GREMLIN Database
Q9HMG5 - 6-phosphogluconate dehydrogenase
UniProt: Q9HMG5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (270)
Sequences: 11365 (7383)
Seq/√Len: 449.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_V147_D3.7801.00
136_E140_D3.4781.00
74_D103_R3.3891.00
27_V47_A3.2271.00
111_A138_A3.0011.00
40_A46_P2.9711.00
2_E25_D2.9201.00
111_A141_D2.8211.00
17_D42_A2.7731.00
4_G53_L2.3561.00
36_R46_P2.3301.00
37_E41_D2.2891.00
48_D52_A2.2741.00
140_D143_V2.2421.00
89_V142_L2.1471.00
20_L44_A2.0791.00
13_R38_D2.0421.00
49_T52_A2.0161.00
24_H148_A2.0071.00
25_D45_T1.9801.00
136_E158_R1.9801.00
51_D55_A1.9091.00
99_E253_E1.9001.00
65_L90_V1.8901.00
111_A135_P1.8631.00
18_R21_D1.8581.00
22_A148_A1.8411.00
250_E253_E1.8121.00
85_D88_D1.8081.00
2_E27_V1.7981.00
105_A162_A1.7971.00
32_D35_A1.7811.00
34_T37_E1.7491.00
33_A37_E1.7421.00
198_D201_A1.7251.00
28_A44_A1.7211.00
27_V56_E1.7111.00
135_P138_A1.7111.00
213_R218_E1.7041.00
77_L90_V1.7041.00
130_L149_V1.6871.00
66_M93_G1.6711.00
113_L134_G1.6611.00
89_V138_A1.6351.00
130_L150_A1.5961.00
262_S266_S1.5861.00
84_L88_D1.5791.00
113_L142_L1.5411.00
107_E135_P1.5341.00
139_Y143_V1.5251.00
27_V45_T1.5091.00
64_W93_G1.5071.00
200_E204_R1.5051.00
139_Y158_R1.4961.00
190_L202_V1.4951.00
51_D83_H1.4931.00
115_C130_L1.4831.00
37_E40_A1.4541.00
18_R127_G1.4421.00
222_E226_E1.4321.00
178_A182_T1.4301.00
69_A72_P1.4281.00
70_G100_D1.4261.00
265_L269_F1.4251.00
159_M168_V1.4171.00
121_P125_E1.4161.00
122_A126_L1.4061.00
263_Q266_S1.4041.00
61_K85_D1.3981.00
53_L60_E1.3931.00
21_D42_A1.3901.00
170_M246_W1.3541.00
102_T162_A1.3381.00
33_A48_D1.3341.00
101_S112_Y1.3291.00
89_V141_D1.3241.00
54_A83_H1.3021.00
81_A108_H1.2781.00
17_D125_E1.2761.00
207_N218_E1.2731.00
50_L83_H1.2721.00
52_A55_A1.2621.00
39_A44_A1.2581.00
128_F151_T1.2581.00
113_L139_Y1.2531.00
252_L262_S1.2521.00
84_L110_F1.2521.00
66_M117_T1.2511.00
91_V142_L1.2451.00
21_D125_E1.2411.00
14_I125_E1.2341.00
142_L146_F1.2331.00
88_D110_F1.2281.00
71_D75_A1.2221.00
62_R89_V1.2191.00
102_T167_Y1.2181.00
16_V26_V1.2121.00
188_E192_E1.1991.00
5_V15_V1.1891.00
62_R145_V1.1841.00
233_T237_H1.1831.00
135_P161_P1.1771.00
4_G60_E1.1741.00
236_D272_R1.1671.00
79_E82_P1.1651.00
38_D41_D1.1631.00
5_V64_W1.1591.00
67_V76_A1.1521.00
249_Q253_E1.1511.00
191_H199_L1.1501.00
193_G254_Q1.1481.00
251_A258_V1.1471.00
177_Y244_G1.1421.00
74_D100_D1.1381.00
93_G130_L1.1351.00
276_G279_G1.1301.00
52_A56_E1.1241.00
17_D21_D1.1201.00
20_L43_G1.1151.00
5_V16_V1.1141.00
257_P262_S1.1121.00
161_P164_A1.1111.00
97_H100_D1.1051.00
201_A204_R1.1041.00
82_P108_H1.1001.00
266_S269_F1.0971.00
93_G149_V1.0951.00
248_V262_S1.0851.00
102_T106_E1.0771.00
70_G97_H1.0751.00
234_V237_H1.0741.00
237_H241_G1.0731.00
10_R121_P1.0721.00
132_V139_Y1.0661.00
33_A46_P1.0381.00
53_L56_E1.0371.00
51_D79_E1.0361.00
