Q9HMG7 - HALSA - GREMLIN Contacts

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Q9HMG7 - Ferrichrome ABC transporter permease

UniProt:	Q9HMG7	Sequences: MSRQSRTRTGLRPSFDGALAGIAVASTAAVVLGALVQVRYGGYQMPLETVWRALFDRAVWTNPDVLATILLGDGHAELLGVYRDTAVLSDATAVVWTQRLPRVVVAVFVGANLAVAGAIFQAITRNELASPYILGVSSGAGFAVVITIVFSLGTSLLPVAAALGGTGAFLLVYAVAWRGGTTPVRLVLAGVVVGTVFNSLQTGVFYFIDSNGAMRTAVSWLAGTLTGVGWTDVELIVVPTLLVVPVALIAARHLDVLLLGERRARALGMRVETIRFGLSVLAILATAAAVSVAGLVGFVGLVVPHAVRTVVGSDYRRLLVGCLFAGPALVVVADVIARLGLGGVQVPVGVVTGLVGGPYFLLLLRRTESFNEF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (319)
Sequences:	13629 (9780)
Seq/√Len:	547.6

ECOLI - FEPG FEPD FECC BTUC FECD FHUB
BACSU - FHUB FHUG YVRB YFHA YFME YFMD FEUB YFIZ YCLN FEUC YCLO
HALSA - Q9HMG7 BTUCA Q9HMG0
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
255_D	314_D	4.562	1.00
111_A	323_L	3.681	1.00
147_T	160_A	3.599	1.00
64_D	332_V	3.582	1.00
119_I	247_A	3.491	1.00
65_V	103_V	3.303	1.00
270_R	273_T	3.217	1.00
112_N	240_T	3.117	1.00
119_I	278_L	3.040	1.00
107_V	327_P	3.011	1.00
106_A	225_L	2.923	1.00
307_V	325_A	2.759	1.00
80_G	91_A	2.681	1.00
105_V	228_V	2.651	1.00
115_V	323_L	2.520	1.00
112_N	285_A	2.503	1.00
112_N	289_A	2.490	1.00
65_V	107_V	2.440	1.00
80_G	83_R	2.415	1.00
142_F	200_L	2.372	1.00
261_E	275_R	2.372	1.00
61_T	328_A	2.292	1.00
109_V	289_A	2.278	1.00
60_W	328_A	2.230	1.00
115_V	244_V	2.193	1.00
118_A	322_C	2.159	1.00
311_V	321_G	2.092	1.00
109_V	293_A	2.059	1.00
239_P	288_A	2.055	1.00
142_F	197_F	2.053	1.00
70_L	78_L	2.026	1.00
61_T	107_V	2.000	1.00
107_V	331_V	1.998	1.00
102_R	334_D	1.994	1.00
253_H	274_I	1.971	1.00
88_L	91_A	1.967	1.00
255_D	315_Y	1.966	1.00
77_E	80_G	1.963	1.00
108_F	237_V	1.937	1.00
122_A	315_Y	1.916	1.00
68_T	103_V	1.901	1.00
120_F	282_A	1.874	1.00
146_I	150_F	1.872	1.00
54_L	321_G	1.835	1.00
250_A	253_H	1.817	1.00
64_D	328_A	1.808	1.00
79_L	83_R	1.799	1.00
145_V	201_Q	1.795	1.00
256_V	269_M	1.785	1.00
89_S	92_T	1.735	1.00
228_V	232_D	1.730	1.00
246_V	281_L	1.718	1.00
243_V	285_A	1.692	1.00
92_T	96_W	1.649	1.00
250_A	277_G	1.616	1.00
165_G	287_A	1.541	1.00
61_T	324_F	1.539	1.00
336_I	340_G	1.539	1.00
118_A	318_L	1.538	1.00
273_T	277_G	1.535	1.00
299_V	330_V	1.524	1.00
144_V	161_A	1.515	1.00
104_V	233_V	1.509	1.00
67_A	70_L	1.488	1.00
84_D	96_W	1.486	1.00
243_V	284_L	1.485	1.00
229_G	232_D	1.466	1.00
337_A	348_V	1.465	1.00
234_E	238_V	1.450	1.00
250_A	274_I	1.446	1.00
57_R	324_F	1.432	1.00
