GREMLIN Database
Q9HMG8 - Uncharacterized protein
UniProt: Q9HMG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (299)
Sequences: 9871 (8040)
Seq/√Len: 465.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_E204_D4.2041.00
194_A203_F3.9781.00
290_D325_T3.9731.00
187_Y211_D3.8401.00
199_E202_R3.6101.00
325_T329_N3.4081.00
195_E200_T3.2971.00
204_D208_S2.8421.00
215_D219_T2.8411.00
191_E207_Q2.8181.00
208_S212_S2.7861.00
213_A350_E2.7701.00
202_R205_A2.7591.00
72_V78_A2.7241.00
129_T132_D2.7221.00
69_T91_T2.4791.00
212_S216_R2.3901.00
285_T288_N2.3721.00
216_R220_A2.3371.00
256_F261_V2.3231.00
211_D215_D2.3201.00
55_M58_V2.2191.00
81_V197_F2.2111.00
316_Q330_G2.2061.00
71_A130_L2.1581.00
313_S317_N2.1571.00
292_D325_T2.1421.00
70_V197_F2.0761.00
229_A262_R2.0641.00
54_S60_D1.9871.00
293_V331_D1.9381.00
205_A209_F1.8971.00
312_V316_Q1.8651.00
158_F161_Q1.8631.00
156_I160_T1.8511.00
325_T328_E1.8501.00
185_S188_E1.8481.00
157_D161_Q1.8071.00
323_R328_E1.7511.00
293_V333_Y1.7491.00
201_D205_A1.7481.00
56_E60_D1.7431.00
215_D218_E1.7401.00
86_H197_F1.7201.00
87_G90_L1.7051.00
139_L193_V1.7001.00
51_Y55_M1.6811.00
309_D313_S1.6591.00
125_V130_L1.6431.00
188_E191_E1.6061.00
71_A133_L1.5841.00
92_A133_L1.5791.00
324_I327_V1.5581.00
208_S211_D1.5571.00
153_R157_D1.5521.00
285_T289_V1.5481.00
283_A318_H1.5451.00
118_V129_T1.5181.00
86_H199_E1.5141.00
313_S316_Q1.5051.00
14_T17_G1.5051.00
294_L326_A1.5001.00
219_T222_P1.4881.00
230_L261_V1.4771.00
253_K257_H1.4751.00
59_G160_T1.4731.00
228_G293_V1.4701.00
52_S55_M1.4691.00
55_M59_G1.4561.00
213_A216_R1.4551.00
212_S215_D1.4541.00
80_M190_F1.4491.00
216_R219_T1.4391.00
209_F213_A1.4301.00
52_S60_D1.4301.00
229_A292_D1.4201.00
52_S62_E1.4161.00
200_T204_D1.4101.00
91_T133_L1.4081.00
128_E284_E1.4061.00
241_F245_L1.4021.00
201_D204_D1.3941.00
202_R206_F1.3791.00
214_L349_T1.3741.00
69_T134_D1.3491.00
209_F212_S1.3441.00
15_L18_L1.3421.00
112_V115_S1.3331.00
86_H90_L1.3321.00
126_T129_T1.3321.00
241_F246_L1.3091.00
57_P61_V1.3021.00
321_A327_V1.2981.00
71_A92_A1.2781.00
293_V356_L1.2781.00
81_V86_H1.2721.00
70_V137_V1.2601.00
152_D155_D1.2531.00
217_L349_T1.2331.00
68_D136_D1.2321.00
140_M168_G1.2271.00
187_Y207_Q1.2231.00
261_V356_L1.2231.00
192_T195_E1.2191.00
227_R262_R1.2031.00
167_L192_T1.1821.00
228_G331_D1.1781.00
188_E192_T1.1701.00
333_Y355_A1.1681.00
264_A289_V1.1661.00
