GREMLIN Database
SYV - Valine--tRNA ligase
UniProt: Q9HMG9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 881 (784)
Sequences: 8774 (4858)
Seq/√Len: 173.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_R74_D5.1551.00
19_D23_E5.1451.00
306_F321_E5.1181.00
25_D28_R4.0661.00
309_L317_Q4.0641.00
108_E111_E3.9111.00
162_A505_A3.8451.00
112_M115_D3.8351.00
527_N533_R3.8061.00
294_T298_H3.5421.00
22_Q129_Q3.4471.00
305_E321_E3.3881.00
480_E503_T3.2411.00
614_S723_E3.1321.00
610_R719_D3.1151.00
545_E569_W3.0421.00
9_D12_S3.0321.00
72_K624_D2.9761.00
679_T683_R2.9521.00
193_E335_E2.9251.00
373_E514_D2.8511.00
370_A380_H2.8261.00
367_D371_D2.7991.00
204_V250_D2.7551.00
363_D367_D2.7521.00
158_E161_D2.7231.00
105_P108_E2.7211.00
412_N448_A2.7011.00
320_E324_D2.6941.00
100_H103_D2.6741.00
209_I267_A2.6591.00
282_W287_L2.6511.00
615_E646_D2.6411.00
301_E307_A2.6331.00
622_D638_S2.5901.00
193_E333_P2.5901.00
320_E323_D2.5671.00
616_L680_A2.5531.00
625_E629_E2.4721.00
483_D513_D2.4641.00
36_T74_D2.4571.00
92_K95_E2.4551.00
733_A737_R2.4041.00
20_E24_R2.3941.00
624_D712_F2.3891.00
191_D335_E2.3581.00
225_I267_A2.3451.00
175_C344_C2.3421.00
321_E325_Q2.3311.00
64_F556_A2.3241.00
618_T723_E2.3151.00
524_E568_Q2.3061.00
439_C442_C2.3021.00
241_T250_D2.2671.00
299_L303_A2.2491.00
28_R138_D2.2461.00
586_T696_I2.2321.00
238_I255_A2.2231.00
372_A500_L2.2131.00
20_E698_Q2.2031.00
364_R508_D2.1951.00
148_Y466_H2.1891.00
317_Q320_E2.1791.00
524_E570_K2.1711.00
158_E162_A2.1691.00
359_E362_Q2.1671.00
405_P449_G2.1651.00
767_R770_T2.1611.00
66_A76_V2.1591.00
154_E158_E2.1551.00
612_L677_A2.1531.00
195_T333_P2.1311.00
321_E324_D2.1241.00
685_L693_T2.1191.00
32_S35_D2.1171.00
514_D630_Y2.1121.00
411_C442_C2.1011.00
377_E380_H2.0931.00
18_Q691_H2.0801.00
621_E625_E2.0781.00
122_D125_K2.0731.00
69_R72_K2.0701.00
224_G254_L2.0641.00
366_L384_V2.0611.00
367_D370_A2.0531.00
231_D261_A2.0401.00
624_D628_S2.0341.00
178_C344_C2.0331.00
125_K129_Q2.0231.00
411_C414_C1.9871.00
68_Y628_S1.9831.00
226_V270_V1.9811.00
191_D337_S1.9801.00
175_C178_C1.9741.00
68_Y72_K1.9581.00
473_G477_D1.9381.00
440_P443_G1.9281.00
414_C442_C1.9081.00
161_D421_G1.8931.00
370_A388_E1.8821.00
370_A384_V1.8731.00
179_E296_D1.8731.00
364_R367_D1.8661.00
69_R628_S1.8611.00
202_D327_Y1.8421.00
770_T774_S1.8381.00
719_D722_A1.8381.00
154_E421_G1.8281.00
99_I103_D1.8251.00
310_A313_D1.8021.00
30_D33_E1.8021.00
368_A371_D1.7841.00
230_D257_D1.7771.00
366_L388_E1.7751.00
258_D281_W1.7581.00
279_V283_M1.7491.00
97_N112_M1.7421.00