67_A	71_L	1.432	1.00
64_D	331_V	1.429	1.00
82_Y	86_A	1.419	1.00
53_A	321_G	1.419	1.00
225_L	330_V	1.382	1.00
50_V	317_R	1.378	1.00
116_A	285_A	1.378	1.00
243_V	281_L	1.373	1.00
143_A	160_A	1.368	1.00
68_T	335_V	1.364	1.00
336_I	351_V	1.362	1.00
105_V	292_V	1.352	1.00
238_V	242_L	1.347	1.00
57_R	321_G	1.332	1.00
196_V	357_G	1.312	1.00
317_R	320_V	1.310	1.00
169_F	283_I	1.308	1.00
168_A	197_F	1.300	1.00
307_V	318_L	1.297	1.00
57_R	325_A	1.294	1.00
143_A	164_G	1.294	1.00
141_G	201_Q	1.291	1.00
250_A	278_L	1.258	1.00
307_V	321_G	1.257	1.00
246_V	250_A	1.254	1.00
137_S	286_T	1.252	1.00
209_D	212_G	1.251	1.00
114_A	303_V	1.241	1.00
234_E	237_V	1.237	1.00
303_V	329_L	1.226	1.00
160_A	164_G	1.215	1.00
293_A	296_V	1.212	1.00
61_T	327_P	1.205	1.00
108_F	233_V	1.198	1.00
93_A	97_T	1.193	1.00
123_I	278_L	1.193	1.00
84_D	92_T	1.192	1.00
265_R	272_E	1.184	1.00
273_T	276_F	1.183	1.00
75_H	78_L	1.183	1.00
141_G	221_L	1.180	1.00
54_L	317_R	1.178	1.00
236_I	292_V	1.160	1.00
303_V	325_A	1.152	1.00
90_D	93_A	1.151	1.00
272_E	275_R	1.142	1.00
263_R	266_A	1.140	1.00
145_V	217_A	1.137	1.00
256_V	267_L	1.129	1.00
57_R	328_A	1.121	1.00
118_A	319_L	1.120	1.00
106_A	331_V	1.119	1.00
274_I	277_G	1.119	1.00
139_G	168_A	1.109	1.00
118_A	315_Y	1.107	1.00
52_R	55_F	1.099	1.00
170_L	174_A	1.098	1.00
105_V	233_V	1.089	1.00
315_Y	318_L	1.089	1.00
149_V	204_V	1.080	1.00
142_F	146_I	1.079	1.00
260_G	264_A	1.078	1.00
338_R	345_Q	1.076	1.00
104_V	230_W	1.074	1.00
111_A	327_P	1.070	1.00
106_A	330_V	1.068	1.00
111_A	114_A	1.068	1.00
108_F	236_I	1.065	1.00
74_G	94_V	1.062	1.00
246_V	277_G	1.061	1.00
247_A	281_L	1.058	1.00
172_V	193_V	1.053	1.00
139_G	164_G	1.052	1.00
272_E	276_F	1.050	1.00
236_I	240_T	1.046	1.00
245_P	249_I	1.038	1.00
177_W	272_E	1.038	1.00
194_G	198_N	1.035	1.00
162_A	284_L	1.033	1.00
50_V	54_L	1.027	1.00
71_L	339_L	1.023	1.00
138_S	197_F	1.002	1.00
336_I	339_L	1.002	1.00
65_V	331_V	1.000	1.00
103_V	335_V	0.988	1.00
328_A	332_V	0.986	1.00
334_D	338_R	0.984	1.00
159_V	163_L	0.983	1.00
167_G	171_L	0.980	1.00
146_I	204_V	0.977	1.00
137_S	295_L	0.977	1.00
84_D	91_A	0.976	1.00
353_G	358_P	0.974	1.00
64_D	335_V	0.971	1.00
203_G	207_F	0.970	1.00
254_L	278_L	0.968	1.00
296_V	330_V	0.968	1.00
70_L	81_V	0.967	1.00
303_V	307_V	0.965	1.00
320_V	323_L	0.965	1.00
51_W	55_F	0.961	1.00
51_W	54_L	0.959	1.00
149_V	208_I	0.957	1.00
311_V	317_R	0.955	1.00
337_A	351_V	0.953	1.00
69_I	103_V	0.952	1.00
81_V	95_V	0.946	1.00
