Q9HMG8 - HALSA - GREMLIN Contacts

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Q9HMG8 - Uncharacterized protein

UniProt:	Q9HMG8	Sequences: MQRRAFLKAGSAATLAGLLAGCSSPDSDATSTAADSATATADETTAGSGSYSVSMEPVGDVEFDAVPDTVAVYESGYADMVVALGHGDALTAVGNSDRFHTDAYDALDGVSVDTSGLVDLVDAGVTRETLLDLDPDVYLMDPNWLTSTFELDRGDIDFLTQRSAPFLGNTIFRRTDAWHDYDYYSLYEAFETVAELFDETDRFDAFQSFHDSALDRLETALPSEGPRGALVWGGSNEPTSFSPYLLSGAGTNKKPFHDLNVRDAIADSGIDALSQSQRSEIDAETLLNVDPDVLFVRGHEDKTAAEFQDTVVSFLQNHDTAGRITAVENGDVYRGGPIYLGPIQHLFLTERLATALYDQVTTTLFDRAELASIITD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	376 (299)
Sequences:	9871 (8040)
Seq/√Len:	465.0

ECOLI - FECB FEPB FHUD BTUF
BACSU - YVRC YFMC YFIY YXEB YCLQ FHUD YHFQ FEUA
HALSA - Q9HMG8 Q9HMF9 Q9HPB0 BTUFA Q9HSB2
SULSO - Q97ZU2 Q980Z0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
191_E	204_D	4.204	1.00
194_A	203_F	3.978	1.00
290_D	325_T	3.973	1.00
187_Y	211_D	3.840	1.00
199_E	202_R	3.610	1.00
325_T	329_N	3.408	1.00
195_E	200_T	3.297	1.00
204_D	208_S	2.842	1.00
215_D	219_T	2.841	1.00
191_E	207_Q	2.818	1.00
208_S	212_S	2.786	1.00
213_A	350_E	2.770	1.00
202_R	205_A	2.759	1.00
72_V	78_A	2.724	1.00
129_T	132_D	2.722	1.00
69_T	91_T	2.479	1.00
212_S	216_R	2.390	1.00
285_T	288_N	2.372	1.00
216_R	220_A	2.337	1.00
256_F	261_V	2.323	1.00
211_D	215_D	2.320	1.00
55_M	58_V	2.219	1.00
81_V	197_F	2.211	1.00
316_Q	330_G	2.206	1.00
71_A	130_L	2.158	1.00
313_S	317_N	2.157	1.00
292_D	325_T	2.142	1.00
70_V	197_F	2.076	1.00
229_A	262_R	2.064	1.00
54_S	60_D	1.987	1.00
293_V	331_D	1.938	1.00
205_A	209_F	1.897	1.00
312_V	316_Q	1.865	1.00
158_F	161_Q	1.863	1.00
156_I	160_T	1.851	1.00
325_T	328_E	1.850	1.00
185_S	188_E	1.848	1.00
157_D	161_Q	1.807	1.00
323_R	328_E	1.751	1.00
293_V	333_Y	1.749	1.00
201_D	205_A	1.748	1.00
56_E	60_D	1.743	1.00
215_D	218_E	1.740	1.00
86_H	197_F	1.720	1.00
87_G	90_L	1.705	1.00
139_L	193_V	1.700	1.00
51_Y	55_M	1.681	1.00
309_D	313_S	1.659	1.00
125_V	130_L	1.643	1.00
188_E	191_E	1.606	1.00
71_A	133_L	1.584	1.00
92_A	133_L	1.579	1.00
324_I	327_V	1.558	1.00
208_S	211_D	1.557	1.00
153_R	157_D	1.552	1.00
285_T	289_V	1.548	1.00
283_A	318_H	1.545	1.00
118_V	129_T	1.518	1.00
86_H	199_E	1.514	1.00
313_S	316_Q	1.505	1.00
14_T	17_G	1.505	1.00
294_L	326_A	1.500	1.00
219_T	222_P	1.488	1.00
230_L	261_V	1.477	1.00