323_D331_T1.7331.00
631_R634_R1.7311.00
619_V638_S1.7141.00
169_E354_E1.7041.00
492_I517_V1.7031.00
635_A688_F1.6981.00
167_R354_E1.6931.00
67_R690_P1.6921.00
50_N123_E1.6901.00
175_C341_C1.6871.00
579_L689_S1.6751.00
150_G472_E1.6711.00
243_E248_G1.6581.00
305_E317_Q1.6481.00
141_Y147_E1.6431.00
726_G729_I1.6381.00
29_F705_G1.6341.00
541_E545_E1.6301.00
375_V514_D1.6281.00
204_V241_T1.6261.00
706_S709_A1.6221.00
411_C439_C1.6181.00
683_R710_A1.6101.00
19_D22_Q1.6051.00
16_K695_E1.5971.00
111_E115_D1.5941.00
620_C684_L1.5921.00
157_S161_D1.5871.00
225_I242_F1.5761.00
68_Y624_D1.5701.00
763_D767_R1.5481.00
40_I66_A1.5461.00
300_N303_A1.5461.00
71_L683_R1.5361.00
75_A478_E1.5361.00
448_A451_T1.5311.00
304_G307_A1.5301.00
254_L281_W1.5301.00
620_C680_A1.5291.00
59_W128_M1.5251.00
280_E283_M1.5241.00
316_T320_E1.5221.00
258_D270_V1.5201.00
136_D139_S1.5141.00
541_E544_A1.5101.00
372_A510_Q1.5031.00
37_Q75_A1.5031.00
616_L620_C1.5021.00
433_D437_E1.4951.00
199_V322_L1.4921.00
733_A736_I1.4841.00
711_T714_S1.4791.00
190_I345_D1.4781.00
179_E295_E1.4701.00
38_Y484_L1.4681.00
178_C341_C1.4561.00
59_W133_F1.4531.00
617_S620_C1.4511.00
618_T720_A1.4451.00
121_I142_R1.4411.00
98_D101_R1.4411.00
423_E427_V1.4391.00
658_R670_A1.4391.00
200_T329_N1.4381.00
414_C439_C1.4381.00
192_R340_S1.4371.00
662_G666_E1.4331.00
209_I253_L1.4321.00
177_R346_T1.4291.00
615_E727_K1.4261.00
130_E544_A1.4191.00
368_A504_G1.4191.00
210_E329_N1.4111.00
381_D385_E1.4011.00
17_W695_E1.3951.00
71_L686_A1.3931.00
643_A681_V1.3931.00
667_R671_E1.3821.00
380_H384_V1.3741.00
721_D725_A1.3731.00
24_R705_G1.3721.00
484_L514_D1.3641.00
97_N101_R1.3601.00
412_N446_D1.3551.00
752_D781_I1.3531.00
734_R737_R1.3521.00
720_A724_L1.3481.00
621_E717_Y1.3431.00
725_A768_L1.3411.00
722_A729_I1.3401.00
177_R344_C1.3341.00
694_E706_S1.3331.00
411_C416_H1.3321.00
165_V396_I1.3321.00
198_Y330_D1.3311.00
627_M688_F1.3311.00
298_H310_A1.3291.00
669_A673_T1.3231.00
204_V243_E1.3201.00
189_N337_S1.3061.00
226_V254_L1.3041.00
155_S506_L1.3041.00
439_C443_G1.3021.00
704_E710_A1.3011.00
609_D651_Y1.2981.00
309_L313_D1.2971.00
17_W698_Q1.2971.00
384_V388_E1.2971.00
299_L314_A1.2961.00
126_A129_Q1.2931.00
115_D118_E1.2891.00
32_S75_A1.2891.00
685_L689_S1.2891.00
570_K573_K1.2871.00
223_V290_R1.2871.00
434_P437_E1.2861.00
84_C144_M1.2851.00
26_V709_A1.2841.00
374_W492_I1.2811.00
736_I777_V1.2811.00
358_V396_I1.2811.00
438_A442_C1.2801.00
461_S502_R1.2781.00
292_V299_L1.2761.00
627_M635_A1.2741.00
585_I648_A1.2721.00
15_P130_E1.2721.00