58_A	62_N	0.946	1.00
289_A	293_A	0.944	1.00
242_L	245_P	0.942	1.00
238_V	241_L	0.942	1.00
235_L	238_V	0.942	1.00
96_W	100_L	0.939	1.00
108_F	240_T	0.938	1.00
230_W	233_V	0.935	1.00
152_L	155_S	0.935	1.00
84_D	95_V	0.935	1.00
59_V	63_P	0.934	1.00
142_F	201_Q	0.933	1.00
317_R	321_G	0.933	1.00
243_V	288_A	0.928	1.00
269_M	274_I	0.921	1.00
83_R	86_A	0.919	1.00
341_L	344_V	0.918	1.00
274_I	278_L	0.917	1.00
358_P	362_L	0.916	1.00
66_L	70_L	0.916	1.00
318_L	322_C	0.908	1.00
72_G	99_R	0.897	1.00
83_R	87_V	0.892	1.00
136_V	165_G	0.892	1.00
92_T	97_T	0.879	1.00
217_A	221_L	0.879	1.00
58_A	324_F	0.873	1.00
255_D	316_R	0.873	1.00
52_R	56_D	0.870	1.00
262_R	265_R	0.867	1.00
132_Y	137_S	0.866	1.00
147_T	157_L	0.866	1.00
116_A	282_A	0.864	1.00
162_A	166_T	0.864	1.00
66_L	78_L	0.863	1.00
111_A	244_V	0.859	1.00
142_F	204_V	0.853	1.00
337_A	347_P	0.851	1.00
310_V	325_A	0.849	1.00
359_Y	362_L	0.849	1.00
53_A	57_R	0.841	1.00
68_T	338_R	0.840	1.00
332_V	336_I	0.839	1.00
53_A	56_D	0.837	1.00
276_F	280_V	0.836	1.00
117_G	304_P	0.833	1.00
314_D	317_R	0.830	1.00
208_I	213_A	0.829	1.00
148_I	157_L	0.827	1.00
103_V	331_V	0.824	1.00
241_L	245_P	0.815	1.00
157_L	160_A	0.811	1.00
308_R	318_L	0.810	1.00
246_V	249_I	0.809	1.00
144_V	157_L	0.808	1.00
279_S	283_I	0.807	1.00
212_G	216_T	0.807	1.00
340_G	343_G	0.804	1.00
315_Y	320_V	0.803	1.00
140_A	165_G	0.796	1.00
261_E	265_R	0.790	1.00
215_R	218_V	0.786	1.00
102_R	338_R	0.782	1.00
100_L	230_W	0.782	1.00
173_Y	272_E	0.778	1.00
271_V	275_R	0.778	1.00
120_F	134_L	0.777	1.00
146_I	151_S	0.777	1.00
251_A	316_R	0.777	1.00
138_S	141_G	0.777	1.00
307_V	311_V	0.775	1.00
231_T	234_E	0.769	1.00
250_A	281_L	0.768	1.00
89_S	93_A	0.768	1.00
88_L	92_T	0.766	1.00
112_N	116_A	0.766	1.00
76_A	95_V	0.766	1.00
264_A	271_V	0.764	1.00
324_F	328_A	0.759	1.00
130_S	133_I	0.758	1.00
247_A	278_L	0.755	1.00
114_A	118_A	0.755	1.00
102_R	345_Q	0.754	1.00
111_A	240_T	0.753	1.00
354_L	358_P	0.753	1.00
70_L	75_H	0.745	1.00
62_N	66_L	0.745	1.00
174_A	177_W	0.745	1.00
232_D	292_V	0.744	1.00
124_T	187_V	0.742	1.00
164_G	168_A	0.737	1.00
341_L	346_V	0.735	1.00
157_L	161_A	0.734	1.00
62_N	65_V	0.733	1.00
339_L	342_G	0.732	1.00
177_W	180_G	0.731	1.00
173_Y	276_F	0.730	1.00
71_L	75_H	0.727	1.00
61_T	65_V	0.725	1.00
145_V	205_F	0.724	1.00
61_T	331_V	0.724	1.00
236_I	288_A	0.724	1.00
307_V	310_V	0.722	1.00
114_A	323_L	0.721	1.00
239_P	243_V	0.720	1.00
136_V	169_F	0.718	1.00
330_V	352_T	0.717	1.00
248_L	251_A	0.717	1.00
