	0.56
106_D	126_D	0.613	0.56
97_E	147_H	0.609	0.56
124_L	176_P	0.609	0.56
117_C	194_V	0.609	0.56
132_I	165_Y	0.607	0.56
143_G	146_Q	0.604	0.55
25_V	92_I	0.604	0.55
59_G	105_E	0.598	0.55
158_N	169_T	0.597	0.55
51_F	172_K	0.596	0.54
166_L	170_C	0.596	0.54
12_E	23_E	0.590	0.54
49_S	149_W	0.589	0.54
72_S	120_S	0.589	0.54
190_F	194_V	0.587	0.53
140_A	149_W	0.586	0.53
115_S	120_S	0.585	0.53
41_R	185_V	0.582	0.53
24_S	87_I	0.580	0.52
139_V	189_L	0.579	0.52
100_C	119_V	0.578	0.52
134_L	160_W	0.575	0.52
133_E	191_E	0.575	0.52
16_R	41_R	0.574	0.52
12_E	178_G	0.572	0.51
145_G	178_G	0.572	0.51
170_C	176_P	0.566	0.51
148_G	169_T	0.563	0.50
143_G	182_D	0.563	0.50
90_A	160_W	0.562	0.50
92_I	113_R	0.560	0.50
55_E	196_R	0.557	0.50
103_E	123_V	0.556	0.49
176_P	179_A	0.553	0.49
83_L	89_E	0.553	0.49
24_S	97_E	0.551	0.49
150_M	154_L	0.550	0.49
125_T	187_V	0.548	0.48
99_S	150_M	0.545	0.48
70_H	86_A	0.542	0.48
42_D	60_R	0.539	0.47
70_H	122_L	0.538	0.47
27_A	30_Q	0.537	0.47
16_R	19_E	0.537	0.47
170_C	181_Q	0.536	0.47
139_V	166_L	0.535	0.47
71_G	120_S	0.535	0.47
64_R	101_G	0.534	0.47
176_P	184_D	0.534	0.47
177_D	183_E	0.533	0.47
90_A	93_E	0.533	0.47
71_G	122_L	0.533	0.47
109_L	112_I	0.525	0.46
66_C	154_L	0.525	0.46
55_E	61_G	0.523	0.45
51_F	66_C	0.522	0.45
49_S	159_D	0.522	0.45
173_A	188_T	0.519	0.45
118_T	193_Q	0.518	0.45
19_E	178_G	0.518	0.45
163_F	167_D	0.517	0.45
175_L	180_W	0.514	0.44
29_V	95_A	0.514	0.44
107_A	163_F	0.514	0.44
148_G	187_V	0.514	0.44
63_L	100_C	0.513	0.44
187_V	192_G	0.513	0.44
48_T	86_A	0.513	0.44
143_G	169_T	0.512	0.44
150_M	155_P	0.512	0.44
14_G	112_I	0.511	0.44
179_A	189_L	0.508	0.44
155_P	169_T	0.507	0.43
90_A	140_A	0.507	0.43
171_R	177_D	0.505	0.43
25_V	93_E	0.504	0.43
66_C	172_K	0.501	0.43
69_A	86_A	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wscA	1	0.9524	100	0.177	Contact Map
1vajA	1	0.9333	100	0.184	Contact Map
1zq7A	4	0.9143	100	0.187	Contact Map
2d2rA	2	0.2952	61.8	0.944	Contact Map
3sgvB	2	0.3571	14.3	0.96	Contact Map
4myzA	4	0.2524	6.9	0.966	Contact Map
4gmvA	1	0.4048	6.3	0.966	Contact Map
3ewtE	1	0.0667	5.2	0.968	Contact Map
2og0A	1	0.2238	4.9	0.968	Contact Map
3tcaA	1	0.3333	4.9	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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