SYV - HALSA - GREMLIN Contacts

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SYV - Valine--tRNA ligase

UniProt:	Q9HMG9	Sequences: MTELPDSYDPNSIEPKWQDEWQERDVYRFDPSESDTQYVIDTPPPYPSGNLHLGHALGWSYIDFVARYRRLKGDAVLFPQGWDCHGLPTEVKVEEVNDIHRTDVPSDEFREMCIDWTEDRIDEMKATMQELGFSQDWDSEYRTMDPEYWGKTQESFSEMADAGMVYRDEHPVNWCPRCETAIADAEVENIDREGTLHYVTFDGVDNGDIEIATTRPELLAACVGIVVSPDDDRYADRIGDTFEVPLFGQDVELLADDDVDADFGSGAVMVCTFGDKQDVEWWMDHDLDLRTVFTEDGHLNEAAGEFAGLAIDDAKTQVAEELDDQGYLNDTEPTEQSVGSCWRCDTAIEILSKEQWFVEVDQDRILDAAADAEWVPEHMHDRLVEWTEGMDWDWVISRQRVFATPIPAWECNECGHWEIAGREQAPVDPTEDDPAVEACPECGGDDWAGETDVMDTWMDSSITPLHLSGWPEGTTLDEFESVDLRPQGHDIIRTWAFYTLLRTGALTDEQPWDDVLVNGMVFGEDGNKMSKSRGNFVQPDEAIAEYSADAVRQALALGGRPGSDVQFQWKEVKSASRFLTKLWNITKFSTGHFDEDTPAIQDPAYRDADRWLLSELSTVCEDVDEAMSEYRFDRALRSLREFAWEDLADDYVELVKGRLYNGRPGERAAAEHTLYTAVTAVTRLLAPFSPHTTEEIWQSLPGTEGSVHAATFPSVEYRDADAELAGKRIAEVAREIRAWKSDQGMPLNADLDRVELYFDDSDDDAARLDTYDLSETVNAPIRLIDGRPDVELVPVDVDGDDSEIGPEFRSDAGTVMEAIAAADPAAIQAQIHSGDTVTVEADGESFDLDADWLTVTEEYRASSGEEVTVIEASFGTVIIYE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	881 (784)
Sequences:	8774 (4858)
Seq/√Len:	173.5

ECOLI - SYV SYI
BACSU - SYV SYI SYL
HALSA - SYV SYI SYL
SULSO - SYV SYI SYL2 SYL1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
69_R	74_D	5.155	1.00
19_D	23_E	5.145	1.00
306_F	321_E	5.118	1.00
25_D	28_R	4.066	1.00
309_L	317_Q	4.064	1.00
108_E	111_E	3.911	1.00
162_A	505_A	3.845	1.00
112_M	115_D	3.835	1.00
527_N	533_R	3.806	1.00
294_T	298_H	3.542	1.00
22_Q	129_Q	3.447	1.00
305_E	321_E	3.388	1.00
480_E	503_T	3.241	1.00
614_S	723_E	3.132	1.00
610_R	719_D	3.115	1.00
545_E	569_W	3.042	1.00
9_D	12_S	3.032	1.00
72_K	624_D	2.976	1.00
679_T	683_R	2.952	1.00
193_E	335_E	2.925	1.00
373_E	514_D	2.851	1.00
370_A	380_H	2.826	1.00
367_D	371_D	2.799	1.00
204_V	250_D	2.755	1.00
363_D	367_D	2.752	1.00
158_E	161_D	2.723	1.00
105_P	108_E	2.721	1.00
412_N	448_A	2.701	1.00
320_E	324_D	2.694	1.00
100_H	103_D	2.674	1.00
209_I	267_A	2.659	1.00
282_W	287_L	2.651	1.00
615_E	646_D	2.641	1.00
301_E	307_A	2.633	1.00
622_D	638_S	2.590	1.00
193_E	333_P	2.590	1.00
320_E	323_D	2.567	1.00
616_L	680_A	2.553	1.00
625_E	629_E	2.472	1.00
483_D	513_D	2.464	1.00
36_T	74_D	2.457	1.00
92_K	95_E	2.455	1.00
733_A	737_R	2.404	1.00
20_E	24_R	2.394	1.00
624_D	712_F	2.389	1.00
191_D	335_E	2.358	1.00
225_I	267_A	2.345	1.00
175_C	344_C	2.342	1.00
321_E	325_Q	2.331	1.00
64_F	556_A	2.324	1.00
618_T	723_E	2.315	1.00
524_E	568_Q	2.306	1.00
439_C	442_C	2.302	1.00
241_T	250_D	2.267	1.00
299_L	303_A	2.249	1.00
28_R	138_D	2.246	1.00
586_T	696_I	2.232	1.00
238_I	255_A	2.223	1.00
372_A	500_L	2.213	1.00
20_E	698_Q	2.203	1.00
364_R	508_D	2.195	1.00
148_Y	466_H	2.189	1.00
317_Q	320_E	2.179	1.00
524_E	570_K	2.171	1.00
158_E	162_A	2.169	1.00
359_E	362_Q	2.167	1.00
405_P	449_G	2.165	1.00
767_R	770_T	2.161	1.00
66_A	76_V	2.159	1.00
154_E	158_E	2.155	1.00
612_L	677_A	2.153	1.00
195_T	333_P	2.131	1.00
321_E	324_D	2.124	1.00
685_L	693_T	2.119	1.00
32_S	35_D	2.117	1.00
514_D	630_Y	2.112	1.00
411_C	442_C	2.101	1.00
377_E	380_H	2.093	1.00
18_Q	691_H	2.080	1.00
621_E	625_E	2.078	1.00
122_D	125_K	2.073	1.00
69_R	72_K	2.070	1.00
224_G	254_L	2.064	1.00
366_L	384_V	2.061	1.00
367_D	370_A	2.053	1.00
231_D	261_A	2.040	1.00
624_D	628_S	2.034	1.00
178_C	344_C	2.033	1.00
125_K	129_Q	2.023	1.00
411_C	414_C	1.987	1.00
68_Y	628_S	1.983	1.00
226_V	270_V	1.981	1.00
191_D	337_S	1.980	1.00
175_C	178_C	1.974	1.00
68_Y	72_K	1.958	1.00
473_G	477_D	1.938	1.00
440_P	443_G	1.928	1.00
414_C	442_C	1.908	1.00
161_D	421_G	1.893	1.00
370_A	388_E	1.882	1.00