253_K	257_H	1.475	1.00
59_G	160_T	1.473	1.00
228_G	293_V	1.470	1.00
52_S	55_M	1.469	1.00
55_M	59_G	1.456	1.00
213_A	216_R	1.455	1.00
212_S	215_D	1.454	1.00
80_M	190_F	1.449	1.00
216_R	219_T	1.439	1.00
209_F	213_A	1.430	1.00
52_S	60_D	1.430	1.00
229_A	292_D	1.420	1.00
52_S	62_E	1.416	1.00
200_T	204_D	1.410	1.00
91_T	133_L	1.408	1.00
128_E	284_E	1.406	1.00
241_F	245_L	1.402	1.00
201_D	204_D	1.394	1.00
202_R	206_F	1.379	1.00
214_L	349_T	1.374	1.00
69_T	134_D	1.349	1.00
209_F	212_S	1.344	1.00
15_L	18_L	1.342	1.00
112_V	115_S	1.333	1.00
86_H	90_L	1.332	1.00
126_T	129_T	1.332	1.00
241_F	246_L	1.309	1.00
57_P	61_V	1.302	1.00
321_A	327_V	1.298	1.00
71_A	92_A	1.278	1.00
293_V	356_L	1.278	1.00
81_V	86_H	1.272	1.00
70_V	137_V	1.260	1.00
152_D	155_D	1.253	1.00
217_L	349_T	1.233	1.00
68_D	136_D	1.232	1.00
140_M	168_G	1.227	1.00
187_Y	207_Q	1.223	1.00
261_V	356_L	1.223	1.00
192_T	195_E	1.219	1.00
227_R	262_R	1.203	1.00
167_L	192_T	1.182	1.00
228_G	331_D	1.178	1.00
188_E	192_T	1.170	1.00
333_Y	355_A	1.168	1.00
264_A	289_V	1.166	1.00
167_L	196_L	1.164	1.00
157_D	160_T	1.163	1.00
319_D	322_G	1.156	1.00
206_F	209_F	1.155	1.00
72_V	81_V	1.154	1.00
127_R	158_F	1.142	1.00
217_L	353_A	1.142	1.00
310_T	313_S	1.140	1.00
63_F	165_P	1.132	1.00
65_A	68_D	1.131	1.00
137_V	167_L	1.129	1.00
13_A	17_G	1.123	1.00
207_Q	211_D	1.123	1.00
83_A	206_F	1.119	1.00
242_S	280_E	1.112	1.00
267_D	289_V	1.110	1.00
190_F	203_F	1.098	1.00
63_F	66_V	1.098	1.00
232_W	256_F	1.098	1.00
218_E	222_P	1.093	1.00
84_L	199_E	1.091	1.00
191_E	211_D	1.076	1.00
70_V	81_V	1.076	1.00
56_E	59_G	1.073	1.00
352_L	356_L	1.072	1.00
191_E	195_E	1.056	1.00
262_R	266_A	1.056	1.00
321_A	324_I	1.048	1.00
214_L	218_E	1.040	1.00
12_A	16_A	1.034	1.00
231_V	291_P	1.032	1.00
160_T	166_F	1.029	1.00
296_V	334_R	1.025	1.00
138_Y	164_A	1.020	1.00
94_G	97_D	1.016	1.00
90_L	117_L	1.013	1.00
15_L	19_L	1.004	1.00
131_L	164_A	1.002	1.00
325_T	331_D	1.001	1.00
350_E	354_T	1.000	1.00
351_R	354_T	0.991	1.00
310_T	314_F	0.988	1.00
231_V	245_L	0.982	1.00
67_P	137_V	0.980	1.00
343_I	346_L	0.980	1.00
93_V	117_L	0.979	1.00
51_Y	195_E	0.973	1.00
264_A	267_D	0.962	1.00
348_L	351_R	0.962	1.00
138_Y	163_S	0.961	1.00
205_A	208_S	0.958	1.00
137_V	196_L	0.957	1.00
233_G	318_H	0.955	1.00
265_I	268_S	0.951	1.00
213_A	346_L	0.945	1.00
