GREMLIN Database
Q9HMH0 - Aminopeptidase homolog
UniProt: Q9HMH0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (348)
Sequences: 1718 (1179)
Seq/√Len: 63.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_G260_A4.9041.00
248_T256_D4.0491.00
254_V311_L3.7971.00
193_R224_A3.7261.00
347_E351_E3.6831.00
19_I25_V3.6371.00
43_R46_E3.5271.00
243_Q261_Q3.3721.00
29_V37_A3.3111.00
263_E267_G3.2141.00
10_E43_R3.1081.00
232_D340_V3.0101.00
226_E251_D2.9471.00
180_E191_T2.8931.00
10_E14_D2.8371.00
12_L131_T2.7871.00
65_Q104_V2.7851.00
344_S355_R2.7611.00
271_E277_K2.7451.00
13_V47_R2.4371.00
228_E248_T2.4331.00
6_E43_R2.4041.00
73_D111_A2.3931.00
13_V40_V2.3721.00
249_F279_L2.3071.00
182_R189_D2.3021.00
352_V355_R2.2991.00
288_R293_F2.2961.00
14_D47_R2.2231.00
19_I88_V2.1101.00
257_Y267_G2.0971.00
246_H258_A2.0561.00
288_R358_T2.0491.00
17_A90_L2.0431.00
270_L277_K2.0221.00
253_E277_K2.0091.00
77_A81_A1.9981.00
169_A173_T1.9701.00
258_A263_E1.9551.00
99_S141_Q1.9521.00
27_L40_V1.9321.00
12_L90_L1.9011.00
197_R320_P1.8511.00
228_E246_H1.8451.00
25_V90_L1.8381.00
173_T177_E1.8291.00
192_M309_L1.7981.00
90_L129_V1.7951.00
267_G271_E1.7811.00
116_H119_I1.7520.99
26_V87_D1.7420.99
41_A60_I1.7320.99
64_Y72_F1.7270.99
24_N50_N1.7200.99
230_H246_H1.7080.99
23_D88_V1.6910.99
225_T278_R1.6910.99
155_D160_D1.6910.99
62_R103_D1.6720.99
91_F130_K1.6480.99
120_R124_M1.6410.99
6_E39_A1.6250.99
44_V49_A1.6080.99
25_V44_V1.6070.99
69_E108_T1.6060.99
253_E278_R1.5970.99
94_G135_T1.5920.99
110_E114_T1.5870.99
157_V213_L1.5860.99
193_R223_T1.5780.99
120_R123_R1.5750.99
257_Y263_E1.5620.99
191_T226_E1.5540.99
174_I178_G1.5170.99
36_L40_V1.5020.98
46_E66_L1.4870.98
307_I338_T1.4840.98
6_E42_E1.4720.98
270_L276_A1.4710.98
237_L242_V1.4700.98
196_G348_V1.4660.98
132_V299_F1.4610.98
62_R65_Q1.4600.98
15_W162_E1.4570.98
254_V270_L1.4440.98
229_V309_L1.4330.98
221_A314_A1.4320.98
250_E255_V1.4270.98
165_A203_A1.4260.98
27_L37_A1.4060.98
221_A318_N1.3930.97
69_E73_D1.3870.97
257_Y270_L1.3660.97
264_G268_E1.3660.97
40_V90_L1.3630.97
293_F358_T1.3590.97
185_T342_E1.3320.97
36_L133_H1.3320.97
179_S348_V1.3260.97
270_L311_L1.3110.96
272_T331_A1.2950.96
54_T82_L1.2820.96
93_G132_V1.2800.96
313_R329_E1.2740.96
165_A202_S1.2710.96
182_R191_T1.2700.96
39_A42_E1.2640.95
345_Y355_R1.2640.95
79_E82_L1.2590.95
186_E342_E1.2510.95
20_E23_D1.2500.95
179_S224_A1.2330.95
268_E271_E1.2300.95
67_G72_F1.2150.94
13_V44_V1.2050.94
307_I343_D1.2040.94
165_A204_A1.2020.94
25_V129_V1.1950.94
65_Q103_D1.1890.94
39_A43_R1.1640.93
124_M313_R1.1600.93
7_E10_E1.1600.93
105_P108_T1.1590.93
28_S54_T1.1510.92
276_A332_V1.1500.92
77_A80_R1.1490.92
121_E124_M1.1440.92
92_I131_T1.1430.92
12_L129_V1.1430.92
309_L338_T1.1360.92