167_L196_L1.1641.00
157_D160_T1.1631.00
319_D322_G1.1561.00
206_F209_F1.1551.00
72_V81_V1.1541.00
127_R158_F1.1421.00
217_L353_A1.1421.00
310_T313_S1.1401.00
63_F165_P1.1321.00
65_A68_D1.1311.00
137_V167_L1.1291.00
13_A17_G1.1231.00
207_Q211_D1.1231.00
83_A206_F1.1191.00
242_S280_E1.1121.00
267_D289_V1.1101.00
190_F203_F1.0981.00
63_F66_V1.0981.00
232_W256_F1.0981.00
218_E222_P1.0931.00
84_L199_E1.0911.00
191_E211_D1.0761.00
70_V81_V1.0761.00
56_E59_G1.0731.00
352_L356_L1.0721.00
191_E195_E1.0561.00
262_R266_A1.0561.00
321_A324_I1.0481.00
214_L218_E1.0401.00
12_A16_A1.0341.00
231_V291_P1.0321.00
160_T166_F1.0291.00
296_V334_R1.0251.00
138_Y164_A1.0201.00
94_G97_D1.0161.00
90_L117_L1.0131.00
15_L19_L1.0041.00
131_L164_A1.0021.00
325_T331_D1.0011.00
350_E354_T1.0001.00
351_R354_T0.9911.00
310_T314_F0.9881.00
231_V245_L0.9821.00
67_P137_V0.9801.00
343_I346_L0.9801.00
93_V117_L0.9791.00
51_Y195_E0.9731.00
264_A267_D0.9621.00
348_L351_R0.9621.00
138_Y163_S0.9611.00
205_A208_S0.9581.00
137_V196_L0.9571.00
233_G318_H0.9551.00
265_I268_S0.9511.00
213_A346_L0.9451.00
95_N119_D0.9401.00
66_V199_E0.9391.00
210_H214_L0.9371.00
259_L356_L0.9271.00
254_K257_H0.9231.00
346_L350_E0.9231.00
114_T117_L0.9201.00
63_F67_P0.9191.00
327_V332_V0.9111.00
316_Q332_V0.9081.00
155_D158_F0.9081.00
92_A121_V0.9061.00
295_F352_L0.9051.00
16_A20_A0.9011.00
286_L324_I0.8991.00
231_V234_G0.8971.00
216_R350_E0.8961.00
231_V286_L0.8901.00
204_D207_Q0.8881.00
265_I289_V0.8851.00
17_G20_A0.8811.00
248_G257_H0.8771.00
66_V198_D0.8741.00
81_V139_L0.8731.00
22_C25_P0.8721.00
80_M193_V0.8671.00
139_L196_L0.8621.00
314_F317_N0.8621.00
113_D116_G0.8591.00
281_I289_V0.8571.00
218_E258_D0.8541.00
11_S15_L0.8481.00
11_S14_T0.8431.00
203_F207_Q0.8431.00
53_V167_L0.8401.00
287_L324_I0.8381.00
233_G294_L0.8371.00
265_I285_T0.8371.00
210_H258_D0.8281.00
111_S115_S0.8251.00
351_R355_A0.8221.00
51_Y58_V0.8171.00
249_A253_K0.8111.00
81_V90_L0.8101.00
213_A217_L0.8101.00
311_V314_F0.8091.00
263_D267_D0.8061.00
16_A19_L0.8021.00
242_S246_L0.8011.00
343_I347_F0.8011.00
10_G14_T0.8001.00
221_L353_A0.7981.00
233_G236_N0.7971.00
73_Y138_Y0.7941.00
295_F333_Y0.7931.00
79_D344_Q0.7911.00
192_T196_L0.7901.00
250_G253_K0.7881.00
51_Y66_V0.7851.00
50_S62_E0.7841.00
53_V58_V0.7841.00
254_K258_D0.7811.00
189_A192_T0.7771.00
287_L323_R0.7751.00
312_V334_R0.7741.00
344_Q347_F0.7731.00
