GREMLIN Database
Q9HMG7 - Ferrichrome ABC transporter permease
UniProt: Q9HMG7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (319)
Sequences: 13629 (9780)
Seq/√Len: 547.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
255_D314_D4.5621.00
111_A323_L3.6811.00
147_T160_A3.5991.00
64_D332_V3.5821.00
119_I247_A3.4911.00
65_V103_V3.3031.00
270_R273_T3.2171.00
112_N240_T3.1171.00
119_I278_L3.0401.00
107_V327_P3.0111.00
106_A225_L2.9231.00
307_V325_A2.7591.00
80_G91_A2.6811.00
105_V228_V2.6511.00
115_V323_L2.5201.00
112_N285_A2.5031.00
112_N289_A2.4901.00
65_V107_V2.4401.00
80_G83_R2.4151.00
142_F200_L2.3721.00
261_E275_R2.3721.00
61_T328_A2.2921.00
109_V289_A2.2781.00
60_W328_A2.2301.00
115_V244_V2.1931.00
118_A322_C2.1591.00
311_V321_G2.0921.00
109_V293_A2.0591.00
239_P288_A2.0551.00
142_F197_F2.0531.00
70_L78_L2.0261.00
61_T107_V2.0001.00
107_V331_V1.9981.00
102_R334_D1.9941.00
253_H274_I1.9711.00
88_L91_A1.9671.00
255_D315_Y1.9661.00
77_E80_G1.9631.00
108_F237_V1.9371.00
122_A315_Y1.9161.00
68_T103_V1.9011.00
120_F282_A1.8741.00
146_I150_F1.8721.00
54_L321_G1.8351.00
250_A253_H1.8171.00
64_D328_A1.8081.00
79_L83_R1.7991.00
145_V201_Q1.7951.00
256_V269_M1.7851.00
89_S92_T1.7351.00
228_V232_D1.7301.00
246_V281_L1.7181.00
243_V285_A1.6921.00
92_T96_W1.6491.00
250_A277_G1.6161.00
165_G287_A1.5411.00
61_T324_F1.5391.00
336_I340_G1.5391.00
118_A318_L1.5381.00
273_T277_G1.5351.00
299_V330_V1.5241.00
144_V161_A1.5151.00
104_V233_V1.5091.00
67_A70_L1.4881.00
84_D96_W1.4861.00
243_V284_L1.4851.00
229_G232_D1.4661.00
337_A348_V1.4651.00
234_E238_V1.4501.00
250_A274_I1.4461.00
57_R324_F1.4321.00
67_A71_L1.4321.00
64_D331_V1.4291.00
82_Y86_A1.4191.00
53_A321_G1.4191.00
225_L330_V1.3821.00
50_V317_R1.3781.00
116_A285_A1.3781.00
243_V281_L1.3731.00
143_A160_A1.3681.00
68_T335_V1.3641.00
336_I351_V1.3621.00
105_V292_V1.3521.00
238_V242_L1.3471.00
57_R321_G1.3321.00
196_V357_G1.3121.00
317_R320_V1.3101.00
169_F283_I1.3081.00
168_A197_F1.3001.00
307_V318_L1.2971.00
57_R325_A1.2941.00
143_A164_G1.2941.00
141_G201_Q1.2911.00
250_A278_L1.2581.00
307_V321_G1.2571.00
246_V250_A1.2541.00
137_S286_T1.2521.00
209_D212_G1.2511.00
114_A303_V1.2411.00
234_E237_V1.2371.00
303_V329_L1.2261.00
160_A164_G1.2151.00
293_A296_V1.2121.00
61_T327_P1.2051.00
108_F233_V1.1981.00
93_A97_T1.1931.00
123_I278_L1.1931.00
84_D92_T1.1921.00
265_R272_E1.1841.00
273_T276_F1.1831.00
75_H78_L1.1831.00
141_G221_L1.1801.00
54_L317_R1.1781.00
236_I292_V1.1601.00
303_V325_A1.1521.00
90_D93_A1.1511.00
272_E275_R1.1421.00