81_V	84_D	0.717	1.00
146_I	200_L	0.711	1.00
156_L	159_V	0.710	1.00
76_A	91_A	0.708	1.00
249_I	253_H	0.707	1.00
299_V	352_T	0.705	1.00
237_V	241_L	0.704	1.00
166_T	287_A	0.702	1.00
139_G	197_F	0.702	1.00
255_D	320_V	0.701	1.00
177_W	181_T	0.701	1.00
165_G	283_I	0.698	1.00
172_V	176_A	0.697	1.00
240_T	289_A	0.696	1.00
288_A	291_S	0.696	1.00
261_E	271_V	0.694	1.00
169_F	279_S	0.691	1.00
309_T	363_L	0.690	1.00
69_I	95_V	0.688	1.00
69_I	100_L	0.688	1.00
104_V	108_F	0.688	1.00
236_I	239_P	0.686	1.00
168_A	172_V	0.684	1.00
63_P	66_L	0.684	1.00
244_V	248_L	0.684	1.00
257_L	271_V	0.682	1.00
109_V	225_L	0.682	1.00
122_A	258_L	0.681	1.00
288_A	292_V	0.680	1.00
115_V	319_L	0.675	1.00
253_H	269_M	0.674	1.00
74_G	78_L	0.673	1.00
115_V	247_A	0.672	1.00
296_V	348_V	0.672	1.00
113_L	299_V	0.670	1.00
163_L	167_G	0.670	1.00
93_A	96_W	0.669	1.00
330_V	348_V	0.667	1.00
329_L	333_A	0.666	1.00
106_A	348_V	0.665	1.00
105_V	236_I	0.665	1.00
362_L	366_R	0.665	1.00
148_I	216_T	0.663	1.00
166_T	283_I	0.662	1.00
93_A	98_Q	0.661	1.00
49_T	53_A	0.659	1.00
209_D	213_A	0.656	1.00
208_I	214_M	0.656	1.00
175_V	189_A	0.653	1.00
87_V	92_T	0.653	1.00
205_F	218_V	0.652	1.00
265_R	271_V	0.651	1.00
327_P	331_V	0.651	1.00
306_A	325_A	0.651	1.00
141_G	295_L	0.650	1.00
81_V	86_A	0.647	1.00
163_L	166_T	0.641	1.00
130_S	300_G	0.639	1.00
137_S	140_A	0.639	1.00
239_P	284_L	0.638	1.00
65_V	69_I	0.637	1.00
111_A	115_V	0.637	1.00
337_A	345_Q	0.637	1.00
57_R	61_T	0.635	1.00
306_A	309_T	0.635	1.00
80_G	87_V	0.634	1.00
333_A	351_V	0.634	1.00
148_I	217_A	0.633	1.00
323_L	327_P	0.632	1.00
218_V	221_L	0.632	1.00
176_A	189_A	0.632	1.00
225_L	348_V	0.631	1.00
169_F	173_Y	0.631	1.00
329_L	355_V	0.631	1.00
302_V	360_F	0.630	1.00
143_A	147_T	0.629	1.00
100_L	104_V	0.627	1.00
243_V	247_A	0.627	1.00
316_R	320_V	0.627	1.00
304_P	322_C	0.626	1.00
230_W	234_E	0.626	1.00
114_A	326_G	0.624	1.00
138_S	194_G	0.622	1.00
56_D	60_W	0.618	1.00
116_A	286_T	0.618	1.00
299_V	329_L	0.618	1.00
306_A	329_L	0.617	1.00
182_T	185_R	0.613	1.00
286_T	290_V	0.611	1.00
253_H	256_V	0.610	1.00
53_A	310_V	0.609	1.00
202_T	220_W	0.608	1.00
119_I	281_L	0.608	1.00
302_V	306_A	0.608	1.00
74_G	77_E	0.607	1.00
210_S	215_R	0.607	1.00
79_L	82_Y	0.604	1.00
63_P	67_A	0.604	1.00
168_A	193_V	0.599	1.00
120_F	129_A	0.598	1.00
332_V	335_V	0.594	1.00
255_D	258_L	0.593	1.00
189_A	192_V	0.592	1.00
124_T	127_E	0.591	1.00
365_R	368_E	0.588	1.00
184_V	187_V	0.588	1.00
302_V	359_Y	0.587	1.00
