GREMLIN Database
Q9HMG4 - Uncharacterized protein
UniProt: Q9HMG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (174)
Sequences: 12823 (8609)
Seq/√Len: 652.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_D173_R3.0401.00
45_G55_A2.7751.00
4_A40_L2.4761.00
124_R151_D2.4021.00
122_D142_D2.3881.00
121_L126_A2.3031.00
124_R152_G2.2631.00
169_H172_E2.2171.00
177_A181_E2.2081.00
22_V171_V2.1661.00
125_P144_R2.1611.00
38_R58_D2.0711.00
172_E177_A2.0031.00
45_G53_T1.9881.00
11_F48_A1.9491.00
150_D169_H1.8441.00
124_R154_V1.8161.00
147_R165_D1.8111.00
26_A171_V1.7481.00
20_Y24_R1.7431.00
47_T53_T1.7331.00
99_H153_T1.7001.00
133_A137_A1.6751.00
125_P151_D1.6481.00
99_H105_I1.6471.00
107_S156_T1.6401.00
179_L182_Q1.6121.00
124_R153_T1.5981.00
175_C179_L1.5941.00
150_D155_L1.5871.00
104_T173_R1.5471.00
13_E17_I1.5191.00
35_V174_E1.5031.00
126_A143_V1.4991.00
23_F167_A1.4991.00
169_H173_R1.4861.00
9_E47_T1.4781.00
5_V20_Y1.4681.00
22_V187_I1.4661.00
94_R98_L1.4471.00
106_A170_V1.4431.00
157_A162_A1.4381.00
66_L104_T1.4221.00
5_V68_V1.4151.00
53_T57_D1.4061.00
107_S115_L1.3971.00
92_P96_D1.3891.00
136_L141_V1.3861.00
99_H154_V1.3841.00
135_D139_Y1.3751.00
92_P118_A1.3721.00
106_A166_L1.3721.00
176_S179_L1.3711.00
59_V62_G1.3681.00
58_D62_G1.3631.00
116_A143_V1.3601.00
93_E97_T1.3471.00
150_D153_T1.3391.00
42_P88_N1.3231.00
89_E93_E1.3221.00
99_H120_L1.3211.00
98_L103_A1.3211.00
7_L16_A1.3031.00
93_E96_D1.2911.00
119_G122_D1.2731.00
102_G105_I1.2541.00
113_M135_D1.2401.00
61_F90_T1.2371.00
125_P142_D1.2371.00
125_P146_E1.2121.00
7_L39_T1.1921.00
97_T101_G1.1881.00
117_D139_Y1.1641.00
11_F16_A1.1571.00
110_T132_A1.1501.00
65_D103_A1.1421.00
104_T174_E1.1371.00
13_E52_L1.1351.00
3_V66_L1.1121.00
102_G153_T1.1051.00
18_G164_I1.0981.00
14_L18_G1.0951.00
42_P90_T1.0901.00
97_T100_G1.0881.00
6_L91_L1.0811.00
35_V175_C1.0691.00
129_H159_G1.0631.00
18_G167_A1.0551.00
11_F54_V1.0351.00
38_R57_D1.0231.00
180_A184_A1.0181.00
98_L101_G1.0171.00
117_D140_D1.0141.00
135_D138_E1.0091.00
99_H102_G0.9971.00
20_Y39_T0.9901.00
22_V167_A0.9891.00
18_G21_E0.9871.00
68_V106_A0.9871.00
21_E24_R0.9841.00
157_A166_L0.9791.00
41_V56_P0.9771.00
90_T93_E0.9691.00
67_V98_L0.9681.00
45_G56_P0.9671.00
178_G182_Q0.9661.00
92_P117_D0.9621.00
125_P149_V0.9611.00
171_V183_V0.9551.00
131_S186_E0.9471.00
21_E25_T0.9461.00
5_V16_A0.9461.00
66_L174_E0.9441.00
134_D138_E0.9381.00
87_E117_D0.9341.00
172_E180_A0.9251.00
155_L169_H0.9241.00
96_D118_A0.9231.00
58_D63_V0.9231.00
108_V163_G0.9061.00
112_A128_T0.8931.00
20_Y37_M0.8721.00
181_E185_T0.8711.00
68_V166_L0.8611.00
5_V19_P0.8601.00
168_L184_A0.8601.00
42_P60_L0.8581.00
127_A149_V0.8571.00
155_L170_V0.8541.00
104_T153_T0.8531.00
16_A39_T0.8531.00
140_D143_V0.8521.00
136_L140_D0.8501.00
107_S112_A0.8441.00
86_V117_D0.8321.00
155_L166_L0.8271.00
5_V37_M0.8191.00