95_N	119_D	0.940	1.00
66_V	199_E	0.939	1.00
210_H	214_L	0.937	1.00
259_L	356_L	0.927	1.00
254_K	257_H	0.923	1.00
346_L	350_E	0.923	1.00
114_T	117_L	0.920	1.00
63_F	67_P	0.919	1.00
327_V	332_V	0.911	1.00
316_Q	332_V	0.908	1.00
155_D	158_F	0.908	1.00
92_A	121_V	0.906	1.00
295_F	352_L	0.905	1.00
16_A	20_A	0.901	1.00
286_L	324_I	0.899	1.00
231_V	234_G	0.897	1.00
216_R	350_E	0.896	1.00
231_V	286_L	0.890	1.00
204_D	207_Q	0.888	1.00
265_I	289_V	0.885	1.00
17_G	20_A	0.881	1.00
248_G	257_H	0.877	1.00
66_V	198_D	0.874	1.00
81_V	139_L	0.873	1.00
22_C	25_P	0.872	1.00
80_M	193_V	0.867	1.00
139_L	196_L	0.862	1.00
314_F	317_N	0.862	1.00
113_D	116_G	0.859	1.00
281_I	289_V	0.857	1.00
218_E	258_D	0.854	1.00
11_S	15_L	0.848	1.00
11_S	14_T	0.843	1.00
203_F	207_Q	0.843	1.00
53_V	167_L	0.840	1.00
287_L	324_I	0.838	1.00
233_G	294_L	0.837	1.00
265_I	285_T	0.837	1.00
210_H	258_D	0.828	1.00
111_S	115_S	0.825	1.00
351_R	355_A	0.822	1.00
51_Y	58_V	0.817	1.00
249_A	253_K	0.811	1.00
81_V	90_L	0.810	1.00
213_A	217_L	0.810	1.00
311_V	314_F	0.809	1.00
263_D	267_D	0.806	1.00
16_A	19_L	0.802	1.00
242_S	246_L	0.801	1.00
343_I	347_F	0.801	1.00
10_G	14_T	0.800	1.00
221_L	353_A	0.798	1.00
233_G	236_N	0.797	1.00
73_Y	138_Y	0.794	1.00
295_F	333_Y	0.793	1.00
79_D	344_Q	0.791	1.00
192_T	196_L	0.790	1.00
250_G	253_K	0.788	1.00
51_Y	66_V	0.785	1.00
50_S	62_E	0.784	1.00
53_V	58_V	0.784	1.00
254_K	258_D	0.781	1.00
189_A	192_T	0.777	1.00
287_L	323_R	0.775	1.00
312_V	334_R	0.774	1.00
344_Q	347_F	0.773	1.00
52_S	59_G	0.766	1.00
230_L	256_F	0.763	1.00
307_F	310_T	0.762	1.00
259_L	349_T	0.761	1.00
135_P	138_Y	0.761	1.00
184_Y	188_E	0.761	1.00
299_H	337_P	0.759	1.00
187_Y	214_L	0.758	1.00
18_L	21_G	0.757	1.00
240_S	245_L	0.755	1.00
193_V	196_L	0.754	1.00
347_F	351_R	0.754	1.00
27_S	30_T	0.752	1.00
345_H	348_L	0.752	1.00
61_V	167_L	0.750	1.00
72_V	90_L	0.748	1.00
13_A	16_A	0.748	1.00
12_A	15_L	0.747	1.00
57_P	156_I	0.747	1.00
115_S	118_V	0.746	1.00
169_N	192_T	0.746	1.00
187_Y	191_E	0.743	1.00
71_A	120_L	0.742	1.00
67_P	136_D	0.741	1.00
74_E	141_D	0.739	1.00
52_S	58_V	0.738	1.00
217_L	346_L	0.736	1.00
231_V	235_S	0.734	1.00
193_V	197_F	0.733	1.00
225_G	228_G	0.725	1.00
220_A	223_S	0.725	1.00
241_F	244_Y	0.724	1.00
224_E	227_R	0.723	1.00
51_Y	64_D	0.723	1.00
53_V	59_G	0.723	1.00
138_Y	159_L	0.719	1.00