342_E356_N1.1340.92
30_G94_G1.1310.92
247_L270_L1.1260.92
34_H55_Y1.1190.91
23_D127_D1.1150.91
190_L309_L1.1130.91
19_I44_V1.1040.91
3_P6_E1.1020.91
254_V277_K1.1010.91
37_A90_L1.0970.91
221_A315_Y1.0900.90
223_T278_R1.0880.90
186_E230_H1.0880.90
181_V282_L1.0860.90
202_S215_S1.0840.90
18_R210_S1.0780.90
136_R140_Q1.0730.90
236_T241_R1.0730.90
344_S352_V1.0680.89
344_S348_V1.0680.89
166_D170_N1.0660.89
130_K315_Y1.0650.89
97_N137_S1.0650.89
69_E111_A1.0480.88
42_E46_E1.0440.88
13_V25_V1.0430.88
43_R47_R1.0410.88
192_M225_T1.0380.88
19_I47_R1.0340.88
42_E66_L1.0310.88
256_D267_G1.0260.87
89_C126_T1.0250.87
229_V338_T1.0240.87
25_V88_V1.0230.87
32_D135_T1.0200.87
219_F317_S1.0140.87
194_I220_T1.0130.87
247_L254_V1.0090.86
91_F315_Y1.0070.86
179_S193_R1.0010.86
203_A210_S0.9960.86
180_E346_M0.9950.86
240_E265_V0.9910.85
180_E350_G0.9900.85
42_E63_A0.9900.85
254_V276_A0.9900.85
267_G277_K0.9890.85
179_S195_A0.9840.85
257_Y271_E0.9820.85
276_A311_L0.9820.85
38_V57_S0.9810.85
272_T332_V0.9550.83
40_V92_I0.9500.83
4_R7_E0.9420.82
190_L225_T0.9420.82
171_M353_V0.9360.82
17_A88_V0.9350.82
183_L190_L0.9210.81
190_L279_L0.9160.81
185_T340_V0.9160.81
158_L164_L0.9100.80
165_A169_A0.9100.80
266_V269_I0.9090.80
134_P150_Q0.9050.80
106_A268_E0.9030.80
187_D246_H0.9000.79
184_V344_S0.8980.79
133_H150_Q0.8970.79
172_K203_A0.8920.79
24_N87_D0.8880.79
311_L332_V0.8860.78
81_A85_H0.8840.78
287_N358_T0.8830.78
222_P279_L0.8810.78
107_T268_E0.8770.78
94_G132_V0.8750.78
246_H256_D0.8710.77
187_D230_H0.8690.77
68_H71_D0.8680.77
245_V336_M0.8680.77
123_R126_T0.8670.77
162_E165_A0.8660.77
235_M297_I0.8660.77
180_E193_R0.8650.77
109_R238_R0.8610.76
183_L192_M0.8610.76
345_Y348_V0.8600.76
4_R154_Y0.8600.76
245_V297_I0.8580.76
235_M334_V0.8540.76
284_I346_M0.8540.76
165_A172_K0.8530.76
30_G33_A0.8520.76
24_N85_H0.8490.75
242_V266_V0.8490.75
13_V19_I0.8480.75
281_E308_H0.8460.75
170_N174_I0.8450.75
308_H333_H0.8430.75
185_T307_I0.8420.75
80_R84_E0.8400.75
160_D272_T0.8370.74
185_T230_H0.8350.74
152_F156_A0.8300.74
113_N238_R0.8280.74
181_V194_I0.8240.73
168_M218_V0.8220.73
4_R151_E0.8140.72
178_G347_E0.8110.72
281_E333_H0.8110.72
196_G223_T0.8090.72
124_M316_E0.8090.72
36_L39_A0.8050.71
107_T111_A0.8000.71
287_N341_S0.8000.71
34_H38_V0.7970.71
183_L343_D0.7900.70
111_A115_A0.7890.70
185_T338_T0.7890.70
253_E274_A0.7880.70
169_A201_N0.7870.70
132_V135_T0.7840.69
307_I354_Q0.7830.69
169_A204_A0.7830.69
12_L130_K0.7820.69
151_E160_D0.7800.69
217_E222_P0.7750.69
178_G348_V0.7750.69
97_N140_Q0.7750.69
171_M360_R0.7740.68
194_I353_V0.7700.68
256_D263_E0.7680.68
275_G330_S0.7670.68
28_S89_C0.7670.68
33_A133_H0.7670.68
183_L282_L0.7670.68
245_V266_V0.7660.68
313_R316_E0.7640.67
26_V83_V0.7610.67