52_S59_G0.7661.00
230_L256_F0.7631.00
307_F310_T0.7621.00
259_L349_T0.7611.00
135_P138_Y0.7611.00
184_Y188_E0.7611.00
299_H337_P0.7591.00
187_Y214_L0.7581.00
18_L21_G0.7571.00
240_S245_L0.7551.00
193_V196_L0.7541.00
347_F351_R0.7541.00
27_S30_T0.7521.00
345_H348_L0.7521.00
61_V167_L0.7501.00
72_V90_L0.7481.00
13_A16_A0.7481.00
12_A15_L0.7471.00
57_P156_I0.7471.00
115_S118_V0.7461.00
169_N192_T0.7461.00
187_Y191_E0.7431.00
71_A120_L0.7421.00
67_P136_D0.7411.00
74_E141_D0.7391.00
52_S58_V0.7381.00
217_L346_L0.7361.00
231_V235_S0.7341.00
193_V197_F0.7331.00
225_G228_G0.7251.00
220_A223_S0.7251.00
241_F244_Y0.7241.00
224_E227_R0.7231.00
51_Y64_D0.7231.00
53_V59_G0.7231.00
138_Y159_L0.7191.00
213_A347_F0.7161.00
8_K18_L0.7151.00
11_S18_L0.7141.00
71_A138_Y0.7141.00
214_L258_D0.7141.00
163_S166_F0.7121.00
255_P349_T0.7071.00
281_I286_L0.7051.00
220_A353_A0.7041.00
63_F196_L0.7011.00
87_G116_G0.7001.00
118_V121_V0.6991.00
232_W297_R0.6971.00
142_P170_T0.6961.00
51_Y65_A0.6861.00
20_A23_S0.6831.00
243_P246_L0.6821.00
129_T133_L0.6821.00
57_P168_G0.6811.00
336_G339_Y0.6811.00
287_L320_T0.6761.00
242_S245_L0.6741.00
64_D165_P0.6721.00
50_S55_M0.6721.00
214_L346_L0.6681.00
114_T118_V0.6681.00
118_V133_L0.6671.00
283_A321_A0.6641.00
256_F259_L0.6641.00
22_C26_D0.6571.00
7_L10_G0.6551.00
253_K266_A0.6531.00
190_F206_F0.6521.00
61_V165_P0.6511.00
63_F137_V0.6511.00
218_E259_L0.6491.00
83_A343_I0.6441.00
217_L221_L0.6431.00
9_A13_A0.6411.00
82_V90_L0.6401.00
71_A135_P0.6391.00
309_D312_V0.6371.00
83_A190_F0.6351.00
49_G198_D0.6341.00
318_H322_G0.6320.99
194_A207_Q0.6290.99
291_P294_L0.6270.99
230_L295_F0.6230.99
241_F247_S0.6220.99
315_L318_H0.6210.99
127_R130_L0.6210.99
12_A18_L0.6200.99
81_V193_V0.6200.99
217_L220_A0.6190.99
25_P28_D0.6190.99
296_V332_V0.6190.99
84_L206_F0.6160.99
69_T136_D0.6160.99
246_L250_G0.6160.99
322_G327_V0.6150.99
84_L202_R0.6150.99
84_L197_F0.6150.99
191_E200_T0.6150.99
63_F167_L0.6140.99
92_A120_L0.6140.99
47_G50_S0.6120.99
113_D117_L0.6110.99
335_G348_L0.6100.99
154_G158_F0.6100.99
156_I166_F0.6080.99
80_M83_A0.6070.99
336_G351_R0.6060.99
251_T254_K0.6050.99
297_R335_G0.6040.99
261_V293_V0.6040.99
127_R155_D0.6040.99
186_L210_H0.6040.99
228_G232_W0.6020.99
28_D31_S0.6020.99
311_V315_L0.6010.99
229_A293_V0.6000.99
82_V87_G0.5990.99
71_A91_T0.5990.99
84_L194_A0.5980.99
51_Y57_P0.5970.99