263_R266_A1.1401.00
145_V217_A1.1371.00
256_V267_L1.1291.00
57_R328_A1.1211.00
118_A319_L1.1201.00
106_A331_V1.1191.00
274_I277_G1.1191.00
139_G168_A1.1091.00
118_A315_Y1.1071.00
52_R55_F1.0991.00
170_L174_A1.0981.00
105_V233_V1.0891.00
315_Y318_L1.0891.00
149_V204_V1.0801.00
142_F146_I1.0791.00
260_G264_A1.0781.00
338_R345_Q1.0761.00
104_V230_W1.0741.00
111_A327_P1.0701.00
106_A330_V1.0681.00
111_A114_A1.0681.00
108_F236_I1.0651.00
74_G94_V1.0621.00
246_V277_G1.0611.00
247_A281_L1.0581.00
172_V193_V1.0531.00
139_G164_G1.0521.00
272_E276_F1.0501.00
236_I240_T1.0461.00
245_P249_I1.0381.00
177_W272_E1.0381.00
194_G198_N1.0351.00
162_A284_L1.0331.00
50_V54_L1.0271.00
71_L339_L1.0231.00
138_S197_F1.0021.00
336_I339_L1.0021.00
65_V331_V1.0001.00
103_V335_V0.9881.00
328_A332_V0.9861.00
334_D338_R0.9841.00
159_V163_L0.9831.00
167_G171_L0.9801.00
146_I204_V0.9771.00
137_S295_L0.9771.00
84_D91_A0.9761.00
353_G358_P0.9741.00
64_D335_V0.9711.00
203_G207_F0.9701.00
254_L278_L0.9681.00
296_V330_V0.9681.00
70_L81_V0.9671.00
303_V307_V0.9651.00
320_V323_L0.9651.00
51_W55_F0.9611.00
51_W54_L0.9591.00
149_V208_I0.9571.00
311_V317_R0.9551.00
337_A351_V0.9531.00
69_I103_V0.9521.00
81_V95_V0.9461.00
58_A62_N0.9461.00
289_A293_A0.9441.00
242_L245_P0.9421.00
238_V241_L0.9421.00
235_L238_V0.9421.00
96_W100_L0.9391.00
108_F240_T0.9381.00
230_W233_V0.9351.00
152_L155_S0.9351.00
84_D95_V0.9351.00
59_V63_P0.9341.00
142_F201_Q0.9331.00
317_R321_G0.9331.00
243_V288_A0.9281.00
269_M274_I0.9211.00
83_R86_A0.9191.00
341_L344_V0.9181.00
274_I278_L0.9171.00
358_P362_L0.9161.00
66_L70_L0.9161.00
318_L322_C0.9081.00
72_G99_R0.8971.00
83_R87_V0.8921.00
136_V165_G0.8921.00
92_T97_T0.8791.00
217_A221_L0.8791.00
58_A324_F0.8731.00
255_D316_R0.8731.00
52_R56_D0.8701.00
262_R265_R0.8671.00
132_Y137_S0.8661.00
147_T157_L0.8661.00
116_A282_A0.8641.00
162_A166_T0.8641.00
66_L78_L0.8631.00
111_A244_V0.8591.00
142_F204_V0.8531.00
337_A347_P0.8511.00
310_V325_A0.8491.00
359_Y362_L0.8491.00
53_A57_R0.8411.00
68_T338_R0.8401.00
332_V336_I0.8391.00
53_A56_D0.8371.00
276_F280_V0.8361.00
117_G304_P0.8331.00
314_D317_R0.8301.00
208_I213_A0.8291.00
148_I157_L0.8271.00
103_V331_V0.8241.00
241_L245_P0.8151.00
157_L160_A0.8111.00
308_R318_L0.8101.00
246_V249_I0.8091.00
144_V157_L0.8081.00
279_S283_I0.8071.00
212_G216_T0.8071.00
340_G343_G0.8041.00
315_Y320_V0.8031.00
140_A165_G0.7961.00
261_E265_R0.7901.00
215_R218_V0.7861.00
102_R338_R0.7821.00
100_L230_W0.7821.00
173_Y272_E0.7781.00
271_V275_R0.7781.00
120_F134_L0.7771.00
146_I151_S0.7771.00