213_A	347_F	0.716	1.00
8_K	18_L	0.715	1.00
11_S	18_L	0.714	1.00
71_A	138_Y	0.714	1.00
214_L	258_D	0.714	1.00
163_S	166_F	0.712	1.00
255_P	349_T	0.707	1.00
281_I	286_L	0.705	1.00
220_A	353_A	0.704	1.00
63_F	196_L	0.701	1.00
87_G	116_G	0.700	1.00
118_V	121_V	0.699	1.00
232_W	297_R	0.697	1.00
142_P	170_T	0.696	1.00
51_Y	65_A	0.686	1.00
20_A	23_S	0.683	1.00
243_P	246_L	0.682	1.00
129_T	133_L	0.682	1.00
57_P	168_G	0.681	1.00
336_G	339_Y	0.681	1.00
287_L	320_T	0.676	1.00
242_S	245_L	0.674	1.00
64_D	165_P	0.672	1.00
50_S	55_M	0.672	1.00
214_L	346_L	0.668	1.00
114_T	118_V	0.668	1.00
118_V	133_L	0.667	1.00
283_A	321_A	0.664	1.00
256_F	259_L	0.664	1.00
22_C	26_D	0.657	1.00
7_L	10_G	0.655	1.00
253_K	266_A	0.653	1.00
190_F	206_F	0.652	1.00
61_V	165_P	0.651	1.00
63_F	137_V	0.651	1.00
218_E	259_L	0.649	1.00
83_A	343_I	0.644	1.00
217_L	221_L	0.643	1.00
9_A	13_A	0.641	1.00
82_V	90_L	0.640	1.00
71_A	135_P	0.639	1.00
309_D	312_V	0.637	1.00
83_A	190_F	0.635	1.00
49_G	198_D	0.634	1.00
318_H	322_G	0.632	0.99
194_A	207_Q	0.629	0.99
291_P	294_L	0.627	0.99
230_L	295_F	0.623	0.99
241_F	247_S	0.622	0.99
315_L	318_H	0.621	0.99
127_R	130_L	0.621	0.99
12_A	18_L	0.620	0.99
81_V	193_V	0.620	0.99
217_L	220_A	0.619	0.99
25_P	28_D	0.619	0.99
296_V	332_V	0.619	0.99
84_L	206_F	0.616	0.99
69_T	136_D	0.616	0.99
246_L	250_G	0.616	0.99
322_G	327_V	0.615	0.99
84_L	202_R	0.615	0.99
84_L	197_F	0.615	0.99
191_E	200_T	0.615	0.99
63_F	167_L	0.614	0.99
92_A	120_L	0.614	0.99
47_G	50_S	0.612	0.99
113_D	117_L	0.611	0.99
335_G	348_L	0.610	0.99
154_G	158_F	0.610	0.99
156_I	166_F	0.608	0.99
80_M	83_A	0.607	0.99
336_G	351_R	0.606	0.99
251_T	254_K	0.605	0.99
297_R	335_G	0.604	0.99
261_V	293_V	0.604	0.99
127_R	155_D	0.604	0.99
186_L	210_H	0.604	0.99
228_G	232_W	0.602	0.99
28_D	31_S	0.602	0.99
311_V	315_L	0.601	0.99
229_A	293_V	0.600	0.99
82_V	87_G	0.599	0.99
71_A	91_T	0.599	0.99
84_L	194_A	0.598	0.99
51_Y	57_P	0.597	0.99
187_Y	210_H	0.596	0.99
67_P	70_V	0.596	0.99
46_A	49_G	0.596	0.99
210_H	213_A	0.595	0.99
294_L	321_A	0.595	0.99
232_W	252_N	0.592	0.99
206_F	210_H	0.592	0.99
118_V	132_D	0.590	0.99
197_F	200_T	0.590	0.99
55_M	61_V	0.589	0.99
306_E	309_D	0.588	0.99
77_Y	139_L	0.586	0.99
217_L	259_L	0.586	0.99
255_P	352_L	0.586	0.99
130_L	159_L	0.584	0.99
87_G	113_D	0.583	0.99
207_Q	210_H	0.582	0.99