235_A271_S1.0301.00
105_A135_P1.0271.00
64_W145_V1.0231.00
30_D35_A1.0221.00
84_L90_V1.0141.00
147_D156_H1.0101.00
38_D42_A1.0101.00
56_E85_D1.0061.00
272_R277_D1.0041.00
113_L132_V1.0031.00
233_T240_G1.0021.00
45_T56_E0.9961.00
47_A52_A0.9941.00
239_A272_R0.9891.00
175_V186_G0.9881.00
77_L80_L0.9871.00
27_V60_E0.9811.00
64_W91_V0.9771.00
245_T265_L0.9761.00
114_D163_G0.9741.00
249_Q252_L0.9721.00
158_R161_P0.9701.00
215_W219_L0.9691.00
100_D103_R0.9621.00
245_T249_Q0.9621.00
171_V190_L0.9571.00
74_D104_R0.9561.00
31_I72_P0.9531.00
73_V96_S0.9441.00
178_A260_L0.9301.00
118_S131_M0.9271.00
8_L39_A0.9211.00
72_P75_A0.9201.00
234_V241_G0.9181.00
18_R149_V0.9161.00
34_T38_D0.9161.00
118_S172_H0.9151.00
86_S109_D0.9121.00
140_D158_R0.9111.00
237_H240_G0.9081.00
171_V186_G0.9081.00
78_D82_P0.9001.00
233_T241_G0.8991.00
89_V111_A0.8981.00
47_A53_L0.8971.00
181_Q260_L0.8951.00
167_Y193_G0.8911.00
159_M164_A0.8881.00
101_S166_H0.8861.00
159_M205_T0.8831.00
167_Y250_E0.8801.00
245_T269_F0.8791.00
203_A221_E0.8761.00
233_T238_V0.8751.00
134_G139_Y0.8741.00
62_R141_D0.8731.00
192_E256_V0.8721.00
13_R17_D0.8711.00
131_M205_T0.8641.00
56_E60_E0.8641.00
8_L28_A0.8621.00
280_R283_R0.8601.00
35_A38_D0.8601.00
269_F273_S0.8551.00
15_V149_V0.8551.00
97_H249_Q0.8521.00
203_A207_N0.8501.00
5_V26_V0.8481.00
3_L24_H0.8371.00
96_S100_D0.8371.00
136_E161_P0.8341.00
144_P147_D0.8321.00
91_V115_C0.8311.00
99_E102_T0.8291.00
2_E61_K0.8251.00
179_L183_Y0.8221.00
102_T163_G0.8181.00
279_G283_R0.8151.00
19_C64_W0.8141.00
235_A241_G0.8141.00
114_D165_G0.8101.00
200_E226_E0.8101.00
174_G261_V0.8061.00
113_L138_A0.8041.00
65_L73_V0.8011.00
20_L42_A0.8001.00
270_G273_S0.7971.00
271_S276_G0.7971.00
139_Y156_H0.7931.00
187_F203_A0.7841.00
63_I80_L0.7791.00
168_V197_L0.7761.00
234_V238_V0.7741.00
138_A141_D0.7711.00
192_E254_Q0.7711.00
234_V240_G0.7701.00
92_D112_Y0.7671.00
103_R106_E0.7661.00
68_P72_P0.7641.00
67_V72_P0.7641.00
5_V66_M0.7631.00
15_V93_G0.7621.00
81_A110_F0.7621.00
138_A142_L0.7621.00
95_N246_W0.7601.00
221_E225_R0.7591.00
27_V53_L0.7591.00
146_F156_H0.7591.00
223_A228_G0.7581.00
270_G274_T0.7501.00
133_G165_G0.7501.00
120_G123_G0.7491.00
111_A137_W0.7491.00
177_Y238_V0.7491.00
65_L77_L0.7461.00
55_A83_H0.7461.00
104_R112_Y0.7421.00
236_D241_G0.7411.00
260_L264_A0.7391.00
200_E225_R0.7341.00
143_V156_H0.7341.00
31_I35_A0.7331.00
19_C26_V0.7301.00
248_V265_L0.7291.00
15_V66_M0.7281.00
175_V183_Y0.7271.00
6_V29_F0.7221.00
28_A36_R0.7211.00
13_R42_A0.7141.00
174_G247_T0.7131.00
250_E254_Q0.7121.00
252_L265_L0.7111.00
62_R91_V0.7101.00
157_D205_T0.7071.00
24_H145_V0.7051.00
221_E224_F0.7041.00
235_A240_G0.7001.00
3_L145_V0.6971.00
188_E191_H0.6931.00
73_V94_G0.6901.00
137_W140_D0.6871.00
6_V50_L0.6821.00
20_L26_V0.6771.00
232_G235_A0.6731.00
205_T208_N0.6691.00
151_T155_G0.6661.00
3_L19_C0.6661.00