370_A	384_V	1.873	1.00
179_E	296_D	1.873	1.00
364_R	367_D	1.866	1.00
69_R	628_S	1.861	1.00
202_D	327_Y	1.842	1.00
770_T	774_S	1.838	1.00
719_D	722_A	1.838	1.00
154_E	421_G	1.828	1.00
99_I	103_D	1.825	1.00
310_A	313_D	1.802	1.00
30_D	33_E	1.802	1.00
368_A	371_D	1.784	1.00
230_D	257_D	1.777	1.00
366_L	388_E	1.775	1.00
258_D	281_W	1.758	1.00
279_V	283_M	1.749	1.00
97_N	112_M	1.742	1.00
323_D	331_T	1.733	1.00
631_R	634_R	1.731	1.00
619_V	638_S	1.714	1.00
169_E	354_E	1.704	1.00
492_I	517_V	1.703	1.00
635_A	688_F	1.698	1.00
167_R	354_E	1.693	1.00
67_R	690_P	1.692	1.00
50_N	123_E	1.690	1.00
175_C	341_C	1.687	1.00
579_L	689_S	1.675	1.00
150_G	472_E	1.671	1.00
243_E	248_G	1.658	1.00
305_E	317_Q	1.648	1.00
141_Y	147_E	1.643	1.00
726_G	729_I	1.638	1.00
29_F	705_G	1.634	1.00
541_E	545_E	1.630	1.00
375_V	514_D	1.628	1.00
204_V	241_T	1.626	1.00
706_S	709_A	1.622	1.00
411_C	439_C	1.618	1.00
683_R	710_A	1.610	1.00
19_D	22_Q	1.605	1.00
16_K	695_E	1.597	1.00
111_E	115_D	1.594	1.00
620_C	684_L	1.592	1.00
157_S	161_D	1.587	1.00
225_I	242_F	1.576	1.00
68_Y	624_D	1.570	1.00
763_D	767_R	1.548	1.00
40_I	66_A	1.546	1.00
300_N	303_A	1.546	1.00
71_L	683_R	1.536	1.00
75_A	478_E	1.536	1.00
448_A	451_T	1.531	1.00
304_G	307_A	1.530	1.00
254_L	281_W	1.530	1.00
620_C	680_A	1.529	1.00
59_W	128_M	1.525	1.00
280_E	283_M	1.524	1.00
316_T	320_E	1.522	1.00
258_D	270_V	1.520	1.00
136_D	139_S	1.514	1.00
541_E	544_A	1.510	1.00
372_A	510_Q	1.503	1.00
37_Q	75_A	1.503	1.00
616_L	620_C	1.502	1.00
433_D	437_E	1.495	1.00
199_V	322_L	1.492	1.00
733_A	736_I	1.484	1.00
711_T	714_S	1.479	1.00
190_I	345_D	1.478	1.00
179_E	295_E	1.470	1.00
38_Y	484_L	1.468	1.00
178_C	341_C	1.456	1.00
59_W	133_F	1.453	1.00
617_S	620_C	1.451	1.00
618_T	720_A	1.445	1.00
121_I	142_R	1.441	1.00
98_D	101_R	1.441	1.00
423_E	427_V	1.439	1.00
658_R	670_A	1.439	1.00
200_T	329_N	1.438	1.00
414_C	439_C	1.438	1.00
192_R	340_S	1.437	1.00
662_G	666_E	1.433	1.00
209_I	253_L	1.432	1.00
177_R	346_T	1.429	1.00
615_E	727_K	1.426	1.00
130_E	544_A	1.419	1.00
368_A	504_G	1.419	1.00
210_E	329_N	1.411	1.00
381_D	385_E	1.401	1.00
17_W	695_E	1.395	1.00
71_L	686_A	1.393	1.00
643_A	681_V	1.393	1.00
667_R	671_E	1.382	1.00
380_H	384_V	1.374	1.00
721_D	725_A	1.373	1.00
24_R	705_G	1.372	1.00
484_L	514_D	1.364	1.00
97_N	101_R	1.360	1.00
412_N	446_D	1.355	1.00
752_D	781_I	1.353	1.00
734_R	737_R	1.352	1.00
720_A	724_L	1.348	1.00
621_E	717_Y	1.343	1.00
725_A	768_L	1.341	1.00
722_A	729_I	1.340	1.00
177_R	344_C	1.334	1.00
694_E	706_S	1.333	1.00
411_C	416_H	1.332	1.00
165_V	396_I	1.332	1.00
198_Y	330_D	1.331	1.00
627_M	688_F	1.331	1.00
298_H	310_A	1.329	1.00
669_A	673_T	1.323	1.00
204_V	243_E	1.320	1.00
189_N	337_S	1.306	1.00
226_V	254_L	1.304	1.00
155_S	506_L	1.304	1.00
439_C	443_G	1.302	1.00
704_E	710_A	1.301	1.00
609_D	651_Y	1.298	1.00
309_L	313_D	1.297	1.00
17_W	698_Q	1.297	1.00
384_V	388_E	1.297	1.00
299_L	314_A	1.296	1.00
126_A	129_Q	1.293	1.00
115_D	118_E	1.289	1.00
32_S	75_A	1.289	1.00
685_L	689_S	1.289	1.00
570_K	573_K	1.287	1.00
223_V	290_R	1.287	1.00
434_P	437_E	1.286	1.00
84_C	144_M	1.285	1.00
26_V	709_A	1.284	1.00
374_W	492_I	1.281	1.00
736_I	777_V	1.281	1.00
358_V	396_I	1.281	1.00
438_A	442_C	1.280	1.00
461_S	502_R	1.278	1.00
292_V	299_L	1.276	1.00
627_M	635_A	1.274	1.00
585_I	648_A	1.272	1.00
15_P	130_E	1.272	1.00
277_Q	280_E	1.272	1.00
615_E	618_T	1.271	1.00
201_F	222_C	1.269	1.00
317_Q	321_E	1.269	1.00
246_L	321_E	1.267	1.00
256_D	281_W	1.262	1.00
203_G	207_G	1.258	1.00
621_E	715_V	1.254	1.00
626_A	638_S	1.250	1.00
579_L	692_T	1.245	1.00
545_E	573_K	1.244	1.00
