GREMLIN Database
Q9HMG3 - Uncharacterized protein
UniProt: Q9HMG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (164)
Sequences: 2437 (1847)
Seq/√Len: 144.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_E181_T4.8791.00
143_G175_T4.7011.00
116_E124_D4.3601.00
145_V173_M4.0261.00
165_D169_E3.9341.00
123_V134_Q3.2771.00
149_E182_A3.0881.00
155_I178_A3.0101.00
118_I184_F2.7311.00
64_G70_G2.5161.00
147_D185_S2.3931.00
144_R172_Y2.3121.00
100_E109_T2.3051.00
122_G129_L2.1631.00
156_R181_T2.1241.00
60_G64_G2.0521.00
158_S179_H2.0371.00
102_E107_G1.9961.00
53_E57_R1.9661.00
36_Q40_E1.9071.00
46_V51_F1.8811.00
36_Q65_A1.8321.00
117_S120_D1.8301.00
60_G76_L1.8031.00
46_V49_T1.7491.00
47_P51_F1.7181.00
98_Y111_E1.6461.00
103_Y122_G1.6411.00
61_G65_A1.6271.00
142_S172_Y1.6141.00
103_Y106_E1.6141.00
112_V121_A1.6111.00
113_A116_E1.5941.00
35_A38_V1.5761.00
45_T49_T1.5161.00
129_L175_T1.4971.00
99_Y105_K1.4841.00
37_D40_E1.4711.00
104_V107_G1.4591.00
55_Y177_T1.4471.00
123_V131_Y1.3991.00
58_S62_G1.3981.00
57_R76_L1.3941.00
48_E51_F1.3651.00
46_V50_D1.3331.00
60_G74_S1.3331.00
157_H168_I1.3301.00
108_E127_W1.3011.00
40_E66_G1.2911.00
145_V155_I1.2761.00
137_Q140_S1.2361.00
119_L131_Y1.2331.00
156_R179_H1.2141.00
167_E171_G1.2141.00
56_N74_S1.1871.00
173_M178_A1.1861.00
110_I125_E1.1661.00
57_R74_S1.1561.00
54_P58_S1.1521.00
38_V42_R1.1420.99
80_E83_D1.1120.99
160_N168_I1.0970.99
25_G28_K1.0810.99
32_E35_A1.0720.99
99_Y107_G1.0200.99
163_L167_E0.9960.99
143_G186_I0.9940.99
171_G174_L0.9840.98
99_Y104_V0.9810.98
45_T48_E0.9560.98
160_N177_T0.9540.98
83_D86_F0.9480.98
163_L171_G0.9450.98
102_E109_T0.9440.98
68_V72_A0.9410.98
119_L123_V0.9290.98
128_D131_Y0.9250.98
157_H177_T0.9220.98
155_I184_F0.9150.97
64_G72_A0.9140.97
25_G29_P0.9130.97
27_S30_P0.9070.97
101_I122_G0.9050.97
116_E121_A0.9020.97
110_I121_A0.8960.97
36_Q61_G0.8960.97
34_I55_Y0.8900.97
22_L27_S0.8880.97
58_S61_G0.8730.97
139_V162_S0.8720.97
140_S143_G0.8700.97
165_D168_I0.8680.97
120_D134_Q0.8670.96
159_N162_S0.8650.96
50_D73_E0.8580.96
112_V180_P0.8440.96
147_D183_S0.8390.96
157_H160_N0.8370.96
104_V185_S0.8370.96
38_V41_H0.8370.96
145_V179_H0.8340.96
62_G65_A0.8320.96
86_F96_V0.8300.95
110_I113_A0.8240.95
54_P59_I0.8120.95
117_S134_Q0.8090.95
85_G88_P0.8060.95
43_A46_V0.8010.95
19_V22_L0.7990.94
164_G177_T0.7990.94
101_I121_A0.7950.94
130_P160_N0.7850.94
147_D184_F0.7830.94
45_T51_F0.7740.93
99_Y182_A0.7740.93
121_A134_Q0.7680.93
63_G72_A0.7650.93
135_Q160_N0.7620.93
53_E56_N0.7610.93
22_L25_G0.7580.93
17_F22_L0.7560.93
61_G64_G0.7550.93
87_D91_I0.7530.93
117_S122_G0.7530.93
116_E120_D0.7450.92
120_D123_V0.7440.92
51_F63_G0.7380.92
112_V118_I0.7340.92
39_L62_G0.7300.91
139_V143_G0.7290.91