72_V	77_Y	0.582	0.99
14_T	18_L	0.582	0.99
221_L	224_E	0.581	0.99
184_Y	187_Y	0.577	0.99
248_G	266_A	0.574	0.99
160_T	165_P	0.573	0.99
77_Y	169_N	0.573	0.99
214_L	217_L	0.571	0.99
120_L	133_L	0.566	0.99
130_L	133_L	0.563	0.99
57_P	160_T	0.562	0.99
51_Y	63_F	0.558	0.99
282_D	285_T	0.558	0.99
190_F	207_Q	0.557	0.99
128_E	282_D	0.557	0.99
61_V	64_D	0.556	0.99
341_G	344_Q	0.555	0.99
229_A	264_A	0.553	0.99
218_E	260_N	0.550	0.99
50_S	53_V	0.549	0.99
191_E	194_A	0.549	0.99
156_I	168_G	0.549	0.99
324_I	328_E	0.548	0.99
321_A	332_V	0.548	0.99
259_L	352_L	0.546	0.99
53_V	63_F	0.546	0.99
69_T	133_L	0.546	0.99
335_G	340_L	0.545	0.98
232_W	235_S	0.545	0.98
295_F	356_L	0.545	0.98
14_T	20_A	0.543	0.98
265_I	269_G	0.543	0.98
84_L	203_F	0.542	0.98
19_L	22_C	0.541	0.98
154_G	157_D	0.540	0.98
230_L	234_G	0.540	0.98
100_H	103_A	0.540	0.98
26_D	29_A	0.540	0.98
74_E	77_Y	0.538	0.98
311_V	316_Q	0.538	0.98
287_L	291_P	0.537	0.98
73_Y	120_L	0.537	0.98
243_P	247_S	0.537	0.98
140_M	151_L	0.536	0.98
230_L	233_G	0.536	0.98
27_S	31_S	0.535	0.98
320_T	323_R	0.534	0.98
172_F	189_A	0.534	0.98
53_V	195_E	0.533	0.98
224_E	228_G	0.532	0.98
91_T	135_P	0.531	0.98
53_V	57_P	0.531	0.98
159_L	166_F	0.528	0.98
248_G	268_S	0.527	0.98
187_Y	258_D	0.524	0.98
227_R	230_L	0.523	0.98
140_M	166_F	0.523	0.98
230_L	292_D	0.519	0.98
84_L	190_F	0.519	0.98
79_D	341_G	0.517	0.98
224_E	261_V	0.516	0.98
67_P	197_F	0.516	0.98
49_G	52_S	0.516	0.98
341_G	345_H	0.514	0.98
231_V	281_I	0.514	0.98
246_L	278_R	0.511	0.98
249_A	254_K	0.510	0.98
51_Y	56_E	0.509	0.98
231_V	294_L	0.509	0.98
58_V	61_V	0.508	0.98
48_S	51_Y	0.507	0.98
211_D	214_L	0.504	0.98
298_G	334_R	0.504	0.98
228_G	261_V	0.503	0.97
243_P	283_A	0.502	0.97
130_L	138_Y	0.502	0.97
7_L	17_G	0.502	0.97
8_K	12_A	0.500	0.97
85_G	202_R	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mo9A	1	0.8218	100	0.273	Contact Map
4n01A	1	0.7766	100	0.273	Contact Map
4hn9A	1	0.8191	100	0.281	Contact Map
4ovkA	1	0.7793	100	0.283	Contact Map
4mlzA	1	0.7872	100	0.299	Contact Map
3pshA	1	0.7872	100	0.31	Contact Map
4pagA	2	0.7766	100	0.312	Contact Map
4inoA	1	0.7553	100	0.321	Contact Map
4ljsA	1	0.8245	100	0.329	Contact Map
2etvA	2	0.7473	100	0.344	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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