277_Q280_E1.2721.00
615_E618_T1.2711.00
201_F222_C1.2691.00
317_Q321_E1.2691.00
246_L321_E1.2671.00
256_D281_W1.2621.00
203_G207_G1.2581.00
621_E715_V1.2541.00
626_A638_S1.2501.00
579_L692_T1.2451.00
545_E573_K1.2441.00
75_A479_F1.2431.00
607_D725_A1.2371.00
242_F253_L1.2361.00
416_H441_E1.2341.00
26_V706_S1.2331.00
613_L676_T1.2221.00
542_A551_V1.2221.00
616_L677_A1.2211.00
309_L314_A1.2211.00
294_T300_N1.2201.00
209_I225_I1.2201.00
227_V255_A1.2191.00
764_D767_R1.2181.00
50_N127_T1.2111.00
228_S231_D1.2091.00
614_S618_T1.2091.00
125_K138_D1.2041.00
313_D317_Q1.1961.00
682_T696_I1.1961.00
227_V253_L1.1941.00
224_G270_V1.1941.00
159_M502_R1.1931.00
727_K730_A1.1921.00
734_R738_A1.1911.00
420_A423_E1.1911.00
220_A299_L1.1911.00
438_A441_E1.1891.00
211_I225_I1.1871.00
601_Q604_A1.1771.00
132_G691_H1.1751.00
228_S261_A1.1721.00
722_A725_A1.1711.00
487_Q496_A1.1701.00
142_R145_D1.1701.00
680_A683_R1.1691.00
15_P19_D1.1671.00
198_Y210_E1.1621.00
16_K19_D1.1611.00
53_L536_F1.1601.00
588_F655_V1.1571.00
359_E393_D1.1551.00
779_A782_R1.1541.00
159_M505_A1.1531.00
12_S16_K1.1521.00
20_E694_E1.1521.00
593_F596_D1.1511.00
34_S75_A1.1501.00
655_V670_A1.1491.00
13_I16_K1.1491.00
764_D768_L1.1461.00
125_K140_E1.1451.00
167_R410_E1.1411.00
484_L516_L1.1361.00
612_L642_F1.1351.00
281_W284_D1.1341.00
301_E304_G1.1331.00
620_C624_D1.1321.00
238_I241_T1.1301.00
341_C344_C1.1281.00
725_A729_I1.1271.00
249_Q290_R1.1261.00
97_N102_T1.1251.00
104_V108_E1.1221.00
98_D102_T1.1211.00
300_N307_A1.1211.00
243_E250_D1.1181.00
148_Y463_T1.1171.00
108_E112_M1.1131.00
99_I104_V1.1091.00
227_V267_A1.1061.00
38_Y65_V1.1011.00
128_M133_F1.1011.00
302_A307_A1.1001.00
270_V281_W1.1001.00
673_T677_A1.0981.00
12_S15_P1.0971.00
118_E144_M1.0971.00
553_Q636_L1.0961.00
623_V635_A1.0941.00
623_V638_S1.0901.00
476_L507_T1.0871.00
554_A575_A1.0861.00
721_D724_L1.0861.00
373_E377_E1.0831.00
44_P148_Y1.0801.00
438_A443_G1.0801.00
609_D669_A1.0791.00
615_E723_E1.0741.00
230_D261_A1.0731.00
226_V281_W1.0731.00
72_K628_S1.0721.00
585_I652_V1.0681.00
306_F317_Q1.0681.00
760_D764_D1.0681.00
605_Y669_A1.0641.00
97_N100_H1.0641.00
686_A708_H1.0641.00
369_A387_T1.0641.00
726_G730_A1.0621.00
128_M135_Q1.0611.00
533_R536_F1.0591.00
753_R756_L1.0581.00
682_T707_V1.0571.00
624_D714_S1.0551.00
619_V642_F1.0551.00
622_D625_E1.0541.00
99_I102_T1.0541.00
626_A634_R1.0521.00
61_Y486_P1.0511.00
722_A726_G1.0491.00
239_G243_E1.0400.99
387_T500_L1.0390.99
618_T622_D1.0360.99
293_F299_L1.0350.99
188_E342_W1.0330.99
226_V256_D1.0310.99