148_A151_E0.7610.67
114_T118_E0.7600.67
28_S56_A0.7590.67
225_T309_L0.7590.67
186_E340_V0.7560.67
184_V189_D0.7560.67
14_D43_R0.7550.66
244_G261_Q0.7530.66
172_K202_S0.7530.66
184_V191_T0.7530.66
21_A48_G0.7490.66
72_F75_D0.7490.66
203_A211_H0.7460.66
63_A66_L0.7450.65
172_K176_D0.7430.65
45_G51_L0.7420.65
61_D101_A0.7420.65
157_V299_F0.7420.65
112_Y116_H0.7420.65
11_V158_L0.7400.65
254_V257_Y0.7390.65
162_E166_D0.7370.65
110_E268_E0.7370.65
216_G285_G0.7370.65
42_E59_E0.7350.64
75_D115_A0.7350.64
4_R160_D0.7330.64
173_T176_D0.7320.64
175_L218_V0.7300.64
283_G286_M0.7300.64
33_A94_G0.7290.64
310_A333_H0.7280.64
70_G151_E0.7270.64
277_K311_L0.7260.63
28_S91_F0.7230.63
212_N298_L0.7180.63
295_D358_T0.7140.62
67_G108_T0.7140.62
35_E59_E0.7140.62
17_A25_V0.7130.62
217_E308_H0.7130.62
67_G71_D0.7110.62
186_E232_D0.7110.62
37_A55_Y0.7100.62
242_V269_I0.7090.62
301_E308_H0.7040.61
75_D116_H0.7030.61
27_L163_A0.7020.61
169_A202_S0.6990.61
222_P308_H0.6970.60
193_R226_E0.6960.60
197_R319_F0.6960.60
230_H244_G0.6950.60
69_E107_T0.6920.60
97_N141_Q0.6920.60
5_V39_A0.6890.59
217_E333_H0.6880.59
314_A329_E0.6880.59
150_Q154_Y0.6870.59
3_P7_E0.6870.59
156_A299_F0.6820.59
322_G326_E0.6790.58
140_Q147_A0.6790.58
285_G302_K0.6780.58
237_L332_V0.6770.58
348_V351_E0.6750.58
352_V356_N0.6710.57
3_P137_S0.6690.57
103_D148_A0.6680.57
178_G353_V0.6650.57
130_K221_A0.6640.57
347_E352_V0.6630.56
174_I351_E0.6580.56
8_H131_T0.6560.56
217_E281_E0.6550.56
160_D213_L0.6510.55
198_Q220_T0.6510.55
20_E211_H0.6500.55
5_V8_H0.6470.55
121_E125_D0.6460.55
301_E333_H0.6460.55
247_L336_M0.6450.54
88_V127_D0.6440.54
50_N71_D0.6440.54
231_F276_A0.6440.54
134_P154_Y0.6440.54
178_G345_Y0.6430.54
226_E250_E0.6410.54
317_S323_S0.6400.54
237_L269_I0.6390.54
66_L108_T0.6380.54
174_I177_E0.6370.54
93_G130_K0.6360.53
126_T129_V0.6350.53
16_S213_L0.6350.53
79_E116_H0.6340.53
50_N74_A0.6340.53
136_R146_F0.6340.53
216_G302_K0.6320.53
244_G267_G0.6320.53
281_E301_E0.6320.53
95_G137_S0.6310.53
192_M282_L0.6300.53
12_L36_L0.6290.53
238_R332_V0.6280.52
28_S294_T0.6280.52
310_A335_D0.6270.52
61_D112_Y0.6240.52
297_I336_M0.6220.52
17_A129_V0.6200.52
124_M314_A0.6180.51
291_D341_S0.6160.51
104_V109_R0.6160.51
122_A159_R0.6160.51
155_D251_D0.6140.51
239_G300_D0.6120.51
29_V33_A0.6120.51
254_V278_R0.6110.51
300_D303_M0.6100.50
179_S347_E0.6080.50
25_V84_E0.6070.50
235_M336_M0.6070.50
320_P323_S0.6060.50
179_S223_T0.6060.50
68_H72_F0.6050.50
60_I63_A0.6050.50
69_E72_F0.6040.50
217_E301_E0.6040.50
35_E39_A0.6020.49
341_S356_N0.6000.49
269_I272_T0.6000.49
71_D74_A0.5980.49
257_Y277_K0.5970.49
248_T251_D0.5960.49
29_V92_I0.5930.48
27_L44_V0.5910.48
157_V221_A0.5890.48
269_I332_V0.5890.48
64_Y69_E0.5880.48
33_A37_A0.5880.48
