Q9HMH0 - HALSA - GREMLIN Contacts

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Q9HMH0 - Aminopeptidase homolog

UniProt:	Q9HMH0	Sequences: MDPRVEEHAEVLVDWSARIEAGDNVVLSVGPDAHELAVAVAERVGERGANLVTTYASGEIDRAYQLGHEGDFDADPAHERALVEHADVCLFIGGGRNTSAAADVPATTREAYNTAHGEIREARMDTDWVKTVHPTRSLAQQANMSFAAYQEFVYDAVLRDWEALADRMANMKTILDEGSEVRLVTEDTDLTMRIAGRQAVNSAASVAYDSHNLPSGEVFTAPTATEGEVHFDVPMTLRGERVQGVHLTFEDGEVVDYAAAQNEGVVGEILETDAGAKRLGELGIGMNRGIDQFTDSILFDEKMGDTIHLALGRAYESNFPAGSEDEANESAVHVDMITDVSEDSYMEVDGEVVQRNGTFRWEDGFSE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	367 (348)
Sequences:	1718 (1179)
Seq/√Len:	63.2

BACSU - AMPS
HALSA - Q9HMH0 Q9HSK5 Q9HMP2 Q9HSS8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
244_G	260_A	4.904	1.00
248_T	256_D	4.049	1.00
254_V	311_L	3.797	1.00
193_R	224_A	3.726	1.00
347_E	351_E	3.683	1.00
19_I	25_V	3.637	1.00
43_R	46_E	3.527	1.00
243_Q	261_Q	3.372	1.00
29_V	37_A	3.311	1.00
263_E	267_G	3.214	1.00
10_E	43_R	3.108	1.00
232_D	340_V	3.010	1.00
226_E	251_D	2.947	1.00
180_E	191_T	2.893	1.00
10_E	14_D	2.837	1.00
12_L	131_T	2.787	1.00
65_Q	104_V	2.785	1.00
344_S	355_R	2.761	1.00
271_E	277_K	2.745	1.00
13_V	47_R	2.437	1.00
228_E	248_T	2.433	1.00
6_E	43_R	2.404	1.00
73_D	111_A	2.393	1.00
13_V	40_V	2.372	1.00
249_F	279_L	2.307	1.00
182_R	189_D	2.302	1.00
352_V	355_R	2.299	1.00
288_R	293_F	2.296	1.00
14_D	47_R	2.223	1.00
19_I	88_V	2.110	1.00
257_Y	267_G	2.097	1.00
246_H	258_A	2.056	1.00
288_R	358_T	2.049	1.00
17_A	90_L	2.043	1.00
270_L	277_K	2.022	1.00
253_E	277_K	2.009	1.00
77_A	81_A	1.998	1.00
169_A	173_T	1.970	1.00
258_A	263_E	1.955	1.00
99_S	141_Q	1.952	1.00
27_L	40_V	1.932	1.00
12_L	90_L	1.901	1.00
197_R	320_P	1.851	1.00
228_E	246_H	1.845	1.00
25_V	90_L	1.838	1.00
173_T	177_E	1.829	1.00
192_M	309_L	1.798	1.00
90_L	129_V	1.795	1.00
267_G	271_E	1.781	1.00
116_H	119_I	1.752	0.99
26_V	87_D	1.742	0.99
41_A	60_I	1.732	0.99
64_Y	72_F	1.727	0.99
24_N	50_N	1.720	0.99
230_H	246_H	1.708	0.99
23_D	88_V	1.691	0.99
225_T	278_R	1.691	0.99
155_D	160_D	1.691	0.99
62_R	103_D	1.672	0.99
91_F	130_K	1.648	0.99
120_R	124_M	1.641	0.99
6_E	39_A	1.625	0.99
44_V	49_A	1.608	0.99
25_V	44_V	1.607	0.99
69_E	108_T	1.606	0.99
253_E	278_R	1.597	0.99
94_G	135_T	1.592	0.99
110_E	114_T	1.587	0.99
157_V	213_L	1.586	0.99
193_R	223_T	1.578	0.99
120_R	123_R	1.575	0.99
257_Y	263_E	1.562	0.99
191_T	226_E	1.554	0.99
174_I	178_G	1.517	0.99
36_L	40_V	1.502	0.98
46_E	66_L	1.487	0.98
307_I	338_T	1.484	0.98
6_E	42_E	1.472	0.98
270_L	276_A	1.471	0.98
237_L	242_V	1.470	0.98
196_G	348_V	1.466	0.98
132_V	299_F	1.461	0.98
62_R	65_Q	1.460	0.98
15_W	162_E	1.457	0.98