75_A	479_F	1.243	1.00
607_D	725_A	1.237	1.00
242_F	253_L	1.236	1.00
416_H	441_E	1.234	1.00
26_V	706_S	1.233	1.00
613_L	676_T	1.222	1.00
542_A	551_V	1.222	1.00
616_L	677_A	1.221	1.00
309_L	314_A	1.221	1.00
294_T	300_N	1.220	1.00
209_I	225_I	1.220	1.00
227_V	255_A	1.219	1.00
764_D	767_R	1.218	1.00
50_N	127_T	1.211	1.00
228_S	231_D	1.209	1.00
614_S	618_T	1.209	1.00
125_K	138_D	1.204	1.00
313_D	317_Q	1.196	1.00
682_T	696_I	1.196	1.00
227_V	253_L	1.194	1.00
224_G	270_V	1.194	1.00
159_M	502_R	1.193	1.00
727_K	730_A	1.192	1.00
734_R	738_A	1.191	1.00
420_A	423_E	1.191	1.00
220_A	299_L	1.191	1.00
438_A	441_E	1.189	1.00
211_I	225_I	1.187	1.00
601_Q	604_A	1.177	1.00
132_G	691_H	1.175	1.00
228_S	261_A	1.172	1.00
722_A	725_A	1.171	1.00
487_Q	496_A	1.170	1.00
142_R	145_D	1.170	1.00
680_A	683_R	1.169	1.00
15_P	19_D	1.167	1.00
198_Y	210_E	1.162	1.00
16_K	19_D	1.161	1.00
53_L	536_F	1.160	1.00
588_F	655_V	1.157	1.00
359_E	393_D	1.155	1.00
779_A	782_R	1.154	1.00
159_M	505_A	1.153	1.00
12_S	16_K	1.152	1.00
20_E	694_E	1.152	1.00
593_F	596_D	1.151	1.00
34_S	75_A	1.150	1.00
655_V	670_A	1.149	1.00
13_I	16_K	1.149	1.00
764_D	768_L	1.146	1.00
125_K	140_E	1.145	1.00
167_R	410_E	1.141	1.00
484_L	516_L	1.136	1.00
612_L	642_F	1.135	1.00
281_W	284_D	1.134	1.00
301_E	304_G	1.133	1.00
620_C	624_D	1.132	1.00
238_I	241_T	1.130	1.00
341_C	344_C	1.128	1.00
725_A	729_I	1.127	1.00
249_Q	290_R	1.126	1.00
97_N	102_T	1.125	1.00
104_V	108_E	1.122	1.00
98_D	102_T	1.121	1.00
300_N	307_A	1.121	1.00
243_E	250_D	1.118	1.00
148_Y	463_T	1.117	1.00
108_E	112_M	1.113	1.00
99_I	104_V	1.109	1.00
227_V	267_A	1.106	1.00
38_Y	65_V	1.101	1.00
128_M	133_F	1.101	1.00
302_A	307_A	1.100	1.00
270_V	281_W	1.100	1.00
673_T	677_A	1.098	1.00
12_S	15_P	1.097	1.00
118_E	144_M	1.097	1.00
553_Q	636_L	1.096	1.00
623_V	635_A	1.094	1.00
623_V	638_S	1.090	1.00
476_L	507_T	1.087	1.00
554_A	575_A	1.086	1.00
721_D	724_L	1.086	1.00
373_E	377_E	1.083	1.00
44_P	148_Y	1.080	1.00
438_A	443_G	1.080	1.00
609_D	669_A	1.079	1.00
615_E	723_E	1.074	1.00
230_D	261_A	1.073	1.00
226_V	281_W	1.073	1.00
72_K	628_S	1.072	1.00
585_I	652_V	1.068	1.00
306_F	317_Q	1.068	1.00
760_D	764_D	1.068	1.00
605_Y	669_A	1.064	1.00
97_N	100_H	1.064	1.00
686_A	708_H	1.064	1.00
369_A	387_T	1.064	1.00
726_G	730_A	1.062	1.00
128_M	135_Q	1.061	1.00
533_R	536_F	1.059	1.00
753_R	756_L	1.058	1.00
682_T	707_V	1.057	1.00
624_D	714_S	1.055	1.00
619_V	642_F	1.055	1.00
622_D	625_E	1.054	1.00
99_I	102_T	1.054	1.00
626_A	634_R	1.052	1.00
61_Y	486_P	1.051	1.00
722_A	726_G	1.049	1.00
239_G	243_E	1.040	0.99
387_T	500_L	1.039	0.99
618_T	622_D	1.036	0.99
293_F	299_L	1.035	0.99
188_E	342_W	1.033	0.99
226_V	256_D	1.031	0.99
237_R	240_D	1.031	0.99
195_T	331_T	1.027	0.99
268_V	281_W	1.027	0.99
51_L	131_L	1.026	0.99
221_A	292_V	1.026	0.99
663_R	666_E	1.024	0.99
753_R	783_L	1.022	0.99
557_L	636_L	1.021	0.99
418_E	447_W	1.021	0.99
298_H	313_D	1.020	0.99
582_L	643_A	1.020	0.99
42_T	59_W	1.019	0.99
612_L	647_L	1.019	0.99
413_E	446_D	1.017	0.99
605_Y	673_T	1.015	0.99
680_A	684_L	1.015	0.99
661_N	666_E	1.015	0.99
541_E	569_W	1.012	0.99
589_S	647_L	1.011	0.99
200_T	210_E	1.008	0.99
20_E	706_S	1.007	0.99
79_P	467_L	1.005	0.99
341_C	346_T	1.005	0.99
300_N	304_G	1.004	0.99
197_H	219_L	1.000	0.99
22_Q	25_D	0.999	0.99
439_C	444_G	0.997	0.99
374_W	515_V	0.994	0.99
220_A	318_V	0.994	0.99
53_L	521_V	0.994	0.99
605_Y	613_L	0.994	0.99
424_Q	427_V	0.992	0.99
471_P	474_T	0.992	0.99
733_A	738_A	0.992	0.99
620_C	713_P	0.991	0.99
606_R	666_E	0.989	0.99
141_Y	148_Y	0.989	0.99
14_E	548_A	0.988	0.99
42_T	135_Q	0.988	0.99
385_E	388_E	0.987	0.99
