Q9HMG4 - HALSA - GREMLIN Contacts

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Q9HMG4 - Uncharacterized protein

UniProt:	Q9HMG4	Sequences: MDVAVLLFEGFDELDAIGPYEVFRTAAELGGDLDVSMRTLVPDEGVTARHGLTVAPDDVLFGVPDLVVVPGGGWTDRDRPGVWSEVENETLPERLDTLHGGGATIASVCTGAMLLADAGLLDGRPAATHASAADDLAEYDVDVRDERYVDDGTVLTAAGVTAGIDLALHVVERECSAGLAEQVATEIEYASTY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	193 (174)
Sequences:	12823 (8609)
Seq/√Len:	652.7

ECOLI - YAJL YHBO
BACSU - YOAZ YDEA YRAA GS18
HALSA - Q9HMG4
SULSO - Q97Z65

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
150_D	173_R	3.040	1.00
45_G	55_A	2.775	1.00
4_A	40_L	2.476	1.00
124_R	151_D	2.402	1.00
122_D	142_D	2.388	1.00
121_L	126_A	2.303	1.00
124_R	152_G	2.263	1.00
169_H	172_E	2.217	1.00
177_A	181_E	2.208	1.00
22_V	171_V	2.166	1.00
125_P	144_R	2.161	1.00
38_R	58_D	2.071	1.00
172_E	177_A	2.003	1.00
45_G	53_T	1.988	1.00
11_F	48_A	1.949	1.00
150_D	169_H	1.844	1.00
124_R	154_V	1.816	1.00
147_R	165_D	1.811	1.00
26_A	171_V	1.748	1.00
20_Y	24_R	1.743	1.00
47_T	53_T	1.733	1.00
99_H	153_T	1.700	1.00
133_A	137_A	1.675	1.00
125_P	151_D	1.648	1.00
99_H	105_I	1.647	1.00
107_S	156_T	1.640	1.00
179_L	182_Q	1.612	1.00
124_R	153_T	1.598	1.00
175_C	179_L	1.594	1.00
150_D	155_L	1.587	1.00
104_T	173_R	1.547	1.00
13_E	17_I	1.519	1.00
35_V	174_E	1.503	1.00
126_A	143_V	1.499	1.00
23_F	167_A	1.499	1.00
169_H	173_R	1.486	1.00
9_E	47_T	1.478	1.00
5_V	20_Y	1.468	1.00
22_V	187_I	1.466	1.00
94_R	98_L	1.447	1.00
106_A	170_V	1.443	1.00
157_A	162_A	1.438	1.00
66_L	104_T	1.422	1.00
5_V	68_V	1.415	1.00
53_T	57_D	1.406	1.00
107_S	115_L	1.397	1.00
92_P	96_D	1.389	1.00
136_L	141_V	1.386	1.00
99_H	154_V	1.384	1.00
135_D	139_Y	1.375	1.00
92_P	118_A	1.372	1.00
106_A	166_L	1.372	1.00
176_S	179_L	1.371	1.00
59_V	62_G	1.368	1.00
58_D	62_G	1.363	1.00
116_A	143_V	1.360	1.00
93_E	97_T	1.347	1.00
150_D	153_T	1.339	1.00
42_P	88_N	1.323	1.00
89_E	93_E	1.322	1.00
99_H	120_L	1.321	1.00
98_L	103_A	1.321	1.00
7_L	16_A	1.303	1.00
93_E	96_D	1.291	1.00
119_G	122_D	1.273	1.00
102_G	105_I	1.254	1.00
113_M	135_D	1.240	1.00
61_F	90_T	1.237	1.00
125_P	142_D	1.237	1.00
125_P	146_E	1.212	1.00
7_L	39_T	1.192	1.00
97_T	101_G	1.188	1.00
117_D	139_Y	1.164	1.00
11_F	16_A	1.157	1.00
110_T	132_A	1.150	1.00
65_D	103_A	1.142	1.00
104_T	174_E	1.137	1.00