254_V	270_L	1.444	0.98
229_V	309_L	1.433	0.98
221_A	314_A	1.432	0.98
250_E	255_V	1.427	0.98
165_A	203_A	1.426	0.98
27_L	37_A	1.406	0.98
221_A	318_N	1.393	0.97
69_E	73_D	1.387	0.97
257_Y	270_L	1.366	0.97
264_G	268_E	1.366	0.97
40_V	90_L	1.363	0.97
293_F	358_T	1.359	0.97
185_T	342_E	1.332	0.97
36_L	133_H	1.332	0.97
179_S	348_V	1.326	0.97
270_L	311_L	1.311	0.96
272_T	331_A	1.295	0.96
54_T	82_L	1.282	0.96
93_G	132_V	1.280	0.96
313_R	329_E	1.274	0.96
165_A	202_S	1.271	0.96
182_R	191_T	1.270	0.96
39_A	42_E	1.264	0.95
345_Y	355_R	1.264	0.95
79_E	82_L	1.259	0.95
186_E	342_E	1.251	0.95
20_E	23_D	1.250	0.95
179_S	224_A	1.233	0.95
268_E	271_E	1.230	0.95
67_G	72_F	1.215	0.94
13_V	44_V	1.205	0.94
307_I	343_D	1.204	0.94
165_A	204_A	1.202	0.94
25_V	129_V	1.195	0.94
65_Q	103_D	1.189	0.94
39_A	43_R	1.164	0.93
124_M	313_R	1.160	0.93
7_E	10_E	1.160	0.93
105_P	108_T	1.159	0.93
28_S	54_T	1.151	0.92
276_A	332_V	1.150	0.92
77_A	80_R	1.149	0.92
121_E	124_M	1.144	0.92
92_I	131_T	1.143	0.92
12_L	129_V	1.143	0.92
309_L	338_T	1.136	0.92
342_E	356_N	1.134	0.92
30_G	94_G	1.131	0.92
247_L	270_L	1.126	0.92
34_H	55_Y	1.119	0.91
23_D	127_D	1.115	0.91
190_L	309_L	1.113	0.91
19_I	44_V	1.104	0.91
3_P	6_E	1.102	0.91
254_V	277_K	1.101	0.91
37_A	90_L	1.097	0.91
221_A	315_Y	1.090	0.90
223_T	278_R	1.088	0.90
186_E	230_H	1.088	0.90
181_V	282_L	1.086	0.90
202_S	215_S	1.084	0.90
18_R	210_S	1.078	0.90
136_R	140_Q	1.073	0.90
236_T	241_R	1.073	0.90
344_S	352_V	1.068	0.89
344_S	348_V	1.068	0.89
166_D	170_N	1.066	0.89
130_K	315_Y	1.065	0.89
97_N	137_S	1.065	0.89
69_E	111_A	1.048	0.88
42_E	46_E	1.044	0.88
13_V	25_V	1.043	0.88
43_R	47_R	1.041	0.88
192_M	225_T	1.038	0.88
19_I	47_R	1.034	0.88
42_E	66_L	1.031	0.88
256_D	267_G	1.026	0.87
89_C	126_T	1.025	0.87
229_V	338_T	1.024	0.87
25_V	88_V	1.023	0.87
32_D	135_T	1.020	0.87
219_F	317_S	1.014	0.87
194_I	220_T	1.013	0.87
247_L	254_V	1.009	0.86
91_F	315_Y	1.007	0.86
179_S	193_R	1.001	0.86
203_A	210_S	0.996	0.86
180_E	346_M	0.995	0.86
240_E	265_V	0.991	0.85
180_E	350_G	0.990	0.85
42_E	63_A	0.990	0.85
254_V	276_A	0.990	0.85
267_G	277_K	0.989	0.85
179_S	195_A	0.984	0.85
257_Y	271_E	0.982	0.85
276_A	311_L	0.982	0.85
38_V	57_S	0.981	0.85
272_T	332_V	0.955	0.83
40_V	92_I	0.950	0.83
4_R	7_E	0.942	0.82
190_L	225_T	0.942	0.82
171_M	353_V	0.936	0.82
17_A	88_V	0.935	0.82
183_L	190_L	0.921	0.81
190_L	279_L	0.916	0.81
185_T	340_V	0.916	0.81
158_L	164_L	0.910	0.80
165_A	169_A	0.910	0.80
266_V	269_I	0.909	0.80
134_P	150_Q	0.905	0.80
106_A	268_E	0.903	0.80
187_D	246_H	0.900	0.79
184_V	344_S	0.898	0.79
133_H	150_Q	0.897	0.79
172_K	203_A	0.892	0.79