187_Y210_H0.5960.99
67_P70_V0.5960.99
46_A49_G0.5960.99
210_H213_A0.5950.99
294_L321_A0.5950.99
232_W252_N0.5920.99
206_F210_H0.5920.99
118_V132_D0.5900.99
197_F200_T0.5900.99
55_M61_V0.5890.99
306_E309_D0.5880.99
77_Y139_L0.5860.99
217_L259_L0.5860.99
255_P352_L0.5860.99
130_L159_L0.5840.99
87_G113_D0.5830.99
207_Q210_H0.5820.99
72_V77_Y0.5820.99
14_T18_L0.5820.99
221_L224_E0.5810.99
184_Y187_Y0.5770.99
248_G266_A0.5740.99
160_T165_P0.5730.99
77_Y169_N0.5730.99
214_L217_L0.5710.99
120_L133_L0.5660.99
130_L133_L0.5630.99
57_P160_T0.5620.99
51_Y63_F0.5580.99
282_D285_T0.5580.99
190_F207_Q0.5570.99
128_E282_D0.5570.99
61_V64_D0.5560.99
341_G344_Q0.5550.99
229_A264_A0.5530.99
218_E260_N0.5500.99
50_S53_V0.5490.99
191_E194_A0.5490.99
156_I168_G0.5490.99
324_I328_E0.5480.99
321_A332_V0.5480.99
259_L352_L0.5460.99
53_V63_F0.5460.99
69_T133_L0.5460.99
335_G340_L0.5450.98
232_W235_S0.5450.98
295_F356_L0.5450.98
14_T20_A0.5430.98
265_I269_G0.5430.98
84_L203_F0.5420.98
19_L22_C0.5410.98
154_G157_D0.5400.98
230_L234_G0.5400.98
100_H103_A0.5400.98
26_D29_A0.5400.98
74_E77_Y0.5380.98
311_V316_Q0.5380.98
287_L291_P0.5370.98
73_Y120_L0.5370.98
243_P247_S0.5370.98
140_M151_L0.5360.98
230_L233_G0.5360.98
27_S31_S0.5350.98
320_T323_R0.5340.98
172_F189_A0.5340.98
53_V195_E0.5330.98
224_E228_G0.5320.98
91_T135_P0.5310.98
53_V57_P0.5310.98
159_L166_F0.5280.98
248_G268_S0.5270.98
187_Y258_D0.5240.98
227_R230_L0.5230.98
140_M166_F0.5230.98
230_L292_D0.5190.98
84_L190_F0.5190.98
79_D341_G0.5170.98
224_E261_V0.5160.98
67_P197_F0.5160.98
49_G52_S0.5160.98
341_G345_H0.5140.98
231_V281_I0.5140.98
246_L278_R0.5110.98
249_A254_K0.5100.98
51_Y56_E0.5090.98
231_V294_L0.5090.98
58_V61_V0.5080.98
48_S51_Y0.5070.98
211_D214_L0.5040.98
298_G334_R0.5040.98
228_G261_V0.5030.97
243_P283_A0.5020.97
130_L138_Y0.5020.97
7_L17_G0.5020.97
8_K12_A0.5000.97
85_G202_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mo9A 1 0.8218 100 0.273 Contact Map
4n01A 1 0.7766 100 0.273 Contact Map
4hn9A 1 0.8191 100 0.281 Contact Map
4ovkA 1 0.7793 100 0.283 Contact Map
4mlzA 1 0.7872 100 0.299 Contact Map
3pshA 1 0.7872 100 0.31 Contact Map
4pagA 2 0.7766 100 0.312 Contact Map
4inoA 1 0.7553 100 0.321 Contact Map
4ljsA 1 0.8245 100 0.329 Contact Map
2etvA 2 0.7473 100 0.344 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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