30_D	34_S	0.984	0.99
178_C	346_T	0.979	0.99
313_D	316_T	0.978	0.99
306_F	309_L	0.978	0.99
82_W	125_K	0.977	0.99
78_F	135_Q	0.971	0.99
276_K	280_E	0.969	0.99
196_L	263_F	0.969	0.99
735_E	738_A	0.969	0.99
190_I	340_S	0.968	0.99
11_N	544_A	0.967	0.99
229_P	255_A	0.963	0.99
228_S	257_D	0.963	0.99
255_A	285_H	0.962	0.99
35_D	74_D	0.959	0.99
181_A	395_V	0.956	0.99
60_S	64_F	0.956	0.99
387_T	497_F	0.956	0.99
94_E	109_F	0.954	0.99
374_W	517_V	0.951	0.99
42_T	128_M	0.949	0.99
68_Y	627_M	0.944	0.99
368_A	510_Q	0.943	0.99
763_D	766_A	0.941	0.99
35_D	75_A	0.941	0.99
273_F	289_L	0.940	0.99
283_M	289_L	0.937	0.99
25_D	138_D	0.935	0.99
620_C	715_V	0.934	0.99
51_L	55_H	0.933	0.99
763_D	786_G	0.931	0.99
521_V	565_V	0.930	0.99
469_G	507_T	0.929	0.99
755_E	758_F	0.929	0.99
364_R	368_A	0.929	0.99
58_G	518_N	0.928	0.99
738_A	742_D	0.925	0.99
295_E	351_L	0.921	0.99
90_E	94_E	0.921	0.99
661_N	664_P	0.919	0.99
464_P	480_E	0.918	0.99
273_F	292_V	0.916	0.99
64_F	627_M	0.916	0.99
319_A	331_T	0.916	0.99
118_E	122_D	0.914	0.99
480_E	509_E	0.914	0.99
759_D	762_D	0.913	0.99
567_F	572_V	0.910	0.99
200_T	241_T	0.910	0.99
303_A	307_A	0.906	0.99
504_G	510_Q	0.905	0.99
442_C	445_D	0.901	0.98
617_S	717_Y	0.899	0.98
86_G	90_E	0.899	0.98
119_D	123_E	0.898	0.98
418_E	440_P	0.897	0.98
658_R	666_E	0.896	0.98
484_L	630_Y	0.896	0.98
39_V	483_D	0.896	0.98
752_D	783_L	0.894	0.98
259_V	263_F	0.894	0.98
694_E	698_Q	0.894	0.98
270_V	282_W	0.894	0.98
510_Q	513_D	0.893	0.98
682_T	693_T	0.893	0.98
292_V	300_N	0.892	0.98
72_K	714_S	0.892	0.98
328_L	331_T	0.891	0.98
24_R	706_S	0.890	0.98
650_D	730_A	0.889	0.98
151_K	470_W	0.888	0.98
770_T	784_I	0.887	0.98
227_V	238_I	0.887	0.98
374_W	383_L	0.885	0.98
360_V	390_M	0.883	0.98
586_T	678_V	0.882	0.98
411_C	447_W	0.881	0.98
156_F	165_V	0.881	0.98
173_N	350_I	0.878	0.98
509_E	513_D	0.876	0.98
365_I	368_A	0.876	0.98
609_D	658_R	0.874	0.98
122_D	126_A	0.874	0.98
223_V	288_D	0.874	0.98
39_V	468_S	0.874	0.98
373_E	629_E	0.871	0.98
540_D	544_A	0.870	0.98
240_D	243_E	0.869	0.98
731_E	735_E	0.869	0.98
228_S	259_V	0.869	0.98
198_Y	212_A	0.868	0.98
155_S	458_M	0.864	0.98
670_A	673_T	0.864	0.98
412_N	444_G	0.864	0.98
65_V	484_L	0.863	0.98
588_F	592_H	0.863	0.98
314_A	318_V	0.861	0.98
724_L	727_K	0.861	0.98
469_G	472_E	0.859	0.98
175_C	346_T	0.858	0.98
280_E	284_D	0.858	0.98
686_A	693_T	0.857	0.98
366_L	370_A	0.856	0.98
100_H	105_P	0.854	0.98
746_P	749_A	0.853	0.98
345_D	532_S	0.853	0.98
4_L	699_S	0.851	0.98
293_F	351_L	0.849	0.98
443_G	446_D	0.848	0.98
157_S	421_G	0.847	0.98
70_R	134_S	0.845	0.98
441_E	444_G	0.844	0.98
150_G	153_Q	0.843	0.98
617_S	716_E	0.842	0.98
538_Q	541_E	0.841	0.98
408_A	417_W	0.840	0.98
93_V	113_C	0.840	0.98
761_S	764_D	0.840	0.98
146_P	150_G	0.838	0.98
41_D	463_T	0.838	0.98
383_L	515_V	0.837	0.98
697_W	710_A	0.836	0.98
26_V	134_S	0.835	0.98
224_G	287_L	0.835	0.98
440_P	444_G	0.834	0.97
617_S	621_E	0.833	0.97
569_W	573_K	0.829	0.97
399_Q	452_D	0.828	0.97
258_D	277_Q	0.828	0.97
151_K	154_E	0.826	0.97
205_D	240_D	0.826	0.97
257_D	284_D	0.825	0.97
94_E	113_C	0.825	0.97
123_E	126_A	0.824	0.97
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787_R	790_V	0.823	0.97
414_C	444_G	0.822	0.97
221_A	299_L	0.820	0.97
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622_D	626_A	0.818	0.97
109_F	113_C	0.817	0.97
345_D	533_R	0.817	0.97
415_G	448_A	0.817	0.97
774_S	782_R	0.816	0.97
291_T	351_L	0.816	0.97
369_A	384_V	0.815	0.97
678_V	700_L	0.815	0.97
719_D	723_E	0.815	0.97
115_D	119_D	0.813	0.97
110_R	113_C	0.812	0.97
668_A	671_E	0.812	0.97
668_A	672_H	0.810	0.97