24_N	87_D	0.888	0.79
311_L	332_V	0.886	0.78
81_A	85_H	0.884	0.78
287_N	358_T	0.883	0.78
222_P	279_L	0.881	0.78
107_T	268_E	0.877	0.78
94_G	132_V	0.875	0.78
246_H	256_D	0.871	0.77
187_D	230_H	0.869	0.77
68_H	71_D	0.868	0.77
245_V	336_M	0.868	0.77
123_R	126_T	0.867	0.77
162_E	165_A	0.866	0.77
235_M	297_I	0.866	0.77
180_E	193_R	0.865	0.77
109_R	238_R	0.861	0.76
183_L	192_M	0.861	0.76
345_Y	348_V	0.860	0.76
4_R	154_Y	0.860	0.76
245_V	297_I	0.858	0.76
235_M	334_V	0.854	0.76
284_I	346_M	0.854	0.76
165_A	172_K	0.853	0.76
30_G	33_A	0.852	0.76
24_N	85_H	0.849	0.75
242_V	266_V	0.849	0.75
13_V	19_I	0.848	0.75
281_E	308_H	0.846	0.75
170_N	174_I	0.845	0.75
308_H	333_H	0.843	0.75
185_T	307_I	0.842	0.75
80_R	84_E	0.840	0.75
160_D	272_T	0.837	0.74
185_T	230_H	0.835	0.74
152_F	156_A	0.830	0.74
113_N	238_R	0.828	0.74
181_V	194_I	0.824	0.73
168_M	218_V	0.822	0.73
4_R	151_E	0.814	0.72
178_G	347_E	0.811	0.72
281_E	333_H	0.811	0.72
196_G	223_T	0.809	0.72
124_M	316_E	0.809	0.72
36_L	39_A	0.805	0.71
107_T	111_A	0.800	0.71
287_N	341_S	0.800	0.71
34_H	38_V	0.797	0.71
183_L	343_D	0.790	0.70
111_A	115_A	0.789	0.70
185_T	338_T	0.789	0.70
253_E	274_A	0.788	0.70
169_A	201_N	0.787	0.70
132_V	135_T	0.784	0.69
307_I	354_Q	0.783	0.69
169_A	204_A	0.783	0.69
12_L	130_K	0.782	0.69
151_E	160_D	0.780	0.69
217_E	222_P	0.775	0.69
178_G	348_V	0.775	0.69
97_N	140_Q	0.775	0.69
171_M	360_R	0.774	0.68
194_I	353_V	0.770	0.68
256_D	263_E	0.768	0.68
275_G	330_S	0.767	0.68
28_S	89_C	0.767	0.68
33_A	133_H	0.767	0.68
183_L	282_L	0.767	0.68
245_V	266_V	0.766	0.68
313_R	316_E	0.764	0.67
26_V	83_V	0.761	0.67
148_A	151_E	0.761	0.67
114_T	118_E	0.760	0.67
28_S	56_A	0.759	0.67
225_T	309_L	0.759	0.67
186_E	340_V	0.756	0.67
184_V	189_D	0.756	0.67
14_D	43_R	0.755	0.66
244_G	261_Q	0.753	0.66
172_K	202_S	0.753	0.66
184_V	191_T	0.753	0.66
21_A	48_G	0.749	0.66
72_F	75_D	0.749	0.66
203_A	211_H	0.746	0.66
63_A	66_L	0.745	0.65
172_K	176_D	0.743	0.65
45_G	51_L	0.742	0.65
61_D	101_A	0.742	0.65
157_V	299_F	0.742	0.65
112_Y	116_H	0.742	0.65
11_V	158_L	0.740	0.65
254_V	257_Y	0.739	0.65
162_E	166_D	0.737	0.65
110_E	268_E	0.737	0.65
216_G	285_G	0.737	0.65
42_E	59_E	0.735	0.64
75_D	115_A	0.735	0.64
4_R	160_D	0.733	0.64
173_T	176_D	0.732	0.64
175_L	218_V	0.730	0.64
283_G	286_M	0.730	0.64
33_A	94_G	0.729	0.64
310_A	333_H	0.728	0.64
70_G	151_E	0.727	0.64
277_K	311_L	0.726	0.63
28_S	91_F	0.723	0.63
212_N	298_L	0.718	0.63
295_D	358_T	0.714	0.62
67_G	108_T	0.714	0.62
35_E	59_E	0.714	0.62
17_A	25_V	0.713	0.62
217_E	308_H	0.713	0.62
67_G	71_D	0.711	0.62
186_E	232_D	0.711	0.62
37_A	55_Y	0.710	0.62
242_V	269_I	0.709	0.62