251_A316_R0.7771.00
138_S141_G0.7771.00
307_V311_V0.7751.00
231_T234_E0.7691.00
250_A281_L0.7681.00
89_S93_A0.7681.00
88_L92_T0.7661.00
112_N116_A0.7661.00
76_A95_V0.7661.00
264_A271_V0.7641.00
324_F328_A0.7591.00
130_S133_I0.7581.00
247_A278_L0.7551.00
114_A118_A0.7551.00
102_R345_Q0.7541.00
111_A240_T0.7531.00
354_L358_P0.7531.00
70_L75_H0.7451.00
62_N66_L0.7451.00
174_A177_W0.7451.00
232_D292_V0.7441.00
124_T187_V0.7421.00
164_G168_A0.7371.00
341_L346_V0.7351.00
157_L161_A0.7341.00
62_N65_V0.7331.00
339_L342_G0.7321.00
177_W180_G0.7311.00
173_Y276_F0.7301.00
71_L75_H0.7271.00
61_T65_V0.7251.00
145_V205_F0.7241.00
61_T331_V0.7241.00
236_I288_A0.7241.00
307_V310_V0.7221.00
114_A323_L0.7211.00
239_P243_V0.7201.00
136_V169_F0.7181.00
330_V352_T0.7171.00
248_L251_A0.7171.00
81_V84_D0.7171.00
146_I200_L0.7111.00
156_L159_V0.7101.00
76_A91_A0.7081.00
249_I253_H0.7071.00
299_V352_T0.7051.00
237_V241_L0.7041.00
166_T287_A0.7021.00
139_G197_F0.7021.00
255_D320_V0.7011.00
177_W181_T0.7011.00
165_G283_I0.6981.00
172_V176_A0.6971.00
240_T289_A0.6961.00
288_A291_S0.6961.00
261_E271_V0.6941.00
169_F279_S0.6911.00
309_T363_L0.6901.00
69_I95_V0.6881.00
69_I100_L0.6881.00
104_V108_F0.6881.00
236_I239_P0.6861.00
168_A172_V0.6841.00
63_P66_L0.6841.00
244_V248_L0.6841.00
257_L271_V0.6821.00
109_V225_L0.6821.00
122_A258_L0.6811.00
288_A292_V0.6801.00
115_V319_L0.6751.00
253_H269_M0.6741.00
74_G78_L0.6731.00
115_V247_A0.6721.00
296_V348_V0.6721.00
113_L299_V0.6701.00
163_L167_G0.6701.00
93_A96_W0.6691.00
330_V348_V0.6671.00
329_L333_A0.6661.00
106_A348_V0.6651.00
105_V236_I0.6651.00
362_L366_R0.6651.00
148_I216_T0.6631.00
166_T283_I0.6621.00
93_A98_Q0.6611.00
49_T53_A0.6591.00
209_D213_A0.6561.00
208_I214_M0.6561.00
175_V189_A0.6531.00
87_V92_T0.6531.00
205_F218_V0.6521.00
265_R271_V0.6511.00
327_P331_V0.6511.00
306_A325_A0.6511.00
141_G295_L0.6501.00
81_V86_A0.6471.00
163_L166_T0.6411.00
130_S300_G0.6391.00
137_S140_A0.6391.00
239_P284_L0.6381.00
65_V69_I0.6371.00
111_A115_V0.6371.00
337_A345_Q0.6371.00
57_R61_T0.6351.00
306_A309_T0.6351.00
80_G87_V0.6341.00
333_A351_V0.6341.00
148_I217_A0.6331.00
323_L327_P0.6321.00
218_V221_L0.6321.00
176_A189_A0.6321.00
225_L348_V0.6311.00
169_F173_Y0.6311.00
329_L355_V0.6311.00
302_V360_F0.6301.00
143_A147_T0.6291.00
100_L104_V0.6271.00
243_V247_A0.6271.00
316_R320_V0.6271.00
304_P322_C0.6261.00
230_W234_E0.6261.00
114_A326_G0.6241.00
138_S194_G0.6221.00
56_D60_W0.6181.00
116_A286_T0.6181.00
299_V329_L0.6181.00
306_A329_L0.6171.00
182_T185_R0.6131.00