199_V	219_L	0.810	0.97
522_F	564_D	0.807	0.97
619_V	623_V	0.805	0.97
107_D	111_E	0.804	0.97
456_T	459_D	0.804	0.97
153_Q	157_S	0.804	0.97
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408_A	419_I	0.804	0.97
582_L	681_V	0.804	0.97
316_T	331_T	0.803	0.97
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600_I	605_Y	0.800	0.97
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177_R	341_C	0.800	0.97
33_E	36_T	0.799	0.97
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752_D	780_P	0.799	0.97
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543_I	548_A	0.797	0.97
164_M	362_Q	0.797	0.97
411_C	418_E	0.796	0.97
438_A	445_D	0.796	0.97
60_S	556_A	0.795	0.97
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197_H	319_A	0.795	0.97
537_V	542_A	0.794	0.97
340_S	345_D	0.794	0.97
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490_D	520_M	0.793	0.97
323_D	328_L	0.791	0.97
732_V	737_R	0.791	0.97
152_T	454_M	0.790	0.97
104_V	112_M	0.790	0.97
769_D	772_D	0.789	0.96
32_S	70_R	0.789	0.96
170_H	395_V	0.788	0.96
239_G	242_F	0.787	0.96
727_K	731_E	0.787	0.96
477_D	509_E	0.786	0.96
20_E	26_V	0.786	0.96
223_V	287_L	0.785	0.96
120_R	123_E	0.785	0.96
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116_W	120_R	0.784	0.96
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423_E	426_P	0.780	0.96
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738_A	741_S	0.773	0.96
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377_E	381_D	0.764	0.96
740_K	743_Q	0.763	0.96
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664_P	667_R	0.760	0.96
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219_L	244_V	0.751	0.95
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293_F	311_I	0.749	0.95
480_E	507_T	0.748	0.95
199_V	211_I	0.748	0.95
416_H	440_P	0.746	0.95
306_F	324_D	0.746	0.95
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623_V	684_L	0.740	0.95
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312_D	315_K	0.739	0.95
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766_A	784_I	0.738	0.95
121_I	125_K	0.738	0.95
414_C	443_G	0.738	0.95
237_R	242_F	0.738	0.95
256_D	270_V	0.737	0.95
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293_F	300_N	0.730	0.95
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344_C	414_C	0.730	0.95
363_D	366_L	0.729	0.95
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382_R	385_E	0.729	0.95
444_G	447_W	0.728	0.95
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297_G	312_D	0.727	0.94
413_E	416_H	0.726	0.94
462_I	502_R	0.726	0.94
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379_M	382_R	0.722	0.94
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311_I	349_E	0.718	0.94
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421_G	424_Q	0.713	0.94
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289_L	352_S	0.710	0.94
316_T	323_D	0.709	0.94
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216_P	319_A	0.707	0.94
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118_E	121_I	0.703	0.93
785_D	789_D	0.703	0.93
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488_G	518_N	0.702	0.93
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619_V	684_L	0.700	0.93
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114_I	118_E	0.698	0.93
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586_T	590_T	0.697	0.93
732_V	735_E	0.696	0.93
211_I	267_A	0.695	0.93
344_C	411_C	0.695	0.93
602_D	605_Y	0.695	0.93
344_C	442_C	0.694	0.93
127_T	540_D	0.694	0.93
235_A	238_I	0.693	0.93
53_L	567_F	0.692	0.93
542_A	569_W	0.692	0.93