237_R240_D1.0310.99
195_T331_T1.0270.99
268_V281_W1.0270.99
51_L131_L1.0260.99
221_A292_V1.0260.99
663_R666_E1.0240.99
753_R783_L1.0220.99
557_L636_L1.0210.99
418_E447_W1.0210.99
298_H313_D1.0200.99
582_L643_A1.0200.99
42_T59_W1.0190.99
612_L647_L1.0190.99
413_E446_D1.0170.99
605_Y673_T1.0150.99
680_A684_L1.0150.99
661_N666_E1.0150.99
541_E569_W1.0120.99
589_S647_L1.0110.99
200_T210_E1.0080.99
20_E706_S1.0070.99
79_P467_L1.0050.99
341_C346_T1.0050.99
300_N304_G1.0040.99
197_H219_L1.0000.99
22_Q25_D0.9990.99
439_C444_G0.9970.99
374_W515_V0.9940.99
220_A318_V0.9940.99
53_L521_V0.9940.99
605_Y613_L0.9940.99
424_Q427_V0.9920.99
471_P474_T0.9920.99
733_A738_A0.9920.99
620_C713_P0.9910.99
606_R666_E0.9890.99
141_Y148_Y0.9890.99
14_E548_A0.9880.99
42_T135_Q0.9880.99
385_E388_E0.9870.99
30_D34_S0.9840.99
178_C346_T0.9790.99
313_D316_T0.9780.99
306_F309_L0.9780.99
82_W125_K0.9770.99
78_F135_Q0.9710.99
276_K280_E0.9690.99
196_L263_F0.9690.99
735_E738_A0.9690.99
190_I340_S0.9680.99
11_N544_A0.9670.99
229_P255_A0.9630.99
228_S257_D0.9630.99
255_A285_H0.9620.99
35_D74_D0.9590.99
181_A395_V0.9560.99
60_S64_F0.9560.99
387_T497_F0.9560.99
94_E109_F0.9540.99
374_W517_V0.9510.99
42_T128_M0.9490.99
68_Y627_M0.9440.99
368_A510_Q0.9430.99
763_D766_A0.9410.99
35_D75_A0.9410.99
273_F289_L0.9400.99
283_M289_L0.9370.99
25_D138_D0.9350.99
620_C715_V0.9340.99
51_L55_H0.9330.99
763_D786_G0.9310.99
521_V565_V0.9300.99
469_G507_T0.9290.99
755_E758_F0.9290.99
364_R368_A0.9290.99
58_G518_N0.9280.99
738_A742_D0.9250.99
295_E351_L0.9210.99
90_E94_E0.9210.99
661_N664_P0.9190.99
464_P480_E0.9180.99
273_F292_V0.9160.99
64_F627_M0.9160.99
319_A331_T0.9160.99
118_E122_D0.9140.99
480_E509_E0.9140.99
759_D762_D0.9130.99
567_F572_V0.9100.99
200_T241_T0.9100.99
303_A307_A0.9060.99
504_G510_Q0.9050.99
442_C445_D0.9010.98
617_S717_Y0.8990.98
86_G90_E0.8990.98
119_D123_E0.8980.98
418_E440_P0.8970.98
658_R666_E0.8960.98
484_L630_Y0.8960.98
39_V483_D0.8960.98
752_D783_L0.8940.98
259_V263_F0.8940.98
694_E698_Q0.8940.98
270_V282_W0.8940.98
510_Q513_D0.8930.98
682_T693_T0.8930.98
292_V300_N0.8920.98
72_K714_S0.8920.98
328_L331_T0.8910.98
24_R706_S0.8900.98
650_D730_A0.8890.98
151_K470_W0.8880.98
770_T784_I0.8870.98
227_V238_I0.8870.98
374_W383_L0.8850.98
360_V390_M0.8830.98
586_T678_V0.8820.98
411_C447_W0.8810.98
156_F165_V0.8810.98
173_N350_I0.8780.98
509_E513_D0.8760.98
365_I368_A0.8760.98
609_D658_R0.8740.98
122_D126_A0.8740.98
223_V288_D0.8740.98
39_V468_S0.8740.98
373_E629_E0.8710.98
540_D544_A0.8700.98