236_D277_D0.6661.00
100_D104_R0.6611.00
175_V179_L0.6551.00
207_N213_R0.6541.00
183_Y217_L0.6521.00
175_V182_T0.6521.00
67_V73_V0.6501.00
36_R40_A0.6491.00
171_V189_L0.6471.00
215_W218_E0.6461.00
11_M15_V0.6461.00
112_Y162_A0.6451.00
133_G158_R0.6451.00
115_C132_V0.6430.99
33_A36_R0.6420.99
143_V158_R0.6420.99
37_E46_P0.6390.99
85_D110_F0.6390.99
97_H246_W0.6380.99
63_I84_L0.6330.99
13_R39_A0.6330.99
77_L104_R0.6320.99
238_V241_G0.6310.99
51_D78_D0.6310.99
132_V146_F0.6290.99
245_T252_L0.6280.99
75_A78_D0.6270.99
244_G268_R0.6260.99
96_S166_H0.6250.99
50_L54_A0.6220.99
248_V252_L0.6190.99
202_V206_W0.6180.99
63_I88_D0.6170.99
75_A79_E0.6140.99
179_L214_S0.6140.99
47_A56_E0.6130.99
30_D33_A0.6110.99
257_P270_G0.6110.99
96_S101_S0.6100.99
8_L16_V0.6100.99
266_S270_G0.6100.99
73_V92_D0.6040.99
29_F50_L0.6030.99
263_Q267_E0.6030.99
73_V100_D0.6030.99
209_G212_I0.6000.99
155_G208_N0.5960.99
123_G128_F0.5940.99
17_D20_L0.5930.99
189_L258_V0.5910.99
178_A264_A0.5910.99
206_W212_I0.5860.99
219_L222_E0.5860.99
30_D72_P0.5860.99
16_V28_A0.5830.99
6_V53_L0.5830.99
207_N217_L0.5830.99
180_M281_F0.5790.99
9_G68_P0.5790.99
71_D74_D0.5780.99
14_I121_P0.5760.99
51_D82_P0.5760.99
146_F150_A0.5750.99
257_P273_S0.5720.99
168_V202_V0.5710.99
115_C146_F0.5710.99
181_Q267_E0.5680.99
98_F167_Y0.5660.99
157_D201_A0.5640.99
197_L202_V0.5620.99
170_M247_T0.5600.99
65_L92_D0.5600.99
132_V156_H0.5590.99
86_S108_H0.5580.99
17_D38_D0.5570.99
136_E139_Y0.5540.98
55_A85_D0.5530.98
2_E56_E0.5530.98
179_L216_L0.5520.98
236_D240_G0.5520.98
36_R39_A0.5440.98
73_V104_R0.5410.98
212_I215_W0.5400.98
204_R221_E0.5400.98
188_E256_V0.5370.98
62_R142_L0.5370.98
2_E60_E0.5340.98
64_W149_V0.5320.98
138_A162_A0.5310.98
18_R22_A0.5310.98
189_L251_A0.5300.98
81_A104_R0.5300.98
91_V146_F0.5290.98
144_P148_A0.5270.98
76_A79_E0.5270.98
174_G189_L0.5260.98
80_L84_L0.5240.98
92_D101_S0.5240.98
164_A167_Y0.5230.98
14_I127_G0.5220.98
239_A269_F0.5220.98
60_E63_I0.5210.98
16_V39_A0.5190.98
50_L79_E0.5180.98
169_K173_N0.5160.98
123_G126_L0.5140.98
130_L146_F0.5140.98
204_R225_R0.5130.98
36_R48_D0.5110.97
137_W141_D0.5100.97
232_G238_V0.5090.97
279_G282_A0.5090.97
50_L53_L0.5060.97
175_V206_W0.5060.97
4_G27_V0.5040.97
231_L234_V0.5040.97
199_L225_R0.5030.97
176_E216_L0.5030.97
145_V148_A0.5020.97
99_E103_R0.5010.97
204_R208_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ckyA 4 0.9443 100 0.401 Contact Map
3obbA 4 0.918 100 0.401 Contact Map
1vpdA 1 0.941 100 0.402 Contact Map
3pduA 4 0.9148 100 0.402 Contact Map
3pefA 5 0.9148 100 0.404 Contact Map
2zydA 2 0.9639 100 0.405 Contact Map
3dojA 3 0.9213 100 0.405 Contact Map
4gbjA 2 0.9344 100 0.406 Contact Map
1yb4A 4 0.9311 100 0.411 Contact Map
3g0oA 3 0.9082 100 0.415 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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