159_M	165_V	0.692	0.93
246_L	322_L	0.691	0.93
595_E	671_E	0.690	0.93
159_M	358_V	0.690	0.93
292_V	302_A	0.688	0.93
558_G	565_V	0.687	0.93
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659_L	674_L	0.686	0.93
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722_A	730_A	0.685	0.93
160_A	165_V	0.683	0.92
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731_E	734_R	0.682	0.92
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119_D	122_D	0.680	0.92
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493_R	497_F	0.680	0.92
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203_G	253_L	0.679	0.92
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613_L	673_T	0.673	0.92
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698_Q	706_S	0.668	0.92
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739_W	743_Q	0.668	0.92
750_D	780_P	0.667	0.92
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735_E	739_W	0.665	0.91
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605_Y	672_H	0.656	0.91
117_T	121_I	0.656	0.91
385_E	389_G	0.655	0.91
416_H	439_C	0.653	0.91
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246_L	325_Q	0.651	0.91
524_E	569_W	0.650	0.90
500_L	511_P	0.650	0.90
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489_H	520_M	0.650	0.90
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283_M	286_D	0.647	0.90
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160_A	419_I	0.644	0.90
99_I	112_M	0.644	0.90
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390_M	501_L	0.641	0.90
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59_W	62_I	0.640	0.90
698_Q	707_V	0.640	0.90
260_D	263_F	0.640	0.90
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662_G	665_G	0.639	0.90
13_I	17_W	0.639	0.90
155_S	465_L	0.639	0.90
732_V	736_I	0.639	0.90
732_V	773_L	0.637	0.90
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725_A	769_D	0.635	0.89
627_M	712_F	0.635	0.89
383_L	500_L	0.634	0.89
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695_E	699_S	0.633	0.89
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485_R	496_A	0.632	0.89
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639_L	685_L	0.630	0.89
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238_I	243_E	0.629	0.89
396_I	454_M	0.629	0.89
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209_I	237_R	0.628	0.89
758_F	784_I	0.628	0.89
36_T	483_D	0.628	0.89
295_E	353_K	0.626	0.89
557_L	575_A	0.626	0.89
193_E	334_T	0.626	0.89
134_S	708_H	0.626	0.89
226_V	258_D	0.626	0.89
37_Q	479_F	0.625	0.89
702_G	705_G	0.624	0.89
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176_P	297_G	0.623	0.89
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306_F	314_A	0.622	0.88
18_Q	130_E	0.621	0.88
723_E	727_K	0.621	0.88
571_E	574_S	0.620	0.88
17_W	694_E	0.620	0.88
412_N	415_G	0.618	0.88
174_W	181_A	0.618	0.88
740_K	751_L	0.616	0.88
232_D	261_A	0.615	0.88
252_E	288_D	0.615	0.88
203_G	209_I	0.614	0.88
553_Q	689_S	0.614	0.88
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634_R	638_S	0.613	0.88
290_R	302_A	0.613	0.88
753_R	779_A	0.613	0.88
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413_E	444_G	0.612	0.88
542_A	567_F	0.612	0.88
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254_L	284_D	0.612	0.88
500_L	510_Q	0.612	0.88
442_C	446_D	0.611	0.88
773_L	779_A	0.610	0.88
201_F	225_I	0.609	0.87
64_F	688_F	0.609	0.87
67_R	708_H	0.608	0.87
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417_W	420_A	0.607	0.87
769_D	776_T	0.607	0.87
442_C	447_W	0.606	0.87
463_T	467_L	0.606	0.87