240_D243_E0.8690.98
731_E735_E0.8690.98
228_S259_V0.8690.98
198_Y212_A0.8680.98
155_S458_M0.8640.98
670_A673_T0.8640.98
412_N444_G0.8640.98
65_V484_L0.8630.98
588_F592_H0.8630.98
314_A318_V0.8610.98
724_L727_K0.8610.98
469_G472_E0.8590.98
175_C346_T0.8580.98
280_E284_D0.8580.98
686_A693_T0.8570.98
366_L370_A0.8560.98
100_H105_P0.8540.98
746_P749_A0.8530.98
345_D532_S0.8530.98
4_L699_S0.8510.98
293_F351_L0.8490.98
443_G446_D0.8480.98
157_S421_G0.8470.98
70_R134_S0.8450.98
441_E444_G0.8440.98
150_G153_Q0.8430.98
617_S716_E0.8420.98
538_Q541_E0.8410.98
408_A417_W0.8400.98
93_V113_C0.8400.98
761_S764_D0.8400.98
146_P150_G0.8380.98
41_D463_T0.8380.98
383_L515_V0.8370.98
697_W710_A0.8360.98
26_V134_S0.8350.98
224_G287_L0.8350.98
440_P444_G0.8340.97
617_S621_E0.8330.97
569_W573_K0.8290.97
399_Q452_D0.8280.97
258_D277_Q0.8280.97
151_K154_E0.8260.97
205_D240_D0.8260.97
257_D284_D0.8250.97
94_E113_C0.8250.97
123_E126_A0.8240.97
676_T680_A0.8230.97
787_R790_V0.8230.97
414_C444_G0.8220.97
221_A299_L0.8200.97
606_R609_D0.8190.97
622_D626_A0.8180.97
109_F113_C0.8170.97
345_D533_R0.8170.97
415_G448_A0.8170.97
774_S782_R0.8160.97
291_T351_L0.8160.97
369_A384_V0.8150.97
678_V700_L0.8150.97
719_D723_E0.8150.97
115_D119_D0.8130.97
110_R113_C0.8120.97
668_A671_E0.8120.97
668_A672_H0.8100.97
199_V219_L0.8100.97
522_F564_D0.8070.97
619_V623_V0.8050.97
107_D111_E0.8040.97
456_T459_D0.8040.97
153_Q157_S0.8040.97
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165_V358_V0.5070.76
623_V712_F0.5070.76
56_A60_S0.5070.76
175_C414_C0.5070.76
147_E151_K0.5060.76
596_D668_A0.5060.76
33_E478_E0.5050.76
69_R76_V0.5050.76
192_R336_Q0.5050.76
756_L759_D0.5050.76
318_V321_E0.5050.76
765_A773_L0.5040.76
34_S37_Q0.5040.76
28_R136_D0.5040.76
106_S433_D0.5040.76
291_T294_T0.5030.76
74_D628_S0.5030.76
663_R667_R0.5020.75
31_P34_S0.5020.75
411_C440_P0.5020.75
77_L479_F0.5010.75
762_D765_A0.5010.75
192_R347_A0.5010.75
59_W135_Q0.5010.75
592_H659_L0.5010.75
87_L400_R0.5000.75
772_D775_E0.5000.75
760_D763_D0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gaxA 1 0.9569 100 0.153 Contact Map
1ffyA 1 0.9421 100 0.214 Contact Map
1ileA 1 0.8388 100 0.293 Contact Map
1wz2A 1 0.9217 100 0.312 Contact Map
2v0cA 1 0.7083 100 0.393 Contact Map
1wkbA 1 0.748 100 0.394 Contact Map
4arcA 1 0.7616 100 0.412 Contact Map
3ziuA 1 0.6538 100 0.524 Contact Map
1rqgA 2 0.6209 100 0.635 Contact Map
4qreA 1 0.5653 100 0.641 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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