13_E	52_L	1.135	1.00
3_V	66_L	1.112	1.00
102_G	153_T	1.105	1.00
18_G	164_I	1.098	1.00
14_L	18_G	1.095	1.00
42_P	90_T	1.090	1.00
97_T	100_G	1.088	1.00
6_L	91_L	1.081	1.00
35_V	175_C	1.069	1.00
129_H	159_G	1.063	1.00
18_G	167_A	1.055	1.00
11_F	54_V	1.035	1.00
38_R	57_D	1.023	1.00
180_A	184_A	1.018	1.00
98_L	101_G	1.017	1.00
117_D	140_D	1.014	1.00
135_D	138_E	1.009	1.00
99_H	102_G	0.997	1.00
20_Y	39_T	0.990	1.00
22_V	167_A	0.989	1.00
18_G	21_E	0.987	1.00
68_V	106_A	0.987	1.00
21_E	24_R	0.984	1.00
157_A	166_L	0.979	1.00
41_V	56_P	0.977	1.00
90_T	93_E	0.969	1.00
67_V	98_L	0.968	1.00
45_G	56_P	0.967	1.00
178_G	182_Q	0.966	1.00
92_P	117_D	0.962	1.00
125_P	149_V	0.961	1.00
171_V	183_V	0.955	1.00
131_S	186_E	0.947	1.00
21_E	25_T	0.946	1.00
5_V	16_A	0.946	1.00
66_L	174_E	0.944	1.00
134_D	138_E	0.938	1.00
87_E	117_D	0.934	1.00
172_E	180_A	0.925	1.00
155_L	169_H	0.924	1.00
96_D	118_A	0.923	1.00
58_D	63_V	0.923	1.00
108_V	163_G	0.906	1.00
112_A	128_T	0.893	1.00
20_Y	37_M	0.872	1.00
181_E	185_T	0.871	1.00
68_V	166_L	0.861	1.00
5_V	19_P	0.860	1.00
168_L	184_A	0.860	1.00
42_P	60_L	0.858	1.00
127_A	149_V	0.857	1.00
155_L	170_V	0.854	1.00
104_T	153_T	0.853	1.00
16_A	39_T	0.853	1.00
140_D	143_V	0.852	1.00
136_L	140_D	0.850	1.00
107_S	112_A	0.844	1.00
86_V	117_D	0.832	1.00
155_L	166_L	0.827	1.00
5_V	37_M	0.819	1.00
7_L	11_F	0.813	1.00
95_L	114_L	0.812	1.00
19_P	68_V	0.811	1.00
107_S	111_G	0.810	1.00
34_D	175_C	0.809	1.00
104_T	155_L	0.808	1.00
96_D	100_G	0.801	1.00
9_E	43_D	0.800	1.00
74_W	84_S	0.798	1.00
18_G	163_G	0.797	1.00
27_A	34_D	0.790	1.00
64_P	97_T	0.786	1.00
12_D	21_E	0.783	1.00
132_A	135_D	0.780	1.00
146_E	149_V	0.779	1.00
4_A	63_V	0.779	1.00
66_L	106_A	0.777	1.00
13_E	50_H	0.770	1.00
19_P	167_A	0.769	1.00
94_R	97_T	0.768	1.00
44_E	55_A	0.764	1.00
13_E	48_A	0.761	1.00
160_V	187_I	0.760	1.00
25_T	187_I	0.757	1.00
16_A	20_Y	0.750	1.00
123_G	142_D	0.747	1.00
147_R	162_A	0.746	1.00
105_I	115_L	0.745	1.00
58_D	64_P	0.735	1.00
40_L	58_D	0.735	1.00
88_N	91_L	0.735	1.00
116_A	121_L	0.733	1.00
89_E	92_P	0.733	1.00
155_L	173_R	0.730	1.00
87_E	92_P	0.722	1.00
95_L	120_L	0.720	1.00
69_V	111_G	0.717	1.00
134_D	137_A	0.715	1.00
92_P	95_L	0.714	1.00
10_G	47_T	0.712	1.00
85_E	88_N	0.711	1.00
44_E	56_P	0.704	1.00
128_T	143_V	0.693	1.00