7_L11_F0.8131.00
95_L114_L0.8121.00
19_P68_V0.8111.00
107_S111_G0.8101.00
34_D175_C0.8091.00
104_T155_L0.8081.00
96_D100_G0.8011.00
9_E43_D0.8001.00
74_W84_S0.7981.00
18_G163_G0.7971.00
27_A34_D0.7901.00
64_P97_T0.7861.00
12_D21_E0.7831.00
132_A135_D0.7801.00
146_E149_V0.7791.00
4_A63_V0.7791.00
66_L106_A0.7771.00
13_E50_H0.7701.00
19_P167_A0.7691.00
94_R97_T0.7681.00
44_E55_A0.7641.00
13_E48_A0.7611.00
160_V187_I0.7601.00
25_T187_I0.7571.00
16_A20_Y0.7501.00
123_G142_D0.7471.00
147_R162_A0.7461.00
105_I115_L0.7451.00
58_D64_P0.7351.00
40_L58_D0.7351.00
88_N91_L0.7351.00
116_A121_L0.7331.00
89_E92_P0.7331.00
155_L173_R0.7301.00
87_E92_P0.7221.00
95_L120_L0.7201.00
69_V111_G0.7171.00
134_D137_A0.7151.00
92_P95_L0.7141.00
10_G47_T0.7121.00
85_E88_N0.7111.00
44_E56_P0.7041.00
128_T143_V0.6931.00
20_Y52_L0.6901.00
69_V95_L0.6881.00
11_F70_P0.6791.00
145_D149_V0.6721.00
130_A159_G0.6661.00
69_V115_L0.6631.00
27_A179_L0.6601.00
158_A162_A0.6591.00
182_Q186_E0.6591.00
73_G76_D0.6591.00
39_T42_P0.6551.00
40_L63_V0.6551.00
126_A141_V0.6471.00
4_A38_R0.6471.00
105_I154_V0.6461.00
84_S87_E0.6461.00
163_G167_A0.6461.00
3_V23_F0.6371.00
113_M132_A0.6371.00
120_L154_V0.6361.00
105_I153_T0.6311.00
7_L56_P0.6301.00
16_A54_V0.6271.00
6_L67_V0.6261.00
26_A179_L0.6251.00
15_D71_G0.6241.00
121_L156_T0.6201.00
35_V39_T0.6191.00
47_T51_G0.6181.00
122_D140_D0.6171.00
19_P163_G0.6131.00
128_T132_A0.6101.00
158_A188_E0.6091.00
19_P108_V0.6091.00
116_A141_V0.6061.00
63_V94_R0.6031.00
89_E96_D0.6001.00
179_L183_V0.5991.00
105_I120_L0.5991.00
126_A136_L0.5981.00
127_A133_A0.5981.00
25_T186_E0.5961.00
15_D160_V0.5941.00
113_M136_L0.5911.00
148_Y169_H0.5871.00
12_D49_R0.5841.00
22_V25_T0.5811.00
4_A94_R0.5731.00
128_T136_L0.5711.00
133_A143_V0.5651.00
98_L102_G0.5591.00
4_A65_D0.5581.00
116_A136_L0.5551.00
18_G22_V0.5541.00
60_L91_L0.5511.00
37_M40_L0.5481.00
72_G114_L0.5401.00
23_F28_E0.5391.00
128_T133_A0.5371.00
158_A165_D0.5371.00
178_G181_E0.5341.00
118_A154_V0.5320.99
96_D120_L0.5320.99
76_D135_D0.5310.99
10_G74_W0.5300.99
161_T164_I0.5290.99
40_L94_R0.5290.99
147_R158_A0.5290.99
67_V94_R0.5280.99
66_L170_V0.5230.99
35_V38_R0.5190.99
26_A183_V0.5180.99
67_V95_L0.5160.99
16_A70_P0.5140.99
13_E16_A0.5130.99
92_P114_L0.5130.99
112_A126_A0.5090.99
115_L118_A0.5080.99
113_M139_Y0.5060.99
5_V23_F0.5040.99
122_D143_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3er6A 2 0.9741 100 0.213 Contact Map
3mgkA 2 0.9378 100 0.216 Contact Map
3graA 2 0.9171 100 0.222 Contact Map
3ewnA 2 0.9275 100 0.223 Contact Map
3noqA 2 0.9275 100 0.229 Contact Map
3bhnA 2 0.9378 100 0.234 Contact Map
4e08A 2 0.9171 100 0.248 Contact Map
2rk3A 2 0.9171 100 0.25 Contact Map
3efeA 2 0.9482 100 0.257 Contact Map
4k2hA 4 0.9119 100 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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