Q9HMG3 - HALSA - GREMLIN Contacts

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Q9HMG3 - Uncharacterized protein

UniProt:	Q9HMG3	Sequences: MVTTLGVTLGLGVTLLFVVLHLAKGSSKPPAEDIAQDVLEHRASTVPETDFPEPYNRSIGGGGGAGAVAGGAESELEDGEEEDDGFDPDAIADDDVEYYEIEYVKEGETIEVASNESILDAGVDEGWDLPYACQQGQCVSCSGRVADGEDAAEYIRHSNNESLGDAEIEEGYMLTCTAHPTASFSIETDETP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	192 (164)
Sequences:	2437 (1847)
Seq/√Len:	144.2

ECOLI - PAAE YEAX HCR
HALSA - Q9HMG3 FER

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_E	181_T	4.879	1.00
143_G	175_T	4.701	1.00
116_E	124_D	4.360	1.00
145_V	173_M	4.026	1.00
165_D	169_E	3.934	1.00
123_V	134_Q	3.277	1.00
149_E	182_A	3.088	1.00
155_I	178_A	3.010	1.00
118_I	184_F	2.731	1.00
64_G	70_G	2.516	1.00
147_D	185_S	2.393	1.00
144_R	172_Y	2.312	1.00
100_E	109_T	2.305	1.00
122_G	129_L	2.163	1.00
156_R	181_T	2.124	1.00
60_G	64_G	2.052	1.00
158_S	179_H	2.037	1.00
102_E	107_G	1.996	1.00
53_E	57_R	1.966	1.00
36_Q	40_E	1.907	1.00
46_V	51_F	1.881	1.00
36_Q	65_A	1.832	1.00
117_S	120_D	1.830	1.00
60_G	76_L	1.803	1.00
46_V	49_T	1.749	1.00
47_P	51_F	1.718	1.00
98_Y	111_E	1.646	1.00
103_Y	122_G	1.641	1.00
61_G	65_A	1.627	1.00
142_S	172_Y	1.614	1.00
103_Y	106_E	1.614	1.00
112_V	121_A	1.611	1.00
113_A	116_E	1.594	1.00
35_A	38_V	1.576	1.00
45_T	49_T	1.516	1.00
129_L	175_T	1.497	1.00
99_Y	105_K	1.484	1.00
37_D	40_E	1.471	1.00
104_V	107_G	1.459	1.00
55_Y	177_T	1.447	1.00
123_V	131_Y	1.399	1.00
58_S	62_G	1.398	1.00
57_R	76_L	1.394	1.00
48_E	51_F	1.365	1.00
46_V	50_D	1.333	1.00
60_G	74_S	1.333	1.00
157_H	168_I	1.330	1.00
108_E	127_W	1.301	1.00
40_E	66_G	1.291	1.00
145_V	155_I	1.276	1.00
137_Q	140_S	1.236	1.00
119_L	131_Y	1.233	1.00
156_R	179_H	1.214	1.00
167_E	171_G	1.214	1.00
56_N	74_S	1.187	1.00
173_M	178_A	1.186	1.00
110_I	125_E	1.166	1.00
57_R	74_S	1.156	1.00
54_P	58_S	1.152	1.00
38_V	42_R	1.142	0.99
80_E	83_D	1.112	0.99
160_N	168_I	1.097	0.99
25_G	28_K	1.081	0.99
32_E	35_A	1.072	0.99
99_Y	107_G	1.020	0.99
163_L	167_E	0.996	0.99
143_G	186_I	0.994	0.99
171_G	174_L	0.984	0.98
99_Y	104_V	0.981	0.98
45_T	48_E	0.956	0.98
160_N	177_T	0.954	0.98
83_D	86_F	0.948	0.98
163_L	171_G	0.945	0.98
102_E	109_T	0.944	0.98
68_V	72_A	0.941	0.98
119_L	123_V	0.929	0.98
128_D	131_Y	0.925	0.98
157_H	177_T	0.922	0.98
155_I	184_F	0.915	0.97
64_G	72_A	0.914	0.97
25_G	29_P	0.913	0.97
27_S	30_P	0.907	0.97
101_I	122_G	0.905	0.97
116_E	121_A	0.902	0.97
110_I	121_A	0.896	0.97
36_Q	61_G	0.896	0.97
34_I	55_Y	0.890	0.97
22_L	27_S	0.888	0.97
58_S	61_G	0.873	0.97
139_V	162_S	0.872	0.97
140_S	143_G	0.870	0.97
165_D	168_I	0.868	0.97
120_D	134_Q	0.867	0.96
159_N	162_S	0.865	0.96
50_D	73_E	0.858	0.96
112_V	180_P	0.844	0.96
147_D	183_S	0.839	0.96
157_H	160_N	0.837	0.96
104_V	185_S	0.837	0.96
38_V	41_H	0.837	0.96
145_V	179_H	0.834	0.96
62_G	65_A	0.832	0.96
86_F	96_V	0.830	0.95
110_I	113_A	0.824	0.95
54_P	59_I	0.812	0.95
117_S	134_Q	0.809	0.95
85_G	88_P	0.806	0.95
43_A	46_V	0.801	0.95
19_V	22_L	0.799	0.94
164_G	177_T	0.799	0.94
101_I	121_A	0.795	0.94
130_P	160_N	0.785	0.94
147_D	184_F	0.783	0.94
45_T	51_F	0.774	0.93
99_Y	182_A	0.774	0.93
121_A	134_Q	0.768	0.93
63_G	72_A	0.765	0.93
135_Q	160_N	0.762	0.93
53_E	56_N	0.761	0.93
22_L	25_G	0.758	0.93
17_F	22_L	0.756	0.93
61_G	64_G	0.755	0.93