320_V	324_F	0.584	1.00
138_S	198_N	0.582	0.99
287_A	291_S	0.581	0.99
202_T	206_Y	0.581	0.99
334_D	345_Q	0.581	0.99
147_T	156_L	0.580	0.99
213_A	216_T	0.580	0.99
147_T	151_S	0.578	0.99
278_L	282_A	0.578	0.99
306_A	359_Y	0.573	0.99
225_L	293_A	0.573	0.99
76_A	84_D	0.572	0.99
77_E	91_A	0.571	0.99
277_G	281_L	0.571	0.99
198_N	221_L	0.569	0.99
254_L	315_Y	0.566	0.99
64_D	67_A	0.565	0.99
171_L	174_A	0.565	0.99
249_I	252_R	0.564	0.99
199_S	302_V	0.562	0.99
140_A	161_A	0.560	0.99
120_F	136_V	0.559	0.99
231_T	235_L	0.559	0.99
71_L	335_V	0.558	0.99
283_I	287_A	0.558	0.99
136_V	172_V	0.558	0.99
247_A	319_L	0.556	0.99
176_A	186_L	0.556	0.99
95_V	100_L	0.554	0.99
270_R	277_G	0.554	0.99
136_V	224_T	0.554	0.99
78_L	82_Y	0.553	0.99
198_N	202_T	0.552	0.99
139_G	193_V	0.552	0.99
54_L	58_A	0.550	0.99
66_L	82_Y	0.550	0.99
240_T	245_P	0.545	0.99
312_G	320_V	0.544	0.99
337_A	340_G	0.542	0.99
68_T	331_V	0.539	0.99
205_F	221_L	0.539	0.99
235_L	239_P	0.537	0.99
282_A	287_A	0.536	0.99
205_F	217_A	0.534	0.99
181_T	185_R	0.534	0.99
85_T	95_V	0.534	0.99
105_V	109_V	0.533	0.99
331_V	335_V	0.532	0.99
56_D	59_V	0.532	0.99
81_V	85_T	0.530	0.99
205_F	214_M	0.529	0.99
130_S	295_L	0.529	0.99
78_L	81_V	0.529	0.99
242_L	246_V	0.529	0.99
306_A	310_V	0.528	0.99
252_R	255_D	0.527	0.99
235_L	288_A	0.524	0.99
257_L	274_I	0.522	0.99
53_A	311_V	0.521	0.99
277_G	280_V	0.520	0.99
240_T	244_V	0.518	0.99
244_V	323_L	0.518	0.99
297_G	302_V	0.518	0.99
325_A	328_A	0.517	0.99
173_Y	177_W	0.517	0.99
233_V	236_I	0.515	0.99
130_S	352_T	0.514	0.99
307_V	322_C	0.514	0.99
105_V	293_A	0.513	0.99
270_R	276_F	0.512	0.99
189_A	193_V	0.512	0.99
70_L	82_Y	0.508	0.99
125_R	261_E	0.507	0.99
301_L	363_L	0.507	0.99
49_T	52_R	0.506	0.99
67_A	335_V	0.506	0.99
199_S	202_T	0.505	0.99
214_M	217_A	0.505	0.99
303_V	333_A	0.505	0.99
214_M	219_S	0.504	0.99
55_F	59_V	0.502	0.99
239_P	242_L	0.502	0.99
196_V	200_L	0.500	0.98
305_H	308_R	0.500	0.98
76_A	94_V	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.8284	100	0.283	Contact Map
4g1uA	2	0.7909	100	0.285	Contact Map
2qi9A	2	0.8606	100	0.292	Contact Map
2m8rA	1	0.185	77.7	0.955	Contact Map
3d31C	2	0.6273	35.1	0.966	Contact Map
4ezcA	3	0.6944	30	0.967	Contact Map
2kogA	1	0.1823	25.5	0.968	Contact Map
4tkrA	2	0.4504	10.1	0.973	Contact Map
3wajA	1	0.7158	9.8	0.974	Contact Map
3rlbA	1	0.4531	9.7	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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