301_E	308_H	0.704	0.61
75_D	116_H	0.703	0.61
27_L	163_A	0.702	0.61
169_A	202_S	0.699	0.61
222_P	308_H	0.697	0.60
193_R	226_E	0.696	0.60
197_R	319_F	0.696	0.60
230_H	244_G	0.695	0.60
69_E	107_T	0.692	0.60
97_N	141_Q	0.692	0.60
5_V	39_A	0.689	0.59
217_E	333_H	0.688	0.59
314_A	329_E	0.688	0.59
150_Q	154_Y	0.687	0.59
3_P	7_E	0.687	0.59
156_A	299_F	0.682	0.59
322_G	326_E	0.679	0.58
140_Q	147_A	0.679	0.58
285_G	302_K	0.678	0.58
237_L	332_V	0.677	0.58
348_V	351_E	0.675	0.58
352_V	356_N	0.671	0.57
3_P	137_S	0.669	0.57
103_D	148_A	0.668	0.57
178_G	353_V	0.665	0.57
130_K	221_A	0.664	0.57
347_E	352_V	0.663	0.56
174_I	351_E	0.658	0.56
8_H	131_T	0.656	0.56
217_E	281_E	0.655	0.56
160_D	213_L	0.651	0.55
198_Q	220_T	0.651	0.55
20_E	211_H	0.650	0.55
5_V	8_H	0.647	0.55
121_E	125_D	0.646	0.55
301_E	333_H	0.646	0.55
247_L	336_M	0.645	0.54
88_V	127_D	0.644	0.54
50_N	71_D	0.644	0.54
231_F	276_A	0.644	0.54
134_P	154_Y	0.644	0.54
178_G	345_Y	0.643	0.54
226_E	250_E	0.641	0.54
317_S	323_S	0.640	0.54
237_L	269_I	0.639	0.54
66_L	108_T	0.638	0.54
174_I	177_E	0.637	0.54
93_G	130_K	0.636	0.53
126_T	129_V	0.635	0.53
16_S	213_L	0.635	0.53
79_E	116_H	0.634	0.53
50_N	74_A	0.634	0.53
136_R	146_F	0.634	0.53
216_G	302_K	0.632	0.53
244_G	267_G	0.632	0.53
281_E	301_E	0.632	0.53
95_G	137_S	0.631	0.53
192_M	282_L	0.630	0.53
12_L	36_L	0.629	0.53
238_R	332_V	0.628	0.52
28_S	294_T	0.628	0.52
310_A	335_D	0.627	0.52
61_D	112_Y	0.624	0.52
297_I	336_M	0.622	0.52
17_A	129_V	0.620	0.52
124_M	314_A	0.618	0.51
291_D	341_S	0.616	0.51
104_V	109_R	0.616	0.51
122_A	159_R	0.616	0.51
155_D	251_D	0.614	0.51
239_G	300_D	0.612	0.51
29_V	33_A	0.612	0.51
254_V	278_R	0.611	0.51
300_D	303_M	0.610	0.50
179_S	347_E	0.608	0.50
25_V	84_E	0.607	0.50
235_M	336_M	0.607	0.50
320_P	323_S	0.606	0.50
179_S	223_T	0.606	0.50
68_H	72_F	0.605	0.50
60_I	63_A	0.605	0.50
69_E	72_F	0.604	0.50
217_E	301_E	0.604	0.50
35_E	39_A	0.602	0.49
341_S	356_N	0.600	0.49
269_I	272_T	0.600	0.49
71_D	74_A	0.598	0.49
257_Y	277_K	0.597	0.49
248_T	251_D	0.596	0.49
29_V	92_I	0.593	0.48
27_L	44_V	0.591	0.48
157_V	221_A	0.589	0.48
269_I	332_V	0.589	0.48
64_Y	69_E	0.588	0.48
33_A	37_A	0.588	0.48
91_F	120_R	0.586	0.48
32_D	37_A	0.586	0.48
270_L	279_L	0.585	0.48
78_H	88_V	0.585	0.48
66_L	111_A	0.585	0.48
154_Y	157_V	0.582	0.47
308_H	335_D	0.582	0.47
174_I	348_V	0.581	0.47
64_Y	101_A	0.580	0.47
283_G	307_I	0.579	0.47
95_G	236_T	0.577	0.47
42_E	65_Q	0.576	0.46
354_Q	358_T	0.576	0.46
26_V	89_C	0.575	0.46
222_P	333_H	0.575	0.46
35_E	192_M	0.573	0.46
19_I	49_A	0.572	0.46
151_E	155_D	0.572	0.46
53_T	82_L	0.571	0.46
76_P	114_T	0.570	0.46
132_V	138_L	0.570	0.46