40_E65_A0.7250.91
118_I173_M0.7250.91
134_Q161_E0.7230.91
53_E79_G0.7230.91
137_Q164_G0.7210.91
98_Y109_T0.7150.90
57_R61_G0.7140.90
47_P50_D0.7120.90
22_L26_S0.7110.90
159_N177_T0.7090.90
172_Y175_T0.7070.90
178_A182_A0.7050.90
97_E183_S0.7010.90
80_E84_D0.6950.89
28_K31_A0.6940.89
59_I66_G0.6890.89
113_A121_A0.6890.89
56_N76_L0.6840.88
167_E172_Y0.6760.88
16_L19_V0.6750.88
100_E111_E0.6730.88
93_D96_V0.6710.87
44_S66_G0.6710.87
180_P185_S0.6700.87
142_S167_E0.6670.87
103_Y110_I0.6640.87
24_K57_R0.6630.87
36_Q62_G0.6610.87
87_D95_D0.6610.87
122_G180_P0.6580.86
33_D38_V0.6550.86
90_A93_D0.6520.86
143_G177_T0.6510.86
55_Y58_S0.6490.86
23_A27_S0.6470.86
45_T50_D0.6460.85
19_V132_A0.6450.85
39_L44_S0.6420.85
143_G146_A0.6420.85
128_D164_G0.6350.84
132_A172_Y0.6310.84
49_T72_A0.6310.84
25_G30_P0.6270.84
140_S157_H0.6250.84
155_I180_P0.6230.83
70_G165_D0.6230.83
162_S166_A0.6210.83
88_P92_A0.6210.83
157_H173_M0.6170.83
163_L168_I0.6170.83
91_I94_D0.6150.83
28_K32_E0.6150.83
60_G70_G0.6140.82
134_Q139_V0.6120.82
91_I95_D0.6120.82
63_G122_G0.6100.82
88_P94_D0.6070.82
23_A26_S0.6050.82
99_Y110_I0.6050.82
98_Y102_E0.6040.81
94_D111_E0.6010.81
58_S81_E0.6010.81
91_I97_E0.5910.80
22_L29_P0.5870.80
100_E107_G0.5850.79
126_G132_A0.5850.79
55_Y112_V0.5830.79
161_E164_G0.5780.79
122_G162_S0.5750.78
56_N161_E0.5740.78
140_S180_P0.5720.78
96_V111_E0.5680.77
167_E170_E0.5680.77
102_E185_S0.5680.77
18_V25_G0.5670.77
36_Q66_G0.5670.77
29_P35_A0.5640.77
123_V135_Q0.5640.77
35_A144_R0.5580.76
56_N77_E0.5580.76
32_E63_G0.5530.75
161_E168_I0.5510.75
39_L59_I0.5490.75
63_G68_V0.5470.75
106_E170_E0.5460.75
115_N121_A0.5450.74
97_E107_G0.5410.74
143_G178_A0.5400.74
135_Q140_S0.5380.73
132_A175_T0.5380.73
76_L177_T0.5360.73
118_I178_A0.5340.73
132_A135_Q0.5340.73
161_E165_D0.5310.73
62_G66_G0.5310.73
33_D54_P0.5280.72
18_V22_L0.5240.72
46_V61_G0.5230.71
64_G95_D0.5220.71
124_D147_D0.5220.71
17_F25_G0.5200.71
44_S48_E0.5170.71
59_I62_G0.5170.71
28_K33_D0.5140.70
34_I59_I0.5120.70
117_S179_H0.5110.70
43_A66_G0.5080.69
96_V113_A0.5060.69
174_L177_T0.5040.69
122_G140_S0.5020.68
142_S146_A0.5010.68
112_V134_Q0.5010.68
102_E106_E0.5010.68
159_N163_L0.5000.68
97_E104_V0.5000.68
31_A34_I0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2piaA 1 0.8281 100 0.481 Contact Map
3zyyX 2 0.4688 99.9 0.582 Contact Map
4n58A 4 0.4688 99.9 0.589 Contact Map
1doiA 5 0.599 99.9 0.608 Contact Map
1qoaA 1 0.474 99.9 0.609 Contact Map
1iueA 1 0.474 99.9 0.61 Contact Map
1frdA 1 0.474 99.8 0.612 Contact Map
1frrA 1 0.4688 99.8 0.614 Contact Map
1wriA 1 0.4635 99.8 0.615 Contact Map
1a70A 1 0.474 99.8 0.615 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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