91_F120_R0.5860.48
32_D37_A0.5860.48
270_L279_L0.5850.48
78_H88_V0.5850.48
66_L111_A0.5850.48
154_Y157_V0.5820.47
308_H335_D0.5820.47
174_I348_V0.5810.47
64_Y101_A0.5800.47
283_G307_I0.5790.47
95_G236_T0.5770.47
42_E65_Q0.5760.46
354_Q358_T0.5760.46
26_V89_C0.5750.46
222_P333_H0.5750.46
35_E192_M0.5730.46
19_I49_A0.5720.46
151_E155_D0.5720.46
53_T82_L0.5710.46
76_P114_T0.5700.46
132_V138_L0.5700.46
233_V292_Q0.5680.46
142_A149_Y0.5680.46
249_F311_L0.5670.45
323_S326_E0.5660.45
13_V43_R0.5650.45
188_T298_L0.5640.45
11_V213_L0.5620.45
157_V160_D0.5620.45
353_V360_R0.5610.45
36_L247_L0.5600.45
31_P55_Y0.5570.44
51_L71_D0.5560.44
163_A167_R0.5560.44
12_L40_V0.5550.44
83_V122_A0.5540.44
318_N323_S0.5530.44
80_R123_R0.5520.44
95_G102_A0.5510.44
112_Y115_A0.5510.44
297_I337_I0.5500.44
177_E182_R0.5480.43
248_T258_A0.5480.43
98_T141_Q0.5480.43
232_D306_T0.5470.43
110_E265_V0.5470.43
225_T236_T0.5470.43
301_E335_D0.5460.43
184_V355_R0.5460.43
229_V307_I0.5450.43
237_L334_V0.5440.43
252_G312_G0.5420.43
243_Q260_A0.5400.42
184_V346_M0.5390.42
101_A104_V0.5390.42
242_V259_A0.5360.42
138_L149_Y0.5340.42
36_L92_I0.5310.41
269_I334_V0.5300.41
192_M224_A0.5300.41
180_E356_N0.5290.41
19_I63_A0.5290.41
111_A148_A0.5280.41
201_N317_S0.5280.41
38_V59_E0.5280.41
4_R155_D0.5280.41
99_S102_A0.5270.41
306_T311_L0.5260.41
273_D330_S0.5260.41
216_G287_N0.5240.41
222_P281_E0.5240.41
195_A221_A0.5240.41
62_R104_V0.5230.40
225_T249_F0.5220.40
187_D341_S0.5210.40
293_F354_Q0.5210.40
186_E359_F0.5200.40
233_V294_T0.5190.40
72_F259_A0.5190.40
183_L338_T0.5180.40
8_H157_V0.5180.40
230_H243_Q0.5180.40
229_V279_L0.5170.40
40_V350_G0.5160.40
229_V249_F0.5160.40
250_E256_D0.5150.40
73_D121_E0.5150.40
44_V262_N0.5150.40
59_E97_N0.5130.39
200_V302_K0.5120.39
267_G270_L0.5120.39
19_I23_D0.5110.39
45_G50_N0.5110.39
157_V282_L0.5110.39
163_A166_D0.5090.39
11_V43_R0.5090.39
256_D271_E0.5080.39
145_S332_V0.5060.39
212_N310_A0.5060.39
75_D79_E0.5050.39
77_A85_H0.5050.39
215_S300_D0.5030.38
236_T297_I0.5030.38
159_R213_L0.5030.38
34_H57_S0.5030.38
194_I199_A0.5030.38
281_E310_A0.5030.38
153_V299_F0.5020.38
92_I133_H0.5020.38
49_A256_D0.5010.38
31_P37_A0.5010.38
202_S337_I0.5000.38
195_A245_V0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ayiA 2 0.9591 100 0.231 Contact Map
4icsA 2 0.9755 100 0.231 Contact Map
1zjcA 2 0.9809 100 0.247 Contact Map
3lygA 2 0.3134 46.4 0.969 Contact Map
3lc0A 2 0.2834 34.6 0.971 Contact Map
3netA 2 0.3052 27.4 0.973 Contact Map
5aigA 1 0.3134 25.5 0.973 Contact Map
3er7A 2 0.2807 21.5 0.974 Contact Map
5aihA 1 0.3188 20.8 0.974 Contact Map
3i0yA 2 0.3243 17 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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