286_T290_V0.6111.00
253_H256_V0.6101.00
53_A310_V0.6091.00
202_T220_W0.6081.00
119_I281_L0.6081.00
302_V306_A0.6081.00
74_G77_E0.6071.00
210_S215_R0.6071.00
79_L82_Y0.6041.00
63_P67_A0.6041.00
168_A193_V0.5991.00
120_F129_A0.5981.00
332_V335_V0.5941.00
255_D258_L0.5931.00
189_A192_V0.5921.00
124_T127_E0.5911.00
365_R368_E0.5881.00
184_V187_V0.5881.00
302_V359_Y0.5871.00
320_V324_F0.5841.00
138_S198_N0.5820.99
287_A291_S0.5810.99
202_T206_Y0.5810.99
334_D345_Q0.5810.99
147_T156_L0.5800.99
213_A216_T0.5800.99
147_T151_S0.5780.99
278_L282_A0.5780.99
306_A359_Y0.5730.99
225_L293_A0.5730.99
76_A84_D0.5720.99
77_E91_A0.5710.99
277_G281_L0.5710.99
198_N221_L0.5690.99
254_L315_Y0.5660.99
64_D67_A0.5650.99
171_L174_A0.5650.99
249_I252_R0.5640.99
199_S302_V0.5620.99
140_A161_A0.5600.99
120_F136_V0.5590.99
231_T235_L0.5590.99
71_L335_V0.5580.99
283_I287_A0.5580.99
136_V172_V0.5580.99
247_A319_L0.5560.99
176_A186_L0.5560.99
95_V100_L0.5540.99
270_R277_G0.5540.99
136_V224_T0.5540.99
78_L82_Y0.5530.99
198_N202_T0.5520.99
139_G193_V0.5520.99
54_L58_A0.5500.99
66_L82_Y0.5500.99
240_T245_P0.5450.99
312_G320_V0.5440.99
337_A340_G0.5420.99
68_T331_V0.5390.99
205_F221_L0.5390.99
235_L239_P0.5370.99
282_A287_A0.5360.99
205_F217_A0.5340.99
181_T185_R0.5340.99
85_T95_V0.5340.99
105_V109_V0.5330.99
331_V335_V0.5320.99
56_D59_V0.5320.99
81_V85_T0.5300.99
205_F214_M0.5290.99
130_S295_L0.5290.99
78_L81_V0.5290.99
242_L246_V0.5290.99
306_A310_V0.5280.99
252_R255_D0.5270.99
235_L288_A0.5240.99
257_L274_I0.5220.99
53_A311_V0.5210.99
277_G280_V0.5200.99
240_T244_V0.5180.99
244_V323_L0.5180.99
297_G302_V0.5180.99
325_A328_A0.5170.99
173_Y177_W0.5170.99
233_V236_I0.5150.99
130_S352_T0.5140.99
307_V322_C0.5140.99
105_V293_A0.5130.99
270_R276_F0.5120.99
189_A193_V0.5120.99
70_L82_Y0.5080.99
125_R261_E0.5070.99
301_L363_L0.5070.99
49_T52_R0.5060.99
67_A335_V0.5060.99
199_S202_T0.5050.99
214_M217_A0.5050.99
303_V333_A0.5050.99
214_M219_S0.5040.99
55_F59_V0.5020.99
239_P242_L0.5020.99
196_V200_L0.5000.98
305_H308_R0.5000.98
76_A94_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.8284 100 0.283 Contact Map
4g1uA 2 0.7909 100 0.285 Contact Map
2qi9A 2 0.8606 100 0.292 Contact Map
2m8rA 1 0.185 77.7 0.955 Contact Map
3d31C 2 0.6273 35.1 0.966 Contact Map
4ezcA 3 0.6944 30 0.967 Contact Map
2kogA 1 0.1823 25.5 0.968 Contact Map
4tkrA 2 0.4504 10.1 0.973 Contact Map
3wajA 1 0.7158 9.8 0.974 Contact Map
3rlbA 1 0.4531 9.7 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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