660_Y	667_R	0.606	0.87
200_T	243_E	0.606	0.87
31_P	478_E	0.606	0.87
686_A	707_V	0.605	0.87
247_F	250_D	0.604	0.87
468_S	482_V	0.603	0.87
689_S	692_T	0.603	0.87
414_C	447_W	0.602	0.87
162_A	508_D	0.600	0.87
529_M	536_F	0.599	0.87
170_H	357_F	0.599	0.87
68_Y	712_F	0.598	0.86
756_L	785_D	0.598	0.86
294_T	301_E	0.597	0.86
223_V	282_W	0.597	0.86
168_D	357_F	0.596	0.86
489_H	517_V	0.596	0.86
365_I	500_L	0.596	0.86
22_Q	126_A	0.595	0.86
265_S	270_V	0.595	0.86
337_S	340_S	0.594	0.86
291_T	299_L	0.594	0.86
151_K	469_G	0.594	0.86
339_G	350_I	0.594	0.86
383_L	387_T	0.593	0.86
504_G	508_D	0.593	0.86
294_T	299_L	0.592	0.86
175_C	442_C	0.592	0.86
258_D	263_F	0.592	0.86
66_A	134_S	0.592	0.86
619_V	622_D	0.592	0.86
537_V	569_W	0.591	0.86
31_P	36_T	0.591	0.86
746_P	751_L	0.590	0.86
420_A	424_Q	0.590	0.86
200_T	208_D	0.590	0.86
639_L	681_V	0.589	0.86
697_W	704_E	0.588	0.86
437_E	440_P	0.587	0.85
757_Y	762_D	0.587	0.85
758_F	761_S	0.587	0.85
254_L	287_L	0.587	0.85
139_S	145_D	0.586	0.85
279_V	289_L	0.586	0.85
766_A	769_D	0.586	0.85
92_K	120_R	0.586	0.85
182_I	342_W	0.585	0.85
176_P	346_T	0.585	0.85
728_R	765_A	0.585	0.85
754_V	783_L	0.584	0.85
129_Q	137_W	0.584	0.85
465_L	469_G	0.584	0.85
773_L	777_V	0.583	0.85
194_G	336_Q	0.583	0.85
439_C	446_D	0.582	0.85
441_E	445_D	0.582	0.85
606_R	669_A	0.581	0.85
229_P	258_D	0.580	0.85
90_E	113_C	0.580	0.85
90_E	101_R	0.580	0.85
523_G	535_N	0.579	0.85
725_A	730_A	0.579	0.85
419_I	423_E	0.578	0.85
372_A	515_V	0.578	0.85
247_F	290_R	0.577	0.84
156_F	454_M	0.577	0.84
589_S	675_Y	0.576	0.84
620_C	716_E	0.576	0.84
418_E	421_G	0.576	0.84
336_Q	340_S	0.576	0.84
606_R	655_V	0.575	0.84
639_L	684_L	0.575	0.84
753_R	757_Y	0.574	0.84
745_M	751_L	0.573	0.84
736_I	779_A	0.573	0.84
172_V	182_I	0.573	0.84
589_S	674_L	0.573	0.84
410_E	450_E	0.572	0.84
529_M	535_N	0.571	0.84
786_G	789_D	0.571	0.84
586_T	699_S	0.570	0.84
299_L	318_V	0.570	0.84
58_G	62_I	0.570	0.84
373_E	513_D	0.569	0.84
520_M	528_K	0.568	0.84
161_D	437_E	0.568	0.84
775_E	778_N	0.568	0.84
488_G	517_V	0.568	0.84
705_G	710_A	0.566	0.83
618_T	621_E	0.566	0.83
619_V	639_L	0.566	0.83
570_K	574_S	0.566	0.83
244_V	248_G	0.566	0.83
770_T	779_A	0.565	0.83
746_P	750_D	0.565	0.83
293_F	298_H	0.565	0.83
369_A	372_A	0.565	0.83
204_V	207_G	0.565	0.83
676_T	679_T	0.565	0.83
18_Q	708_H	0.565	0.83
119_D	126_A	0.564	0.83
751_L	780_P	0.564	0.83
232_D	235_A	0.564	0.83
750_D	778_N	0.564	0.83
678_V	696_I	0.563	0.83
36_T	72_K	0.562	0.83
225_I	251_V	0.562	0.83
736_I	753_R	0.562	0.83
411_C	441_E	0.561	0.83
291_T	300_N	0.560	0.83
620_C	623_V	0.560	0.83
322_L	327_Y	0.560	0.83
173_N	348_I	0.560	0.83
205_D	208_D	0.559	0.83
435_A	438_A	0.559	0.83
536_F	539_P	0.558	0.82
157_S	424_Q	0.557	0.82
128_M	137_W	0.557	0.82
600_I	604_A	0.557	0.82
263_F	334_T	0.557	0.82
752_D	793_V	0.556	0.82
64_F	632_F	0.556	0.82
619_V	635_A	0.555	0.82
525_D	533_R	0.555	0.82
671_E	675_Y	0.555	0.82
365_I	497_F	0.554	0.82
15_P	544_A	0.553	0.82
586_T	589_S	0.553	0.82
153_Q	409_W	0.552	0.82
605_Y	609_D	0.551	0.82
777_V	782_R	0.551	0.82
195_T	319_A	0.551	0.82
705_G	709_A	0.550	0.82
355_Q	395_V	0.550	0.82
293_F	349_E	0.550	0.82
123_E	127_T	0.549	0.81
682_T	700_L	0.549	0.81
437_E	442_C	0.548	0.81
498_Y	512_W	0.547	0.81
200_T	327_Y	0.547	0.81
758_F	762_D	0.547	0.81
203_G	208_D	0.547	0.81
754_V	757_Y	0.544	0.81
57_L	565_V	0.543	0.81
78_F	133_F	0.543	0.81
601_Q	605_Y	0.543	0.81
319_A	323_D	0.542	0.81
772_D	776_T	0.542	0.81
5_P	699_S	0.541	0.81
201_F	211_I	0.540	0.80
222_C	269_M	0.540	0.80
608_A	654_L	0.540	0.80
355_Q	399_Q	0.540	0.80
634_R	637_R	0.540	0.80
53_L	538_Q	0.539	0.80