233_V	292_Q	0.568	0.46
142_A	149_Y	0.568	0.46
249_F	311_L	0.567	0.45
323_S	326_E	0.566	0.45
13_V	43_R	0.565	0.45
188_T	298_L	0.564	0.45
11_V	213_L	0.562	0.45
157_V	160_D	0.562	0.45
353_V	360_R	0.561	0.45
36_L	247_L	0.560	0.45
31_P	55_Y	0.557	0.44
51_L	71_D	0.556	0.44
163_A	167_R	0.556	0.44
12_L	40_V	0.555	0.44
83_V	122_A	0.554	0.44
318_N	323_S	0.553	0.44
80_R	123_R	0.552	0.44
95_G	102_A	0.551	0.44
112_Y	115_A	0.551	0.44
297_I	337_I	0.550	0.44
177_E	182_R	0.548	0.43
248_T	258_A	0.548	0.43
98_T	141_Q	0.548	0.43
232_D	306_T	0.547	0.43
110_E	265_V	0.547	0.43
225_T	236_T	0.547	0.43
301_E	335_D	0.546	0.43
184_V	355_R	0.546	0.43
229_V	307_I	0.545	0.43
237_L	334_V	0.544	0.43
252_G	312_G	0.542	0.43
243_Q	260_A	0.540	0.42
184_V	346_M	0.539	0.42
101_A	104_V	0.539	0.42
242_V	259_A	0.536	0.42
138_L	149_Y	0.534	0.42
36_L	92_I	0.531	0.41
269_I	334_V	0.530	0.41
192_M	224_A	0.530	0.41
180_E	356_N	0.529	0.41
19_I	63_A	0.529	0.41
111_A	148_A	0.528	0.41
201_N	317_S	0.528	0.41
38_V	59_E	0.528	0.41
4_R	155_D	0.528	0.41
99_S	102_A	0.527	0.41
306_T	311_L	0.526	0.41
273_D	330_S	0.526	0.41
216_G	287_N	0.524	0.41
222_P	281_E	0.524	0.41
195_A	221_A	0.524	0.41
62_R	104_V	0.523	0.40
225_T	249_F	0.522	0.40
187_D	341_S	0.521	0.40
293_F	354_Q	0.521	0.40
186_E	359_F	0.520	0.40
233_V	294_T	0.519	0.40
72_F	259_A	0.519	0.40
183_L	338_T	0.518	0.40
8_H	157_V	0.518	0.40
230_H	243_Q	0.518	0.40
229_V	279_L	0.517	0.40
40_V	350_G	0.516	0.40
229_V	249_F	0.516	0.40
250_E	256_D	0.515	0.40
73_D	121_E	0.515	0.40
44_V	262_N	0.515	0.40
59_E	97_N	0.513	0.39
200_V	302_K	0.512	0.39
267_G	270_L	0.512	0.39
19_I	23_D	0.511	0.39
45_G	50_N	0.511	0.39
157_V	282_L	0.511	0.39
163_A	166_D	0.509	0.39
11_V	43_R	0.509	0.39
256_D	271_E	0.508	0.39
145_S	332_V	0.506	0.39
212_N	310_A	0.506	0.39
75_D	79_E	0.505	0.39
77_A	85_H	0.505	0.39
215_S	300_D	0.503	0.38
236_T	297_I	0.503	0.38
159_R	213_L	0.503	0.38
34_H	57_S	0.503	0.38
194_I	199_A	0.503	0.38
281_E	310_A	0.503	0.38
153_V	299_F	0.502	0.38
92_I	133_H	0.502	0.38
49_A	256_D	0.501	0.38
31_P	37_A	0.501	0.38
202_S	337_I	0.500	0.38
195_A	245_V	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ayiA	2	0.9591	100	0.231	Contact Map
4icsA	2	0.9755	100	0.231	Contact Map
1zjcA	2	0.9809	100	0.247	Contact Map
3lygA	2	0.3134	46.4	0.969	Contact Map
3lc0A	2	0.2834	34.6	0.971	Contact Map
3netA	2	0.3052	27.4	0.973	Contact Map
5aigA	1	0.3134	25.5	0.973	Contact Map
3er7A	2	0.2807	21.5	0.974	Contact Map
5aihA	1	0.3188	20.8	0.974	Contact Map
3i0yA	2	0.3243	17	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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