87_D	91_I	0.753	0.93
117_S	122_G	0.753	0.93
116_E	120_D	0.745	0.92
120_D	123_V	0.744	0.92
51_F	63_G	0.738	0.92
112_V	118_I	0.734	0.92
39_L	62_G	0.730	0.91
139_V	143_G	0.729	0.91
40_E	65_A	0.725	0.91
118_I	173_M	0.725	0.91
134_Q	161_E	0.723	0.91
53_E	79_G	0.723	0.91
137_Q	164_G	0.721	0.91
98_Y	109_T	0.715	0.90
57_R	61_G	0.714	0.90
47_P	50_D	0.712	0.90
22_L	26_S	0.711	0.90
159_N	177_T	0.709	0.90
172_Y	175_T	0.707	0.90
178_A	182_A	0.705	0.90
97_E	183_S	0.701	0.90
80_E	84_D	0.695	0.89
28_K	31_A	0.694	0.89
59_I	66_G	0.689	0.89
113_A	121_A	0.689	0.89
56_N	76_L	0.684	0.88
167_E	172_Y	0.676	0.88
16_L	19_V	0.675	0.88
100_E	111_E	0.673	0.88
93_D	96_V	0.671	0.87
44_S	66_G	0.671	0.87
180_P	185_S	0.670	0.87
142_S	167_E	0.667	0.87
103_Y	110_I	0.664	0.87
24_K	57_R	0.663	0.87
36_Q	62_G	0.661	0.87
87_D	95_D	0.661	0.87
122_G	180_P	0.658	0.86
33_D	38_V	0.655	0.86
90_A	93_D	0.652	0.86
143_G	177_T	0.651	0.86
55_Y	58_S	0.649	0.86
23_A	27_S	0.647	0.86
45_T	50_D	0.646	0.85
19_V	132_A	0.645	0.85
39_L	44_S	0.642	0.85
143_G	146_A	0.642	0.85
128_D	164_G	0.635	0.84
132_A	172_Y	0.631	0.84
49_T	72_A	0.631	0.84
25_G	30_P	0.627	0.84
140_S	157_H	0.625	0.84
155_I	180_P	0.623	0.83
70_G	165_D	0.623	0.83
162_S	166_A	0.621	0.83
88_P	92_A	0.621	0.83
157_H	173_M	0.617	0.83
163_L	168_I	0.617	0.83
91_I	94_D	0.615	0.83
28_K	32_E	0.615	0.83
60_G	70_G	0.614	0.82
134_Q	139_V	0.612	0.82
91_I	95_D	0.612	0.82
63_G	122_G	0.610	0.82
88_P	94_D	0.607	0.82
23_A	26_S	0.605	0.82
99_Y	110_I	0.605	0.82
98_Y	102_E	0.604	0.81
94_D	111_E	0.601	0.81
58_S	81_E	0.601	0.81
91_I	97_E	0.591	0.80
22_L	29_P	0.587	0.80
100_E	107_G	0.585	0.79
126_G	132_A	0.585	0.79
55_Y	112_V	0.583	0.79
161_E	164_G	0.578	0.79
122_G	162_S	0.575	0.78
56_N	161_E	0.574	0.78
140_S	180_P	0.572	0.78
96_V	111_E	0.568	0.77
167_E	170_E	0.568	0.77
102_E	185_S	0.568	0.77
18_V	25_G	0.567	0.77
36_Q	66_G	0.567	0.77
29_P	35_A	0.564	0.77
123_V	135_Q	0.564	0.77
35_A	144_R	0.558	0.76
56_N	77_E	0.558	0.76
32_E	63_G	0.553	0.75
161_E	168_I	0.551	0.75
39_L	59_I	0.549	0.75
63_G	68_V	0.547	0.75
106_E	170_E	0.546	0.75
115_N	121_A	0.545	0.74
97_E	107_G	0.541	0.74
143_G	178_A	0.540	0.74
135_Q	140_S	0.538	0.73
132_A	175_T	0.538	0.73
76_L	177_T	0.536	0.73
118_I	178_A	0.534	0.73
132_A	135_Q	0.534	0.73
161_E	165_D	0.531	0.73
62_G	66_G	0.531	0.73
33_D	54_P	0.528	0.72
18_V	22_L	0.524	0.72
46_V	61_G	0.523	0.71
64_G	95_D	0.522	0.71
124_D	147_D	0.522	0.71
17_F	25_G	0.520	0.71
44_S	48_E	0.517	0.71
59_I	62_G	0.517	0.71
28_K	33_D	0.514	0.70
34_I	59_I	0.512	0.70
117_S	179_H	0.511	0.70
43_A	66_G	0.508	0.69
96_V	113_A	0.506	0.69
174_L	177_T	0.504	0.69
122_G	140_S	0.502	0.68
142_S	146_A	0.501	0.68
112_V	134_Q	0.501	0.68
102_E	106_E	0.501	0.68
159_N	163_L	0.500	0.68
97_E	104_V	0.500	0.68
31_A	34_I	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2piaA	1	0.8281	100	0.481	Contact Map
3zyyX	2	0.4688	99.9	0.582	Contact Map
4n58A	4	0.4688	99.9	0.589	Contact Map
1doiA	5	0.599	99.9	0.608	Contact Map
1qoaA	1	0.474	99.9	0.609	Contact Map
1iueA	1	0.474	99.9	0.61	Contact Map
1frdA	1	0.474	99.8	0.612	Contact Map
1frrA	1	0.4688	99.8	0.614	Contact Map
1wriA	1	0.4635	99.8	0.615	Contact Map
1a70A	1	0.474	99.8	0.615	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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