219_L	325_Q	0.537	0.80
37_Q	74_D	0.537	0.80
29_F	479_F	0.537	0.80
248_G	325_Q	0.537	0.80
304_G	321_E	0.537	0.80
677_A	681_V	0.536	0.80
592_H	660_Y	0.536	0.80
291_T	295_E	0.536	0.80
29_F	709_A	0.536	0.80
590_T	699_S	0.536	0.80
91_V	95_E	0.535	0.80
473_G	476_L	0.535	0.80
610_R	613_L	0.535	0.80
254_L	270_V	0.534	0.80
604_A	669_A	0.534	0.80
768_L	771_Y	0.534	0.80
199_V	246_L	0.533	0.80
30_D	75_A	0.533	0.80
181_A	297_G	0.533	0.80
319_A	333_P	0.533	0.80
464_P	503_T	0.532	0.79
151_K	471_P	0.532	0.79
91_V	177_R	0.532	0.79
753_R	791_E	0.532	0.79
38_Y	630_Y	0.531	0.79
51_L	538_Q	0.531	0.79
754_V	785_D	0.531	0.79
602_D	718_R	0.531	0.79
659_L	671_E	0.531	0.79
252_E	285_H	0.530	0.79
666_E	670_A	0.530	0.79
598_P	675_Y	0.530	0.79
56_A	537_V	0.529	0.79
154_E	425_A	0.529	0.79
410_E	417_W	0.529	0.79
588_F	652_V	0.529	0.79
614_S	720_A	0.528	0.79
225_I	253_L	0.528	0.79
503_T	509_E	0.528	0.79
228_S	258_D	0.527	0.79
554_A	571_E	0.527	0.79
88_P	342_W	0.527	0.79
47_P	93_V	0.526	0.79
340_S	344_C	0.526	0.79
489_H	519_G	0.525	0.79
457_W	460_S	0.525	0.79
147_E	472_E	0.525	0.79
769_D	777_V	0.525	0.79
434_P	438_A	0.525	0.79
756_L	787_R	0.524	0.78
165_V	454_M	0.524	0.78
111_E	118_E	0.524	0.78
790_V	793_V	0.523	0.78
469_G	473_G	0.523	0.78
561_P	633_D	0.523	0.78
38_Y	483_D	0.522	0.78
647_L	681_V	0.522	0.78
99_I	108_E	0.521	0.78
194_G	334_T	0.521	0.78
432_D	435_A	0.521	0.78
419_I	422_R	0.520	0.78
196_L	332_E	0.520	0.78
588_F	674_L	0.520	0.78
53_L	551_V	0.520	0.78
608_A	726_G	0.520	0.78
31_P	711_T	0.520	0.78
369_A	380_H	0.520	0.78
596_D	675_Y	0.519	0.78
201_F	251_V	0.519	0.78
729_I	769_D	0.519	0.78
418_E	441_E	0.519	0.78
172_V	348_I	0.519	0.78
592_H	674_L	0.518	0.78
560_R	633_D	0.518	0.78
344_C	347_A	0.518	0.78
421_G	425_A	0.517	0.77
246_L	327_Y	0.517	0.77
597_T	668_A	0.517	0.77
79_P	475_T	0.517	0.77
102_T	179_E	0.517	0.77
246_L	314_A	0.517	0.77
70_R	76_V	0.516	0.77
413_E	445_D	0.516	0.77
675_Y	679_T	0.516	0.77
181_A	399_Q	0.516	0.77
542_A	572_V	0.515	0.77
729_I	733_A	0.515	0.77
542_A	546_Y	0.515	0.77
529_M	537_V	0.515	0.77
172_V	181_A	0.515	0.77
739_W	793_V	0.514	0.77
657_G	661_N	0.513	0.77
751_L	793_V	0.513	0.77
170_H	353_K	0.513	0.77
204_V	208_D	0.512	0.77
98_D	103_D	0.512	0.77
676_T	713_P	0.512	0.77
41_D	468_S	0.510	0.77
489_H	492_I	0.510	0.77
766_A	773_L	0.510	0.77
689_S	693_T	0.510	0.77
612_L	673_T	0.510	0.77
610_R	614_S	0.509	0.76
605_Y	610_R	0.509	0.76
436_V	442_C	0.507	0.76
165_V	358_V	0.507	0.76
623_V	712_F	0.507	0.76
56_A	60_S	0.507	0.76
175_C	414_C	0.507	0.76
147_E	151_K	0.506	0.76
596_D	668_A	0.506	0.76
33_E	478_E	0.505	0.76
69_R	76_V	0.505	0.76
192_R	336_Q	0.505	0.76
756_L	759_D	0.505	0.76
318_V	321_E	0.505	0.76
765_A	773_L	0.504	0.76
34_S	37_Q	0.504	0.76
28_R	136_D	0.504	0.76
106_S	433_D	0.504	0.76
291_T	294_T	0.503	0.76
74_D	628_S	0.503	0.76
663_R	667_R	0.502	0.75
31_P	34_S	0.502	0.75
411_C	440_P	0.502	0.75
77_L	479_F	0.501	0.75
762_D	765_A	0.501	0.75
192_R	347_A	0.501	0.75
59_W	135_Q	0.501	0.75
592_H	659_L	0.501	0.75
87_L	400_R	0.500	0.75
772_D	775_E	0.500	0.75
760_D	763_D	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1gaxA	1	0.9569	100	0.153	Contact Map
1ffyA	1	0.9421	100	0.214	Contact Map
1ileA	1	0.8388	100	0.293	Contact Map
1wz2A	1	0.9217	100	0.312	Contact Map
2v0cA	1	0.7083	100	0.393	Contact Map
1wkbA	1	0.748	100	0.394	Contact Map
4arcA	1	0.7616	100	0.412	Contact Map
3ziuA	1	0.6538	100	0.524	Contact Map
1rqgA	2	0.6209	100	0.635	Contact Map
4qreA	1	0.5653	100	0.641	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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