20_Y	52_L	0.690	1.00
69_V	95_L	0.688	1.00
11_F	70_P	0.679	1.00
145_D	149_V	0.672	1.00
130_A	159_G	0.666	1.00
69_V	115_L	0.663	1.00
27_A	179_L	0.660	1.00
158_A	162_A	0.659	1.00
182_Q	186_E	0.659	1.00
73_G	76_D	0.659	1.00
39_T	42_P	0.655	1.00
40_L	63_V	0.655	1.00
126_A	141_V	0.647	1.00
4_A	38_R	0.647	1.00
105_I	154_V	0.646	1.00
84_S	87_E	0.646	1.00
163_G	167_A	0.646	1.00
3_V	23_F	0.637	1.00
113_M	132_A	0.637	1.00
120_L	154_V	0.636	1.00
105_I	153_T	0.631	1.00
7_L	56_P	0.630	1.00
16_A	54_V	0.627	1.00
6_L	67_V	0.626	1.00
26_A	179_L	0.625	1.00
15_D	71_G	0.624	1.00
121_L	156_T	0.620	1.00
35_V	39_T	0.619	1.00
47_T	51_G	0.618	1.00
122_D	140_D	0.617	1.00
19_P	163_G	0.613	1.00
128_T	132_A	0.610	1.00
158_A	188_E	0.609	1.00
19_P	108_V	0.609	1.00
116_A	141_V	0.606	1.00
63_V	94_R	0.603	1.00
89_E	96_D	0.600	1.00
179_L	183_V	0.599	1.00
105_I	120_L	0.599	1.00
126_A	136_L	0.598	1.00
127_A	133_A	0.598	1.00
25_T	186_E	0.596	1.00
15_D	160_V	0.594	1.00
113_M	136_L	0.591	1.00
148_Y	169_H	0.587	1.00
12_D	49_R	0.584	1.00
22_V	25_T	0.581	1.00
4_A	94_R	0.573	1.00
128_T	136_L	0.571	1.00
133_A	143_V	0.565	1.00
98_L	102_G	0.559	1.00
4_A	65_D	0.558	1.00
116_A	136_L	0.555	1.00
18_G	22_V	0.554	1.00
60_L	91_L	0.551	1.00
37_M	40_L	0.548	1.00
72_G	114_L	0.540	1.00
23_F	28_E	0.539	1.00
128_T	133_A	0.537	1.00
158_A	165_D	0.537	1.00
178_G	181_E	0.534	1.00
118_A	154_V	0.532	0.99
96_D	120_L	0.532	0.99
76_D	135_D	0.531	0.99
10_G	74_W	0.530	0.99
161_T	164_I	0.529	0.99
40_L	94_R	0.529	0.99
147_R	158_A	0.529	0.99
67_V	94_R	0.528	0.99
66_L	170_V	0.523	0.99
35_V	38_R	0.519	0.99
26_A	183_V	0.518	0.99
67_V	95_L	0.516	0.99
16_A	70_P	0.514	0.99
13_E	16_A	0.513	0.99
92_P	114_L	0.513	0.99
112_A	126_A	0.509	0.99
115_L	118_A	0.508	0.99
113_M	139_Y	0.506	0.99
5_V	23_F	0.504	0.99
122_D	143_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3er6A	2	0.9741	100	0.213	Contact Map
3mgkA	2	0.9378	100	0.216	Contact Map
3graA	2	0.9171	100	0.222	Contact Map
3ewnA	2	0.9275	100	0.223	Contact Map
3noqA	2	0.9275	100	0.229	Contact Map
3bhnA	2	0.9378	100	0.234	Contact Map
4e08A	2	0.9171	100	0.248	Contact Map
2rk3A	2	0.9171	100	0.25	Contact Map
3efeA	2	0.9482	100	0.257	Contact Map
4k2hA	4	0.9119	100	0.262	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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